ARPA-H STREAM Program: Funding, Deadline, and How to Apply
Below is a brief summary. Please check the full solicitation before applying (link in resources section).
Quick Answer
The STREAM program (Systems for Tracking and Resilience in Efficient Agricultural-input Management) is an ARPA-H research initiative that funds breakthrough technology to control weeds while reducing herbicide exposure for farmers, farm workers, consumers, and the environment. Launched by the Department of Health and Human Services through ARPA-H on August 17, 2026, STREAM seeks solutions across four technical areas: next-generation herbicides and formulations, precision and nonchemical weed control, low-cost chemical monitoring, and methods to remove or degrade herbicides in soil and water. Applications are made as Solution Summaries through the Scalable Solutions Office Innovative Solutions Opening (ISO), notice ID ARPA-H-SOL-24-105, which is posted and maintained on SAM.gov. Solution Summaries that select STREAM are due no later than September 14, 2026 at 11:59 pm ET. STREAM is funded through Other Transactions rather than SBIR or STTR grants, so awards are negotiated per project and there is no fixed application dollar cap published in the announcement.
Program Overview
STREAM is ARPA-H's push to modernize American agriculture at the intersection of crop chemistry and human health. Herbicides keep food affordable, support regenerative farming, and help farmers stay productive, but some herbicides and their formulation ingredients can affect people, animals, fish, and pollinators. Farmers, farm workers, and consumers are exposed through food, water, soil, and air, while weeds grow more resistant and off-target runoff harms nearby habitats and rural communities. Alternatives have been sought for years without resolving the core tradeoff between efficacy, health, safety, ecological impact, soil dynamics, and cost.
STREAM aims to close that gap. The program funds safer alternative crop protection formulations, better monitoring of where herbicides travel, and practical ways to break down or remove agricultural chemicals before they reach consumers. If it succeeds, STREAM will lower the cumulative chemical burden on consumers and agricultural workers, protect the soil and water the food supply depends on, and give farmers economically viable alternatives to the products they rely on today.
The program is one piece of a broader interagency commitment. HHS, the U.S. Department of Agriculture, and the U.S. Environmental Protection Agency have pledged to invest more than one billion dollars in farm modernization and long-term food security, and STREAM advances that effort along with the federal push toward regenerative agriculture. That one billion dollar figure is the joint interagency envelope, not a single STREAM award pool, so applicants should not read it as a per-project budget.
What ARPA-H Is Looking For
STREAM is organized around four coordinated technical areas. A submission must address one or more of these areas to be considered, and ARPA-H encourages interdisciplinary teams drawn from agricultural and weed sciences, artificial intelligence and machine learning, advanced chemistry, drone development, sensing, and related fields.
Technical Area 1: Next-generation herbicides and formulations. Use artificial intelligence and machine learning to discover novel chemical compounds, biologically derived herbicides, and advanced biological treatments that selectively target weeds, including resistant species, while minimizing impacts on the surrounding ecosystem. The goal is efficacy against hard-to-kill weeds without the collateral health and environmental cost of current products.
Technical Area 2: Precision and nonchemical weed control. Advance cost-effective physical weed-control approaches such as laser ablation and miniature autonomous weeders, machine vision-guided targeted herbicide application, real-time drift modeling, and U.S.-manufactured drone-based precision application systems. The aim is to cut chemical inputs while keeping farms productive. Domestic manufacturing of the drone platforms is called out specifically.
Technical Area 3: Improved monitoring of herbicides and associated chemicals. Develop accurate, low-cost, continuous sensing technologies for compounds that are currently difficult and expensive to measure. Better sensing enables community-level monitoring and faster response when a problem appears, rather than waiting on slow or costly lab analysis.
Technical Area 4: Remove or degrade herbicides and associated chemicals. Create methods to rapidly break down agricultural chemicals in soil and water, intercept runoff before it reaches waterways, and reduce residues absorbed by crops. This is the cleanup and containment side of the program, ensuring chemicals are removed from the environment after they do their work.
ARPA-H funds revolutionary rather than incremental ideas, and its programs typically target early-stage technologies with a clear path to maturity. Teams that combine a bold technical concept with a credible plan to reach real-world deployment tend to fit the agency's model best.
Funding and Award Structure
There is an important structural point that startups should understand before applying. STREAM is not an SBIR or STTR opportunity. It runs through a Mission Office Innovative Solutions Opening, and ARPA-H primarily uses Other Transactions and cooperative agreements rather than traditional grants. Other Transactions are flexible business arrangements that let the government adopt commercial-style terms and negotiate scope, milestones, intellectual property, reporting, and payments on a per-award basis.
Because awards are negotiated, the STREAM announcement does not publish a fixed dollar ceiling for applications. For context, ARPA-H operates on an annual budget of roughly 1.5 billion dollars and has historically supported large, milestone-driven awards that can range from single millions to tens of millions of dollars per project, depending on scope. Your budget is built in the Cost Proposal that accompanies a full proposal, and it must reconcile with the milestones and level of effort you commit to.
A few cost-related details from the current ISO documents are worth noting when you plan your budget. Proposers must provide supporting documentation for planned materials and equipment purchases once the unit cost reaches ten thousand dollars, an increase from the prior five thousand dollar threshold. Profit or fee is treated as not applicable unless you specifically include it in the Cost Proposal Workbook. The ISO also defines burdened labor rate and fully burdened labor rate for clarity, and it notes that fully burdened labor rates are not used in the Cost Proposal Workbooks.
Eligibility
ARPA-H opportunities are open to a broad range of performers, including companies, small businesses, startups, universities, and nonprofit research organizations, and the agency encourages collaborative teams. STREAM specifically invites experts across agricultural science, artificial intelligence, chemistry, drones, and sensing to team up on its objectives.
Two eligibility constraints matter for planning. ARPA-H prioritizes awards to domestic recipients, and it cannot award funding to entities organized under the laws of a covered foreign country, which include Russia, Iran, North Korea, and China. Applicants should also be prepared to address organizational conflicts of interest, research security, human and animal subjects considerations where relevant, and biosecurity, since the ISO documents include disclosure requirements in each of these areas.
Timeline
The program was launched on August 17, 2026. Solution Summaries that select STREAM are due no later than September 14, 2026 at 11:59 pm ET. After you submit a Solution Summary, you should wait to hear back from ARPA-H with feedback before proceeding to a full proposal. Only summaries that receive encouragement move forward, which protects you from investing in a full proposal that is not aligned.
It helps to understand how STREAM sits inside the broader solicitation. STREAM submissions flow through the Scalable Solutions Office ISO, notice ID ARPA-H-SOL-24-105, which is a rolling solicitation that remains active on SAM.gov with a much later administrative closing date in 2029. STREAM itself carries the firm September 14, 2026 cutoff, so treat that as your working deadline regardless of the ISO's longer horizon.
How to Apply
STREAM applications are made through the Scalable Solutions Office ISO on SAM.gov, and the steps are as follows.
First, access the Scalable Solutions solicitation, notice ID ARPA-H-SOL-24-105, on SAM.gov. This solicitation and its attachments provide the full details on eligibility, submission requirements, evaluation criteria, contacts, and the link to apply.
Second, download all documents in the Attachment section, including the ISO document, the Solution Summary template (Appendix A), and the bundle of attachments. Follow the instructions in the ISO document and its associated files when preparing your Solution Summary.
Third, submit your Solution Summary using the link provided in the solicitation documents, at the ARPA-H Solutions site. When prompted, select STREAM from the Solution Summary dropdown list. A sign-in is required to submit, and your summary must be in by September 14, 2026 at 11:59 pm ET.
Fourth, await feedback. Do not begin a full proposal until you hear back from ARPA-H on your Solution Summary.
If you have questions about the opportunity, submit them through the Ask A Question form on the ARPA-H Solutions site, select STREAM from the dropdown, and note that a sign-in is required.
How BW&CO Consulting Supports STREAM Applicants
BW&CO Consulting helps deep-tech, biotech, MedTech, agtech, and dual-use founders pursue non-dilutive federal funding across ARPA-H, NIH, NSF, DoD, NASA, DOE, and other agencies. Because STREAM runs on an Other Transactions ISO rather than a conventional SBIR or STTR grant, it rewards a sharp technical narrative, a credible commercialization and manufacturing story, and a milestone plan that a program manager can act on quickly. If you are weighing a STREAM Solution Summary, we can assess fit against the four technical areas, shape the concept for the ARPA-H model, and prepare a competitive submission ahead of the September 14, 2026 deadline. Reach out to start a fit conversation.
Frequently Asked Questions
What is the ARPA-H STREAM program? STREAM, short for Systems for Tracking and Resilience in Efficient Agricultural-input Management, is an ARPA-H program that funds breakthrough technology to control weeds while reducing herbicide exposure for farmers, farm workers, consumers, and the environment. It was launched by HHS through ARPA-H on August 17, 2026.
Who runs STREAM and what agency funds it? STREAM is run by the Advanced Research Projects Agency for Health (ARPA-H), which sits within the U.S. Department of Health and Human Services. The program manager is James Coburn, CAPT.
When is the STREAM application deadline? Solution Summaries that select STREAM are due no later than September 14, 2026 at 11:59 pm ET.
How do I apply to STREAM? You apply by submitting a Solution Summary through the Scalable Solutions Office ISO, notice ID ARPA-H-SOL-24-105, which is posted on SAM.gov. Download the solicitation attachments, prepare your Solution Summary using the provided template, submit it at the ARPA-H Solutions site, and select STREAM from the dropdown.
What are the four STREAM technical areas? The four technical areas are next-generation herbicides and formulations, precision and nonchemical weed control, improved low-cost monitoring of herbicides and associated chemicals, and methods to remove or degrade those chemicals in soil and water. A submission must address at least one of these areas.
How much funding does STREAM provide? STREAM does not publish a fixed award ceiling in its announcement because awards are negotiated per project through Other Transactions. For context, ARPA-H typically supports milestone-driven awards ranging from single millions to tens of millions of dollars, and STREAM advances a broader interagency commitment of more than one billion dollars in farm modernization shared across HHS, USDA, and EPA.
Is STREAM an SBIR or STTR opportunity? No. STREAM is offered through a Mission Office Innovative Solutions Opening and uses Other Transactions and cooperative agreements, not SBIR or STTR grants. This means the application pathway, budgeting, and terms differ from a standard SBIR solicitation.
What funding mechanism does ARPA-H use? ARPA-H primarily uses Other Transactions and cooperative agreements. Other Transactions are flexible, commercial-style agreements that allow scope, milestones, intellectual property, reporting, and payment terms to be negotiated on a per-award basis.
Who is eligible to apply for STREAM? Eligibility is broad and includes companies, startups, small businesses, universities, and nonprofit research organizations, and teaming is encouraged. ARPA-H prioritizes domestic recipients and cannot award funding to entities organized under the laws of a covered foreign country, including Russia, Iran, North Korea, and China.
Can startups and small businesses apply? Yes. Startups and small businesses can apply and are well suited to STREAM's emphasis on bold, early-stage technology, provided they can present a credible technical concept and a plan to reach real-world deployment.
What is a Solution Summary? A Solution Summary is a short initial submission that describes your proposed solution against the program objectives. ARPA-H reviews it and provides feedback before inviting a full proposal, which saves applicants from investing in a full proposal that is not aligned.
What happens after I submit a Solution Summary? After you submit, you wait for feedback from ARPA-H. You should not begin a full proposal until you have heard back, and only encouraged summaries advance to the full proposal stage.
Where do I submit my STREAM application? Solution Summaries are submitted at the ARPA-H Solutions site using the link in the solicitation documents, with STREAM selected from the dropdown. The underlying solicitation, ARPA-H-SOL-24-105, is accessed and downloaded from SAM.gov, and questions go through the Ask A Question form on the same ARPA-H Solutions site.
