ARPA-H Resilient Systems Office (RSO) BAA

Executive Summary:

ARPA-H’s Resilient Systems Office (RSO) is accepting innovative Solution Summaries and full proposals—on a rolling basis—aimed at strengthening the adaptability, reliability, and interoperability of the U.S. health ecosystem. Multiple awards are anticipated under flexible Other Transaction (OT) agreements. The ISO is open now and remains open until March 5, 2029.

How much funding would I receive?

The solicitation does not specify dollar amounts or funding ceilings. Awards are made as Other Transaction (OT) agreements at the government’s discretion, with specific payment structures negotiated individually. As a rule of thumb, companies should request only what they need to reach a meaningful technical or commercialization milestone—a concrete point that clearly demonstrates feasibility, enables transition, or unlocks follow-on investment.

What could I use the funding for?

The Resilient Systems Office (RSO), one of ARPA-H’s mission offices, seeks project proposals that drive innovations to enhance the adaptability, reliability, and interoperability of the health ecosystem. Submissions should aim for groundbreaking ideas that solve systemic challenges across the health landscape, leveraging cutting-edge technologies that address long-standing gaps in the quality, consistency, personalization, and efficacy of care.

RSO is interested in innovations that take a systems level approach in areas including, but not limited to, systems biology, data systems, biophysical systems, health IT systems, sociotechnical systems, health-related systems engineering, and other systems with the potential to improve health outcomes. While RSO welcomes “out of the box” ideas to address the above gaps, the mission office encourages proposals that address the following areas:

• Fortifying systems to improve robustness:

  Novel system designs and modular capabilities that extend the shelf-life of systems, ensuring peak performance across a broad range of healthcare environments and use cases. Applications of interest include, but are not limited to, the adaptability and robustness of biological systems; digital platforms for secure and efficient management of information; and socio-technical systems to maintain access to care and critical information.

• Removing barriers to enhance system efficiency and efficacy:

  Approaches that provide paradigm shifts in system dynamics to improve health outcomes. This includes improvements to system interoperability, process, and transparency; foundational capabilities to enable integration of emerging technology solutions; overcoming systemic barriers driven by misaligned incentives; user-centric tools that improve patient care coordination and user experience; and clinical and research solutions to boost efficiency, reduce cognitive load, and accelerate scientific discovery and its application.

• Early detection and interventions to mitigate disruptions to the healthcare ecosystem:

  Agile interventions to reduce the impact of disruptions and enhance readiness to manage and recover from large-scale health events. This spans the entire health system, including supply chains, manufacturing, and logistics.

Are there any additional benefits I would receive?

Beyond the formal funding award, there are significant indirect benefits to receiving an ARPA-H Resilient Systems Office (RSO) agreement:

• Government Validation and Credibility:
  Being selected by ARPA-H—the nation’s newest high-impact biomedical research agency—signals exceptional scientific credibility and alignment with the federal government’s most forward-leaning health innovation priorities. This “ARPA-H validation” often accelerates partnerships with major healthcare systems, research institutions, and investors who recognize the rigor and selectivity of government-vetted innovation.

• Enhanced Market Visibility and Notoriety:
  Award recipients are frequently featured in ARPA-H announcements, federal health innovation communications, and national press coverage. This visibility positions your company as a recognized leader in translational health technology and attracts new collaborators, talent, and private-sector investment.

• Ecosystem Access and Collaboration Opportunities:
  ARPA-H performers gain access to a broad innovation ecosystem spanning federal health agencies, academic research centers, and industry partners. These relationships foster collaboration, facilitate regulatory readiness, and open pathways to follow-on contracts, pilot deployments, and commercialization opportunities within the U.S. health system.

• Nondilutive Growth and Strategic Leverage:
  Because funding is nondilutive, companies can scale and validate core technologies without giving up equity. This validation and maturity achieved under government sponsorship often lead to higher valuations and greater leverage in future fundraising or acquisition discussions.

What is the timeline to apply and when would I receive funding?

Open period: now through March 5, 2029.

• Step 1 (required): Submit a Solution Summary via the ARPA-H Solution Submission Portal. ARPA-H strives to provide written feedback within 30 business days of submission.

• Step 2: If encouraged, you’ll generally have 45 calendar days from feedback to submit a full proposal (unless ARPA-H specifies otherwise).

• Review cadence: ARPA-H reviews proposals on a rolling basis and strives to issue a decision within 60 calendar days of receiving a full proposal.

• Award timing: After selection, final negotiations for an Other Transaction (OT) award are completed rapidly, and invoicing is handled through Payment Management Services.

Because of this streamlined process, most ARPA-H applicants move from initial Solution Summary to award decision in approximately 4–5 months—making ARPA-H one of the fastest federal funders for high-impact health innovation projects.

Where does this funding come from?

The Advanced Research Projects Agency for Health (ARPA-H), a federal R&D agency within HHS, issuing awards under the authority of 42 U.S.C. § 290c(g)(1)(D) via OT agreements.

Who is eligible to apply?

Academia, non-profit organizations, for-profit entities, hospitals, community health centers, and non-federal research centers. Non-U.S. entities may participate if compliant with all applicable laws.

What companies and projects are likely to win?

Reviewers assess (in descending importance):

1. Scientific/technical merit—innovative, complete plans with clear deliverables, risks, and mitigations;

2. Contribution & relevance to ARPA-H’s mission—transformative potential, unmet need, commercialization/transition thinking, and IP/software approaches that enable adoption (preference for open standards/OSS where appropriate);

3. Team capabilities/experience—track record delivering similar efforts on budget/schedule;

4. Cost/budget alignment with the technical approach. ARPA-H encourages proposing the best technical solution over low-risk/minimal-uncertainty concepts.

Are there any restrictions I should know about?

• Standards & IP: strong preference for open, consensus-based standards (e.g., FHIR/TEFCA, DICOM) and commercial-friendly open-source licenses when feasible; proposals must justify any deviations/standard extensions and may need a pre-submission meeting for exceptions. Provide good-faith IP rights representations; pre-publication review may be required when sensitive info could be disclosed.

• Compliance: Human Subjects (IRB), Animal Subjects (IACUC), NIH Genomic Data Sharing (if applicable), CUI handling, research security disclosures (including CHIPS/NPSM-33 requirements), and OCI disclosures/mitigation.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive full proposal under this BAA will likely take 120–160 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available for a flat fee of $4,000 to submit a solution summary.

Fractional support is $300 per hour.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.