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NHLBI Catalyze RFA-HL-26-019: Product Definition for Medical Devices, Diagnostics and Research Tools
Deadline: February 11th, 2027
Budget: Up to $300k/yr direct costs, up to 3 years
Description: NHLBI funds early-stage medical device, diagnostic assay, and research tool prototypes for heart, lung, blood, and sleep disorders. See funding fit, focus areas, and how to apply via the Catalyze R61/R33 program.
NIH Highlighted Topic: Leveraging All of Us Biospecimens to Advance Precision Medicine Research
Deadline: January 5 and April 5, 2027
Budget: Up to $700k Phase I, up to $3m Phase II
Description: More than 20 NIH Institutes and Offices highlight multiomic and biomarker research using All of Us biospecimens. See funding fit, focus areas, and how to apply via NIH SBIR.
NIH Highlighted Topic: Advancing Precision Research for Lung Cancer in Never Smokers and Its Risk Factors
Deadline: January 5 and April 5, 2027
Budget: Up to $700k Phase I, up to $2.5m Phase II
Description: NCI, NIEHS, and NIMHD highlight precision research on lung cancer in never smokers, from risk factors to early detection and therapy. See funding fit, focus areas, and how to apply via NIH SBIR.
NIH Highlighted Topic: Intergenerational Interventions to Promote Health and Reduce Risk for Chronic Disease
Deadline: January 5 and April 5, 2027
Budget: Up to $700k Phase I, up to $3m Phase II
Description: NCI, NHLBI, NIMH, NIDA, NIAAA, NINR, and other NIH Institutes highlight preventive interventions that work across two or more generations. See funding fit, focus areas, and how to apply via NIH SBIR.
Army SBIR ARM27BX01-DP001: G-TEAD USAREUR-AF ACE 27-02: Spectrum Enabled Warfare Powered by xTech
Deadline: October 23, 2026 (xTech white paper)
Funding Award Size: $2m
Description: Army xTech competition and Direct to Phase II topic for electromagnetic spectrum operations on NATO's Eastern Flank. White papers due October 23, 2026. See funding fit and how to apply.
OSW SBIR OSW27BZ01-NV001: Counter-Unmanned Aerial Systems Rapid Maturation
Deadline: November 25, 2026
Funding Award Size: $300k
Description: OSW Phase I topic for counter-UAS detection, identification, and defeat against Group 1 and 2 drones, with a 2 page technical volume. See funding fit and how to apply via DSIP.
OSW SBIR OSW27BZ01-DV002: Counter-Unmanned Aerial Systems Rapid Maturation
Deadline: November 25, 2026
Funding Award Size: $2m
Description: OSW Direct to Phase II topic to mature counter-UAS detection, identification, and defeat technology against Group 1 and 2 drones in 12 months. See funding fit and how to apply via DSIP.
Navy SBIR DON27BZ01-NV005: Intermediate Temperature Cooling Unit
Deadline: November 25, 2026
Funding Award Size: $315k
Description: Navy Phase I topic for a compact 65 F intermediate temperature cooling unit to cool DDG 51 electronics more efficiently. See funding fit and how to apply via DSIP.
Navy SBIR DON27BZ01-NV004: Input-Output Unit (IOU) for Secure Processing and Routing of Hull, Mechanical, & Electrical (HM&E) and Navigation Signals
Deadline: November 25, 2026
Funding Award Size: $315k
Description: Navy Phase I topic for an IP54 rugged input-output unit that routes legacy HM&E and navigation signals over redundant shipboard Ethernet. See funding fit and how to apply via DSIP.
Navy SBIR DON27BZ01-NV003: Improved Cargo Door Actuator
Deadline: November 25, 2026
Funding Award Size: $315k
Description: Navy Phase I topic for a corrosion-resistant cargo door actuator for DDG 51 destroyers. See funding fit, design constraints, and how to apply via DSIP.
Navy SBIR DON27BZ01-NV002: Fire Resistant Joiner Bulkhead
Deadline: November 25, 2026
Funding Award Size: $315k
Description: Navy Phase I topic for a lightweight, fire-resistant joiner bulkhead that improves compartment fire containment on ships. See funding fit, constraints, and how to apply via DSIP.
Navy SBIR DON27BZ01-NV001: Cleaner for the Time Domain Reflectometer Tank Level Indicator
Deadline: November 25, 2026
Funding Award Size: $315k
Description: Navy Phase I topic to clean fouled TDR tank level sensors in place on DDG 51 destroyers without defueling. See funding fit, phases, and how to apply via DSIP.
Navy SBIR DON27BX01-NP001: ONR Open Topic for Low-Cost Heads Up Displays (HUDs) for Virtual & Augmented Reality (VR/AR)
Deadline: November 25, 2026
Funding Award Size: $315k
Description: ONR Phase I open topic for low-cost, NDAA-compliant heads-up displays with 6DOF tracking for FPV drone pilots and forward observers. See funding fit and how to apply via DSIP.
DAF STTR DAF27TZ01-DV003: Fusion of Cooperative Information Sharing for Uncrewed Air Systems (FOCISAUS)
Deadline: November 25, 2026
Funding Award Size: $2m
Description: Air Force STTR Direct to Phase II topic for cooperative perception and sensor fusion across uncrewed air systems under tight bandwidth. See funding fit and how to apply via DSIP.
DAF STTR DAF27TZ01-DV002: Cyber Resiliency for Fog and Edge Computing Devices
Deadline: November 25, 2026
Funding Award Size: $2m
Description: Air Force STTR Direct to Phase II topic to make fog and edge computing devices resilient to cyber attack in contested environments. See funding fit and how to apply via DSIP.
DAF STTR DAF27TZ01-DV001: AI-Enabled Computed Vision Air-to-Air Refueling Performance Assessment and Automated Pilot Debrief System
Deadline: November 25, 2026
Funding Award Size: $2m
Description: Air Force STTR Direct to Phase II topic for AI computer vision that scores aerial refueling performance and automates pilot debriefs. See funding fit, tasks, and how to apply via DSIP.
DAF SBIR DAF27BZ01-NV006: High Speed, Low Temperature Hyperspectral Imager for High Enthalpy Ground Testing
Deadline: November 25, 2026
Funding Award Size: $300k
Description: Air Force Phase I topic for a fast, low-temperature hyperspectral imager to measure surface temperature and emissivity in high enthalpy testing. See funding fit and how to apply via DSIP.
DAF SBIR DAF27BZ01-NV005: Luminescence-Based Surface Measurement Technique for Simultaneous Pressure and Temperature Measurements within Non-Oxygen Based Hypersonic Ground Test Facilities
Deadline: November 25, 2026
Funding Award Size: $300k
Description: Air Force Phase I topic for a luminescent paint technique that measures pressure and temperature in nitrogen hypersonic wind tunnels. See funding fit, phases, and how to apply via DSIP.
DAF SBIR DAF27BZ01-NV004: Long Rod Delivery System
Deadline: November 25, 2026
Funding Award Size: $300k
Description: Air Force Phase I topic for a precise launcher that fires long rod projectiles at 1,400 to 2,300+ m/s with controlled orientation for live fire testing. See funding fit and how to apply via DSIP.
DAF SBIR DAF27BZ01-NV003: Multiple Telemetry Site Signal Source Synchronization
Deadline: November 25, 2026
Funding Award Size: $300k
Description: Air Force Phase I topic to synchronize telemetry signal simulators across multiple range sites for end-to-end pre-flight checks. See funding fit, phases, and how to apply via DSIP.