NIH Highlighted Topic: Enhancing Data Usage and Utility to Advance Biomedical Research

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on maximizing the utilization of publicly accessible, high-quality datasets to enhance reproducibility, enable data-driven hypothesis generation, and accelerate scientific discovery. This highlighted topic aims to advance computational methods, novel biostatistical approaches, and privacy-preserving strategies that turn NIH's substantial investments in data infrastructure and FAIR data management into improved disease prevention, diagnosis, and treatment.

NIH notes that while multiple institutes have independently invested in demonstrating the value of data sharing and reuse, greater strategic alignment and coordination across NIH is needed to address ongoing data underutilization. NIH is particularly interested in projects that develop AI/ML methods for data discovery and integration across distributed ecosystems, enhance rigor and reproducibility through cross-cohort validation, and implement privacy-preserving strategies such as federated learning and differential privacy to enable responsible data sharing.

Areas of interest include secondary analyses elucidating tumor initiation and therapeutic resistance mechanisms, harmonizing eye imaging modalities across devices and institutions, leveraging genomic and multi-omic datasets to improve rare disease diagnostic yield, secondary analyses of longitudinal cohorts to identify drivers of Alzheimer's disease and aging-related conditions, integrating clinical and omics data using established cohorts like All of Us and ABCD to study alcohol use disorder, harmonizing datasets for arthritis and musculoskeletal disease research, leveraging environmental exposure and geospatial data for exposome characterization, and incorporating sex as a biological variable and developing female-specific common data elements across research designs.

Note: as with prior topics, this is a Highlighted Topic rather than a standalone NOFO, so applicants apply through an appropriate NIH Parent Funding Announcement or other broad opportunity on Grants.gov rather than a dedicated solicitation with its own SBIR/STTR dollar figures.

This highlighted topic is supported by an unusually broad coalition of ICOs, including the National Cancer Institute (NCI), National Center for Complementary and Integrative Health (NCCIH), National Eye Institute (NEI), National Human Genome Research Institute (NHGRI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute on Drug Abuse (NIDA), National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Environmental Health Sciences (NIEHS), National Institute of Mental Health (NIMH), National Library of Medicine (NLM), Office of Data Science Strategy (ODSS), and Office of Research on Women's Health (ORWH), reflecting how central secondary data analysis and data infrastructure have become across nearly every NIH institute's research priorities.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NIH Highlighted Topic: Behavioral and Cognitive Signals of Aging in Real-World Contexts

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on identifying reproducible, interpretable behavioral and cognitive signals from real-world data to advance understanding of aging, disease progression, and functional decline. This highlighted topic aims to translate computational models of temporally structured human behavior into life span developmental and aging research through the development of "cognitive vital signs" and behavioral pattern analysis.

Recent computational advances have highlighted the value of studying recurring behavioral patterns, such as sequences, transitions, and rhythms of daily activity, rather than isolated events or aggregate summary measures. NIH notes that growing interest in continuous, real-world cognitive assessment has motivated development of longitudinal indicators derived from everyday behavior, speech, and interaction patterns that complement traditional clinic-based assessments. NIH is particularly interested in projects that ensure these behavioral and cognitive signals are interpretable, robust, and valid across diverse real-world settings, populations, and contexts.

Areas of interest include characterizing recurring behavioral patterns like sleep-wake cycles, navigation routines, and social interaction rhythms as indicators of functional change with aging, developing and validating cognitive vital signs from speech, response timing, and repeated task performance, building computational methods to extract and compare temporally structured behavioral patterns, detecting early or preclinical stages of dementia through subtle daily cognition changes, identifying behavioral signals linked to cancer-related cognitive impairment and accelerated aging in survivors, and validating interpretable digital biomarkers from passive sensing and speech for mental health risk and resilience.

Note: as with prior topics, this is a Highlighted Topic rather than a standalone NOFO, so applicants apply through an appropriate NIH Parent Funding Announcement or other broad opportunity on Grants.gov rather than a dedicated solicitation with its own SBIR/STTR dollar figures.

This highlighted topic is supported primarily by the National Institute on Aging (NIA), with additional participation from the National Cancer Institute (NCI), Office of Behavioral and Social Sciences Research (OBSSR), and National Institute of Mental Health (NIMH), all of which are seeking research that translates real-world behavioral and cognitive signals into meaningful markers of aging, disease, and functional change.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NIH Highlighted Topic: Data Science and Artificial Intelligence Approaches for Biomedical, Biobehavioral and Social Science Research

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on developing and validating AI and data science approaches that harmonize, decipher, and extract complex patterns from the massive multimodal, high-dimensional data generated by biomedical research and electronic health records. This highlighted topic aims to advance interpretable, reproducible, and scalable AI methods that improve modeling of risk and resilience trajectories, disease mechanisms, and integrated prevention and treatment services.

Data science and AI hold significant promise for addressing complex biomedical problems, yet NIH notes that heterogeneous, fragmented data lacking uniform standards remains a major barrier to widespread adoption in research and clinical practice. This topic is issued as part of the Make America Healthy Again initiative, aligning with NIH's expanded focus on mental health and addiction research, screentime effects in children and adolescents, and an AI-driven approach to pediatric cancer research and clinical trials. NIH is particularly interested in projects that make large-scale biomedical data AI-ready and integrate disparate systems, such as EHRs, surveillance, and community services, for coordinated longitudinal care.

Areas of interest include interpretable and explainable AI for mechanistic insight, AI modeling of longitudinal risk and disease trajectories across substance use, HIV, and comorbidities, generative AI applications for chronic recurrent eye disorders and precision diagnostics, multimodal data integration for Alzheimer's disease and aging biology, AI/ML models for alcohol use disorder prevention using real-world environmental and social data, computational tools for complementary and integrative health approaches, AI applications across hearing, balance, taste, smell, voice, speech, and language disorders, and sex-based biology modeling for chronic disease risk, relapse, and treatment response in women.

Note: as with prior topics, this is a Highlighted Topic rather than a standalone NOFO, so applicants apply through an appropriate NIH Parent Funding Announcement or other broad opportunity on Grants.gov rather than a dedicated solicitation with its own SBIR/STTR dollar figures.

This highlighted topic is supported by an especially broad coalition of ICOs, including the National Institute on Drug Abuse (NIDA), National Center for Complementary and Integrative Health (NCCIH), National Cancer Institute (NCI), National Eye Institute (NEI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Mental Health (NIMH), National Institute of Nursing Research (NINR), National Library of Medicine (NLM), Office of Data Science Strategy (ODSS), and Office of Research on Women's Health (ORWH), reflecting how foundational AI and data science approaches have become across nearly every corner of NIH's research mission.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NIH Highlighted Topic: Digital Health and Artificial Intelligence Tools for Biomedical and Behavioral Research: Validity and Utility

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on evaluating the validity and clinical utility of digital health and artificial intelligence (AI) tools across biomedical and behavioral research. This highlighted topic aims to advance rigorous validation of computing platforms, sensors, wearables, telehealth, and AI-based risk assessment and diagnostic algorithms used in healthcare and health-related research.

Rapidly evolving digital and AI technologies have accelerated scientific breakthroughs and surpassed human performance on several task-specific benchmarks, yet NIH notes their analytical validity, clinical validity, reliability, and utility in real-world research and clinical settings have often not been thoroughly examined. NIH is particularly interested in projects that assess these tools' impact and utility across the lifespan and among populations with limited access to traditional healthcare, with strong emphasis on risk assessment, data security, AI governance, and minimizing bias in underlying datasets.

Areas of interest include validating digital and AI tools for cancer risk factor measurement and cancer control continuum applications, assessing AI/ML tools for heart, lung, blood, and sleep condition diagnosis and monitoring, evaluating multimodal AI analysis of aging biology and Alzheimer's disease/related dementias biomarkers, validating smartphone and wearable sensing tools for alcohol use and relapse risk detection, developing AI clinical decision support tools for mental health and HIV prevention with attention to bias and model drift, validating digital tools for substance use disorder treatment (including SBIR/STTR-eligible commercialization pathways), and building generalizable, disease-agnostic benchmarking frameworks for digital health AI.

Note: as with prior topics, this is a Highlighted Topic rather than a standalone NOFO, so applicants apply through an appropriate NIH Parent Funding Announcement or other broad opportunity on Grants.gov rather than a dedicated solicitation with its own SBIR/STTR dollar figures. That said, NIDA explicitly calls out SBIR/STTR applications as encouraged where market need and commercialization potential are well defined, so this topic may be worth flagging for wearable medtech or digital health clients with clear commercial pathways.

This highlighted topic is supported by an unusually broad coalition of ICOs, including the Office of Behavioral and Social Sciences Research (OBSSR), National Center for Complementary and Integrative Health (NCCIH), National Cancer Institute (NCI), National Heart, Lung, and Blood Institute (NHLBI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NICHD, National Institute on Drug Abuse (NIDA), National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Mental Health (NIMH), National Library of Medicine (NLM), Office of Data Science Strategy (ODSS), and Office of Research on Women's Health (ORWH), reflecting how central digital health and AI validation has become across nearly every NIH institute's research priorities.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NIH Highlighted Topic: Research on the Role of Post-Translational Modifications in Human Health and Disease

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on the mechanistic roles of understudied post-translational modifications (PTMs) and PTM crosstalk in human health and disease, including cancer, aging, and substance use disorders. This highlighted topic aims to broaden the field beyond a narrow set of well-characterized modifications and reveal previously overlooked roles and functions of PTMs.

More than 400 different kinds of PTMs have been detected, yet only about a quarter have been linked to human disease, with phosphorylation, acetylation, methylation, and ubiquitination accounting for the largest share of known disease-associated modifications while others such as glycosylation, lactylation, and sumoylation remain understudied. NIH notes that current research also concentrates narrowly on a few substrate types like histones, transcription factors, and signaling molecules, leaving a knowledge gap around how varied PTMs crosstalk to influence protein function and cellular state. NIH is particularly interested in projects that leverage recent technological breakthroughs, including mass spectrometry enrichment, single-cell omics, and AlphaFold protein structure databases, to study diverse PTMs and their coordinated roles.

Areas of interest include dissecting mechanisms of understudied PTMs and PTM crosstalk in cancer initiation and progression, defining the role of PTM readers, writers, and erasers, evaluating PTM-based biomarkers for cancer risk assessment and early detection, mapping PTM landscapes across tissues, cell types, sex, and lifespan in aging and Alzheimer's disease/related dementias, studying PTMs that drive drug-seeking behavior and addiction-relevant neuronal plasticity, and examining sex-specific differences and comorbid conditions such as HIV infection affecting PTM-mediated substance use vulnerability.

Note: as with prior topics, this is a Highlighted Topic rather than a standalone NOFO, so applicants apply through an appropriate NIH Parent Funding Announcement or other broad opportunity on Grants.gov rather than a dedicated solicitation with its own SBIR/STTR dollar figures.

This highlighted topic is supported primarily by the National Cancer Institute (NCI), with additional participation from the National Institute on Aging (NIA), National Institute on Drug Abuse (NIDA), and National Institute of Dental and Craniofacial Research (NIDCR), all of which are seeking mechanistic research into understudied PTMs and their disease relevance.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NIH Highlighted Topic: Cellular Quiescence, Senescence, and Cell Death in Aging and Disease

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on understanding the mechanistic and functional interrelationships among cellular quiescence, senescence, regulated cell death, and other cell-fate decisions. This highlighted topic aims to uncover the molecular logic governing cell fate under stress and during aging, moving beyond simple classification to establish a foundation for next-generation therapeutics targeting aging and age-related diseases.

While a decade of senescence research has revealed extraordinary heterogeneity among senescent cells shaped by stressors, tissue origin, and organismal age, NIH notes that fundamental mechanistic questions remain unresolved, including whether quiescence, senescence, and apoptosis represent separate endpoints, a continuum, or probabilistic outcomes of cell-cycle re-entry. NIH is particularly interested in projects that clarify how aging reshapes these decision pathways and whether they can be therapeutically redirected to prevent or delay age-related disease and extend healthspan.

Areas of interest include determining whether quiescence and senescence are discrete or continuum-based cell fates, defining molecular factors governing senescence versus apoptosis, identifying cell fate decisions that can be selectively promoted or redirected during aging, examining cell fate determination in brain aging including post-mitotic neurons and glial populations, evaluating how senolytics affect quiescent and reprogramming cell populations, and characterizing cell-cycle exit and re-entry mechanisms in quiescent, senescent, stem, progenitor, and dormant tumor or stromal cells relevant to cancer initiation, progression, and therapy response.

Note: as with prior topics, this is a Highlighted Topic rather than a standalone NOFO, so applicants apply through an appropriate NIH Parent Funding Announcement or other broad opportunity on Grants.gov rather than a dedicated solicitation with its own SBIR/STTR dollar figures.

This highlighted topic is supported primarily by the National Institute on Aging (NIA), with additional participation from the National Cancer Institute (NCI), both of which are seeking mechanistic research into cell-fate decision pathways relevant to aging, cancer, and age-related disease.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NIH Highlighted Topic: New Approach Methodologies (NAMs) for Dietary Supplement and Nutrition research

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on human-relevant new approach methodologies (NAMs)—such as organoids, tissue chips, microphysiological systems, multi-omics technologies, and computational models—to evaluate the safety and efficacy of foods, food components, and dietary supplements for health optimization and chronic disease risk reduction across the lifespan.

Traditional diet-related health research has relied heavily on animal studies and population-level endpoints, which NIH notes have limited relevance to human biology and metabolism, poor sensitivity for detecting subtle or life-stage-specific effects, and an inability to assess complex foods, novel ingredients, or matrix effects. NIH is particularly interested in projects that develop and validate human-based NAMs to investigate nutrient absorption, distribution, and metabolic processes, and to simulate health-relevant interactions between cellular, organ, and body systems in response to complex food or supplement matrices. This topic is issued as part of the Make America Healthy Again initiative, and the EPA, FDA, and NIH have all committed to expanding use of NAMs moving forward.

Areas of interest include identifying and validating bioactive compound exposure biomarkers, quantifying bioaccessibility and bioavailability of nutrients in multi-ingredient supplements or processed foods, modeling diet-related chronic diseases such as obesity, diabetes, and cystic fibrosis, examining nutrition's role in ocular health and vision-loss conditions, capturing age-related changes in nutrient metabolism among older adults, validating dietary assessment methodologies and noninvasive biomarkers relevant to heart, lung, blood, and sleep outcomes, assessing dietary supplement interactions in cancer risk and treatment contexts, and characterizing dietary bioactive substances' impact on fetal and early childhood neurodevelopment.

Note: as with prior topics, this is a Highlighted Topic rather than a standalone NOFO, so applicants apply through an appropriate NIH Parent Funding Announcement or other broad opportunity on Grants.gov rather than a dedicated solicitation with its own SBIR/STTR dollar figures.

This highlighted topic is supported primarily by the Office of Dietary Supplements (ODS), with additional participation from the National Center for Complementary and Integrative Health (NCCIH), National Cancer Institute (NCI), National Eye Institute (NEI), National Institute on Aging (NIA), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Office of Nutrition Research (ONR), and National Heart, Lung, and Blood Institute (NHLBI), all of which are seeking human-relevant methodologies to advance nutrition and dietary supplement science.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NIH Highlighted Topic: Breaking Barriers: Integrating Immunology and Neuroscience to Transform AD/ADRD Research and Bring a Better Understanding of the Aging Brain

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on integrating immunology, neuroscience, and biogerontology to advance the prevention, treatment, and understanding of Alzheimer's disease (AD) and Alzheimer's Disease-Related Dementias (ADRD). This highlighted topic aims to accelerate discovery at the intersection of immune-nervous system interactions across the aging lifespan and support development of improved diagnostics, risk stratification tools, and immunotherapeutic strategies.

Accumulating evidence implicates dysregulation of both innate and adaptive immune responses in the aging brain as a significant contributor to AD/ADRD pathogenesis, with clinical studies reporting changes in T-cells, B-cells, the complement system, and disease-specific autoantibodies in individuals living with AD/ADRD. NIH notes that a major obstacle to progress has been insufficient sustained collaboration between immunologists, infectious disease experts, and neuroscientists, leaving critical knowledge gaps around the links between autoimmunity, infectious disease, and neurodegeneration. NIH is particularly interested in projects using cutting-edge technology, including AI and novel model systems such as organoids and microphysiological systems, to close these gaps.

Areas of interest include innate and adaptive immunity crosstalk in healthy aging and AD/ADRD, links among immunosenescence, neuroinflammation, infection, and autoimmunity, mechanisms of immune dysfunction underlying neuropsychiatric symptoms, novel biomarker discovery and validation, environmental exposure effects on the immune-brain axis, sex-specific and lifespan immunophenotype changes, and chronic immune dysregulation accelerating neuroimmune senescence in the context of people with HIV.

Note: as with prior topics, this is a Highlighted Topic rather than a standalone NOFO, so applicants apply through an appropriate NIH Parent Funding Announcement or other broad opportunity on Grants.gov rather than a dedicated solicitation with its own SBIR/STTR dollar figures.

This highlighted topic is supported primarily by the National Institute on Aging (NIA), with additional participation from the National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Environmental Health Sciences (NIEHS), and National Institute of Mental Health (NIMH), all of which are seeking interdisciplinary research that bridges immunology and neuroscience to transform understanding of the aging brain and AD/ADRD.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NIH Highlighted Topic: School Mental and Behavioral Health: Expanding Access to Evidence-Based Interventions and Services

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on optimizing and testing mental and behavioral health interventions and service delivery models within school and afterschool settings. This highlighted topic aims to advance approaches that can be rapidly deployed and sustained using existing school personnel, contracted providers, and referral networks, rather than requiring extensive new infrastructure.

Schools function as de facto points of service for health promotion in many communities, and NIH is particularly interested in research that validates sustainable strategies for detecting at-risk students, matching them to appropriate interventions, and building decision-support tools to guide selection of research-informed approaches based on available resources. Projects addressing the full multitiered system of supports continuum, from universal prevention to indicated treatment, are of interest, along with strategies to promote adoption and sustained fidelity of evidence-based practices, including the judicious use of non-specialty providers to extend a stretched mental health workforce.

Areas of interest include community-engaged research addressing access barriers, workforce shortages, and privacy concerns in schools, research-practice partnerships leveraging existing infrastructure such as SAMHSA-supported behavioral health services, substance use risk screening and prevention programming for high-risk youth, nurse-led preventive interventions incorporating students' daily living conditions, sex-specific strategies for detecting and treating at-risk girls and young women, and rigorous multi-site or cluster randomized trials evaluating school-based service delivery models.

Note: as with prior topics, this is a Highlighted Topic rather than a standalone NOFO, so applicants apply through an appropriate NIH Parent Funding Announcement or other broad opportunity on Grants.gov rather than a dedicated solicitation with its own SBIR/STTR dollar figures.

This highlighted topic is supported primarily by the National Institute of Mental Health (NIMH), with additional participation from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute on Drug Abuse (NIDA), National Institute on Minority Health and Health Disparities (NIMHD), National Institute of Nursing Research (NINR), Office of Disease Prevention (ODP), and Office of Research on Women's Health (ORWH), all of which are seeking research that expands sustainable, evidence-based mental and behavioral health access in school settings.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NIH Highlighted Topic: Implementation Science to Optimize Alcohol Misuse Prevention and Treatment in the Criminal Justice System

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on preventing alcohol misuse and treating alcohol use disorder (AUD) within the U.S. criminal justice and juvenile justice systems. This highlighted topic aims to advance prevention interventions, treatment approaches, and implementation strategies that address the under-detection and under-treatment of alcohol problems in these settings.

Criminal justice populations, including jail, parole, probation, juvenile justice, and prison populations, report elevated levels of AUD and high-risk drinking compared to the general population, often alongside co-morbid drug use disorders. NIH notes that alcohol misuse research in these settings is challenging given rapid cycling of detainees back into the community, and that individuals face a critical gap in care upon release, where relapse risk increases with renewed exposure to people, places, and things tied to substance use. NIH is particularly interested in projects that build on promising approaches such as brief motivational interviewing-based interventions and extended-release naltrexone, which require confirmation through larger, longer-duration studies combined with behavioral interventions.

Areas of interest include developing and testing brief motivational interviewing-based alcohol interventions for integration into criminal justice settings, optimizing Screening, Brief Intervention and Referral to Treatment (SBIRT) models for these populations, evaluating pre-release motivational interventions to reduce substance use and relapse risk post-release, combining motivational enhancement with cognitive behavioral therapy, building implementation strategies for care linkages as individuals return to the community, developing remote intervention technology adapted for correctional settings, and creating cost-effective prevention and treatment approaches for corrections officials themselves.

Note: as with prior topics, this is a Highlighted Topic rather than a standalone NOFO, so applicants apply through an appropriate NIH Parent Funding Announcement or other broad opportunity on Grants.gov rather than a dedicated solicitation with its own SBIR/STTR dollar figures.

This highlighted topic is supported primarily by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), with additional input from the Office of Disease Prevention (ODP), both of which are seeking implementation science that closes gaps in alcohol misuse prevention and treatment across criminal justice settings.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NIH Highlighted Topic: Increasing Engagement in Treatment for Behavioral Health

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on increasing engagement with treatment among individuals with psychiatric disorders, particularly conditions with significant treatment gaps. This highlighted topic aims to advance outreach strategies, care design, and access improvements that help patients both initiate and sustain evidence-based treatment.

Psychiatric disorders affect an estimated 1-20% of the U.S. population depending on diagnosis, yet the majority of affected individuals never receive specific treatment, worsening prognosis and increasing burden on individuals and communities. Alcohol use disorder illustrates this gap starkly, impacting roughly 10% of U.S. adults while fewer than 20% receive treatment, and NIH notes that many psychiatric conditions have lengthy prodromal phases that offer a window for preventive intervention before severe disease onset. NIH is particularly interested in projects that address not just initial engagement but sustained retention in care, given high dropout rates for chronic mental illness.

Areas of interest include qualitative research and provider education to identify best practices for treatment engagement, screening and brief intervention models embedded in general mental health settings, digital and telehealth interventions for alcohol-related and co-occurring disorders, integration of complementary and integrative health approaches into primary care for mild-to-moderate symptoms, implementation-effectiveness studies of integrated care models, and AI- and technology-based approaches to reach rural, underserved, and high-risk youth populations.

Note: as with prior topics, this is a Highlighted Topic rather than a standalone NOFO, so applicants apply through an appropriate NIH Parent Funding Announcement or other broad opportunity on Grants.gov rather than a dedicated solicitation with its own SBIR/STTR dollar figures.

This highlighted topic is supported primarily by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Center for Complementary and Integrative Health (NCCIH), and the National Institute on Drug Abuse (NIDA), with additional behavioral and social science input from the Office of Behavioral and Social Sciences Research (OBSSR), all of which are seeking strategies to close persistent gaps in behavioral health treatment engagement.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NIH Highlighted Topic: Characterizing Indoor Exposures to Advance Exposome Research

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on characterizing indoor environmental exposures as a critical, understudied component of the human exposome. This highlighted topic aims to advance exposure detection technologies, measurement tools, and biomarkers that improve understanding of how indoor pollutants and conditions contribute to overall exposure and health burden across the lifespan.

People spend 80-90% of their time indoors on average, making indoor environments a primary determinant of total exposure, yet thousands of contaminants from building materials, furnishings, cleaning products, and biological sources like mold remain difficult to assess with existing tools. NIH is particularly interested in projects that address the complex mixture effects, secondary chemical reaction products, and multiple exposure sources that current single-pollutant studies fail to capture.

Areas of interest include developing novel biomarkers and personal monitoring devices for indoor exposure assessment, characterizing the chemical and biological composition of indoor exposure mixtures across residential, school, work, and mixed-use settings, understanding how combined indoor exposures and chemical reactions shape the exposome's impact on health, and developing measurement metrics to evaluate interventions such as HEPA filtration.

Note: as with the RNA metabolism topic, this is a Highlighted Topic rather than a standalone NOFO, so applicants apply through an appropriate NIH Parent Funding Announcement or other broad opportunity on Grants.gov rather than a dedicated solicitation with its own SBIR/STTR dollar figures.

This highlighted topic is supported primarily by the National Institute of Environmental Health Sciences (NIEHS), which is seeking innovative exposure assessment technologies and biomarker-driven strategies to better understand and manage indoor exposure's contribution to human health outcomes.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NIH Highlighted Topic: RNA Metabolism in Aging and Healthy Lifespan

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The National Institutes of Health (NIH) is encouraging innovative research focused on understanding the molecular mechanisms by which RNA metabolism influences aging and aging-related diseases. This highlighted topic aims to advance studies on RNA editing, alternative splicing, and RNA modification, and how these processes drive cellular deterioration, disease etiology, and biomarker discovery for age-related conditions.

RNA metabolism governs how genetic information moves from DNA to functional protein, and NIH notes that over 170 distinct post-transcriptional chemical modifications have been identified in cellular RNAs, each shaping RNA function in different ways. NIH is particularly interested in projects that leverage cutting-edge sequencing and RNA modification detection technologies to dissect the complexity and specificity of aging processes, including in populations affected by substance use.

Areas of interest include characterizing RNA metabolism changes associated with aging and aging-related diseases, determining causal roles of RNA changes in aging or disease etiology, identifying reliable RNA-based biomarkers of aging, discovering therapeutic targets among "non-druggable" proteins via their RNA regulators, and elucidating RNA-mediated mechanisms linking aging, drug use, and comorbidities such as HIV infection and polysubstance use.

This highlighted topic is supported primarily by the National Institute on Aging (NIA) and the National Institute on Drug Abuse (NIDA), both of which are seeking research that identifies mechanistic, biomarker, and therapeutic insights into how RNA metabolism shapes aging and age-related disease.

How much funding would I receive?

Awards provide up to $323,090 for Phase I projects (up to 2 years) and $2,153,927 for Phase II projects (up to 3 years). Some topics approved by NIH may exceed these limits. Fast-Track and Phase IIB (follow-on) options allow continuous or extended funding beyond Phase II.

What could I use the funding for?

Funding may support the research, development, validation, and commercialization of technologies, clinical tools, software platforms, and evidence-based interventions related to augmentative and alternative communication (AAC).

Eligible activities may include:

• Development of speech-generating devices and AAC communication platforms

• AI and machine learning tools for adaptive communication support

• Personalized AAC assessment and recommendation systems

• Precision measurement tools for tracking communication outcomes

• Digital health platforms supporting AAC users and caregivers

• Literacy instruction technologies for AAC users

• Mobile applications supporting non-speaking and minimally verbal individuals

• Predictive analytics and communication profiling systems

• User-centered design and accessibility research for AAC technologies

• Tools supporting communication partner engagement and training

• Clinical software for AAC implementation and therapy management

• Mixed-methods research platforms for communication needs analysis

• Technologies supporting lifelong AAC adaptation and personalization

• Remote monitoring and telehealth solutions for speech and communication therapy

• Assistive technologies supporting autism, ALS, cerebral palsy, and related conditions

• Research evaluating quality-of-life and well-being outcomes for AAC users

• Prototype development, validation studies, and usability testing

• Commercialization planning and implementation strategy development

Funding may also support personnel, software development, usability studies, clinical testing, cloud infrastructure, AI model development, accessibility design, data collection, intellectual property protection, regulatory preparation, and commercialization activities necessary to advance a scalable and commercially viable AAC solution aligned with NIH priorities.

Are there any additional benefits I would receive?

Beyond the formal funding award, awardees gain several strategic advantages:

• Government Validation and Credibility:
  Being selected for an NIH-backed SBIR grant signals technical excellence and alignment with national health and biomedical priorities. This validation builds investor and partner confidence.

• Enhanced Visibility and Market Recognition:
  Awardees are featured in NIH and HHS announcements, helping attract partnerships, media attention, and future contracting opportunities.

• Access to the Federal Innovation Ecosystem:
  Recipients join a national network of researchers and agencies advancing life science innovation, often opening doors to collaborations with NIH laboratories and federal health programs.

• Stronger Commercial and Exit Potential:
  By maturing technology through nondilutive funding, companies strengthen valuation, de-risk commercialization, and increase attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Applications are accepted each year on January 5th, April 5th, and September 5th. Funding is received approximately 9 months after submission.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services, with statutory set-asides requiring NIH, CDC, and FDA to devote portions of their extramural R&D budgets (3.2% for SBIR, 0.45% for STTR) to support small business innovation.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

Projects that demonstrate:

• A clear unmet medical or public-health need,

• Strong scientific rationale and feasibility,

• High commercialization potential, supported by a realistic market and regulatory strategy, and

• Alignment with an NIH Institute’s or CDC/FDA Center’s specific research mission (e.g., infectious disease, digital health, diagnostics, therapeutics, or data analytics).

Competitive applicants often have an early prototype, preliminary data, and a defined path to market adoption.

Are there any restrictions I should know about?

• Companies must complete multiple federal registrations (SAM.gov, Grants.gov, eRA Commons, SBA Company Registry) before applying.

• Foreign entities are not eligible.

• Disclosure of foreign affiliations and compliance with national security screening are mandatory. Currently we do not recommend any sort of foreign affiliation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

Review solicitation here.

NASA ROSES A.13: Accelerating Earth Solutions (AES)

Quick Answer

NASA's Accelerating Earth Solutions (AES) program element is a newly amended addition to ROSES-2025 that consolidates what were previously separate program elements, including agriculture, disaster resilience, natural resources, health and air quality, water resources, wildland fire, energy systems, and resilient infrastructure, into a single, broader solicitation. The program seeks to accelerate the use of Earth-observing satellite data in real-world decision-making by funding work across three distinct tracks: Needs and Opportunities, Solutions Development, and Scaling Impact.

Selection priority is given to proposals that align with US resilience, resources, economic growth, health, and security; that increase the use of AI and machine learning; that cross boundaries between Earth Action thematic areas; that translate basic research or remote sensing advances into deployable solutions; and that draw on data from NASA's Earth observing missions, particularly NISAR, PACE, and SWOT, including combined approaches that pair NASA data with commercial satellite data available under the CSDA program.

Three Funding Sub-Elements

1. Needs and Opportunities (up to 1 year)

Supports early-stage engagement with federal, state, local, tribal, and territorial decision-makers to identify needs, build partnerships, and co-design solution concepts so that NASA Earth data can be meaningfully integrated into decision-making frameworks. Required activities include understanding societal decision-making challenges, identifying relevant end-user organizations, assessing end-user needs and data practices, evaluating end-user capacity to adopt new solutions, and determining feasibility and viability of potential solution concepts. Deliverables include a project/engagement plan, a midpoint report, communications materials, and a final report identifying opportunities for integrating NASA Earth data into future solutions.

2. Solutions Development (up to 3 years)

Focused on co-developing, validating, and transitioning solutions into operational deployment within an end-user's decision-making workflow. Applicants must have already identified users and conceptualized a solution determined to be desirable, feasible, and viable. At least one end-user representative with direct decision-making authority must be a formal member of the project team. Continuation beyond Year 1 depends on quarterly progress reports and an annual report demonstrating assessed end-user needs and expected outputs from models, applications, or decision support tools.

3. Scaling Impact (up to 2 years)

Aimed at expanding existing NASA Earth observation decision-support capabilities, either horizontally (reaching more users) or vertically (new tools or new observations), building on existing operational systems whether or not previously NASA-funded. Proposers with prior NASA Applied Sciences or Earth Action funding must document the achieved impact of that prior work and show how it informs the proposed scaling effort. As with Solutions Development, at least one end-user representative with decision-making authority must be on the project team, and continuation beyond Year 1 depends on quarterly and annual reporting demonstrating end-user needs assessment, how existing capabilities inform the scaling effort, and expected outputs.

Proposers may submit multiple proposals but each individual proposal may address only one sub-element, and multiple proposals within the same sub-element must be differentiated by distinct topics, goals, or objectives.

Scope of Solicited Work

Proposed work must primarily benefit the United States, focusing on US states, territories, and tribal lands, or demonstrating direct benefit to national priorities. Eligible thematic areas include agriculture, disasters, natural resources, health and air quality, water, wildland fire, energy, and infrastructure, with cross-cutting challenges especially encouraged. Examples cited in the solicitation include wind damage risk assessments, agricultural pest and nutrient stress management (including screwworm and armyworm), early warning systems for infectious and vector-borne disease, integrated terrestrial and coastal water monitoring, conservation and hunting/fishing community support, urban and rural infrastructure resilience, and improved real-time multi-sensor Earth observability.

Eligibility

Open to US institutions of all types, including academic institutions, non-governmental organizations, non-profits, and private sector for-profit entities. Non-traditional and cross-sector partners are explicitly welcomed. Work that relies on proprietary data or methods that will not be publicly disseminated is ineligible for this element and should instead be directed to ROSES element A.10 (INNOVATE). Federal agencies other than NASA are not eligible for funding under this element, though government personnel may participate as unfunded collaborators. Non-US organizations may participate on a no-exchange-of-funds basis, with their portion of the work funded through other sources.

Proposal Format and Page Limits

The Science/Technical/Management (S/T/M) section is limited to 10 pages, excluding references and the Table of Work Effort. All proposals must describe alignment with the Scope of Solicited Work and the Earth Science to Action (ES2A) strategy. Needs and Opportunities proposals must describe the user engagement and co-design strategy and the potential for improving decision-making. Solutions Development and Scaling Impact proposals must additionally describe current and expected decision-making methods, the end-user's authority to act on project results, at least one supporting NASA Earth observation or model, methodology rationale (including AI/ML use where applicable), anticipated impact, and a transition plan. Scaling Impact proposals must also describe existing decision-support capabilities and the demonstrated impact of prior solutions.

Dual-Anonymous Peer Review

All proposals will be evaluated under NASA's dual-anonymous peer review (DAPR) process, meaning proposers do not know reviewer identities and reviewers do not learn proposer identities until after evaluation. The anonymized proposal document may name the end-user organization but not the individual Co-I representing it. Required anonymized components include the S/T/M section (with numerically formatted reference callouts), references, an anonymized Table of Personnel and Work Effort, and a redacted budget and budget narrative. A separate, non-anonymized "Expertise and Resources Not Anonymized" document must be uploaded containing team member roles and affiliations, a non-anonymized Table of Personnel and Work Effort, biographical sketches and Current and Pending Support in SciENcv format, letters of support, and facilities/equipment descriptions. The Open Science and Data Management Plan (2 pages) must also be anonymized. Total Budget must be uploaded separately and unredacted. Proposals that fail to follow anonymization or formatting requirements may be returned without review.

Research Security Training Requirement

Effective August 5, 2026, all PIs and any Co-Is dedicating 10% or more of their time to a proposed award must certify completion of research security training, satisfied by either the four NSF Research Security Training modules or the SECURE Center's condensed equivalent.

Evaluation Criteria

Proposals are evaluated on Intrinsic Merit, Relevance, and Cost. Relevance evaluation considers alignment with the program's priority topics, the Scope of Solicited Work, and the ES2A strategy, along with the scalability and substance of the proposed decision-making impact. For Needs and Opportunities, Intrinsic Merit considers the quality of the user engagement and needs assessment strategy and its potential for lasting impact. For Solutions Development and Scaling Impact, Intrinsic Merit considers the likelihood of substantive, scalable impact; the quality of the co-development and adoption strategy; clarity around the end-user's decision-making authority and process; innovation and technical feasibility; and the quality of the transition plan into user operations. Cost evaluation includes the quality of the management plan and project timeline.

What are the formatting and page limits?

Technical proposals are capped at 15 pages (graphs, charts, and tables may run up to 10 additional oversized pages), submitted as unclassified PDFs in 12-point Times New Roman with one-inch margins. The mandatory cover page and signed Representation and Certification (Attachment 0002) are excluded from the page count, as are supplementary appendices.

Data and Publication Policy

All useful data, software, and peer-reviewed publications resulting from funded work must be made publicly available by the end of the award period of performance, consistent with NASA's Science Information Policy. The program also seeks science conducted per Executive Order 14303, Restoring Gold Standard Science, meaning work that is reproducible, transparent, communicative of error and uncertainty, collaborative, interdisciplinary, skeptical of its own findings, structured for falsifiability, and treats negative results as valid outcomes.

Pre-Proposal Teleconference

NASA will hold an optional pre-proposal teleconference on Monday, August 31, 2026, from 1:00 to 2:30 PM Eastern Time, on a first-to-dial-in basis with no advance reservation required. The session will be hosted by program officer Dr. Erin Urquhart. Connection details:

Submission Logistics

Proposals must be submitted electronically through NSPIRES at https://nspires.nasaprs.com. No hard copies are permitted. Applicants who need to submit via Grants.gov must request access at least 30 days before the due date from the main point of contact, with a copy to sara@nasa.gov. The Grants.gov funding opportunity number is NNH25ZDA001N-AES.

Additional Resources

Contact our team for the PDF solicitation.

Cornerstone CIR CS-24-1801: Defense Industrial Base Workforce Development Initiative

Quick Answer

CIR CS-24-1801 is a Cornerstone Other Transaction Agreement (OTA) solicitation from Army Contracting Command-Rock Island seeking fixed-price prototype proposals to build workforce development programs across Critical Minerals, Kinetics, Industrial Manufacturing Technologies, and Microelectronics, with the Government planning to award at least ten agreements and proposals due October 30, 2026.

What is CIR CS-24-1801?

It is a Project Call issued under the overarching SAMDIB Cornerstone Initiative Request, administered by Army Contracting Command-Rock Island in support of the Combat Capabilities Development Command Chemical Biological Center. It falls under the Cornerstone Other Transaction Agreement (COTA), meaning only registered Cornerstone consortium members are eligible to respond.

What problem is this initiative trying to solve?

The defense industrial base is losing ground to persistent technical skill gaps, an aging workforce, and rising system complexity across four sectors the Department of War considers pivotal to production capacity and readiness: Critical Minerals, Kinetics (hypersonics, UAS, munitions), Industrial Manufacturing Technologies (castings and forgings, robotics and automation, additive and subtractive manufacturing), and Microelectronics. Without a modernized, scalable talent pipeline, the Department sees a direct risk to its ability to build and sustain next-generation defense systems.

What is the Government actually looking to fund?

Scalable workforce development models that combine modernized, industry-aligned curricula with hands-on apprenticeship or internship components. Classroom-only or purely theoretical programs will not meet the intent of the call. Proposals are expected to be built around Public-Private-Academic Partnerships (PPAP), incorporate industry-recognized certification pathways (examples cited include NIMS for machining and AWS for welding), integrate K-12 STEM outreach to build a longer-term pipeline, and include a system for tracking personnel trained, certified, and placed within the DIB.

Are there "above and beyond" capabilities the Government wants to see?

Yes. The solicitation includes a wish list of stretch capabilities offerors can incorporate to strengthen a proposal, including AI, quantum computing, and biotechnology workforce pilots; XR/VR and digital twin training environments for high-cost equipment like semiconductor fabs; regional training hubs in defense-dense locations such as Huntsville and Guam; predictive analytics platforms for employer-candidate matching; robotic welding and AI-driven quality control training; alignment with allied workforce standards such as AUKUS; and wraparound apprentice support like housing, transportation, and childcare.

How many awards will the Government make, and what type?

The Government intends to award at least ten fixed-price prototype Other Transaction agreements, though it reserves the right to award more, fewer, or none if submissions don't meet the bar. Period of performance runs up to four years, with the potential for a follow-on production award under 10 U.S.C. 4022(f) if a prototype is completed successfully. There is no guarantee of follow-on work.

Who is eligible to submit a proposal?

Offerors must be registered Cornerstone consortium members and must hold an active Joint Certification Program (JCP) registration in order to handle the unclassified military technical data associated with this initiative. Given the sensitivity of the Kinetics and Microelectronics focus areas, programs must also prioritize training for U.S. citizens eligible for security clearances and adhere to ITAR/EAR requirements.

What does the proposal need to include?

At minimum: an innovative technical approach to the problem statement, available and planned facilities, positive impact across four IBAS Workforce lines of effort (recruiting and awareness, training and capacity increase, hiring and retention, and data and analytics), a method for collecting and presenting return on investment, and risk mitigation factors. A separate fixed-price cost proposal is required, with any cost sharing clearly identified per 10 U.S.C. 4022.

What are the formatting and page limits?

Technical proposals are capped at 15 pages (graphs, charts, and tables may run up to 10 additional oversized pages), submitted as unclassified PDFs in 12-point Times New Roman with one-inch margins. The mandatory cover page and signed Representation and Certification (Attachment 0002) are excluded from the page count, as are supplementary appendices.

What is the timeline?

The CIR was issued July 9, 2026. Questions must be submitted by 12:00 PM Central on August 31, 2026, and proposals are due by 12:00 PM Central on October 30, 2026. Proposals must remain valid for six months from the closing date.

How are proposals evaluated?

This is a one-step evaluation weighing technical merit, feasibility of implementation, past performance on similar efforts, and total project risk, with proposed price, schedule, and data rights assertions considered as part of the overall risk-reward assessment. The Government places specific emphasis on how innovative and unique the proposed approach is relative to the stated requirements.

What happens to intellectual property?

IP terms are negotiated case-by-case, generally under Government Purpose Rights or Limited Rights. Offerors submit their data rights assertions using the template provided in Enclosure 2 of the CIR.

Additional Resources

Contact our team for the PDF solicitation.

Autonomous Eradication Technologies Challenge: $550K DoD Prize Competition for Guam's Brown Tree Snake

Quick Answer

The Autonomous Eradication Technologies Challenge is a DoD-sponsored prize competition offering up to $550,000 in cash awards for autonomous detection, tracking, and control technologies to address Guam's invasive brown tree snake population, with potential Other Transaction Authority (OTA) pathways to direct procurement.

What is the Autonomous Eradication Technologies Challenge?

It is a recurring, rolling-cycle prize challenge sponsored by Headquarters Marine Corps (HQMC), the Strategic Environmental Research and Development Program / Environmental Security Technology Certification Program (SERDP/ESTCP), and DARPA. Central Florida Tech Grove administers the challenge and hosts the Virtual Demonstration Days where finalists present to government stakeholders. The same opportunity is also listed on InnoCentive under the title "Autonomous Eradication Technologies for Guam's Invasive Brown Tree Snakes."

What problem is this challenge trying to solve?

Guam's brown tree snake has caused decades of ecological and economic damage. The snake has driven the local extinction or decline of most native forest bird species on the island and causes roughly $4.5 million a year in economic losses through power outages from snakes contacting electrical infrastructure. It also poses a risk to military installations and personnel on Guam, a strategically critical U.S. Indo-Pacific location. Traditional control methods, including aerial delivery of acetaminophen-treated bait, have had limited success in Guam's dense forest canopy and rugged terrain. Island-wide eradication is considered nearly impossible without new technology.

What technologies are sponsors looking for?

The challenge is intentionally broad. Priority technology areas include:

• Drones and unmanned systems

• Autonomous robotics

• Advanced sensors and detection systems

• Artificial intelligence and machine learning

• Predictive modeling and data analytics

• Communications and decision-support tools

Solutions must be able to operate in dense forest canopy, rugged terrain, and night conditions, detect hidden targets, and support large-area autonomous surveillance missions.

How much prize money is available?

Up to $550,000 in total cash prizes. The listing does not publish a per-cycle or per-tier award breakdown. For comparison, other Central Florida Tech Grove and NavalX-funded DoD prize challenges have structured single-cycle awards at roughly $50,000 for first place, $30,000 for second, and $20,000 for third. Separately, federal Brown Tree Snake Control Program grant funding through the Department of the Interior has run between approximately $3.4 million and $4.1 million annually across multiple agencies, indicating a sustained, well-funded federal program behind this challenge rather than a one-off pilot.

Is this just a cash prize, or is there a path to a contract?

Both. Beyond the cash award, selected participants may qualify for Other Transaction Authority (OTA) pathways, direct procurement discussions, and field demonstration opportunities on Guam with U.S. military and federal agency stakeholders. The challenge is structured as a recurring feeder program, not a one-time grant.

Who is eligible to participate?

Participation is broad. Startups, universities, defense contractors, AI and drone teams, robotics developers, sensor engineers, and environmental technology innovators are all eligible. No prior experience with brown tree snakes, wildlife management, or Guam is required.

Do I need to submit by a single deadline?

No. This runs as a recurring, rolling-cycle prize challenge with monthly submission, evaluation, and virtual presentation windows. The current listed deadline is December 1, 2026 at 21:59 CST, but organizations may submit multiple solutions and resubmit in future cycles as their technology matures.

What happens after I submit?

Submissions are reviewed by a panel of government stakeholders. A limited number of organizations are selected for a Virtual Demonstration Day, where they present and demonstrate their capabilities directly to government end users. Selection can lead to prize awards and, potentially, follow-on opportunities to develop, transition, produce, and deploy the solution.

Do I keep ownership of my technology and IP?

Yes. Solvers retain all IP rights to their submissions. Submitting a solution does not transfer ownership or exclusive rights to the government or challenge sponsors. Only a non-exclusive, royalty-free license is requested, and solely for evaluation purposes.

Are there any restrictions on what I can propose or submit?

Yes, two worth noting. First, submissions must not contain Controlled Unclassified Information (CUI). Second, some brown tree snake control methods, notably acetaminophen-based toxicants, are restricted by the EPA to trained government personnel; any submission proposing a regulated intervention must describe a realistic compliance pathway.

Additional Resources

Review the solicitation here.

U.S. SBA’s Office of Investment and Innovation - Supply Chain Acceleration and Logistics Enablement (SCALE) Program - SBA-OIIGA-26-001

Quick Answer

The Supply Chain Acceleration and Logistics Enablement (SCALE) Program is a new FY 2026 grant opportunity from the U.S. Small Business Administration's Office of Investment and Innovation. SCALE funds organizations that deliver accelerator programming, technical assistance, and industry engagement to help small businesses overcome supply chain barriers in strategically important industries.

Funding Opportunity Number: SBA-OIIGA-26-001

How Much Funding Is Available Through SCALE?

SBA has allocated $9,000,000 in total FY 2026 funding under the Consolidated Appropriations Act of 2026. SBA expects to make approximately 20 awards, each up to $500,000, over a 24-month period of performance. Awards begin September 30, 2026.

When Is the SCALE Program Deadline?

The application window opened July 7, 2026 and closes August 7, 2026 at 4:00 p.m. Eastern Time. Applications must be submitted electronically through Grants.gov. Late submissions are rejected without evaluation, and Grants.gov registration alone can take one to two weeks, so organizations should begin the process immediately.

Who Is Eligible to Apply for SCALE Funding?

Eligible applicants are public or private entities, for-profit organizations, nonprofits, or institutions that plan to deliver accelerator programming, technical assistance, or industry engagement supporting small businesses in one of six priority supply chains:

• Advanced Manufacturing

• Biotechnology and Biomanufacturing Supply Chains

• Defense Industrial Base Technologies and Components

• Energy, Critical Materials, and Industrial Inputs

• Food Supply and Agricultural Systems

• Transportation, Logistics, and Industrial Infrastructure

Each applicant may submit only one proposal. Organizations must have an active Unique Entity Identifier (UEI) through SAM.gov to register on Grants.gov and receive an award.

Who Is Ineligible for the SCALE Program?

Applications are automatically rejected without evaluation if the organization:

• Owes an unresolved financial obligation to the federal government

• Is currently suspended or debarred from federal awards

• Has an unresolved Single Audit Act deficiency within the past three years

• Filed for bankruptcy within the past five years

• Proposes to act as a pass-through entity

• Was convicted of a federal felony, or had an officer or agent convicted, within the preceding two years

What Does a SCALE Proposal Need to Include?

A complete SCALE application consists of five parts:

1. Cover Letter (1 page)

2. Technical Approach and Organizational Qualifications (5 pages each, single-spaced, 12-point Times New Roman)

3. Attachments and Exhibits, including resumes, consulting agreements, and an organizational chart

4. Budget Information, including SF-424, SF-424A, a Budget Detail Worksheet, Budget Narrative, Cost Policy Statement, and Indirect Cost Statement

5. Certification Forms and Assurances, including a recent A-133 audit or financial statements

How Are SCALE Applications Scored?

Applications are evaluated on a 100-point scale:

• Technical Approach: 80 points total, covering Supply Chain Challenge and Opportunity (20 points), Small Business Support Programming (45 points), and Key Milestones and Outcomes (15 points)

• Organizational Qualifications: 20 points total, covering Organizational Mission and Long-Term Viability (4 points), Project Team and Management Approach (4 points), Data Collection and Performance Management (4 points), and Relevant Experience and Past Performance (8 points)

SBA sets a minimum acceptable score before evaluation begins and also considers overall portfolio balance, meaning a high-scoring proposal can still be passed over if it duplicates the industry focus of another selected applicant. Per Executive Order 14332, SBA gives preference to organizations with lower indirect costs when all else is equal.

How BW&CO Can Help

BW&CO Consulting helps deep-tech, biotech, medtech, healthtech, and defense-adjacent organizations position competitive federal funding applications, including complex multi-part submissions like SCALE. Our team supports technical narrative development, budget structuring, partnership alignment, and Grants.gov submission logistics so applicants can meet the August 7, 2026 deadline with a complete, evaluation-ready package.

Contact BW&CO Consulting to discuss SCALE Program eligibility and proposal strategy.

Additional Resources

Review the solicitation here: Subnet BAA

DLA SUBNET BAA (SP4701-26-B-0003):

Quick Answer

The Defense Logistics Agency (DLA) Subsistence Network (SUBNET) Broad Agency Announcement is a five-year, unrestricted BAA (posted July 14, 2026) offering up to $35 million through Fiscal Year 2030 for R&D that modernizes the military's food supply chain. Small businesses in food technology, smart packaging, robotics, AI, and autonomous logistics are strongly encouraged to apply. There are no set-asides, but no minimum size standard exclusions either: any responsible small business can compete directly against large primes, and the program is explicitly designed to reward innovation over incumbency.

What Is the SUBNET BAA?

SUBNET (BAA SP4701-26-B-0003) is a Defense Logistics Agency-sponsored Department of War Manufacturing Technology Program focused on Class I (Subsistence) supply chain modernization. It funds an initiative called ALICE, the Advanced Logistics Initiative for Contested Environments, which is shifting DLA away from pure "pull-based" resupply toward a hybrid push-pull model built on three pillars:

Agile & Predictive Acquisition — rapid acquisition pathways for shelf-stable, freeze-dried, vacuum-sealed, and UHT-processed rations with 5-7+ year shelf lives.

Smart Packaging & Strategic Pre-Positioning — packaging with embedded real-time tracking, environmental sensors, and chemical indicators for food safety and quality.

Autonomous & Resilient Distribution — unmanned ground vehicles, cargo drones, and robotics for last-tactical-mile delivery in contested environments.

Beyond these pillars, DLA lists 20 additional areas of interest, including AI-driven supply chain optimization, additive manufacturing (3D food printing), sustainable food production, robotics and automation for ration assembly, food safety and defense, and circular economy/waste reduction solutions.

Key Facts at a Glance

Solicitation Number: BAA SP4701-26-B-0003

Issuing Agency: Defense Logistics Agency (DLA), Troop Support

Posted: July 14, 2026

BAA Duration: 5 years (open through 2030/2031)

Total Program Ceiling: Up to $35 million, FY2026 to FY2030

Typical Award Duration: 6 to 36 months

Set-Asides: None (unrestricted, but small businesses are actively encouraged)

Small Business Size Standard: 1,000 employees

NAICS Code: 541715

Subcontracting Plan Trigger: Required for large businesses/non-profits on awards over $750,000

Certified Cost/Pricing Data Trigger: Required for proposals of $2 million or more

Who Should Apply?

This BAA is unusually broad and directly relevant to deep-tech and dual-use startups that may not think of themselves as "defense food" companies. If your company works in any of the following, SUBNET is worth a look:

Combat rations, shelf-stable food, or nutrition science

Smart packaging, IoT sensors, or cold-chain/condition monitoring

Robotics and automation (including ration assembly or warehouse automation)

Autonomous ground vehicles or cargo drones for last-mile logistics

AI/ML for supply chain and demand forecasting

Additive manufacturing (3D printing) applied to food or materials

Sustainable or alternative food production (vertical farming, plant-based protein, lab-grown nutrients)

Water security and hydration technology

Cybersecurity applied to supply chain condition monitoring (CMMC Level 1 relevant)

Teaming with established combat ration assemblers (such as AmeriQual, Baxters, or Sopakco) is encouraged but not required.

How the Two-Stage Process Works

SUBNET uses a staged, low-burden approach designed to reduce risk for both DLA and offerors.

Stage I: Feasibility Study (up to 12 months)

No prototype is required. Offerors deliver a feasibility study that includes a Concept of Operations (CONOPS), functional and system requirements, preliminary metrics (KPPs/KPIs/KSAs), and an estimated Technology Readiness Level (TRL). DLA evaluates the study as Acceptable or Unacceptable and may invite the offeror to propose for Stage II.

Stage II: Prototype or Conceptual Solution Development (up to 24 months)

Offerors choose one of two paths:

COA A (Analytical Study or Conceptual Solution): in-depth modeling, simulation, or process recommendations ready for DLA to adopt.

COA B (Prototype Development): a physical prototype at a minimum of TRL 7, with formal test and evaluation.

Fast-track option:

Companies with a documented history of successful past SUBNET performance may skip Stage I entirely and propose directly for Stage II.

How to Apply: White Paper First

DLA does not accept unsolicited full proposals. The process starts with a White Paper, limited to 6 pages (cover sheet, 1-page executive summary, and up to 4 pages covering goals, technical plan, capabilities, and cost/schedule). The mandatory template is provided in Attachment A of the BAA.

The White Paper must answer four questions:

What is the proposed work attempting to accomplish?

How is it done today, and what are the limitations?

Who benefits, and what is the impact if successful?

How much will it cost, and how long will it take?

White papers are not scored competitively. DLA either responds that the concept is not of interest, or invites a full technical and cost proposal. Only proposals invited after a white paper will be evaluated.

Submit white papers by email to:

Andrea.Nicolucci@dla.mil

Lauren.Runowski@dla.mil

CC: RandD.DCSO@dla.mil

How Proposals Are Evaluated

If invited to submit a full proposal, technical proposals (20 pages max) are evaluated through a peer/scientific review process on four factors, each rated Highly Acceptable, Acceptable, or Not Acceptable:

Feasibility (Overall Scientific and Technical Merit): Is the technology real or realistically achievable? TRL 4+ approaches score highest.

Viability: Can DoW/DLA actually adopt this given policy, cybersecurity, and FedRAMP constraints?

Desirability: Will end users actually want and use it?

Past Performance: Relevant experience in the last three years. Companies without past performance are rated neutrally, not penalized.

Cost proposals are evaluated separately for cost realism and are not the controlling factor in award decisions.

Why This Matters for Small Businesses

Unlike many defense R&D vehicles, SUBNET carries no set-asides, which means there is no artificial ceiling on small business participation. It also has no dedicated small business allocation, so small businesses compete on technical merit alongside large primes. Combined with the low-burden Stage I feasibility study (no prototype required, no per-project page-heavy proposal until DLA is already interested), this is a comparatively accessible entry point into Department of War-adjacent funding for companies that have never held a defense contract.

Frequently Asked Questions

What is the DLA SUBNET BAA?

DLA SUBNET (BAA SP4701-26-B-0003) is a Broad Agency Announcement from the Defense Logistics Agency funding R&D that modernizes the military's Class I subsistence (food) supply chain, with up to $35 million available through Fiscal Year 2030.

Is SUBNET set aside for small businesses?

No. SUBNET is an unrestricted acquisition with no set-asides, because DLA determined the research areas could not practically be reserved. However, DLA actively encourages small businesses, including SDBs, WOSBs, HUBZone firms, VOSBs, and SDVOSBs, to submit white papers.

Do I need a prototype to apply?

No. Stage I is a feasibility study only, with no prototype development required. A physical prototype is only required in Stage II, and only if the offeror selects Course of Action B (Prototype Development).

How do I submit a proposal to SUBNET?

You cannot submit a full proposal directly. You must first submit a 6-page White Paper using the mandatory template in Attachment A. If DLA finds it of interest, the Contracting Officer will invite a full technical and cost proposal.

How long does SUBNET funding last?

Individual awards typically run 6 to 36 months. The BAA itself remains open for five years, from Fiscal Year 2026 through Fiscal Year 2030.

What technologies is DLA looking for under SUBNET?

Priority areas include shelf-stable and freeze-dried rations, smart packaging with embedded sensors, autonomous ground vehicles and cargo drones for last-mile delivery, AI-driven supply chain optimization, robotics for ration assembly, additive manufacturing (3D food printing), and sustainable food production methods.

Who is the point of contact for the SUBNET BAA?

White papers and questions should be directed to Andrea Nicolucci and Lauren Runowski at Andrea.Nicolucci@dla.mil and Lauren.Runowski@dla.mil, with a copy to RandD.DCSO@dla.mil.

How BW&CO Can Help

• Assess whether your technology fits SUBNET's Areas of Interest and whether Stage I or a direct-to-Stage II path makes sense for you

• Draft and refine your 6-page White Paper using DLA's mandatory template

• Build out the CONOPS, functional requirements, and TRL positioning DLA evaluators expect

• Prepare your technical and cost proposal if invited past the White Paper stage

• Identify teaming partners, including combat ration assemblers, if a partnership strengthens your proposal

Additional Resources

Review the solicitation here: Subnet BAA

Air Force Research Laboratory (AFRL) Enterprise Commercial Solutions Opening (CSO) - FA8652-26-S-C003

Last updated: July 12, 2026. Verify current status of any referenced Spiral on SAM.gov before submitting — Spirals open, close, and are added on a rolling basis.

Below is a brief summary. Please check the full solicitation before applying (link in Additional Resources).

Quick Answer

The AFRL Enterprise CSO is a standing, indefinite-duration umbrella announcement that the Air Force Research Laboratory uses to launch specific competitive solicitations, called Spirals, across nearly 100 technology Areas of Interest spanning air, space, cyber/electronic warfare, cross-domain, and basic research. Companies don't apply to the Enterprise CSO directly; they respond to an individual Spiral issued under it, using either a one-step process (Commercial Solutions Proposal) or a two-step process (Commercial Solutions Brief, followed by an invited Commercial Solutions Proposal). Awards can be FAR Part 12 commercial contracts or Other Transaction Prototype agreements.

Unlike many CSOs, foreign participation here is prohibited outright — this is not a "restricted but possible" eligibility gate.

Key Facts at a Glance

•     Administering agency: Air Force Research Laboratory (AFRL)

•     Solicitation number: FA8652-26-S-C003 (Amendment 01, 8 July 2026)

•     Authority: 10 U.S.C. § 3458; R-DFARS Subpart 212.70; NDAA FY22 § 803

•     Opportunity type: Enterprise-level CSO umbrella — actual competitions occur under individual Spirals

•     Duration: Active indefinitely; updated annually until terminated

•     Areas of Interest: Approximately 94 sub-areas across five domains (Air, Space, Cyber/Electronic Warfare, Cross-Domain, Basic Research)

•     Application format: One-Step: Commercial Solutions Proposal (CSP). Two-Step: Commercial Solutions Brief (CSB) — PowerPoint plus white paper — then an invited CSP

•     Award mechanisms: FAR Part 12 fixed-price contract, or Other Transaction for Prototype (OTP) under 10 U.S.C. § 4022, including follow-on production

•     Typical award size: Not specified in the solicitation. Awards under comparable DoD CSO/OTP mechanisms have ranged from roughly $100,000 for early feasibility efforts to $10 million or more for larger prototype demonstrations — actual amounts depend entirely on the Spiral and funding available

•     Who can apply: U.S. commercial companies, small businesses, nontraditional defense contractors, nonprofit research institutions

•     Who cannot apply: Foreign persons and FOCI (foreign-owned, controlled, or influenced) entities — prohibited outright, no exceptions stated

•     Security requirement: NIST SP 800-171 compliance for Covered Defense Information; a Science and Technology Protection Initial Risk Review for selectable proposals

How This CSO Actually Works: Enterprise CSO + Spirals

This is the single most important structural fact to understand before pursuing this opportunity: FA8652-26-S-C003 is not itself a solicitation you submit against. It's a framework document that authorizes AFRL Mission Organizations (its internal directorates) to issue individual Spirals — the actual competitive solicitations — at any time, tied to specific Areas of Interest.

Each Spiral specifies its own Areas of Interest in scope, submission format, dates, and evaluation criteria, and states whether it's Open (accepts submissions on a rolling basis) or Closed (narrows scope, hard deadline — late submissions are handled per FAR 52.212-1(c) and generally not considered). It will also state whether it uses a One-Step or Two-Step process.

One-Step Spiral (Commercial Solutions Proposal): Submit a complete CSP directly — technical proposal, price proposal, and Statement of Work. Evaluated once, then categorized as Selectable, Selectable/Insufficient Funding, or Not Selectable.

Two-Step Spiral (Commercial Solutions Brief, then Commercial Solutions Proposal): Step 1 is a CSB — a PowerPoint briefing plus a white paper (the Government may substitute a Pitch instead). It's evaluated on Technical Merit/Applicability and Funding Availability, weighted equally. If categorized Selectable, you're invited to Step 2: a full CSP (technical proposal, price proposal, SOW), evaluated on Technical Merit/Applicability, Importance to Agency Programs, Price, and Funding Availability, all weighted equally.

Because new Spirals can be issued at any time against any of the roughly 94 Areas of Interest, companies with relevant dual-use technology should monitor SAM.gov regularly rather than treating this as a one-time application.

Active Spiral as of This Writing

As of mid-2026, AFRL has an active Centralized, Open Two-Step Spiral (FA8652-26-S-C005) accepting Commercial Solutions Briefs, currently scoped to the Foundational Technologies (AFRL/RE) mission organization, open April 30, 2026 through April 30, 2027. This is a live, actionable entry point today — but confirm current scope and status on SAM.gov, since additional Spirals may have opened, or this one may have been amended, since this page was last updated.

Areas of Interest

Solution Briefs and Proposals must map to one or more of the Areas of Interest below. Each AOI sits within one of five domains; the specific Spiral you respond to will define which AOIs are currently in scope.

1. Air Domain Technologies

•     Human Performance Optimization — physical, cognitive, and human-machine interface techniques that enhance warfighter capability and resilience.

•     Aerospace Medicine and Operational Health — physiological monitoring, environmental protection, and medical support for air, space, and cyber operations.

•     Warfighter Survivability and Protection — personal protective equipment, threat detection, casualty care, and directed-energy protection.

•     Cognitive and Behavioral Sciences — perception, decision-making, and human-system interaction in complex environments.

•     Advanced Air Vehicles — next-generation aircraft: high-speed flight, maneuverability, stealth, optionally-manned configurations.

•     Air Propulsion Systems — turbine engines, scramjets and ramjets, and advanced powerplants.

•     Aerodynamics and Flight Sciences — flight control, stability, and performance research for maneuverability and endurance.

•     Hypersonics — materials, propulsion, guidance, and control for Mach 5+ flight.

•     Advanced Weapons Technologies — smart munitions, precision-guided munitions, novel warhead designs.

•     Energetics and Propellants — advanced energetic materials, propellants, and explosives with improved safety and performance.

•     Guidance Navigation and Control — accuracy, maneuverability, and target discrimination systems.

•     Munitions Survivability and Countermeasures — munition robustness against countermeasures and hostile environments.

•     Rocket Systems — solid, liquid, and hybrid rocket motors, propellants, thrust vector control, and tactical missile integration.

•     Nuclear Deterrence Technologies — strategic delivery platform modernization, NC3 systems, and fuzing/guidance for deterrence.

2. Space Domain Technologies

•     Space Access and Orbital Systems — launch vehicles, space propulsion, and maneuvering systems for reliable access to space.

•     Spacecraft and Satellite Technologies — satellite bus design, payloads, communications, and on-orbit servicing.

•     Space Power and Propulsion — solar arrays, energy storage, and electric propulsion for satellite life and maneuverability.

•     On-Orbit Operations and Autonomy — autonomous spacecraft operations, rendezvous and proximity operations, and debris mitigation.

•     Space Domain Awareness — sensors and analytics to detect, track, and characterize space objects and threats.

•     Resilient and Survivable Space Architecture — distributed constellations and hardened systems for contested environments.

•     Space Environment and Effects — space weather and radiation effects mitigation for space assets.

•     Position, Navigation, and Timing (PNT) From and For Space — space-based positioning, navigation, and timing systems.

•     Satellite Assembly, Integration & Testing — processes and facilities for spacecraft integration and environmental test/verification.

3. Cyberspace / Electronic Warfare Domain Technologies

•     Cyber Operations and Cybersecurity — offensive and defensive cyber capabilities, threat intelligence, and incident response.

•     Communications and Networks — software-defined radios, dynamic spectrum management, and resilient tactical networks.

•     Electronic Warfare and Spectrum Operations — electromagnetic spectrum dominance: signal processing, electronic attack and protection.

•     Quantum Technologies — quantum computing, communication, and sensing; algorithms for intractable problems.

•     Electro-Optical and Infrared Sensors — imaging and sensing across visible, infrared, and ultraviolet spectra for detection and tracking.

•     Radar and Radio Frequency Sensors — AESA, synthetic aperture radar, and low-probability-of-intercept/detection radar for target tracking.

•     Multispectral and Hyperspectral Sensing — multi-band sensors for material discrimination and camouflage detection.

•     Signal Processing and Sensor Fusion — multi-sensor integration for target recognition and situational awareness.

•     Quantum Sensing and Advanced Properties — photonic and quantum devices for sensitivity, resolution, and miniaturization.

•     Directed Energy Sensing and Countermeasures — sensors detecting and characterizing directed-energy threats.

•     High-Energy Laser Systems — scalable high-power lasers (solid-state, fiber) and beam control for weaponization.

•     Photonics — light-based capabilities for sensing, quantum information science, and directed energy.

•     High-Power Electromagnetic Technologies — high-power microwave sources, pulse power, and antennas for non-kinetic disable/disrupt effects.

•     High Power Electromagnetic Effects — physics-level and system-level testing of high-power microwave and particle-beam effects.

•     High Power Electromagnetic Applications — end-to-end high-power electromagnetic system design, build, integration, and field testing.

•     Beam Control and Adaptive Optics — beam steering and atmospheric compensation for laser accuracy.

•     Directed Energy Effects and Countermeasures — physical and operational effects of directed-energy weapons and defensive countermeasures.

•     Cybersecurity for Digital Environments — threat detection, vulnerability assessment, and resilient digital architectures.

•     Navigation Warfare and Counter PNT — disrupting adversary PNT and protecting friendly PNT in GPS-denied environments.

4. Cross-Domain Technologies

•     Human Systems Integration — human factors engineering, user interface design, and cognitive support for system usability.

•     Human-Machine Teaming and Interfaces — improving interaction between humans and AI-enabled systems.

•     Training and Simulation Technologies — virtual reality, augmented reality, serious gaming, and adaptive learning for readiness and mission rehearsal.

•     Rapid Multi-Domain Integration — interoperable, networked systems combining air, space, cyber, EW, and ground capabilities.

•     Advanced Systems Engineering — requirements engineering, architecture, modeling and simulation, and verification/validation.

•     Integrated Vehicle Health Management — real-time platform monitoring and diagnostics for safety and readiness.

•     Power and Thermal Management — power generation, storage, distribution, and thermal dissipation technologies.

•     Advanced Materials Development — high-temperature ceramics, lightweight composites, metamaterials, and bio-inspired materials.

•     Additive Manufacturing — on-demand production of complex geometries and multi-material components.

•     Materials Processing and Fabrication — nanomanufacturing, advanced joining, surface engineering, and coatings.

•     Materials Characterization and Testing — experimental and computational methods to understand material performance.

•     Environmentally Responsive and Smart Materials — adaptive, sensing, and self-healing materials.

•     Microelectronics — micro-scale electronics and integrated circuits for defense and aerospace systems.

•     Model-Based Systems Engineering, Digital Engineering, and Digital Thread — digital twins and virtual prototypes across the system lifecycle.

•     Advanced Simulation and Virtual Prototyping — computer-aided engineering simulation and testing before physical creation.

•     Data Analytics and Artificial Intelligence — machine learning and AI for predictive analytics, pattern recognition, and automated reasoning.

•     Additive Manufacturing Digital Integration — generative design, topology optimization, and in-situ additive manufacturing process monitoring.

•     Low C-SWAP Alternative PNT for Attritable Systems — affordable, expendable PNT for disposable unmanned aircraft in GPS-denied environments.

•     Modular Open Architecture for Resilient PNT — standardized-interface PNT systems enabling rapid upgrades.

•     Robotics Technologies — autonomous and semi-autonomous robots for logistics, maintenance, and hazardous-environment tasks.

•     Software Systems Development — DevSecOps, modular open architecture, and AI/ML/autonomy software.

•     Physiological Operations — systems exploiting human cognition to influence adversary decision-making.

•     Runtime Assurance (RTA) for AI — real-time safety monitoring that reverts AI systems to a trusted backup controller.

•     Autonomy (for Airborne Platforms) — uncrewed aerial systems that navigate and execute missions with minimal human input.

5. Basic Research Technologies (AFOSR-Aligned)

•     Energetic Solid-State Physics and Mechanochemistry — chemistry and physics of solid-state energetic materials under extreme conditions.

•     Energy, Combustion, and Non-Equilibrium Thermodynamics — chemical energy conversion for propulsion, electricity, and directed energy.

•     Aerodynamic Sciences — fundamental flowfield physics across internal and external configurations.

•     High-Speed Aerodynamics — high-speed, high-temperature non-equilibrium flow physics.

•     Aerospace Composite Materials — chemistry, physics, and mechanics of novel composite materials.

•     Aerospace Structures — emerging structural materials, meta-architectures, and intelligent subsystems.

•     Propulsion and Power — fundamental discovery to enable enhanced maneuver and power capabilities.

•     Agile Science for Test and Evaluation (T&E) — metrology and test methods across autonomy, hypersonics, and cyber/microelectronics.

•     Computational Cognition and Machine Intelligence — mathematical and computational foundations of machine intelligence and human-machine alignment.

•     Computational Mathematics — algorithms for large-scale engineering, design, and predictive simulation.

•     Dynamical Systems and Control Theory — mathematics of analysis and control for complex dynamical systems.

•     Dynamic Data and Information Processing — real-time model refinement using measured or simulated data.

•     Information Assurance and Cybersecurity — securing distributed systems, nanoscale devices, and quantum information.

•     Mathematical Optimization — theory and algorithms for allocation, planning, logistics, and scheduling problems.

•     Science of Information, Computation, Learning, and Fusion — extracting information from large, heterogeneous, multi-modal data.

•     Trust and Influence — social and cognitive principles of trust between humans and intelligent agents.

•     Complex Networks — structural analysis of large, dynamic, interdependent network systems.

•     Cognitive and Computational Neuroscience — neural mechanisms of perception, cognition, and behavior; brain-inspired computing.

•     Atomic and Molecular Physics — cold and ultra-cold quantum gases, precision measurement, and matter-wave optics.

•     Electromagnetics — linear and nonlinear electromagnetics and signal processing.

•     Optoelectronics and Photonics — light-matter interaction at the nanoscale for communications and computation.

•     High-Energy Radiation-Matter Systems — interaction of electromagnetic energy and matter for directed-energy weapons and sensors.

•     Quantum Information Sciences — non-classical phenomena for information analysis, storage, and protection.

•     Physics of Sensing — fundamental physics of remote detection and object characterization.

•     Space Physics — solar-terrestrial environment effects on tracking, communications, and navigation.

•     Ultrashort Pulse Laser-Matter Interactions — physical phenomena from ultrashort-pulse laser interactions with matter.

•     Condensed Matter Physics — new quantum phases and macroscopic properties in solid-state materials.

•     Astrodynamics — physics of motion and control of natural and artificial objects in Earth/Moon/Sun gravity fields.

Which AFRL Directorate Owns Which Domain

Every Area of Interest is mapped to one or more AFRL Mission Organizations in Attachment 1 — this determines who within AFRL actually reviews your submission. At a domain level:

•     Air Warfare (AFRL/RA): concentrated in Air Domain Technologies, plus select Cross-Domain and Basic Research areas

•     Foundational Technologies / AFOSR (AFRL/RE): the dominant directorate across nearly all of Basic Research Technologies, plus broad Cross-Domain coverage

•     Information & Spectrum Warfare (AFRL/RF): heavy coverage across Air, Space, and especially Cyberspace/Electronic Warfare Domain Technologies

•     Space Warfare (AFRL/RJ): broad coverage across Air, Space, Cyber/EW, Cross-Domain, and Basic Research

•     Digital Capabilities (AFRL/IZ): narrower, concentrated in select Cyber/EW and Cross-Domain digital topics

•     711th Human Performance Wing (711HPW): Air Domain human performance and medicine topics, plus human-machine teaming and physiological operations

•     Technology Transition (AFRL/RR) and Systems Technology Office (AFRL/STO): not mapped to specific Areas of Interest in the alignment table; these function as cross-cutting/transition support rather than topic owners

Because a single Area of Interest can map to multiple directorates, and because the specific Spiral, not the Enterprise CSO, determines which directorate actually evaluates your submission, confirming the right directorate fit before drafting is worth doing early. This is exactly the kind of fit assessment BW&CO does at kickoff.

Frequently Asked Questions

How much funding would I receive?

The solicitation does not specify award amounts — funding is set at the individual Spiral level and depends on availability. Awards may be structured as FAR Part 12 fixed-price contracts or as Other Transactions for Prototype (OTP) under 10 U.S.C. § 4022, including follow-on production agreements. Based on comparable DoD CSO/OTP mechanisms, awards have ranged from roughly $100,000 for early feasibility or component-level efforts up to $10 million or more for larger prototype and production-representative demonstrations. The Government may incrementally fund any award and reserves the right to fund all, some, or none of a proposal, including funding only part of a submission it deems Selectable.

What could I use the funding for?

Funding supports "innovative" solutions as legally defined: technology, processes, or methods (or new applications of existing ones) that are new as of your proposal's submission date. This spans advanced component development through full operational systems development, and can include prototype projects under OTP authority. A narrower category, Studies and Analysis funded with Operations and Maintenance appropriations, covers short-term (generally one year or less), non-developmental investigative work addressing urgent, near-term Air Force and Space Force needs.

What is the actual timeline to apply?

There is no single application deadline. You apply by responding to an individual Spiral, and each Spiral sets its own timeline. Open Spirals accept submissions on a rolling basis; Closed Spirals set a hard deadline, after which late submissions are handled under FAR 52.212-1(c) and generally not considered for award. The Enterprise CSO itself remains active indefinitely, refreshed annually until terminated, with new Spirals issued at any time. As of mid-2026, an active Centralized, Open Two-Step Spiral (FA8652-26-S-C005) covering the Foundational Technologies mission organization is open through April 30, 2027 — verify current status and scope on SAM.gov.

Who is eligible to apply?

U.S. commercial companies, small businesses, nontraditional defense contractors, and nonprofit research institutions registered in SAM.gov and determined "responsible" under FAR Subpart 9.1 are eligible. For awards structured as OTPs specifically, at least one of the following must also be true: a nontraditional defense contractor or nonprofit research institution participates significantly; all significant non-government participants are small businesses or nontraditional defense contractors; at least one-third of total project cost comes from non-federal sources; or the agency's Senior Procurement Executive documents exceptional circumstances justifying the transaction.

Who is NOT eligible to apply?

Foreign persons and foreign-owned, controlled, or influenced (FOCI) entities are prohibited from participating in awards under this announcement — full stop, with no stated exception. This is a meaningfully harder line than many other DoD CSOs, including some Army CSOs, which permit foreign-owned businesses to compete subject to review and approval. Companies should also expect exclusion if suspended or debarred from federal contracting, prohibited by law from receiving federal awards, or unable to meet required security clearances for a given effort.

What companies and projects are likely to win?

Companies with technology that's genuinely new as of the proposal date, not incremental refinement of an existing government-known capability, and that map cleanly to a specific, currently-open Spiral's Areas of Interest are best positioned. CSB submissions are weighed equally on Technical Merit/Applicability and Funding Availability; CSP submissions add Importance to Agency Programs and Price to that mix, still weighted equally. Because the Government can categorize a submission "Selectable" yet unfundable, technical merit alone doesn't guarantee an award — timing against available budget matters just as much.

How competitive will this be?

The solicitation doesn't disclose award volume or success rates, and competitiveness will vary enormously by Spiral and Area of Interest. With roughly 94 Areas of Interest spanning basic research through operational systems, and eight separate mission organizations issuing their own Spirals independently, this functions less like a single competition and more like dozens of parallel, narrower competitions, each with its own funding pool and evaluation timeline.

What restrictions should I know about?

Key constraints beyond eligibility: submissions containing Controlled Unclassified Information must go through DoD SAFE, not standard email; awards involving military-critical technical data may require a certified DD Form 2345 and Defense Logistics Agency registration under ITAR/EAR; awarded efforts are subject to NIST SP 800-171 safeguarding requirements for Covered Defense Information; and non-government advisors (FFRDCs, SETA, and A&AS contractors) under signed NDAs may review your proposal on the Government's behalf.

How long will it take to prepare an application?

Preparation time isn't specified and depends on the Spiral, but the barrier to entry is intentionally low for Step 1. A Two-Step CSB is a PowerPoint briefing plus a white paper (or a Pitch, if the Spiral requires one), not a full proposal. Only companies invited to Step 2, or those responding to a One-Step Spiral, need to prepare a complete Commercial Solutions Proposal with a technical volume, price volume, and Statement of Work.

How BW&CO Can Help

The AFRL Enterprise CSO's structure — an indefinite umbrella document with dozens of independently-issued Spirals across eight mission organizations — makes "which opportunity should I actually respond to" a harder question than it looks. BW&CO helps companies:

•     Fit assessment — Identify which currently-open Spiral, and which of the roughly 94 Areas of Interest, fits your technology

•     Mechanism strategy — Determine whether your submission is better positioned as a FAR Part 12 contract or an OTP, and confirm OTP eligibility criteria are met

•     Proposal development — Draft compelling Commercial Solutions Briefs and Proposals within the required page and slide limits

•     Compliance — Navigate NIST SP 800-171, export control, and Science and Technology Protection review requirements before they become a late-stage surprise

•     Monitoring — Track SAM.gov for new and amended Spirals aligned to your capabilities

Additional Resources

Review the solicitation here: SAM.gov — FA8652-26-S-C003

United States Army Combat Capabilities Development Command (DEVCOM) Ground Vehicle Systems Center (GVSC) Commercial Solutions Opening (CSO)

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The U.S. Army DEVCOM Ground Vehicle Systems Center (GVSC) Commercial Solutions Opening (CSO) is an ongoing solicitation designed to help the Army rapidly identify and acquire innovative commercial technologies that support the modernization of military ground vehicle capabilities. Unlike a traditional grant or procurement with a single application deadline, this CSO contains multiple Areas of Interest (AoIs) covering a wide range of technologies including robotics, artificial intelligence, autonomous systems, cybersecurity, advanced manufacturing, power systems, vehicle survivability, software engineering, modeling and simulation, and next-generation vehicle electronics.

Most Areas of Interest accept solution briefs on a rolling basis while the CSO remains open. However, individual AoIs may establish their own submission deadlines, which take precedence over the general solicitation timeline. Companies should carefully review the specific AoI before preparing a submission.

Unlike many Department of Defense opportunities that seek early-stage research, this CSO emphasizes innovative commercial technologies that can be demonstrated, adapted, integrated, or rapidly transitioned into Army applications through commercial contracts, Other Transaction Agreements (OTAs), Cooperative Agreements, or other acquisition mechanisms. Awards may support commercially available products, prototype demonstrations, pilot programs, technology maturation, and other activities that improve Army ground vehicle capabilities.

Companies may submit solution briefs for any open Area of Interest. The Government may evaluate submissions through a multi-phase process consisting of a written Solution Brief, an optional presentation or demonstration, and an invitation to submit a Commercial Solution Proposal (CSP). The Government also reserves the right to skip phases or move directly to a proposal request when appropriate.

Because new Areas of Interest may be added throughout the life of the solicitation and existing topics may be amended, companies with dual-use technologies should periodically monitor the CSO for new opportunities that align with their capabilities.

How much funding would I receive?

The solicitation does not specify award amounts, funding ranges, or the number of anticipated awards. Most awards coming from these CSOs range from the $500,000 to $5 million range.

Award values will depend on the individual Area of Interest, available funding, and the proposed commercial solution. The Government states that Requests for Commercial Solution Proposals (CSPs) are subject to the availability of funds, and that no specific dollars have been reserved for awards under the CSO.

Areas of Interest:

The following technology areas are currently included within the DEVCOM GVSC Commercial Solutions Opening. Unless otherwise stated within an individual Area of Interest, solution briefs may be submitted while the CSO remains open. Certain topics include separate submission deadlines, which take precedence over the general solicitation timeline.

GROUND VEHICLE ADVANCED POWER SYSTEMS:

This effort focuses on advancing electrical power systems up to 1.5MW of power for use on Military ground vehicles. The goal of this campaign is to meet the Army’s increasing electrical power needs while improving vehicle efficiency and the power density of power electronics. This will be made possible by exploiting the gains made in emerging power electronic designs and the use of cutting-edge electrical components. These advances will significantly impact future Army vehicle design and will enable the Army to have a decisive overmatch to near peer adversaries.

a. Power System Architecture up to 1.5MW: The objective of power system architecture topic develop architectures that are suitable for delivery of up to 1.5MW of power to vehicle systems and mission payloads. These architectures need to account for hybrid electric or all electric powertrains, high energy loads like cooling system, energy weapons, power export, and legacy 28Vdc/600Vdc power systems. There are three (3) key areas of investigation for this effort: 1) what safety features are needed to make the architecture a viable product; 2) is a voltage greater than 600Vdc needed; and 3) are electric components available at these voltage/power levels.

b. Advance Power Electronic Design: This topic focuses on taking advantage of cutting-edge power electronic design to significantly increase power density and power efficiency which will result in smaller devices that require less cooling and are easier to package. This topic includes, but is not limited to, advanced designs such as wideband gap semiconductors, soft switch, zero-volt switching, zero-current switch, modular multi-level converter, active filtering, and all other techniques to meet the focus of increased power density and power efficiency.

c. Artificial Intelligence or Machine Learning (AI/ML) in Power Management Systems: This topic focuses on advancement in power management systems for ground vehicles as power management will enable more efficient vehicles. This topic incorporates advancements in AI/ML algorithms and knowledge base to adapt to how the vehicle is being used and learn the most efficient way to operate the vehicle. This topic also has two (2) key enablers in advancing AI/ML power system development: 1) power system modeling; and 2) hardware in-the loop software development.

d. Wireless Power Transfer: This topic focuses on wireless power transfer up to 1MW of power as there are two (2) target areas for wireless power transfer on Army ground vehicles. The first focus area is a safe, reliable way to recharge the vehicles through wireless recharge stations. The second focus area is wireless power transfer to transfer power between a hull and turret, bypassing the slipring.

e. Power System Physical Interfaces: Often when developing advance power electronics, the height and width of the design is dictated by the physical interface components, such as connectors, coolant fitting, and cabling. This topic focuses on the necessary advancement of interface components to reduce the physical size of the design. Also, these physical interface components often have very long lead times which can be problematic for procurement and integration, so advanced manufacturing approaches to reduce component lead time will also be explored under this topic.

f. Ground Vehicle MIL-Rugged Computing Architectures for Artificial Intelligence Applications: The US Army is interested in ruggedized computing architectures designed for running AI applications on military ground vehicles. In order to be considered rugged, the computers would need to meet ATPD-2404 requirements such as operating through pressure washing, submergence in 1 meter of water, gun shock, and operating in a 71C environment with little to no airflow. AI applications for mobility, autonomy, or target recognition largely depend on GPU or GPU-like processing ability with quick access to large amounts of memory. Utilizing MIL-STD-1275F or MIL-STD-3072 electrical power input, what products are available or could be developed to provide the most processing capability in a Standardized A-Kit Vehicle Envelope (SAVE) space claim or smaller and still meet the required environmental conditions?

g. Advanced Power Production and Storage: The US Army is interested in advanced power production and storage technologies, including novel batteries and fuel cells. Objectives include those that provide improved durability, reduced costs, and increased energy density, making them an attractive option for military vehicle applications. These technologies also include the ancillary enabling technologies, such as production of hydrogen for hydrogen fuel cells. These may come from industries such as automotive, aerospace, and energy.

h. Prototype Vehicle Experimentation Technical Support. The US Army is seeking technical support for high voltage vehicles during soldier touchpoint and demonstration events. Objectives include CONUS and OCONUS field repair and component replacement for the high voltage vehicles and are required to include the following: provide safety and driver training to select Government and military personnel; provide onsite technical/repair support (as needed) during vehicle events; order and field receipt of repair parts and supplies; diagnose, develop and execute plans for field maintenance and repair; arrange vehicle transportation to and from experimentation sites or for major repairs or regular maintenance; conduct major repairs and regular maintenance (as required); provide reach back technical and engineering support (as required). Working knowledge of the specific vehicle is required.

GROUND VEHICLE ROBOTICS (GVR):

The GVR mission is to develop, experiment, demonstrate, test and transition autonomy enabled ground system capabilities and technologies to meet and shape Army requirements.

The U.S. Army DEVCOM Ground Vehicle Systems Center (GVSC) seeks innovative commercial solutions that advance Autonomous Multidomain Robotic Systems. As the Army accelerates modernization toward multi-domain operations (MDO), the integration of heterogeneous robotic and autonomous systems (RAS) operating cohesively across ground, air, and sea domains represents a critical capability gap and strategic priority. GVSC, in support of CPE Mission Autonomy's future efforts, is interested in technologies and approaches that enable unmanned systems to function as a unified, intelligent combat team to execute complex missions with minimal human intervention while preserving human decision authority where necessary.

a. Agile Development of Logistics Material and Technical Services. To rapidly demonstrate and test GVR vehicle autonomy system innovative commercially available solutions for logistics material development that leverage existing autonomy systems, documentation, software and displays. Reducing cost and delivery time is required across the full spectrum of logistics material development. Application of Agile Development Process for maintenance, operation, supply, training materials and services is desired. Leveraging innovative commercial technologies, capabilities, processes, and techniques along with demonstrating the benefits of continuous integration and delivery during the development of operator and maintainer training, technical manuals, publications, and field support is desired. Additionally, the Government seeks alternative methods of delivering the materials to the soldier and collecting feedback and validating the new methods as well as supporting the transition of the new processes to programs of record is desired.

b. Cybersecurity. Commercial software and hardware to address cyber threats, which are a threat in the battlespace. Of particular interest is commercial software that enables the Army and its ground vehicle fleet to adapt to this environment with advancing cybersecurity technologies to become resilient to such threats. This includes applications of AI and quantum decryption as part of cyber security.

c. C-UAS. Commercial technology to counter the threat of drone-based attacks on ground vehicles and their sustainment and command and control support systems. Counter UAS capabilities of particular interest include one or more of the following technologies:

1) Sensing, such as radar, lidar, acoustic detectors, and optical sensors, which can detect, identify, classify, and track drones in real-time.

2) Hostable Portable software suitable for Fire Control, Blue Force deconfliction, Threat Point Of Origin (POO) and Track Triangulation, Sensor Fusion, Protection Projection, threat intent classification, payload identification, and weapon system handoff ( on and off platform), crew notification and interaction

3) Effectors to include but not limited to Kinetic Hard Kill (to include purely kinetic, fragmentation, and blast warheads), Electronic Warfare, Directed Energy, High Power Microwave, Electro Magnetic Pulse, Laser Dazzlers, and permanent sensor induced damage / degradation.

4) The ability to host complimentary capabilities within the Modular APS Controller (MAC) level and Modular APS Framework (MAF).

Seeking whitepapers that clearly identify a near term pathway to capabilities that can be demonstrated via experimental soldier touchpoints within 6-12 months and subsequent expedited fielding via PdM VPS or equivalent.

e. Textile Based Camouflage System. Commercial textile-based technology that will reduce the probability of a vehicle being detected by sensors and detectors whether the vehicle is stationary or on the move. Of particular interest are commercial solutions that allow adequate air flow to prevent damage to the textile-based technology, and that do not impede driver vision.

f. Thermal and HD Pan Tilt Zoom (PTZ) Camera. Commercial technology that provides day / night, real-time surveillance, 24/7 observation through degraded environments that allows for response to threats. Of particular interest is commercial solutions that allow for 360 degree visibility and allow for rapid integration onto multiple platforms.

g. Multi-Payload Launcher. This topic focuses on a system that can rapidly deploy multiple drones/payloads, either simultaneously or in quick succession, with each drone/payload potentially equipped to perform a distinct task. This creates a coordinated, multi-faceted capability that can be managed by a single operator or an autonomous control system.

The key to the system's versatility lies in its ability to launch a variety of drones/payloads, each tailored for a specific function. This "flexible loadout" can include:

1. Loitering Munitions: Designed for precision strikes against targets, with some variants capable of defeating armored vehicles.

2. Intelligence, Surveillance, and Reconnaissance (ISR): Designed to provide real-time video, intelligence, and situational awareness for ground troops.

3. Electronic Warfare (EW): Designed to jam enemy communications or spoof their navigation systems.

4. Counter-Drone Systems: Designed to intercept and neutralize hostile drones.

h. Autonomous Commercial Vehicle (ACV). This topic focuses on the ACV capability which is a transformational unmanned ground platform designed to redefine maneuver warfare. Equipped with Modular Mission Payloads (MMPs), it provides Army units flexible options for reconnaissance, security, direct action, fires support, logistics, and deception. Leveraging mass-produced vehicle technologies, the ACV reduces cost, maintenance, and complexity while delivering lethal and non-lethal effects at the commander’s discretion.

Built for fast, distributed operating environments, the ACV enhances survivability and lethality through scalable production and vendor supply chains. It expands battlefield geometry, enabling commanders to shape engagements by employing Robotic and Autonomous Systems (RAS) for time, space, and cross-domain maneuver advantage. At the point of need, it delivers advanced battlefield capabilities.

i. Aided Detection Target Recognition (AiDTR) System. This topic focuses on a sophisticated Artificial Intelligence (AI) that employs machine learning to autonomously identify and categorize threats from sensor data, such as enemy combatants or vehicles. The primary goal of AiDTR is to reduce the cognitive burden on soldiers while increasing probability of threat detection and lowering false alarm rates, enabling faster threat identification and superior situational awareness. It is engineered for seamless integration with vehicles and advanced sensor systems.

j. Modular Obscuration System. This topic focus is seeking a mature, production-ready technology for a modular obscuration system. The desired system will provide a non-lethal effect to degrade enemy reconnaissance, surveillance, and target acquisition (RSTA) capabilities and defeat visually and infrared-guided weapon systems. The primary objective is to hamper battlespace visibility, thereby increasing warfighter and platform survivability. Desired specifications include:

1. Obscure wavelengths from the visual through the near-infrared (NIR) portion of the electromagnetic spectrum.

2. Generation of a visually impermeable screening effect in less than two minutes.

3. The obscuration effect should be sustained for more than 12 minutes from a single dissemination.

4. Man-portable and capable of being operated by a single soldier.

5. Support both dismounted and mounted operations.

6. Offers flexible control options: remotely via a wireless signal or directly through a wired connection.

k. Mission Autonomy Common Control Architecture Strategies, Prototypes & Solutions. Program Manager Robotic Command and Integration (PM RCI) seeks innovative commercial solutions and professional services to provide rapid, on demand technical expertise that accelerates Mission Autonomy (MA) development through advanced architecture maturation, mission engineering, modeling and simulation, cybersecurity analysis, and rapid acquisition and technical prototyping. Desired specialties also include multidisciplinary engineering and human factor analysis of MA systems and operations. Required capabilities include evolving the Mission Autonomy Common Control Architecture (MACCA); producing mission level modeling and architectural artifacts; conducting multidisciplinary engineering analysis; evaluation and verification (virtual and physical); system prototyping and integration; and delivering autonomy focused cybersecurity products such as threat models, attack surface assessments, survivability requirements, and adversarial testing strategies. PM RCI also requires commercial partners capable of shaping and executing sound acquisition strategies that shorten procurement timelines, drive faster prototype delivery, and apply innovative contracting methods aligned with DoW’s Acquisition Transformation Strategy to promote rapid, iterative development. Solutions should enable rapid task activation, scalable team deployment, and streamlined deliverables, while integrating commercial best practices that accelerate fielding and expand PM RCI’s ability to assess, secure, and integrate autonomous system technologies. This includes command and control, autonomy architecture, and tactical networking capabilities essential for synchronized air and ground robotic operations across Army missions.

l. Unified Command and Common Control (UC3) for Multi-Entity Mission Autonomy (MEMA) for Robotic Operations. The U.S. Army’s Capability Program Executive for Mission Autonomy (CPE MA), through PM RCI, seeks innovative solutions that advance architectures and technologies for Multi Entity Mission Autonomy (MEMA). The goal is to accelerate integration of autonomous capabilities across ground, air, maritime/surface, subsurface systems, payloads, and sensors. PM RCI requires scalable, modular hardware and software to support a Unified Command and Common Control (UC3) framework enabling and integrating coordinated operations among diverse autonomous systems. Solutions must provide safety assured control for crewed and uncrewed platforms operating in remote, supervised, or fully autonomous modes. Capabilities should reduce operator burden, enable one to many control, and adapt to varying supervision levels through independently verifiable, safety critical autonomy. Solutions should also address current UxS limitations, such as high operator to platform ratios, fragmented interfaces, stovepiped data, and challenges in Denied, Degraded, Intermittent, and Limited (DDIL) environments. PM RCI seeks prototype or mature product demonstrations of robust, interoperable UC3 frameworks using a Modular Open Systems Approach (MOSA). Desired elements include a mission level C2 Orchestrator and platform level Mission Autonomy Agents that enhance distributed processing, resilience in contested environments, and seamless data orchestration across tactical networks. Solutions should support development of Mission Autonomy Common Control Architecture (MACCA) to ensure interoperability across Army, Joint, and allied autonomous systems.

m. Unified Combat Teaming. GVSC is seeking the connective architecture, control, and integration capability that turns a diverse, multi-vendor mix of unmanned ground, air, and sea systems into a single, scalable, controllable combat team, not a proprietary autonomy stack or isolated platform. We invite architecture-led and tooling-led innovators to address one or more of six interlocking Technical Workstreams (TW#) and/or Enabling Workstream (EW#) areas: open, severable modular architectures that let one vendor's system be cleanly swapped for another's [EW1]; common control and data standards (e.g., JAUS, DDS, TAK, STANAG) proven by dissimilar systems sharing one operational picture in Electronic Warfare/GPS-contested conditions [EW2]; onboarding tooling and SDKs that make third-party integration repeatable, not bespoke [EW3]; dynamic, decentralized task allocation and mission planning that lets one Soldier direct a multi-vendor formation as one team [TW1]; human-machine teaming that grows the agents one Soldier commands without growing the workload [TW2]; and the experimentation and evaluation harness to measure, replay, and compare teaming across simulation and hardware [TW3].

We value capability that is demonstrated, not asserted, works with platforms you did not build, carries a clear MOSA underpinning, and proves itself through physical experimentation, with a credible simulation path to scale preferred over a large fleet. We invite you to propose your open, interoperable technology that can show real results on a few systems today and a defensible path to large multi-vendor formations tomorrow, evaluable in a Hardware In the Loop or live settings within 6 to 12 months of award, whether addressing a single area or spanning several.

Please see attachment, “Area of Interest - Unified Combat Teaming” for all additional information regarding this AoI.

Solution briefs may address one or more of the six workstreams described in the attachment. Multi-workstream and integrated system proposals spanning the full Unified Combat Teaming capability are strongly encouraged.

While this Area of Interest will remain open, the Army will make initial award(s) based on White Papers submitted by 01 August 2026.

FORCE PROJECTION TECHNOLOGY (FPT):

The FPT provides mission lifecycle engineering for Army Combat Support and Combat Service Support equipment for gap crossing, petroleum & water systems, combat engineering, material handling, and fluid and petroleum quality surveillance. Its laboratories facilitate research, development, and engineering services to support fuels, fluids, water, wastewater and military bridging systems to keep the US Army in motion anytime, anywhere.

a. Demand Reduction

i. Alternative Sources of Water / Atmospheric Water Extraction (AWE). The Army has gaps in the ability to supply potable water to distributed, semi-independent units conducting multi-domain operations in a contested logistics environment. Currently, Large Tactical Water Purification Units that must be stationary during operation are used to produce bulk drinking water, which is then stored, bottled, and distributed tethering units to long lines of resupply.

b. Predictive Logistics and Maintenance. GVSC is interested in commercial software and integrated hardware solutions that provide the Army, and joint and multinational partners where possible, with improved sustainment posture through improved precision and accuracy in sustainment operations, such as maintenance and equipment status, and tracking of classes of supply, such as major end items, fuel, water, and spare parts. Specific interests in this area follow.

i. Logistics Tracking and Planning. GVSC is pursuing improved tracking of classes of supply, to include through multinational partners and channels. The purpose is to provide improved status reports to facilitate rapid, accurate decision making. Ideal solutions will provide not only Army visibility, but compatibility or integration into joint and multinational partners. While envisioned as software, integrated software-hardware solutions will be considered. Training, modelling, and simulation software to facilitate improved understanding, tracking, and decision making may be applicable here as well. In general, ideal proposals will include or culminate in successful demonstrations and pilot implementations that show paths to transition.

ii. Smart Fuel Metering and Management. Provide near real-time understanding of fuel status, fuel (supply) availability/quantity, location, and supply actions. The objective is to extend the operational reach and readiness of the Warfighter by providing fuel awareness and fuel management decision support for commanders in Multi Domain Operations throughout the range of military operations.

Commercial sensors, software, or integrated hardware-software solutions to support this project will support the ability to collect fuel measurement data from collapsible bags at fuel points during field experiments with the Army and United States Marine Corps (USMC) operations. Additionally, commercial solutions to assist in the development of a fuel management system to enable commodity managers to track and account for material as it is received, stored, transported, issued, and consumed delivering end-to-end visibility shared across the enterprise. Selection will be made on the basis of enabling the warfighter to improve decisions, manage multiple fuel sources, reduce demand, balance loads, and improve efficiencies within contingency bases, optimizing fuel management in expeditionary environments.

c. Advanced Manufacturing. New and novel technologies in the realm of advanced manufacturing technologies to include innovative technologies and processes to produce high-quality products with increased efficiency and reduced waste. This includes the integration of digital technologies, such as artificial intelligence, robotics, and the Internet of Things (IoT), to create smart factories that can adapt to changing production demands for supply of parts and services of interest to GVSC.

d. Autonomous Resupply. GVSC is interested in technologies that allow the Army to enhance multi domain distribution, extend reach, and increase the volume of supplies to dispersed formations through advanced platforms.

e. Advanced Power and Energy Solutions. GVSC is interested in technologies that allow the Army to field alternative energy solutions through advanced solutions such as fuel cells, advanced batteries, microgrids.

f. Bridging and Gap Defeat. Develop, test, experiment with, or demonstrate new innovative technology or mature existing technologies to defeat manmade or natural gaps found on the battlefield. Areas of interest include materiel solutions focused towards either wet or dry gaps and over a variety of defeat lengths, as well as the addition of AI/ML capabilities to new or existing materiel for both assault as well as logistical support missions. Efforts in this area support assured mobility in assault operations and the efficient execution of logistics in disbursed contested environments.

g. Fuel Handling Equipment. The Army is interested in advanced tactical fuel handling equipment. Areas of interest include but are not limited to fuel storage, distribution, filtration, and monitoring technologies and hardware. These efforts will increase fuel distribution capacity and tempo to extend operational reach, enable dispersion, and increase lethality as required for Joint All Domain Operations.

GROUND VEHICLE MATERIALS ENGINEERING (GVME)

The GVME mission is to provide materials technologies and engineering support to ground systems from cradle to grave to enhance warfighter readiness. GVME supports a diverse materials mission to include corrosion, coatings, joining, additive

manufacturing, and material and manufacturing applications, all supported by a characterization and failure analysis branch with in-house testing capabilities.

a. Ceramic Material Technologies. Ceramic materials for application in military parts to take advantage of properties such as exceptional hardness, wear resistance, corrosion resistance and applicability for high temperature environments. Areas of particular interest include applications for lightweighting, non- conductive, and non-magnetic applications.

b. Composites. Applications for composite materials that offer enhanced strength-to-weight ratios, improved corrosion resistance and increased durability compared to traditional materials. Of particular

interest are applications for composite rubbers for tracks and wheeled vehicle systems and applications of advanced composites for protective systems.

c. Composite and Transparent Armor. Commercial armor and advanced armor technologies to include transparent armor, reactive armors, and advanced material solutions for enhanced survivability for vehicles, payloads, and personnel.

d. Coatings. Coatings provide means of enhancing the properties of existing materials and components beyond what they are typically capable of. Advanced coating technologies, such as nanocoatings and thin- film coatings, offer improved properties, such as self-cleaning, antimicrobial, and anti-reflective characteristics. Coatings are also used to reduce friction, improve fuel efficiency, and minimize waste. Overall, coating technologies play a critical role in enhancing the performance, reliability, and lifespan of materials and components, while also reducing maintenance and operational costs.

e. Castings and Forging. GVSC is interested in advanced technologies which can support low volume, flexible, and responsive production of castings and forgings. This includes additive technologies, which enable substitution of the additive manufactured parts; incremental forming technologies; enabling technologies for rapid production of molds and dies; and computational tools to accelerate design and qualification of large castings and forgings with location-specific property prediction.

f. Tooling. GVSC is interested in advanced technologies which can support low volume, flexible, and responsive production of tooling. This includes technologies for rapid production of low volume tooling for composites, plastics, and other techniques suitable for low to medium volume production.

GROUND VEHICLE SURVIVABILITY AND PROTECTION:

Focuses on advancing vehicle and crew survivability for tracked and wheeled tactical and combat ground vehicles. The goal is to meet the Army’s increasing goal for higher mobility while maintaining or improving the survivability of the combat fleet. This will be made possible by exploiting increased computer power and implementation of AI in emerging active protection systems as well as innovative passive material solutions.

a. Next-Generation Vehicle Protection Systems Base Kit. Seeking innovative partners to deliver a critical technology for our next-generation vehicle protection strategy: the Vehicle Protection Systems Base Kit (VBK). This is a unique opportunity to contribute to a revolutionary, Modular Open Systems Architecture (MOSA)-based Active Protection System (APS) framework designed to dramatically enhance soldier survivability and reduce lifecycle costs.

The VBK: A Foundation for Adaptable Protection

The VBK program is focused on creating a flexible, scalable, and rapidly adaptable APS framework – instantiated by the VBK Controller – that can be seamlessly integrated with a wide range of APS subsystems across diverse missions and platforms. We are partnering with industry leaders to build the core components of this framework, including the Modular Active Controller (MAC), Safety Control Interface Panel (SCIP)/User Interface Control Panel (UICP) and the optional Power Management Distribution System (PMDS).

Seeking a partner to build and deliver production-intent VBK prototypes based on Government-provided Technical Data Packages (TDPs).

The MAC, the main component of the VBK control system, is a high-performance 3U VPX chassis featuring:

• SOSA-Compliant Architecture: Ensuring interoperability and future-proofing.

• Powerful Compute Capabilities: Supporting advanced algorithms with multiple compute-intensive payload slots (3-5) and options for Intel Xeon or NVIDIA Jetson AGX (Orin or Thor) based processing.

• Versatile I/O Connectivity: A cutting-edge FPGA I/O card enabling high-speed data transfer via 1/10 Gigabit TSN Ethernet, RS-422, CAN, SDI, DisplayPort, HDMI, and a comprehensive range of discrete signals.

Deliverables & Impact:

Seeking delivery of fully functional, production-ready VBK prototypes, including individual Line Replaceable Units (LRUs) based on the Government-provided Technical Data Packages (TDPs) for the MAC, SCIP, UICIP and PMDS plus all necessary support components (cables, breakout connectors, special tools, mounting hardware).

By responding to this area of interest, you will:

• Shape the Future: Contribute to a groundbreaking system that will enable vehicle protection for years to come.

• Leverage Government Investment: Utilize provided TDPs to accelerate development and reduce risk.

• Become a Key Partner: Establish a strong relationship with the GVSC and the U.S. Army.

We invite qualified organizations with expertise in hardware development, firmware integration, and MOSA principles to submit proposals for delivery of 10 VBK prototypes, with a follow-on option to deliver additional kits.

See attachment 0001 and 0002

Suspense date for submittal under this AOI is 01/30/2026.

b. Signature Management Technologies. Seeking innovative commercial solutions to mitigate ground vehicle and marine vehicle signatures. The signatures being requested include thermal, acoustic, and radio frequency, but others will also be considered. The technologies may be applique or coatings.

SOFTWARE ENGINEERING CENTER (SEC):

SEC provides full software lifecycle management; to engineer, develop, integrate and field precise software solutions; to improve Current Force effectiveness; and to provide superior software capabilities for the Future Force.

a. Government-Off-the-Shelf (GOTS) Common Operating System. The Army seeks innovative support to advance its Government-Off-the-Shelf (GOTS) Operating System (OS) for ground vehicle platforms. This initiative aims to establish a common, government-owned software foundation to reduce costs associated with commercial licensing, maintenance, and complex systems integration. Leveraging a standardized GOTS OS promotes software reuse, enhances cybersecurity through a common security posture, and ensures long-term scalability and maintainability across the fleet. The goal is to accelerate fielding schedules and reduce duplicative engineering efforts by providing a pre-accredited, adaptable operating system architecture for all vehicle programs.

Closing date for submittal under this AoI is 05/15/2026.

b. Embedded Software Maintenance. SEC is focused on providing software maintenance and sustainment for multiple vehicle platforms including Bradley Fighting Vehicles. This includes specific software development, integration, testing, validation, and fielding. The goal is to understand and innovate software solutions to integrate emerging technology and capabilities as it relates to obsolescence issues with legacy vehicle systems and equipment.

• Focus will be on tactical code development with military approved software (VXWorks, GHS, AdaCore) and communication systems (MIL-STD-1553, RS232/RS422/RS485)

• Automated and hybrid testing methodologies include simulation conception, testing development linking requirements traceability, and lab hardware/vehicle platform test management.

• Innovative hardware solutions to support design and building testing platforms, experimental/prototype vehicle integration efforts, and support priority equipment needs for software testing and validation.

g. Software & Hardware Integration and Fielding Support for Ground Vehicle Platforms - Data Integration for Ground Systems (DIGS) & Digital Logbook (DLB). The Army seeks innovative support to advance the integration and sustainment of the DIGS Kit and DLB for ground vehicle platforms. This initiative aims to automate manual processes, enhance equipment readiness visibility, and improve sustainment operations by digitizing maintenance tasks, streamlining Preventative Maintenance Checks and Services (PMCS), and error-proofing parts ordering. DIGS leverages vehicle sensors to capture usage and fault data, enabling the generation of accurate 5988-E forms and supporting commanders in making informed decisions.

The DLB, installed on the Operator Support Device (OSD), ensures vehicle configuration management, provides access to specific technical manuals based on vehicle configurations, restricts NSN ordering errors, and maintains updated Interactive Electronic Technical Manuals (IETMs) via network architecture. DLB facilitates guided PMCS steps, fault recording, and requisition validation, seamlessly integrating with the Global Combat Support System - Army (GCSS-A) for fault and requisition communication. Additionally, DLB supports disconnected operations through QR code generation and network printing capabilities.

The SEC is focused on providing full software lifecycle management, including development, integration, testing, validation, and fielding of DIGS kits and DLB software. The goal is to innovate software solutions that integrate emerging technologies and address obsolescence issues in legacy vehicle systems and equipment, ensuring operational efficiency and readiness across multiple vehicle platforms.

h. Diagnostic Software (DS) for Vehicle Maintenance. The Army seeks innovative support to advance DS Viper, the latest generation of Army standard diagnostic software. DS Viper is designed to maintain Army Ground Combat Systems, Tactical Wheeled Vehicles, and Watercraft, providing a unified diagnostic solution to enhance maintenance operations across diverse platforms. DS Viper delivers decoupled diagnostics to support the Army’s transition to a single viewer, the Interactive Authoring and Display Software (IADS). As part of the Project Director Test, Measurement, and Diagnostic Equipment (PD TMDE) Maintenance Support Device (MSD) system image, DS Viper ensures seamless integration, cybersecurity compliance, and eliminates licensing fees. The software simplifies training requirements by offering a standardized look and feel across platforms, reducing complexity and improving operational efficiency.

The SEC is focused on providing full software lifecycle management, including development, software sustainment/maintenance, integration, testing, and validation of the DS Viper software. The goal is to innovate software solutions that integrate emerging technologies and address obsolescence issues in legacy vehicle systems and equipment, ensuring operational efficiency and readiness across multiple vehicle platforms. This government-owned diagnostic solution underscores the Army’s commitment to delivering a cost-effective, scalable, and secure tool that enhances vehicle maintenance operations and supports readiness across the fleet.

i. Software Configuration Management (SCM). The SCM team is soliciting a user-friendly tool that can integrate with Source Management and code tools (Atlassian or GitLab) to track and manage final deliverables for all the projects we support. It needs to be able to establish what we expect to receive for each Release per Project and track if it was received, dates, from who, etc. with a hierarchy of deliverables and sub-components maintained. Store location information for both physical and electronic versions. Additionally, it needs to track physical and electronic receipt of information from external sources, who, what, where and their storage locations.

j. CI/CD Pipelines. The SEC is seeking an industry partner with GovCloud development experience to test and validate capabilities between our on-premise infrastructure and AWS cloud environment. Must have demonstrated experience in automation, responsible for developing Infrastructure as Code (IaC), with tools like Terraform or CloudFormation, and building CI/CD pipelines to ensure seamless building and integration of software source code and automated test. A strong background in AWS services, scripting (Python/Bash), and hybrid cloud security along with experience in the Army RMF process.

k. Artificial Intelligence in Software Engineering and Development. This topic focuses on the use of Artificial Intelligence (AI) technologies to assist software engineering professionals throughout the software development lifecycle—including requirements, architecture, design, implementation, and testing—to improve software quality and accelerate development.

Areas of interest include, but are not limited to:

- Code generation models trained specifically for embedded, military, or safety-critical software development environments.

-AI-assisted expansion of unit testing in legacy code bases, including automated test generation and identification of gaps in test coverage.

-AI-assisted modernization of legacy software systems, including migration from legacy or military-centric programming languages to modern or general-purpose programming languages.

-AI-assisted acceleration of model-based software engineering, including generation of Unified Modeling Language (UML)/Systems Modeling Language (SysML) models from legacy documentation and/or source code.

- AI-assisted analysis of software engineering artifacts, including gap analysis and evaluation of design documentation and UML/SysML models.

-AI-assisted comprehension of legacy code bases, including extraction of architecture, interfaces, and system behavior from existing source code.

-AI-assisted refactoring and restructuring of software systems to improve maintainability, modularity, and performance.

-AI-assisted generation and maintenance of software documentation, including design descriptions, interface documentation, and developer guidance.

-AI-assisted traceability analysis across requirements, models, source code, and test artifacts.

-AI-assisted detection of software defects, vulnerabilities, and violations of safety or security coding standards.

-AI-powered developer assistants integrated into software development environments to support code generation, debugging, and refactoring.

l. Simulated/Emulated Hardware Targets for Automated Testing and Digital Twins. Provide subject matter expertise on the development of simulated/emulated hardware targets for embedded systems that can be used for automated testing and digital twin applications. The intent is to gain visibility on the state-of-the-art tools and practices for abstracting from hardware, understand in what situations to use specific tools, and potentially develop a reference architecture (e.g., a sample robot or vehicle) that can be used to assess capabilities and grow competency on how to build integrated pipelines and automation.

m. Multi-Tenant Cloud Solutions for Embedded Software Development. Provide subject matter expert support to bring industry best practices into the architectural design, implementation, and maintenance of a multi-tenant based cloud solution for hosting software development and test projects, with a primary focus on embedded software. This effort seeks experts to assist the government team in deploying concepts within government-owned cloud environments (e.g., SPDS, GDEV-C). The solution should provide projects with scalable, isolated cloud resources by default and include the ability for the defense industrial base to use the environment. A key focus is on automation, the adoption of AI (including pipeline development), and DevSecOps practices in alignment with DoW modernization goals. Subject matter experts will work with the government team and could form the basis of a persistent operations team or, at a minimum, inform the government on how best to organize such a team and identify the skills/resources needed to support the effort operationally.

n. Adoption and Use of Containerization in Embedded Systems. Provide subject matter expert support to bring industry best practices into the adoption and use of containerization within software development and test activities, including those with an embedded system focus. This effort seeks to leverage expert knowledge to address current gaps in security and utilization, and to discover more effective ways to use containerization to its fullest potential. A specific focus is desired on the hardening of containers and the enabling infrastructure, along with general supply chain management considerations. This includes various levels of usage for containers, from deploying enterprise solutions versus VMs, looking at how to do builds/tests for things like CIE, the possible application on actual embedded targets, and the general use of containers for tools and builds in general pipelines.

o. Software Test Automation. The SEC is advancing an enterprise Software Test Automation capability to modernize verification and validation across Army ground vehicle platforms. This initiative integrates automated and hybrid testing methodologies into the full software lifecycle, enabling continuous regression, requirements traceability, and objective digital evidence generation. Leveraging reusable automation frameworks (CATS), centralized orchestration platforms (CTAP), and Software-in-the-Loop (SITL) and Hardware-in-the-Loop (HITL) environments, SEC reduces manual regression cycles, improves defect detection, and accelerates software fielding. The capability supports tactical code validation across approved military software environments and communication interfaces (e.g., MIL-STD-1553, CAN, serial protocols), while enhancing cybersecurity validation and sustainment readiness. The objective is to convert repetitive manual testing effort into scalable, reusable infrastructure that improves quality, lowers lifecycle cost, and supports rapid capability integration across current and future vehicle platforms.

p. Software Safety. The SEC provides comprehensive Software Safety engineering support across Army ground vehicle platforms to ensure safe, reliable, and mission-assured system operation. This capability includes support for Preliminary Hazard Analysis (PHA), Functional Hazard Analysis (FHA), system and software hazard tracking, enforcement of coding standards such as MISRA, and implementation of safety-critical test requirements including C/DC and MC/DC coverage. SEC conducts independent technical reviews of software design, code, and verification artifacts while maintaining bidirectional traceability from hazards through requirements, architecture, implementation, and test results. The objective is to reduce safety risk, ensure compliance with Army and DoD safety standards, and support safe integration of new capabilities into both legacy and future vehicle systems.

q. Digital Distribution. The SEC seeks innovative support to advance its Digital Distribution capability to modernize the delivery and sustainment of software for ground vehicle platforms. Digital Distribution provides a secure, centralized platform for the rapid deployment of software updates, patches, and new capabilities, eliminating the need for physical media. This approach ensures that all systems remain up-to-date with the latest approved software versions, reducing downtime and enhancing mission readiness. By leveraging encryption and authentication protocols, Digital Distribution protects against unauthorized access and tampering, ensuring the integrity of critical software. The objective is to streamline version control and ensures consistency across the fleet, enabling faster and more efficient software fielding.

r. Software Bill of Materials (SBOM). The SEC seeks to enhance its SBOM capability to improve transparency and security across the software lifecycle. SBOM provides a comprehensive inventory of all software components, libraries, and dependencies used in a system, enabling proactive management of vulnerabilities and compliance with government standards. By identifying and tracking software components, SBOM ensures rapid detection and mitigation of cybersecurity risks, reducing the potential for exploitation. It also facilitates lifecycle management by addressing obsolescence issues and ensuring long-term maintainability. This objective is to support the Army’s efforts to improve software quality, enhance cybersecurity, and ensure compliance with Executive Order 14028 on improving the nation’s cybersecurity.

s. Hardware Line Replaceable Unit (LRU) Simulation. The SEC seeks to advance its Hardware LRU Simulation capability to modernize its software development and testing processes. Hosted in the cloud, this simulation environment provides a scalable and cost-effective solution for testing and validating software without the need for physical hardware. Hardware LRU Simulation enables developers to replicate the behavior of hardware components and systems, allowing for early detection of defects and interoperability issues. This approach accelerates development timelines, reduces costs associated with hardware procurement and maintenance, and supports the integration of emerging technologies. The objective is to provide a virtual environment for testing and have Hardware LRU Simulations to ensures that software is thoroughly validated and ready for deployment, enhancing the reliability and performance of Army ground vehicle platforms.

GROUND VEHICLE POWER AND MOBILTIY (GVPM):

GVPM provides the Army with solutions in Ground Vehicle Mobility, Power, and Propulsion. GVPM has developed powertrains, power generation, power distribution and energy storage systems. GVPM facilities encompass labs in engine research, engine/electric machine testing and development, and vehicle performance testing under all climate conditions.

Priority is placed on near term solutions that have the potential for rapid transition to a high Technology Readiness Level (TRL). GVPM maintains interest in longer term technology that advances the performance or enables compact power generation and propulsion systems. In addition, GVPM has interest in emerging technologies for ground vehicle applications for high power, power dense generators, and advanced power electronics that have been integrated into demonstrations as part of a vehicle.

a. Durable Replacement Track System for M88A2 Vehicle. Seeking a drop-in replacement for the M88A2 vehicle existing track systems. The desired solution should require minimal changes to the vehicle, limited to components such as the sprocket and carrier. It is highly desirable to retain the current OEM roadwheels. The solution should leverage proven, commercially available technologies that balance performance and durability with affordability. The T107 track system is currently on the Readiness Driver List, which could inversely affect the vehicles’ availability. PM Mounted Armored Vehicles (MAV) seeks an optimized and modern track solution that can be integrated into the M88A2 platform with minimal modifications while providing better availability, durability and value for the Government.

Requirements

The replacement track system must meet the following preliminary requirements:

1) Compatibility: The track system must be compatible with the current M88A2 platform, requiring minimal modifications (e.g., sprocket and carrier changes). It is highly desirable to retain the current OEM roadwheels.

2) Durability: The track system must demonstrate significantly improved durability compared to the current system, with reduced failure rates while following current OMS/MP (20% Primary roads, 40% secondary and 40% Cross Country roads. 30% of each of these will be completed in “Towed” conditions).

a) Track Pads: 1,000 miles Threshold (T) 2,000 Objective (O)

b) Track Body: 2,000 miles Threshold (T) 3,000 Objective (O)

3) Size and Weight: The track system must conform to the size and weight constraints of the 70T M88A2 vehicle. There is not a specific requirement for a maximum allowed track weight, however track weight and its impact on vehicle performance and life-cycle cost could be used for rating purposes.

4) Performance: The track system must maintain or improve the vehicle's mobility, traction, and operational performance in diverse terrains. Improved tractive effort during towing operations on sloped surfaces is highly desirable.

5) Proven Solution: The track system should be an existing, commercially available product with a proven track record of performance. Solutions used in Foreign Military Sales (FMS) or similar vehicles are encouraged.

6) Ease of Integration: The track system must be designed for straightforward integration into the M88A2 platform without requiring extensive modifications or redesign. Simplicity of integration is a key factor in reducing overall program cost.

7) Cost-Effectiveness: Solutions must demonstrate value through a low Total Cost of Ownership (TCO). Respondents should describe how their solution minimizes costs over the entire life cycle, including acquisition, maintenance, and replacement.

Offeror must submit country of Origin for the proposed track system or percentage of the system that is made in the USA.

Suspense date for submittal under this AOI is 04/06/2026.

b. Vehicle Power Generation and Distribution. These systems or kits install a power generation capability to a vehicle at power levels 30kW to 350kW. Power dense packaging allows minimal engineering for installation in a vehicle with severe space availability. Utilize mechanical power takeoff interfaces from transmissions or engines. These solutions can include components that convert, condition, and provide connection for power to the common end user voltages (i.e. 600VDC, 440VAC 60hz, 208VAC 60hz, 110VAC 60hz, 24VDC, 12VDC, et. Al). Solutions showing previous demonstrations in a vehicle are of interest.

c. Components Required to Enable Vehicle Power Generation and Power Distribution. GVPM has interest in highly integrated electric machines/systems that are highly compact, nearing serial production, and installed on a vehicle system. Also, interest lies in innovative packaging of electric machines, power controllers and thermal management systems to allow complete compact packaging under space constrained conditions. Capabilities at power levels 30kW to 350kW demonstrated on a vehicle are of interest.

d. Propulsion Systems. Highly integrated power dense drive systems integrating electric machines, energy storage (regen and et. al), braking, and gear reduction. End system applications for 8000lbs to 75000lbs GVW. Any integrated combination of multiple component functions mentioned are also of interest. Solutions showing previous demonstrations in a vehicle are of great interest.

.MODELING AND SIMULATION (M&S)

The GVSC M&S mission is to accelerate innovation through rapid prototyping and experimentation, leveraging industry expertise and soldier feedback to quickly iterate and refine Army ground platform capabilities, optimize design and performance by reducing development time and costs to rapidly evaluate multiple design approaches and incorporate continuous soldier feedback for enhanced usability and operational effectiveness, and inform strategic decisions by maintaining a competitive advantage with data-driven insights by quantifying capabilities, identifying critical technology gaps, and illuminating capability investment opportunities. This effort focuses on advancing modeling and simulation tools and capabilities through industry partnerships and collaborations.

a. Innovative Training Aids and Simulators. With increases in onboard capabilities and increasing technical sophistication of ground vehicles, GVSC is interested in commercial solutions that can improve training, fielding, and maintenance of ground vehicles. This includes providing training and simulations using on- board computing capabilities but also includes standalone equipment.

b. Applying Artificial Intelligence Algorithms to Expedite the Platform Concepting Process for Early

Requirements Shaping and Trade Studies. GVSC M&S is looking to develop an on-premises, SME-credible AI-assisted ground-vehicle concepting demonstration that produces constraint-checked, auditable platform concepts suitable for early requirements shaping and trade studies. While the scope of this project includes expediting concept generation using a wide array of available AI methods, emphasis is placed on using LLM prompts to directly generate/expedite usable Computer-Aided Design (CAD) components. This work will be using decades worth of Government generated data and concepts and will not require additional contractor data. These AI methods must be usable within a U.S. government environment with expectations that the U.S. government will own rights to both the data being used as input but also for the resulting models.

c. Relocatable Facility Accreditation: Agile SCIF Security Oversight. The Government is executing a rapid prototyping effort to design, construct, build and deploy a relocatable facility, the Cybersecurity and Vehicle Cyber Center (CVCC), which requires accreditation for classified use up to the Top Secret level with eligibility for SCI access. This facility is being designed, constructed, built and deployed in the United States. Historically, applying the rigid Intelligence Community Directive (ICD) 705 security standards to rapid, commercially modified prototyping programs has proven difficult to execute without causing significant schedule delays. This creates a critical need for a dedicated Site Security Manager (SSM) to bridge the gap between commercial manufacturing processes and strict government security oversight to include interactions with an Accrediting Official.

The Government seeks innovative commercial solutions to provide comprehensive security oversight. The traditional, sequential methodology for ICD 705 compliance is often incompatible with the speed of commercial prototyping. Therefore, the Government requires an "agile compliance process"—a solution that successfully integrates and enforces legacy ICD 705 government security oversight within a rapid, commercially driven prototyping program for a relocatable facility.

The Government is seeking industry partners capable of acting as the Site Security Manager (SSM) to ensure the aforementioned prototyping effort achieves full ICD 705 accreditation. The company shall have a Top Secret Facility Clearence Level. Submissions should demonstrate innovative methodologies for integrating security into the commercial prototyping lifecycle. Specific areas of interest include:

• Lifecycle Site Security Management (SSM) Oversight: This sub-topic seeks the provision of a qualified SSM to serve as the primary liaison between the commercial prototyping vendor, the Government Program Office, and the Accrediting Official (AO) / Certified TEMPEST Technical Authority (CTTA). The SSM must provide continuous oversight of architectural designs, material procurement, and physical construction, ensuring all deviations or commercial modifications are evaluated for their impact on ICD 705 compliance. The person shall have a Top Secret clearance with eligibility for SCI access.

• Agile Construction Security Plan (CSP) Development and Execution: This sub-topic focuses on the development, approval, implementation, and management of a CSP that adapts to a rapid commercial build schedule. The solution must meet the stringent physical, acoustic, and technical (TEMPEST) requirements of ICD 705 and ICS 705-1. Desired outcomes include innovative approaches to conducting security inspections, documenting construction phases, performing construction surveillance duties, and managing secure supply chains without halting commercial manufacturing timelines.

• Accelerated Accreditation Documentation and Delivery: This sub-topic focuses on the streamlined generation and management of all required accreditation artifacts. The desired solution will enable the agile preparation of the Fixed Facility Checklist (FFC), TEMPEST addendums, acoustic testing reports, and the final accreditation package to ensure the facility is ready for immediate operational deployment and AO approval upon delivery.

Anticipated Schedule: four months design activities, followed by five months pre-construction activities, followed by 11 months on site construction work immediately after award.

Suspense date for submittal under this AOI is 06/19/2026

VEHICLE ELECTRONICS AND ARCHITECTURE (VEA):

The VEA mission is to design, integrate and deliver vehicle electronics systems by leveraging advanced technologies to provide enhanced capabilities for military ground vehicles.

a. High Performance Compute Solution: The US Army is actively researching and evaluating embedded high-performance computing solutions to support next-generation capabilities in challenging operational environments. We are particularly interested in MOSA-based platforms capable of seamlessly hosting and integrating emerging technologies, including AiTR (AI-enabled Targeting & Recognition), Anti-jamming, Automated Lethality, Survivability, Electronic Warfare (EW) and Defense. The goal is to take current algorithms for these technologies as well as Artificial Intelligence/ Machine Learning (AI/ML) capabilities and evaluate them for true processing needs. We are interested in learning more about system architecture, processing power (specifically relating to AI/ML workloads), ruggedization, thermal cooling, security features, C-UAS, power efficiency, and demonstrated performance in similar applications.

DETROIT ARSENAL PROTOTYPE INTEGRATION FACILITY (DTA PIF):

The DTA PIF mission is to provide robust, innovative solutions to our customer requirements for our shared military missions.

a. Advance Vehicle Development - Rapid Response Hardware Solutions. To address emergent capability gaps, DTA-PIF is soliciting innovative commercial solution briefs targeting rapid response hardware solution focused on dual-use, modular, and easily deployable systems. The objective is to procure tangible hardware solutions capable of being manufactured, configured, and fielded in an expedited manner, rather than the months or years associated with traditional defense hardware programs. This initiative seeks industry partners to provide end-to-end development and delivery of turn-key hardware systems, from initial concept through low-volume manufacturing and sustainment.

What could I use the funding for?

Depending on the applicable Area of Interest, awards may support activities such as:

• Commercial technology adaptation

• Prototype development

• Pilot projects

• Demonstrations

• Agile software development

• Commercial integration

• Technology maturation

• Testing and validation

• Systems integration

• Sustainment activities

The Government also states that awards may support commercially available technologies, commercial technologies enhanced through strategic investment, existing government-owned capabilities, or concepts intended for broader defense applications.

Are there any additional benefits I would receive?

In addition to potential funding, selected companies may receive opportunities to:

• Demonstrate technology directly to Army subject matter experts.

• Participate in Army experimentation activities.

• Collaborate with Government technical experts.

• Mature commercial technologies for military applications.

• Potentially transition technologies into future Army programs.

The solicitation also provides flexibility to use several acquisition pathways, including commercial contracts under FAR Part 12, Other Transaction Agreements (OTAs), and Cooperative Agreements, depending on the specific effort.

What is the timeline to apply and when would I receive funding?

Most Areas of Interest remain open for solution brief submissions unless an individual AoI specifies its own submission deadline.

The solicitation states that awards may be made throughout 2029, and additional Areas of Interest may be added at any time during the life of the CSO. Companies are encouraged to regularly monitor SAM.gov for new or amended topics.

The general evaluation process consists of:

1. Phase 1 – Solution Brief

2. Phase 2 – Presentation or Demonstration (if requested)

3. Phase 3 – Invitation to submit a Commercial Solution Proposal (CSP)

The Government may bypass phases, request additional information, or accelerate evaluations based on program priorities and available funding. Funding timelines are not specified in the solicitation.

Where does this funding come from?

This Commercial Solutions Opening is administered by the U.S. Army Combat Capabilities Development Command (DEVCOM) Ground Vehicle Systems Center (GVSC) under the authority provided by 10 U.S.C. 3458 for Commercial Solutions Openings.

GVSC is the Army's research and development organization for advanced ground vehicle technologies and supports Army modernization priorities across numerous technical disciplines including autonomy, mobility, survivability, power systems, software engineering, cyber engineering, manufacturing, and modeling and simulation.

Who is eligible to apply?

The solicitation is intended for companies and organizations with innovative commercial technologies that can help advance Army ground vehicle capabilities.

The solicitation specifically defines and references the following entity types:

• Commercial companies

• Small businesses

• Nontraditional Defense Contractors

• Nonprofit institutions

• Foreign-owned businesses (subject to applicable approvals and restrictions)

• Other organizations capable of providing innovative commercial products, technologies, or services

Companies must also satisfy standard federal contracting requirements before receiving an award, including obtaining a Unique Entity ID (UEI), maintaining an active SAM registration, registering in the required government invoicing system, and being determined responsible by the Contracting Officer.

Who is not eligible to apply?

The solicitation does not provide a general list of ineligible applicants.

However, organizations may be unable to receive an award if they:

• Are suspended or debarred from doing business with the Federal Government.

• Are prohibited by law or Executive Order from receiving federal awards.

• Cannot satisfy required registration requirements.

• Cannot obtain any required security approvals associated with a particular project.

Foreign-owned businesses may submit solution briefs independently or as part of a team. However, the solicitation notes that the ability to ultimately receive an award may depend upon obtaining the necessary clearances and approvals required for the proposed work.

What companies and projects are likely to win?

The solicitation does not prescribe a preferred company size or business model. Instead, GVSC emphasizes commercially viable, innovative technologies that can rapidly address Army modernization needs.

During Phase 1, solution briefs are evaluated primarily on:

• Responsiveness to the Area of Interest.

• Technical merit.

• Innovation.

• Commercial applicability.

• Availability of funding.

Across later evaluation phases, the Government also considers:

• Technical feasibility.

• Technology maturity.

• Schedule realism.

• Price reasonableness.

• Business viability.

• Intellectual property considerations.

• Ability to support Army requirements with commercially available or rapidly adaptable technology.

Overall, companies with mature commercial technologies that require limited additional development before Army demonstration or transition are likely to be well aligned with this CSO.

How competitive will this solicitation be?

The solicitation does not specify the expected number of awards or anticipated success rate.

Several factors suggest this opportunity will be highly competitive:

• It remains open across numerous technology areas.

• It is available to a broad range of commercial innovators.

• New Areas of Interest may be added throughout the life of the solicitation.

• Funding availability may vary by topic.

• The Government reserves the right to select all, some, or none of the submitted solutions.

Because solution briefs are evaluated against the published criteria rather than directly against competing submissions, applicants should focus on demonstrating clear alignment with the specific Area of Interest and providing a compelling commercial solution.

Are there any restrictions I should know about?

Important requirements include:

• Solution briefs, presentations, and proposals must be Unclassified.

• Individual solution briefs may address only one concept for a given Area of Interest.

• Companies may submit multiple solution briefs if each represents a separate concept.

• The Government generally expects a period of performance of 12 months or less, unless otherwise specified within an Area of Interest.

• Technical data with military applications may require export approvals.

• Proposal preparation costs are not reimbursed unless specifically stated.

• Proprietary information should be properly marked.

• Additional submission instructions may vary by Area of Interest.

Applicants should always review the individual AoI before preparing a submission, as additional technical requirements or deadlines may apply.

How long will it take me to prepare an application?

The solicitation does not specify how long applicants should expect to prepare a submission.

The initial Phase 1 submission is intentionally brief.

Unless otherwise stated by the applicable Area of Interest, Phase 1 consists of either:

• A written solution brief of no more than five single-sided pages, or

• A presentation deck of no more than fifteen slides.

Companies invited to later phases should expect additional preparation for presentations and Commercial Solution Proposals.

How can BW&CO help?

The DEVCOM GVSC CSO is significantly different from a traditional federal grant competition. Rather than preparing a lengthy proposal upfront, companies typically begin with a concise Solution Brief that must quickly demonstrate technical merit, commercial innovation, and alignment with the Army's Area of Interest.

BW&CO helps companies:

• Determine which Area(s) of Interest best align with their technology.

• Develop compelling Phase 1 Solution Briefs.

• Position commercial technologies for defense applications.

• Strengthen commercialization and transition strategies.

• Prepare presentation materials for later evaluation phases.

• Develop Commercial Solution Proposals (CSPs) when invited.

• Navigate the unique requirements of Commercial Solutions Openings, OTAs, and Army acquisition pathways.

Additional Resources

Review the solicitation here.