Request for Information (RFI) Special Notice DARPA-SN-26-96 Advancing Autonomous Science for Biological Applications DARPA BTO

Updated October 2026: This opportunity is closed. The deadline for this opportunity has passed. Browse currently open opportunities in our funding database.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

Application deadline: July 22, 2026, at 5:00 p.m. Eastern Time (ET). This is a Request for Information (RFI) issued by the Defense Advanced Research Projects Agency (DARPA) Biological Technology Office (BTO)—not a funding opportunity or solicitation for proposals. DARPA is seeking input from the scientific and technical community on the current state of autonomous science for biological applications, key technical challenges, and future investment opportunities that could inform future DARPA programs. Organizations with expertise in autonomous science, AI, robotics, laboratory automation, and related technologies should consider submitting a response before July 22, 2026, at 5:00 p.m. Eastern Time (ET) to help shape potential future research initiatives.

How much funding would I receive?

This RFI does not provide funding. Award amounts, contract values, or grant funding are not specified because this is an information-gathering request rather than a solicitation for proposals. This information can be used to apply to the DARPA BTO Broad Agency Announcement for awards under $2 million.

REQUESTED INFORMATION:

Responses should address Informatics Technologies, Physical Technologies, or Both Informatics and Physical Technologies for autonomous science. In each case, a response must address at least one of the following research areas:

1. Current state of the art of autonomous science and transformational enabling technologies to advance that state of the art

• Key existing enabling technologies broadly transferrable across scientific workflows.

• Technologies in development that will be transformational in enabling autonomous science.

• Metrics of success for judging the current state of the art and emerging technologies to surpass it (e.g., throughput, reproducibility, power usage, continuous runtime, cost per assay, etc.).

2. Key technical, organizational, or operational bottlenecks in deploying autonomous science at scale or in new domains

• Challenges to enabling rapid development and exchange of new autonomous workflows, including equipment or assays that provide unique challenges to automation.

• Challenges to interoperability between laboratories and the exchange of data and protocols.

• Measures of success in promoting more efficient, effective, and portable workflow development.

3. Application areas in which new investments could have the greatest impact and best demonstrate the unique advantages of autonomous science to solve problems not amenable to conventional approaches

• Problems of national interest where autonomous science can achieve results infeasible via conventional science, including specific applications for national security.

• Enabling technologies available or emerging to achieve those results.

• Metrics for establishing improvement over conventional approaches.

• Current commercialization strategies and business cases for future development of autonomous science.

4. Safety and security considerations in the operation of highly automated laboratories and ways these might be addressed, for example through simulation, AI digital twins, or formal verification

• Risks to safety and security in the operation of autonomous laboratories.

• Current safeguards, system-level security, traceability, and other approaches to biosecurity.

• Enabling technologies to resolve these risks.

• Measures of success for safe operation.

5. New technologies, opportunities, and challenges for maximizing productive interaction between human operators and autonomous agents in hybrid human-AI workflows

• Applications of national interest that can be achieved only by humans augmented by autonomous scientific facilities.

• Key barriers to productive interaction between human scientists and autonomous laboratories or their AI agents.

• Enabling technologies to overcome these barriers.

• Metrics of success demonstrating the advancement of human-machine partnering over unassisted human or purely autonomous systems.

Are there any additional benefits I would receive?

Submitting a response gives organizations an opportunity to:

• Provide input that may influence future DARPA program development.

• Share perspectives on the current state of autonomous science in biological domains.

• Highlight emerging technologies, technical challenges, commercialization strategies, and national security applications.

Entities that have not previously worked with DARPA are also encouraged to engage with DARPAConnect, which offers educational resources, one-on-one guidance, and outreach to help organizations understand how to engage with DARPA.

What is the timeline to apply and when would I receive funding?

Response deadline: July 22, 2026, at 5:00 p.m. Eastern Time (ET).

Responses must be submitted electronically in PDF format to AutoSci-RFI@darpa.mil.

There is no funding timeline because this is an RFI rather than a funding opportunity. DARPA states that responses may be used to inform future program development, but no subsequent solicitation schedule is provided.

Where does this funding come from?

This RFI was issued by the Defense Advanced Research Projects Agency (DARPA), Biological Technology Office (BTO).

Because this is an RFI, no funding source or funding program is specified.

Who is eligible to apply?

DARPA welcomes responses from all capable sources, including but not limited to:

• Private companies

• Public companies

• Individuals

• Universities

• University-affiliated research centers

• Not-for-profit research institutions

• U.S. Government-sponsored laboratories

Who is not eligible to apply?

The RFI does not specify any excluded applicant categories.

However:

• Classified information must not be submitted.

• DARPA encourages submission of non-proprietary information, and proprietary information must be clearly marked if included.

What companies and projects are likely to win?

This is not a competitive funding opportunity, so there are no awards or winners.

DARPA is seeking responses addressing one or more research areas related to autonomous science, including:

• State-of-the-art autonomous science technologies

• Technical, organizational, and operational bottlenecks

• High-impact application areas

• Safety and security for autonomous laboratories

• Human-autonomous system collaboration

Responses may focus on:

• Informatics Technologies

• Physical Technologies

• Both Informatics and Physical Technologies

How competitive will this solicitation be?

DARPA states that this RFI is issued solely for information and program planning purposes and does not constitute a formal solicitation for proposals or proposal abstracts. Responses are voluntary and will not result in a contract or funding.

Are there any restrictions I should know about?

Key submission requirements include:

• Responses are limited to 7 pages maximum using 12-point font, 1-inch margins, and standard letter-sized pages.

• Responses must be submitted as an unprotected Microsoft Word document or PDF.

• Classified information must not be included.

• Proprietary information must be clearly labeled.

• DARPA will not reimburse response preparation costs.

• Responses are voluntary.

• Proposal abstracts or formal proposals submitted in response to this RFI will be disregarded.

• DARPA is under no obligation to acknowledge or provide feedback on submissions.

How long will it take me to prepare an application?

Responses must include:

• A one-page cover page

• Up to three pages describing the technical approach

• One page of references

• Optional summary slides

Organizations should also identify which technology category and research area(s) their response addresses.

How can BW&CO help?

BW&CO can help organizations prepare a concise, DARPA-ready RFI response by:

• Aligning your response with DARPA's requested research areas.

• Clearly articulating technical capabilities, challenges, and proposed solutions.

• Developing commercialization and national security narratives where supported by your technical work.

• Ensuring compliance with formatting, page limits, and submission requirements.

• Producing a polished submission designed to communicate your organization's expertise effectively.

Additional Resources

Review the solicitation here.

CDMRP: FY26 Reconstructive Transplant Research Program (RTRP)

Updated October 2026: This opportunity is closed. The FY26 application cycle for this program has closed. See our CDMRP guide for the next fiscal year’s announcements. Browse currently open opportunities in our funding database.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The FY26 Reconstructive Transplant Research Program (RTRP) Concept Award supports highly innovative, high-risk research that could open new directions in reconstructive transplantation. The program is designed to fund new concepts and untested theories rather than incremental advances to existing work. Projects must address at least one FY26 RTRP Focus Area and be relevant to improving outcomes for catastrophically injured Service Members, Veterans, their families, caregivers, clinicians, and the American public. Clinical trials are not allowed.

This is a relatively small, early-stage funding opportunity intended to help researchers generate foundational insights that could lead to future development and larger follow-on efforts. The Defense Health Agency expects to fund approximately three awards. The application deadline is 11:59 p.m. ET, September 16, 2026. Organizations interested in applying should begin preparing immediately because a required Letter of Intent must be submitted first by 5:00 p.m. Eastern Time (ET), September 2, 2026.

How much funding would I receive?

Applicants may request up to $200,000 in total costs for the entire project period. The maximum period of performance is 18 months.

The FY26 RTRP expects to allocate approximately $0.6 million to fund approximately three Concept Award applications.

Cost sharing is not required.

What could I use the funding for?

Funding is intended to support highly innovative research addressing important problems in reconstructive transplantation and vascularized composite allotransplantation (VCA). The award specifically supports exploration of new concepts and untested theories rather than continuation of established research programs.

Projects must address at least one of the following FY26 RTRP Focus Areas:

• Improve or optimize VCA immunosuppression.

• Identify and/or validate prognostic or diagnostic biomarkers, methods, or tools for monitoring VCA graft rejection and immunosuppression.

• Advance VCA preservation strategies.

• Develop tools for measuring VCA outcomes, including performance-based, patient-reported, and neurocognitive outcomes.

Allowable costs may include:

• Research activities supporting the proposed project.

• Travel supporting multi-institutional collaborations.

• Travel for one investigator to present project findings at one scientific or technical meeting per year.

• Required travel for the Principal Investigator to present results at one Department of War-sponsored meeting during the award period.

Are there any additional benefits I would receive?

In addition to funding, awardees gain the opportunity to conduct research within a Department of Defense-funded program focused on advancing reconstructive transplantation and improving outcomes for catastrophically injured Service Members and Veterans.

Award recipients may also be invited to present project progress at annual RTRP In-Progress Review meetings.

What is the timeline to apply and when would I receive funding?

Key dates include:

• Letter of Intent deadline: 5:00 p.m. Eastern Time (ET), September 2, 2026

• Full application deadline: 11:59 p.m. ET, September 16, 2026

• End of application verification period: 5:00 p.m. ET, September 21, 2026

• Peer review: November 2026

• Programmatic review: January 2027

Awards supported with FY26 funds will be made no later than September 30, 2027.

Where does this funding come from?

This funding opportunity is offered through the Defense Health Agency Contracting Activity (DHACA) and managed by the Congressionally Directed Medical Research Programs (CDMRP) as part of the Reconstructive Transplant Research Program (RTRP).

Congress initiated the RTRP in 2012 to support research that refines reconstructive transplantation approaches and expands access to reconstructive transplants and immunotherapy. The FY26 appropriation for the RTRP is $12 million.

Who is eligible to apply?

Eligible applicant organizations include:

• Extramural and intramural U.S. Department of War organizations.

• Foreign organizations.

• Domestic organizations.

• For-profit organizations.

• Nonprofit organizations.

• Public entities.

• Private entities.

Eligible Principal Investigators include:

• Investigators at or above the level of postdoctoral fellow.

• Investigators affiliated with an eligible organization.

• Investigators regardless of ethnicity, nationality, or citizenship status.

• Investigators from academic or non-academic organizations.

An investigator may serve as PI on no more than two FY26 RTRP Concept Award applications.

Who is not eligible to apply?

The solicitation states that:

• Individuals cannot receive awards directly because awards are made to organizations.

• Investigators below the level of postdoctoral fellow are not eligible to serve as PI.

• Investigators serving as PI on more than two FY26 RTRP Concept Award applications are not eligible beyond the first two submissions received.

Applications may also be administratively withdrawn if:

• A clinical trial is proposed.

• Human subjects or specimen studies do not qualify for exempt or expedited review.

• The PI does not meet eligibility requirements.

• Required pre-application materials are not submitted.

What companies and projects are likely to win?

The program is seeking projects that are:

• Highly innovative.

• High-risk with the potential to reveal new avenues of investigation.

• Focused on at least one FY26 RTRP Focus Area.

• Relevant to military health and catastrophic injury recovery.

• Supported by a strong scientific rationale despite the absence of preliminary data.

• Designed with rigorous and reproducible research methods.

Applications leveraging findings from solid organ transplantation for testing in VCA may be competitive when the rationale and potential benefits are clearly justified.

The review criteria place the greatest emphasis on:

1. Innovation

2. Relevance

3. Research Strategy and Feasibility

4. Personnel

5. Transition Plan

6. Research Sharing Plan

7. Budget

8. Environment

9. Application Presentation

How competitive will this solicitation be?

This appears to be a highly competitive opportunity.

The program expects to fund approximately three awards from a total funding pool of approximately $0.6 million.

The solicitation also notes that since FY15, the RTRP Concept Award mechanism has received 196 applications, with 26 recommended for funding.

Are there any restrictions I should know about?

Key restrictions include:

• Clinical trials are not allowed.

• Preliminary data cannot be included.

• Research involving human subjects or specimens must qualify for exempt status or expedited review.

• Projects involving painful research using domestic cats or dogs are not supported except for studies relating to military or service animals.

• Classified research data or research likely to generate classified outcomes may result in withdrawal.

• Duplicate submissions of the same research project within the RTRP during the same fiscal year are prohibited.

How long will it take me to prepare an application?

The application process includes both:

1. A required Letter of Intent submission.

2. A full application package.

The solicitation does not specify how long preparation will take. However, applicants must prepare multiple application components, including a Project Narrative, Statement of Work, Innovation Statement, Post-Award Transition Plan, budget materials, supporting documentation, and other required forms.

How can BW&CO help?

BW&CO can help your team:

• Evaluate whether your concept aligns with one or more FY26 RTRP Focus Areas.

• Position your project around the program’s primary review criteria, particularly innovation and military relevance.

• Develop a compliant Letter of Intent and full application package.

• Build a compelling research strategy and transition plan.

• Prepare budgets, supporting documentation, and submission materials.

• Manage the application process through submission and compliance review.

Additional Resources

Review the solicitation here.

CDMRP: FY26 Rare Cancers Research Program (RCRP)

Updated October 2026: This opportunity is closed. The FY26 application cycle for this program has closed. See our CDMRP guide for the next fiscal year’s announcements. Browse currently open opportunities in our funding database.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The FY26 Rare Cancers Research Program (RCRP) is a Department of Defense-funded grant program that supports research on cancers affecting six or fewer persons per 100,000 people per year in the United States. The program aims to improve outcomes for people with rare cancers through discovery, community building, and expansion of knowledge across the cancer landscape. Research must be relevant to Service Members, Veterans, military beneficiaries, and the American public.
RCRP offers three separate funding opportunities in FY26:

• Concept Award – supports highly innovative, untested, potentially groundbreaking ideas.
• Idea Development Award – supports promising research ideas that are ready for further development and could generate high-impact findings.
• Resource and Community Development Award – supports development of research resources, datasets, infrastructure, and community-building platforms for rare cancers research.

Applicants interested in the Idea Development Award or Resource and Community Development Award must submit a required preproposal by 5:00 p.m. Eastern Time (ET), August 19, 2026. Applicants interested in the Concept Award must submit a required Letter of Intent by 5:00 p.m. Eastern Time (ET), September 16, 2026, and a full application by 11:59 p.m. ET, September 30, 2026.

How much funding would I receive?

Funding depends on the award mechanism selected:

Concept Award

• Up to $140,000 total costs

• Maximum period of performance: 2 years

• Approximately 18 awards expected

Idea Development Award

• Up to $490,000 total costs

• Maximum period of performance: 3 years

• Approximately 15 awards expected

Resource and Community Development Award

• Up to $1.12 million total costs

• Maximum period of performance: 4 years

• Approximately 5 awards expected

What could I use the funding for?

Projects must address rare cancers and align with one or more FY26 RCRP focus areas.

Concept Award and Idea Development Award focus areas

• Biology

• Preclinical Research Models

• Therapy, including drug repurposing

• Artificial Intelligence (AI) and Machine Learning (ML) Models
  Resource and Community Development Award focus areas

• Platform Development

• Artificial Intelligence (AI) and Machine Learning (ML) Models

Examples of activities supported under the Resource and Community Development Award include:

• Biospecimen repositories

• Patient registries

• Databases and centralized data-sharing platforms

• Omics resources

• Longitudinal natural history studies

• Resource-sharing infrastructure

• AI/ML-enabled discovery platforms

Are there any additional benefits I would receive?

In addition to funding, successful applicants gain access to a nationally recognized Department of Defense cancer research program focused on advancing rare cancers research and improving outcomes for patients, Service Members, Veterans, and their families.

The Resource and Community Development Award specifically supports the creation of lasting research resources, stakeholder networks, and community infrastructure intended to continue benefiting the field beyond the award period.

What is the timeline to apply and when would I receive funding?

Concept Award

• Letter of Intent Deadline: 5:00 p.m. Eastern Time (ET), September 16, 2026

• Full Application Deadline: 11:59 p.m. ET, September 30, 2026

• Peer Review: December 2026

• Programmatic Review: March/April 2027

• Awards supported with FY26 funds will be made no later than September 30, 2027.

Idea Development Award

• Preproposal Deadline: 5:00 p.m. Eastern Time (ET), August 19, 2026

• Invitation to Submit Full Application: September 30, 2026

• Full Application Deadline: 11:59 p.m. ET, November 18, 2026

• Peer Review: February 2027

• Programmatic Review: March/April 2027

• Awards supported with FY26 funds will be made no later than September 30, 2027.

Resource and Community Development Award

• Preproposal Deadline: 5:00 p.m. Eastern Time (ET), August 19, 2026

• Invitation to Submit Full Application: September 30, 2026

• Full Application Deadline: 11:59 p.m. ET, November 18, 2026

• Peer Review: February 2027

• Programmatic Review: March/April 2027

• Awards supported with FY26 funds will be made no later than September 30, 2027.

Where does this funding come from?

The Rare Cancers Research Program is managed by the Congressionally Directed Medical Research Programs (CDMRP) within the Defense Health Agency Research and Development organization. Congress established the program in 2020 to support research of exceptional scientific merit in rare cancers. The FY26 appropriation is $17.5 million.

Who is eligible to apply?

Eligible applicants include:

• Foreign and domestic organizations

• For-profit organizations

• Nonprofit organizations

• Public entities

• Private entities

• Extramural and intramural organizations
  Principal Investigator eligibility varies by mechanism:

Concept Award

• Independent investigators at or above the level of postdoctoral fellow (or equivalent)

Idea Development Award

• Independent investigators at all career levels

Resource and Community Development Award

• Independent investigators at all career levels

Who is not eligible to apply?

The solicitation does not provide additional eligibility exclusions beyond the stated organizational and investigator requirements.

However:

• Awards are made to organizations, not individuals. - An investigator may only serve as Principal Investigator on one application within each FY26 RCRP award mechanism.

What companies and projects are likely to win?

The strongest applications will closely align with the intent of the selected mechanism.

Concept Award

• Highly innovative, untested, potentially groundbreaking concepts

• High-risk ideas that open entirely new avenues of investigation

• Novel approaches that challenge existing paradigms in rare cancers research

Idea Development Award

• Research supported by preliminary data

• Projects with strong scientific rationale

• Ideas capable of generating high-impact findings and major advancements in rare cancers research

Resource and Community Development Award

• Platforms, datasets, repositories, and infrastructure that fill major gaps in rare cancers research

• Projects with strong plans for community engagement, dissemination, sustainability, and resource sharing

• Efforts that can benefit multiple rare cancer types or subtypes

How competitive will this solicitation be?

The program is expected to be highly competitive.

Historical data provided in the solicitations show:

Concept Award

• 979 applications received

• 90 recommended for funding

Idea Development Award

• 862 applications received

• 85 recommended for funding

Resource and Community Development Award

• 103 applications received

• 23 recommended for funding

Are there any restrictions I should know about?

Across all three mechanisms:

• Clinical trials are not allowed. - Projects must focus on cancers affecting six or fewer persons per 100,000 people per year in the United States. - Research must be relevant to Service Members, Veterans, military beneficiaries, and the American public.
  Additional Resource and Community Development Award requirements include:

• At least two rare cancer Patient Advocates must participate as integral members of the research team.

• Community building, dissemination, and sustainability plans are required.

How long will it take me to prepare an application?

Preparation effort depends on the mechanism selected.

Concept Award

• Requires a Letter of Intent and a short blinded application package.

• Generally expected to require the least preparation effort of the three mechanisms.

Idea Development Award

• Requires a preproposal followed by an invited full application.

• Preliminary data with disease-specific rationale are required.
  Resource and Community Development Award

• Requires a preproposal followed by an invited full application.

• Requires extensive planning around community engagement, patient advocacy, dissemination, sustainment, and resource-sharing infrastructure.

How can BW&CO help?

BW&CO can support applicants with:

• Opportunity assessment and mechanism selection

• Eligibility and project fit review

• Preproposal and Letter of Intent development

• Full proposal writing and editing

• Scientific and commercialization positioning

• Reviewer-focused narrative development

• Patient advocate engagement strategy

• Budget development and compliance review

• Final submission support

Additional Resources

Review the solicitation here.

CDMRP: FY26 Kidney Cancer Research Program (KCRP)

Updated October 2026: This opportunity is closed. The FY26 application cycle for this program has closed. See our CDMRP guide for the next fiscal year’s announcements. Browse currently open opportunities in our funding database.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The Department of Defense Congressionally Directed Medical Research Programs (CDMRP) has released three Fiscal Year 2026 Kidney Cancer Research Program (KCRP) funding opportunities designed to support innovative kidney cancer research, develop future leaders in the field, and accelerate new discoveries that improve outcomes for patients. Collectively, these opportunities represent approximately $10.2 million in anticipated funding across three award mechanisms.

The FY26 KCRP continues to focus on advancing the biology of kidney cancer, developing new therapeutic approaches, improving patient care and survivorship, addressing health disparities, and expanding research capacity through investigator development and collaboration.

Researchers can apply through one of three mechanisms:

Concept Award
Supports highly innovative, untested, and potentially groundbreaking ideas in kidney cancer research. This mechanism is intended for high-risk concepts that could open entirely new avenues of investigation. Preliminary data are not allowed. Awards provide up to $120,000 in total costs over one year.

Idea Development Award
Supports hypothesis-driven research projects backed by preliminary data and a well-developed scientific rationale. Projects must address important questions in kidney cancer research or clinical care and demonstrate potential for significant impact. Awards provide up to $900,000 for a single Principal Investigator or up to $1.2 million through the Partnering Principal Investigator option over three years.

Academy of Kidney Cancer Investigators – Early-Career Scholar Award
Supports promising early-career investigators pursuing independent careers in kidney cancer research. In addition to funding a research project, awardees join a national mentoring and networking academy that provides intensive mentorship, scientific collaboration opportunities, leadership development, and career support. Awards provide up to $1.2 million over four years.

All three mechanisms require submission of a Letter of Intent prior to full application submission and do not allow clinical trials. Applicants should begin preparing immediately to ensure sufficient time for project development, institutional approvals, collaborator coordination, and application assembly.

The earliest deadline is the Concept Award Letter of Intent due July 28, 2026, 5:00 p.m. Eastern Time. The Idea Development Award and Academy of Kidney Cancer Investigators – Early-Career Scholar Award both require Letters of Intent by September 14, 2026, 5:00 p.m. Eastern Time.

How much funding would I receive?

Funding depends on the mechanism selected.

Concept Award

• Up to $120,000 total costs

• Maximum period of performance: 1 year

• Approximately 7 awards anticipated

Idea Development Award

• Single PI Option: Up to $900,000 total costs

• Partnering PI Option: Up to $1.2 million total costs

• Maximum period of performance: 3 years

• Approximately 8 awards anticipated

Academy of Kidney Cancer Investigators – Early-Career Scholar Award

• Up to $1.2 million total costs

• Maximum period of performance: 4 years

• Approximately 2 awards anticipated

What could I use the funding for?

All three mechanisms support research addressing at least one FY26 KCRP focus area, including:

• Understanding kidney cancer biology, progression, metastasis, and prevention

• Developing new screening, diagnostic, prognostic, and imaging approaches

• Advancing treatments for rare kidney cancers

• Creating novel therapeutic strategies

• Improving quality of life and survivorship

• Addressing outcomes in high-risk and underserved populations

• Expanding research capacity and developing future kidney cancer researchers

The Concept Award is intended for exploratory, high-risk concepts.

The Idea Development Award supports mature research projects with preliminary data and a clearly defined hypothesis.

The Early-Career Scholar Award supports both a research project and a structured career-development program designed to establish long-term independence in kidney cancer research.

Are there any additional benefits I would receive?

The Idea Development Award includes a Partnering Principal Investigator option that supports formal collaborations between two investigators contributing distinct expertise to a single project.

The Academy of Kidney Cancer Investigators – Early-Career Scholar Award provides:

• Intensive mentorship from established kidney cancer investigators

• National networking opportunities

• Scientific collaborations

• Monthly academy programming

• Annual and biennial workshops

• Leadership and career development training

• Access to a national peer network of kidney cancer researchers

All three mechanisms encourage multidisciplinary collaborations involving academia, industry, the Department of Defense, the Department of Veterans Affairs, and other federal agencies.

What is the timeline to apply and when would I receive funding?

Concept Award

• Letter of Intent Deadline: July 28, 2026, 5:00 p.m. Eastern Time

• Application Deadline: August 11, 2026, 11:59 p.m. Eastern Time

• Peer Review: October 2026

• Programmatic Review: December 2026

Idea Development Award

• Letter of Intent Deadline: September 14, 2026, 5:00 p.m. Eastern Time

• Application Deadline: September 28, 2026, 11:59 p.m. Eastern Time

• Peer Review: December 2026

• Programmatic Review: March 2027

Academy of Kidney Cancer Investigators – Early-Career Scholar Award

• Letter of Intent Deadline: September 14, 2026, 5:00 p.m. Eastern Time

• Application Deadline: September 28, 2026, 11:59 p.m. Eastern Time

• Peer Review: December 2026

• Programmatic Review: March 2027

Awards funded through FY26 appropriations are expected to be made no later than September 30, 2027.

Where does this funding come from?

Funding comes from the Department of Defense Congressionally Directed Medical Research Programs through the Kidney Cancer Research Program.

Congress established the KCRP in 2017 to support research with exceptional scientific merit and high potential impact. The program received $15 million in FY26 appropriations.

The program's mission is to promote rigorous, innovative, high-impact kidney cancer research for the benefit of Service Members, Veterans, their families, and the American public.

Who is eligible to apply?

Concept Award

• Investigators at all career levels, including postdoctoral fellows or equivalent

• Foreign and domestic organizations

• For-profit and nonprofit organizations

• Public and private entities

Idea Development Award

• Investigators at or above the level of Assistant Professor (or equivalent)

• Foreign and domestic organizations

• For-profit and nonprofit organizations

• Public and private entities

Academy of Kidney Cancer Investigators – Early-Career Scholar Award

• Investigators within seven years of their most recent postdoctoral research position, clinical fellowship, or equivalent

• Must meet Early-Career Scholar eligibility requirements

• Must identify a qualified Designated Mentor

• Foreign and domestic organizations

• For-profit and nonprofit organizations

• Public and private entities

Who is not eligible to apply?

Concept Award

• Investigators below the postdoctoral fellow level (or equivalent)

Idea Development Award

• Investigators below the Assistant Professor level (or equivalent)

Academy of Kidney Cancer Investigators – Early-Career Scholar Award

• Individuals currently in postdoctoral positions, clinical fellowships, or equivalent training positions at the application deadline

• Investigators more than seven years removed from their last postdoctoral position, fellowship, or equivalent training experience

Additional eligibility restrictions apply to mentors participating in the Academy mechanism.

What companies and projects are likely to win?

Competitive applications will closely align with KCRP priorities and demonstrate clear potential to advance the field.

For the Concept Award, reviewers are looking for:

• Highly innovative ideas

• Novel concepts

• New research paradigms

• Research that goes beyond incremental advances

For the Idea Development Award, reviewers are looking for:

• Strong preliminary data

• Well-developed hypotheses

• Rigorous research strategies

• Significant potential impact on kidney cancer research or patient care

For the Early-Career Scholar Award, reviewers are evaluating:

• The investigator's potential to become an independent leader in kidney cancer research

• Quality of the mentoring plan

• Strength of the career-development strategy

• Scientific merit of the proposed research

Across all mechanisms, projects that directly address FY26 KCRP focus areas and demonstrate strong scientific rationale are likely to be most competitive.

Are there any restrictions I should know about?

Across all three mechanisms:

• Clinical trials are not allowed.

• Applications must address at least one FY26 KCRP focus area.

• Applications must address at least one eligible kidney cancer disease type.

• Cost sharing is not required.

• Awards are made to organizations rather than individuals.

Additional mechanism-specific restrictions include:

Concept Award

• Preliminary data are not allowed.

• Applications undergo blinded review.

• Applications may not contain identifying information about investigators or institutions.

Idea Development Award

• Preliminary data are required.

Academy of Kidney Cancer Investigators – Early-Career Scholar Award

• Preliminary data are required.

• Applicants must meet specific career-stage requirements.

• Applicants must identify an eligible Designated Mentor.

How competitive will this solicitation be?

The FY26 KCRP funding opportunities are expected to be highly competitive.

Historical funding data demonstrates significant demand:

Concept Award

• 587 applications received since FY17

• 73 recommended for funding

Idea Development Award

• 610 applications received since FY17

• 124 recommended for funding

Academy of Kidney Cancer Investigators – Early-Career Scholar Award

• 40 applications received since FY19

• 14 recommended for funding

Applicants should expect strong competition and should clearly demonstrate alignment with program priorities, innovation, feasibility, and potential impact.

How long will it take me to prepare an application?

Preparation effort varies significantly by mechanism.

Concept Award
Typically requires the least preparation because preliminary data are prohibited and the narrative is intentionally brief. However, applicants must carefully comply with blinded-review requirements.

Idea Development Award
Requires substantial preparation due to the need for preliminary data, a comprehensive research strategy, detailed supporting documentation, impact statements, and progression planning.

Academy of Kidney Cancer Investigators – Early-Career Scholar Award
Typically requires the greatest preparation effort because applicants must develop both a research plan and a comprehensive career-development strategy while coordinating mentor participation and institutional commitments.

How can BW&CO help?

BW&CO can help applicants determine which KCRP mechanism best aligns with their technology, scientific maturity, and career stage.

Our team can support:

• Opportunity assessment and go/no-go decisions

• Mechanism selection

• Research strategy development

• Hypothesis refinement

• Innovation positioning

• Impact narrative development

• Mentor and collaborator coordination

• Compliance review

• Proposal writing and editing

• Grants.gov and submission support

Additional Resources

Review the solicitation here.

National Science Foundation (NSF) Small Business Innovation Research Program (NSF SBIR/STTR)

Updated October 2026: NSF has posted a new SBIR/STTR Phase I solicitation (NSF 26-510). Upcoming deadlines are November 4, 2026, March 4, 2027, and July 7, 2027. An invited Project Pitch is still required before you submit a full proposal.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The NSF SBIR/STTR program provides non-dilutive funding to U.S.-based startups and small businesses developing high-risk, high-impact technologies with strong commercial potential. NSF states it funds “nearly everything from biotechnology to wireless communications to quantum to semiconductors.” Companies begin by submitting a required Project Pitch to determine fit with the program before being invited to submit a full proposal.

NSF began accepting new Project Pitches under the current solicitations (NSF 26-510 and 26-511) on Tuesday, June 2, 2026. Full proposal submission deadlines are:

• November 4 2026

• March 4 2027

• July 7 2027

Proposal submission is due by 5:00 PM submitter’s time on the specified due date. November 4, 2026 is also the last date NSF lists for two transition groups: companies with an unused Project Pitch invitation issued on or after July 3, 2025, and Phase I awardees whose award started on or after November 6, 2023 and who have not yet submitted a Phase II proposal.

NSF emphasizes that the program is intended for technologies requiring substantial high-risk R&D and not “straightforward engineering or incremental product development tasks.” The process is highly competitive, with historical NSF SBIR/STTR Phase I funding rates between 10% and 20%.

How much funding would I receive?

If your proposal is awarded, NSF states you may receive:

• Up to $305,000 for a Phase I award.

• Up to $1,250,000 over two years for a Phase II award.

NSF does not set award minimums, and voluntary committed cost sharing is prohibited. Fast-Track awards, new at NSF, combine both phases for up to $1,555,555, including $400,000 for the Phase I portion. NSF 26-510 anticipates about $210 million in total, with roughly 180 SBIR and 50 STTR Phase I awards, 80 SBIR and 10 STTR Phase II awards, and 15 SBIR and 3 STTR Fast-Track awards. Each company can receive up to $2 million in NSF SBIR/STTR R&D funding, and NSF has no Direct-to-Phase II option.

What could I use the funding for?

NSF states funding is intended for:

• High-risk research and development

• Deep technologies

• Foundational science and engineering innovations

• New products, services, and scalable solutions

• Technologies with strong commercial potential and societal impact

The program specifically supports technologies that:

• Require substantial technical innovation

• Address significant societal or national problems

• Create sustainable competitive advantages

• Demonstrate meaningful market pull and scalability

NSF explicitly states it does not fund:

• Straightforward engineering

• Incremental product development tasks

Example Technology Areas (NSF funds nearly all technology areas and does not solicit specific technologies)

• Advanced Manufacturing (M)

  The Advanced Manufacturing topic aims to support emerging innovations in manufacturing with the potential to stimulate the nation’s manufacturing sector by improving efficiency, competitiveness and sustainability. Proposals should be driven by a foundational technology that significantly advances the way products are made. This can include, but is not exclusive to, technologies in new manufacturing processes, equipment, automation, modeling, and materials/minerals.

  Sub-Topics

  M1. Building and Infrastructure
  M2. Carbon Sequestration
  M3. Cybermanufacturing
  M4. Distributed Manufacturing
  M5. Ecomanufacturing
  M6. Modeling and Simulation
  M7. Natural Resources and Critical Minerals
  M8. Quantum Device Manufacturing
  M9. Sustainable Chemical Manufacturing
  M10. Other Manufacturing Technologies

• Advanced Materials (AM)

  The Advanced Materials topic addresses the development of new and improved materials for a wide variety of commercial and industrial applications. Proposals may focus on the creation of innovative material systems and/or on critical fabrication, processing or manufacturing challenges involved in the successful demonstration and commercialization of novel advanced materials. A broad range of applications areas will be considered as part of this topic.

  Sub-Topics

  AM1. Advanced Engineering Materials
  AM2. Coatings and Surface Modifications
  AM3. Metals and Ceramics
  AM4. Novel Advanced Materials-based Sensors
  AM5. Structural and Infrastructural Materials
  AM6. Other Advanced Materials Technologies

• Advanced Systems for Scalable Analytics (AA)

  The Advanced Systems for Scalable Analytics topic focuses on innovations needed for building systems that organize and process large and ever-increasing volumes of structured, semi-structured and unstructured data to reveal actionable new insights. It also includes innovative knowledge management and data mining technologies that complement deep learning. Sample topics include data and knowledge management technologies for data acquisition, integration, annotation, governance and provenance; hardware and software for addressing the performance needs of analytical systems; technologies for continual learning in dynamic environments; technologies in data mining, visualization and optimization; and marketplaces for data and models.
  
  These subtopics are only meant to serve as examples. All proposals focused on the development of a new high-risk technical innovation and significant potential commercial and societal impact are welcome to apply, regardless of subtopic.

  Sub-Topics

  AA1. Building Analytical System for Learning from Dynamic Environments
  AA2. Data Mining, Machine Learning (Non-deep learning-based), and Reinforcement Learning
  AA3. Decision Support and Optimization
  AA4. Knowledge and Data Management Technologies
  AA5. Marketplaces for Data and Models
  AA6. Novel Visualization Technologies
  AA7. Software Technologies for Scalable Analytical Systems
  AA8. Other Novel Technologies

• Agricultural Technologies (AG)

  The Agricultural Technologies topic supports innovations enabling farm production ecosystems that support the proper utilization of natural resources. Such technologies may encompass systems-level and multidisciplinary solutions to enable complex agricultural practices that support increased biodiversity balanced with yield production.

  Sub-Topics

  AG1. Agroforestry
  AG2. Expanding Access to Farming
  AG3. Food Waste Mitigation
  AG4. Harvesting Complex Systems
  AG5. Improved Resilience through Interspecies Interchange
  AG6. Nature-based Solutions
  AG7. Polyculture Systems
  AG8. Precision Agriculture
  AG9. Resilient Supply & Distribution
  AG10. Other Agricultural Technologies

• Artificial Intelligence (AI)

  The Artificial Intelligence topic focuses on cutting-edge technologies in the field of deep learning-based AI systems and AI-based hardware. The recent successes in computer vision, machine translation, natural-language processing and speech recognition have led to widespread use of learning-based systems in production and an unprecedented growth in AI systems that interact frequently with and/or on behalf of humans in highly personalized contexts. This topic especially emphasizes next-generation AI technologies that are not only safe and reliable but also fair, robust against sophisticated adversaries, privacy preserving, and efficient in terms of computational resources, energy, training data size, etc. It also includes cutting-edge hardware technologies needed for sustainable AI (i.e., novel devices and architectures to support the tremendous processing power needed by AI technologies), edge devices (i.e., intelligent systems on a chip for applications such as voice assistants) and AI technologies that lead to better hardware systems.
  
  These subtopics are only meant to serve as examples. All proposals that are focused on developing a new high-risk technical innovation and that have significant potential commercial and societal impact are welcome to apply, regardless of subtopic.  

  Sub-Topics

  AI1. Cognitive Science-based Technologies
  AI2. Computer Vision Based AI Technologies
  AI3. Conversational AI Technologies
  AI4. Language-Based AI Technologies
  AI5. Novel AI Hardware Technologies (e.g. Neuromorphic Computing, High-performance Technologies for AI, Smart and Secure Edge Devices, etc.)
  AI6. Sustainable AI Technologies for Low Resource Environments
  AI7. Technologies for Trustworthy AI (safe, fair, transparent, privacy-preserving, explainable, and/or secure)
  AI8. Other Novel Technologies

• Augmented Virtual and Mixed Reality (AV/VR/MR)

  The Augmented, Virtual and Mixed Reality (AR/VR/MR) topic aims to support entrepreneurs and startups at the earliest stages of development of innovative, differentiated and novel hardware/software that can create shared experiences to translate research-based insights into commercializable opportunities for scalable, real-world application.
  
  Technologies in this portfolio include those applying AI in education or workforce development, training tools, upskilling an aging workforce, improving health and wellbeing, as well as technologies as an enabling platform to deliver shared experiences, virtual collaboration, and experiential learning.

  Sub-Topics

  AV1. Differentiated Hardware Technologies for AR/VR/MR
  AV2. Differentiated Software Technologies for AR/VR/MR
  AV3. UI/UX for Immersive AR/VR/MR
  AV4. Advanced Analytics for Collaboration in AR/VR/MR
  AV5. Other Augmented, Virtual, and Mixed Reality Technologies

• Biological Technologies (BT)

  The Biological Technologies topic covers a wide range of technology areas to advance engineering and science innovation across the biological spectrum. Biological technologies have disrupted decades-old chemical, agricultural and medical products and services, producing a new bioeconomy. Potential breakthroughs in this space are on course to make major socioeconomic contributions by boosting productivity in industrial and agricultural processes, improving human health, and making advances toward environmental sustainability.
  
  Proposed projects should be focused on using or modifying living organisms, systems or biological processes to develop new technologies to produce biochemicals and medical and agricultural products. They may involve bioengineering to improve function in molecules, cells and tissues in humans, plants, animals and microbes. NSF also encourages proposals for enabling new technologies, such as new tools for genomics, proteomics and drug discovery; instruments for biological applications; computational and bioinformatic tools; and new manufacturing technologies for cells, tissues, organs and biologics (with the exception of clinical trials and schedule I substances).
  
  Subtopics are not aimed at supporting or conducting clinical trials, clinical efficacy or safety studies, the development pre-clinical or clinical-stage drug candidates or medical devices, or work performed primarily for regulatory purposes. Limited studies with human subjects may be acceptable to the extent that they are performed in support of feasibility, such as proof-of-concept studies of early-stage technologies. Proposals that request support for clinical studies will be deemed noncompliant with the SBIR/STTR solicitations and returned without review.

  Sub-Topics

  BT1. Animal Biotechnology
  BT2. Aquaculture
  BT3. Bio-Inspired Technologies
  BT4. Bioinstruments and Biosensors
  BT5. Cell and Tissue Engineering
  BT6. Fermentation
  BT7. Life Science Research Tools
  BT8. Microbiome and Microbial Diversity
  BT9. Plant Biotechnology
  BT10. Synthetic Biology and Metabolic Engineering
  BT11. Other Biological Technologies

• Biomedical Technologies (BM)

  The Biomedical Technologies topic aims to support the early-stage development of novel products, processes or services that will enable the delivery of high-quality, economically efficient healthcare.
  
  Subtopics are not aimed at supporting or conducting clinical trials, clinical efficacy or safety studies, the development pre-clinical or clinical-stage drug candidates or medical devices, or work performed primarily for regulatory purposes. Limited studies with human subjects may be acceptable to the extent that they are performed in support of feasibility, such as proof-of-concept studies of early-stage technologies. Proposals that request support for clinical studies will be deemed noncompliant with the SBIR/STTR solicitations and returned without review.
  

  Sub-Topics

  BM1. Diagnostics
  BM2. Drug Delivery Methods
  BM3. Materials for Biomedical Applications
  BM4. Medical Imaging
  BM5. Monitoring Devices
  BM6. Other Biomedical Technologies

• Chemical Technologies (CT)

  The Chemical Technologies topic covers a wide range of technology areas of current and emerging commercial significance to many areas, including the broad chemical industry; food processing and technology; agrochemicals; chemical alternatives and organics; green chemicals; water treatment and separations; advanced catalysts and materials; and biochemicals. Sensing, data and advanced analytics technologies relevant to these fields are also appropriate for this topic area. Beyond improvement on technical specifications, it is important to also clearly identify the competitive landscape of what is currently possible and why the proposed innovation will have an impact commercially and/or from a societal benefit standpoint.

  Sub-Topics

  CT1. Biochemicals
  CT2. Catalysts, Advanced Chemicals and Materials
  CT3. Chemical and Environmental Sensing and Data
  CT4. Food Processing, Chemicals and Agriculture
  CT5. Green Chemicals and Chemical Alternatives
  CT6. Separations and Water Treatment
  CT7. Other Chemical Technologies

• Cloud and High-Performance Computing (CH)

  The Cloud and High-Performance Computing (HPC) topic focuses on innovations that result in substantial improvements to cloud computing or high-performance computing platforms. These improvements may be to computing power and efficiency, energy management, data storage, latency, data integrity and availability, cost, or any other factor of importance in such platforms, and may result from software- or hardware-based innovations. These subtopic areas are meant to serve as examples; all proposals with technical innovation and significant commercial potential are welcome, regardless of the specific area of focus of the project.

  Sub-Topics

  CH1. Algorithms and Applications
  CH2. Computational Architecture
  CH3. Convergence of AI and Cloud/HPC
  CH4. Edge Computing
  CH5. Energy Efficiency and Sustainability
  CH6. In-memory Processing
  CH7. Interconnects
  CH8. Middleware
  CH9. Performance Monitoring
  CH10. Processing on Encrypted Data
  CH11. Processor Architecture and Design
  CH12. Resilience and Resource Management
  CH13. Other Cloud and High-Performance Computing Technologies

• Cybersecurity and Authentication (CA)

  The Cybersecurity and Authentication topic focuses on innovations related to the security and integrity of data and data processing and the authentication of people and devices. These subtopic areas are meant to serve as examples; all proposals with technical innovation and significant commercial potential are welcome, regardless of the specific area of focus of the project.

  Sub-Topics

  CA1. Computation on Encrypted Data
  CA2. Cryptography, including Post-quantum Cryptography
  CA3. Data Privacy and Integrity
  CA4. Device Authentication
  CA5. Distributed Ledger
  CA6. Encryption, including Homomorphic Encryption
  CA7. Network and Device Security
  CA8. Personal Authentication
  CA9. Secure and Trusted Computing
  CA10. Secure Machine-to-Machine Communication
  CA11. Security of Cloud and High Performance Computing (HPC) Platforms
  CA12. Other Cybersecurity and Authentication Technologies

• Digital Health (DH)

  The Digital Health topic aims to support entrepreneurs and startups at the earliest-stages of development of innovative, differentiated and novel technologies that aim to improve physical or mental wellbeing or health, enable or assist individuals to increase or regain independence and quality of life and improve the delivery of healthcare including efficiency, reducing cost or improving outcomes.
  
  Technologies in this portfolio include those applying AI in healthcare or general wellness (medical image analysis, personalized medicine, EHR/EMR, Clinical decision support, Computer aided diagnostics, support or therapy, smart/connected medical devices) as well as technologies that enable or provide assistance to aging or disabled populations and individuals undergoing rehabilitation.

  Sub-Topics

  DH1. Assistive, Enabling and Rehabilitative technologies
  DH2. AI in healthcare and drug discovery
  DH3. Healthcare Workflow, Economics and Delivery
  DH4. Medical Diagnostics and Devices
  DH5. Physical, Mental and Behavioral Health
  DH6. Other Digital Health Technologies

• Emerging Technologies (EM)

  Breakthroughs at the edge of science and engineering are reshaping industries, redefining human capabilities, and creating new market spaces. The Emerging Technologies topic within the NSF Small Business Innovation Research/Small Business Technology Transfer program is designed for startups working on transformative innovations that defy conventional classifications — pioneering discoveries that could set the stage for the next technological revolution.
  

  This topic is for radical, high-risk ideas that leverage deep science and engineering to push beyond existing limitations. Proposals should introduce disruptive, category-defining solutions that may not fit within traditional NSF topic areas but have the potential to create entirely new industries or fundamentally alter how we interact with the world.
  

  Examples include, but are not limited to:

  • Post-Silicon Computation & Intelligent Systems: Quantum logic, molecular computing or bio-inspired artificial intelligence architectures

  • Matter & Machines at the Extreme: Self-assembling nanostructures, programmable materials, or biohybrid robotic systems that blur the lines between biology and engineering

  • Living Technologies & Engineered Evolution: Synthetic biology innovations that harness evolution to create self-improving therapeutics, biocomputers, or sustainable biomaterials

  • Radical Energy & Resilient Earth Innovations: Zero-point energy exploration, deep-space resource utilization, or engineered photosynthesis for planetary-scale impact

  • Cognition & Human Augmentation: Direct brain-machine integration, digital telepathy, or neuroplasticity-enhancing interfaces that redefine intelligence

  • Unconventional Sensing & Interaction: Quantum sensors, femtosecond imaging, or technologies enabling new dimensions of perception If your startup is pioneering a new technological paradigm, building something that did not exist before, and pushing the limits of what's possible, the Emerging Technologies topic is your opportunity to secure early-stage funding for world-changing innovation.

  Sub-Topics

  EM1. Emerging Technologies

• Environmental Technologies (ET)

  Environmental Technologies covers a variety of areas of current and emerging commercial significance including environmental sensing, data, and advanced analytics. Please highlight any aspects of the proposed technology or approach that address a problem without a current solution, or one which is underdeveloped.

  Sub-Topics

  ET1. Conservation, Adaptation and Restoration
  ET2. Digital Ecosystem for the Environment
  ET3. Emission or Waste Reduction and the Circular Economy
  ET4. Food, Regenerative Agriculture, and Energy
  ET5. Measurement
  ET6. Resiliency
  ET7. Sustainable Community Systems
  ET8. Water Treatment, Resilience, and Sanitation
  ET9. Other Environmental Technologies

• Human-Computer Interaction (HC)

  The Human-Computer Interaction (HC) topic aims to support entrepreneurs and startups at the earliest stages of development of innovative, differentiated and novel HCI in the context of domains, such as health, education, families, or work to design new computing systems to amplify humans’ physical, cognitive, and social capabilities which translate research-based insights into commercializable opportunities for scalable, real-world application.
  
  Technologies in this portfolio include multimedia and multimodal interfaces, such as haptic, tangible, gestural, spatial, and wearable; brain-computer interfaces; intelligent and interactive user interfaces; affective computing; human state estimation involving interaction; and methods for interaction with artificial intelligence. This topic includes commercialization of computational methods and systems for creating and authoring video, audio, textual, visual, and multimedia forms in support of creative expression and ideation and includes technology-supported human-to-human communication and systems which foster innovation and dismantle barriers to scientific progress in science, technology, engineering, and mathematics (STEM) and the development of information, interaction, networks, systems, and other forms of computation in response to human needs, desires, and intentions.

  Sub-Topics

  HC1. Multimedia and Multimodal Interfaces
  HC2. HC Computational Methods and Systems
  HC3. Smart Integrated Systems
  HC4. Human-to-Human Communication Systems via Technology
  HC5. Other Human-Computer Interaction Technologies

• Instrumentation and Hardware Systems (IH)

  The Instrumentation and Hardware Systems topic addresses the research and development of new and improved instrumentation and related systems for a wide variety of commercial and industrial applications. Proposals in this topic may deal with new instruments for use in scientific, industrial, engineering or manufacturing environments, among others. Systems and tools designed for the purposes of detection, manipulation, characterization, measurement, processing, control or monitoring will be considered. A wide variety of applications areas will be considered as part of this topic.

  Sub-Topics

  IH1. Instrumentation or Hardware Systems for Actuation, Control, and Manipulation
  IH2. Instrumentation or Hardware Systems for Detection and Characterization
  IH3. Instrumentation or Hardware Systems for Imaging
  IH4. Other Instrumentation or Hardware Systems Technologies

• Internet of Things (I)

  The Internet of Things (IoT) is a rapidly evolving field that involves the interconnection and interaction of smart objects (objects or devices with embedded sensors, onboard data processing capability, and a means of communication) to provide automated services that would otherwise not be possible. IoT is not a single technology, but rather involves the convergence of sensor, actuator, information and communication technologies. Emerging IoT implementations will use smaller and more energy-efficient embedded sensor technologies, more sophisticated actuators, enhanced communications and advanced data analytics to collect and aggregate information. These new tools will enable intelligent systems that understand context, track and manage complex interactions and anticipate requirements. Market verticals that are potentially impacted by innovations in this area include connected cities and homes, smart transportation, smart agriculture, industrial IoT, and retail IoT.

  Sub-Topics

  I1. IoT Communications
  I2. IoT Integrated Systems
  I3. IoT Sensors and Actuators
  I4. Networking
  I5. Other IoT Technologies

• Learning and Cognition Technologies (LC)

  The Learning and Cognitions Technologies topic aims to support entrepreneurs and startups at the earliest stages of development of innovative, differentiated and novel innovations which disrupt educational norms, challenge conventional methods of content delivery and workforce development with measurable results while remaining firmly anchored in foundational research. They equip individuals for success in emerging industries and undefined roles, bridging the gap between established curricula and the swiftly evolving knowledge landscape.
  
  Technologies in this portfolio include those applying AI in education or workforce development, training tools, upskilling an aging workforce, improving health and wellbeing, as well as technologies as an enabling platform to deliver innovative approaches to learning and cognition development which leverage groundbreaking technological advancements rooted in research.
  
  Limited studies with human subjects may be acceptable to the extent that they are performed in support of feasibility, such as proof-of-concept studies of early-stage technologies. Proposals that request support for clinical studies will be deemed noncompliant with the SBIR/STTR solicitations and returned without review.

  Sub-Topics

  LC1. Advanced Learning Technologies
  LC2. Workforce Development and Upskilling
  LC3. Advanced Analytics for Learning and Cognition
  LC4. Innovative Approaches to Multimodal Learning
  LC5. Other Learning and Cognition Technologies

• Medical Devices (MD)

  The Medical Devices topic aims to develop novel medical device platforms, introduce innovative medical technologies or translate emerging scientific principles into health practice. Proposals should be considered leading edge innovations, typically based on a discovery, new approach or new scientific principle to medical devices or technologies.
  
  Limited human subject clinical studies may be acceptable if they are performed in support of feasibility or proof-of-concept objectives. The program does not support proposals to conduct clinical trials for sample size calculations, statistically demonstrate safety or efficacy or the development of pre-clinical or clinical-stage drug candidates. Clinical work performed primarily for regulatory purposes or post market surveillance are also not allowed. Proposals requesting support for clinical trials are noncompliant with the SBIR/STTR solicitation and returned without review.

  Sub-Topics

  MD1. Diagnostic Imaging or Monitoring
  MD2. General Medical Devices
  MD3. Implantable
  MD4. Manufacturing Processes or Prototyping Methods
  MD5. Materials (non biological)
  MD6. Procedural Technologies or Visualization
  MD7. Rehabilitation
  MD8. Wearables
  MD9. Women's Health

• Mobility (MO)

  The Mobility topic encourages novel innovations in the land, air, and sea-based movement of goods and people that improve sustainability and resiliency. Proposals responsive to this topic may include technical breakthroughs that address infrastructure and flow issues in global, urban and rural environments. Interdisciplinary and collaborative innovations to address multiple mobility grand challenges are welcome. All proposed innovations must be capable of a sustainable business model.

  Sub-Topics

  MO1. Traffic Congestion and Routing
  MO2. Safety and Navigation
  MO3. Disaster Resilience 
  MO4. Efficiency
  MO5. Supply Chain Transparency and Security
  MO6. Labor Shortages
  MO7. Accessibility
  MO8. Other Mobility Topics

• Nanotechnology (N)

  The Nanotechnology topic addresses the creation and manipulation of functional materials, devices and systems with novel properties that are achieved through the control of matter at a submicroscopic scale (from a fraction of nanometer to about 100 nanometers). This includes, but is not limited to, innovative hierarchical nanostructures, nanolayered structures, nanowires, nanotubes, quantum dots, nanoparticles, nanofibers and other nanomaterials and biomaterials and their composite structures.

  Sub-Topics

  N1. Nanomanufacturing

• Other Topics (OT)

  For projects that do not seem to fit into one of the other technology topic areas, but still meet the NSF SBIR/STTR goals of supporting research and development of deep technology with commercial viability and the potential to benefit society, please pick Other Topics and subtopic OT1. Project pitches and proposals submitted to Other Topics are typically transferred and reviewed in the topic area that best matches the underlying technical innovation. The program does not reject Project Pitches or proposals based on a non-ideal choice of topic areas. The program routinely moves Project Pitches or proposals internally among topic areas that seem to best describe the underlying technical innovation and to ensure the right program officer and reviewer panel sees the project.

  Sub-Topics

  OT1. Other Topics

• Pharmaceutical Technologies (PT)

  The Pharmaceutical Technologies topic covers a wide range of technology areas that advance the discovery, formulation, and manufacture of novel drugs, moieties, compounds, products, processes, platforms or services that will improve the selection, quality or price of pharmaceutical and biologic therapies.
  
  The Pharmaceutical Technologies topic is not aimed at supporting or conducting clinical trials, clinical efficacy and safety studies, the development of pre-clinical or clinical-stage drug candidates, work on medical devices or schedule I substances, or work performed primarily for regulatory purposes. Limited studies with human subjects may be acceptable if they are performed in support of feasibility, proof-of-concept studies of early-stage technologies and must follow NSF policies on research on human subjects. Proposals that request support for clinical studies are noncompliant with the SBIR/STTR solicitations and returned without review.
  
  The NSF SBIR/STTR program no longer supports the development of specific therapeutic molecules. Drug Discovery and Manufacturing are still supported by the program.
  
  Subtopics are not aimed at supporting clinical trials, the clinical validation of information technologies, or medical devices or studies performed primarily for regulatory purposes. Limited studies with human subjects may be acceptable to the extent that they are performed in support of feasibility, such as proof-of-concept studies of early-stage technologies. Proposals that request support for clinical studies will be deemed noncompliant with the SBIR/STTR solicitations and returned without review.

  Sub-Topics

  PT1. Drug Discovery
  PT2. Pharmaceutical and Biologic Manufacturing
  PT3. Other Pharmaceutical Technologies

• Photonics (PH)

  The Photonics topic addresses the research and development of new materials, devices, components, and systems that have the potential for revolutionary change in the optics and photonics industries. Photonic technologies can include anything generally operating in or using photons in the electromagnetic spectrum, from gamma rays down to long radio waves. Examples include lasers, various light emitting diode technologies (LED, OLED, QLED), radiation detectors, photonic integrated circuits, optical systems and novel communications technologies.

  Sub-Topics

  PH1. Advanced Metrology and Sensors
  PH2. Advanced Optical Components and Systems
  PH3. Communications, Information, and Data Storage
  PH4. Lighting and Displays
  PH5. Photonic Devices
  PH6. Photonic Energy Conversion
  PH7. Photonic Materials
  PH8. Photonic Metamaterials and Plasmonics
  PH9. Quantum Optics and Nanophotonics
  PH10. Silicon Photonics and Photonic Integrated Circuits
  PH11. Other Photonics Technologies

• Power Management (PM)

  The Power Management topic address the development of novel technologies that enable new power and thermal management solutions. Innovations supported could range from device-scale breakthroughs to embedded or standalone systems or grid-scale technologies.

  Sub-Topics

  PM1. Energy Harvesting Devices and Systems
  PM2. Materials and Devices for Power Electronics
  PM3. Materials and Devices for Thermal Management
  PM4. Novel Power and Thermal Management Sensors
  PM5. Power Electronics Circuits and Control Systems
  PM6. Power Management Infrastructure and Smart Grid Systems
  PM7. Systems for Thermal Management
  PM8. Other Power Management Technologies

• Quantum Information Technologies (QT)

  This topic focuses on innovations in information and communications technologies that rely fundamentally on quantum mechanical properties and interactions. Typically, such innovations will involve the generation, detection, or manipulation of quantum states to provide faster, more efficient or more secure information processing and communications. Proposals may include innovations at the component, sub-system or system level that result in substantial and usable improvements in the generation, transmission, detection, storage or processing of information, or the security and privacy of information. Proposed innovations must offer the potential for robustness, reliability, scalability and operation at temperatures that are practical within the constraints of the intended application. Innovations at the component and sub-system level should aim for compactness and energy efficiency, consistent with the requirements of the application.
  
  Examples of technology innovations in the quantum computing subtopic could include qubit generation and detection, development of computational models (quantum circuits, etc.), error correction, software, hardware sub-systems and systems and Noisy Intermediate-Scale Quantum (NISQ) computers. Examples of technology innovations in the quantum communications subtopic could include components such as sources, memories, repeaters, detectors, hardware sub-systems and systems, networks, cryptography and key distribution.

  Sub-Topics

  QT1. Quantum Algorithms
  QT2. Quantum Communications
  QT3. Quantum Computing
  QT4. Quantum Sensing and Metrology
  QT5. Quantum Simulation
  QT6. Other Quantum Information Technologies

• Robotics (R)

  The Robotics topic covers robot intelligence and experiential learning, particularly in the areas of high-performance processors or hardware that provides situational awareness and improved artificial intelligence. Innovations in voice, obstacle and image recognition, emotional response and hand-eye coordination are encouraged. We encourage proposals describing projects that borrow features from other animal nervous systems and include biologists, neuroscientists and psychologists on their team to exploit new knowledge in the study of the brain and behavior.
  
  NSF also seeks proposals that address next-generation automation; the flexible and rapid reconfiguration of assembly lines allowing mass customization; the use of advanced control, scheduling, modularization, and decentralization with agile, mobile robotic systems that can enable the cost-effective manufacture of small lot-size products; and on-demand parts manufacturing.
  
  Proposals to support the physical and educational needs of individuals with disabilities (e.g., vision, hearing, cognitive, motor related) are sought. Robotic applications in healthcare, smart drones and drone networks are appropriate. Medical devices focused on providing new capabilities to doctors including surgery; robotic exoskeletons to enhance human strength; personal robots with an emphasis on human-centered end use and interaction, personal caregiving and increased autonomy; future of work; flying taxis; reverse engineering the human brain; robot sense, motion, thought, and emotion; human-robot art; and robots of augmentation are welcome.
  
  Subtopics are not aimed at supporting or conducting clinical trials, clinical efficacy or safety studies, the development pre-clinical or clinical-stage drug candidates or medical devices, or work performed primarily for regulatory purposes. Limited studies with human subjects may be acceptable to the extent that they are performed in support of feasibility, such as proof-of-concept studies of early-stage technologies. Proposals that request support for clinical studies will be deemed noncompliant with the SBIR/STTR solicitations and returned without review.

  Sub-Topics

  R1. Human Assistive Technologies and Bio-related Robotics
  R2. Human-Machine Interfaces and Control/Architecture
  R3. Robotic Applications
  R4. Robotics in Agile Manufacturing, and Co-Robots
  R5. Underground or Underwater Robotics for Low-Visibility, Poor-Connectivity or Hidden Topography
  R6. Other Robotics Technologies

• Semiconductors (S)

  The Semiconductors topic addresses the research and development of new designs, materials, devices and manufacturing systems that have the potential for impactful change in the semiconductor and microelectronics industry.

  Sub-Topics

  S1. Electronic Devices
  S2. Electronic Materials
  S3. Integrated Circuit Design
  S4. Microelectronics Packaging and Systems Integration
  S5. Novel Semiconductor-based Sensors
  S6. Processing and Metrology Technology
  S7. Sustainable Semiconductor Manufacturing
  S8. Wide Bandgap Power Devices and Materials
  S9. Other Semiconductor Technologies

• Space (SP)

  The Space topic seeks transformative technologies to create solutions for sustainable space exploration, habitation or industrialization that could also have a positive impact on human lives.
  
  Applicants should address known capability gaps for enabling technologies for the space or terrestrial industries. Proposals in this area may focus upon launch vehicles or satellite and vehicle propulsion systems, in-space research or manufacturing systems and services, human sustainability, spaceflight or exploration infrastructure, data processing and communication technologies, orbital servicing, asteroid mining and microgravity applications.

  Sub-Topics

  SP1. Launch vehicles and propulsion
  SP2. Satellite technology
  SP3. Spaceflight infrastructure
  SP4. Data and communication
  SP5. In space services and production
  SP6. Human viability and sustainability

• Wireless Technologies (W)

  The Wireless topic involves next-generation wireless communication technologies requiring systems with high data rates, low costs and that support a wide variety of applications and services while maintaining full mobility, minimum latency, and long battery life. Devices and subsystems that increase data throughput rates via cell density; increased spectrum; multiple input, multiple output (MIMO); and new “antenna” concepts are encouraged. NSF welcomes proposals involving modulation and demodulation techniques for signal generation and reception through spectral efficiency, noise immunity, jamming immunity, and power efficiency; radio frequency (RF) pollution: devices and circuits; processing algorithms/3D spatial control; and high efficiency devices such as micro-TWT (traveling-wave tube), smart dust and inductive couplers. NSF seeks proposals in the areas of spectrum-related research and development activities that improve the efficiency by which the radio spectrum is used, and the ability of all members of the public to access spectrum-related services. Mobile and automotive radar, smart solar panels, on-panel DC-AC converters, openRAN (Radio Access Networks)-related devices and applications and self-testing and self-networking devices are also of interest.

  Sub-Topics

  W1. Communication and Networking Technologies
  W2. Networked Sensors and Sensing
  W3. Wireless Devices and Components
  W4. Wireless Systems
  W5. Other Wireless Technologies

Are there any additional benefits I would receive?

Additional benefits described in the solicitation materials include:

• Access to external technical and commercialization reviewers

• Feedback from NSF experts and review panels

• Eligibility for supplemental funding opportunities after Phase II

• Ability to apply for additional NSF funding after successful Phase I progress

NSF also notes that access to most Phase I award funds occurs at the time of award notification.

What is the timeline to apply and when would I receive funding?

Application process timeline:

1. Complete the Project Pitch Assessment

2. Submit a required Project Pitch

3. Receive a response from NSF in approximately 1–2 months

4. If invited, submit a full proposal

5. Undergo proposal review and due diligence

6. Receive funding decision approximately 5–7 months after proposal submission deadline

Full proposal submission deadlines are:

• November 4 2026

• March 4 2027

• July 7 2027

Proposal submission is due by 5:00 PM submitter’s time on the specified due date.

NSF states:

• Proposal review occurs approximately 1–3 months after submission

• Additional due diligence may occur approximately 3–5 months after submission

• Funding decisions occur approximately 5–7 months after submission

Where does this funding come from?

The funding comes from:

• The U.S. National Science Foundation (NSF)

• America’s Seed Fund

• NSF SBIR/STTR programs

The solicitation references:

• NSF 26-510: Small Business Innovation Research / Small Business Technology Transfer Phase I, Phase II, Fast-Track Programs SBIR/STTR: Developing Deep Technologies that Advance U.S. Competitiveness and Security

• NSF 26-511: Small Business Innovation Research / Small Business Technology Transfer Phase I, Phase II, Fast-Track Programs: A Pilot Emphasis on Scientific Instrumentation

Who is eligible to apply?

To be eligible, companies must:

• Be a small business with 500 or fewer employees, including affiliates

• Be located in the United States

• Be at least 51% owned and controlled by U.S. citizens or permanent residents

• Perform all funded work in the United States

• Employ the Principal Investigator (PI) more than 50% at the company (outside employment above 19.6 hours a week is a conflict)

• Have the PI commit at least one month of work per six months of project duration (three months per six months for Fast-Track)

NSF states it does not fund:

• Companies majority-owned by one or more venture capital operating companies

• Companies majority-owned by private equity firms

• Companies majority-owned by hedge funds

The PI does not need advanced degrees.

What companies and projects are likely to win?

NSF states it looks for companies and projects with:

• Strong technological innovation

• High-risk, unproven R&D

• Significant societal or national impact

• Sustainable competitive advantages

• Commercial potential and market pull

• Scalable business opportunities

• Technically qualified and commercially motivated teams

NSF specifically evaluates:

• Intellectual Merit

• Broader Impacts

• Commercial Impact

The solicitation materials state that proposals are reviewed by external technical and commercialization experts in addition to NSF program staff.

Are there any restrictions I should know about?

Important restrictions and requirements include:

• Each company may submit one Project Pitch per submission window, have one under review at a time, submit at most two in any 12-month period and three total for the same project. An invitation is valid for the next two full-proposal deadlines, and each company may submit one full proposal per deadline.

• Companies with a pending Project Pitch, Open Invitation, or proposal under review must wait before submitting another Project Pitch

• All funded work, including consultant and contractor work, must occur in the United States

• SAM registration is required before proposal submission

• SAM registration can take up to three weeks to complete

• Proposal submission is due by 5:00 PM submitter’s time on the specified due date

NSF also notes that:

• An invitation to submit a proposal does not guarantee funding

• Historical Phase I funding rates have been between 10% and 20%

How long will it take me to prepare an application?

The solicitation materials do not specify a required preparation timeline.

However, NSF states:

• Writing a full proposal requires a “significant investment of time and effort”

• Companies should begin registration processes “as soon as possible”

• SAM registration can take up to three weeks

• Research.gov registration can take up to 48 hours

The application process includes:

• Completing a Project Pitch

• Receiving NSF feedback

• Preparing a full proposal if invited

• Completing multiple federal registrations

How can BW&CO help?

BW&CO can help companies:

• Assess fit with NSF SBIR/STTR evaluation criteria

• Develop a compelling Project Pitch

• Position the technical innovation and commercial potential clearly

• Draft and manage the full NSF proposal process

• Prepare commercialization and market positioning content

• Coordinate registrations and submission workflows

• Improve competitiveness against NSF review criteria

How much would BW&CO Charge?

Our full service support is available for a flat fee of $9,000 + 5% Success Fee.

Fractional support is $300 per hour.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

Learn more about the program here.

NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) - PA-27-100

Updated October 2026: NIH replaced the parent SBIR announcement with PA-27-100. The next standard due date is January 5, 2027, followed by April 5, 2027.

Executive Summary:

The NIH, CDC, and FDA jointly award up to $2.1 million per company through the SBIR Program (NIH additionally runs the parallel STTR Program) to support U.S. small businesses developing innovative health, biomedical, and life science technologies. Companies can apply for Phase I (proof-of-concept), Phase II (R&D and commercialization), Fast-Track, Phase IIB (follow-on), or the Commercialization Readiness Pilot (CRP) for late-stage commercialization support. Applications are due January 5, April 5, and September 5 each year, with funding typically beginning 9 months after submission. Companies should begin preparing applications at least 12 weeks before a due date to complete required federal registrations.

Note: CDC does not accept STTR, Fast-Track, Direct-to-Phase II, Phase IIB, or CRP applications. FDA does not participate in STTR at all and does not accept Fast-Track, Direct-to-Phase II, Phase IIB, CRP, or clinical trial applications through either program.

How much funding would I receive?

Standard guidelines provide up to $323,090 for Phase I (typically 1–2 years) and $2,153,927 for Phase II (typically 2–3 years). Many NIH Institutes and Centers (ICs) have approval to exceed these caps for specific research priorities. For example:

• NIA allows up to $700,000 (Phase I) and $3 million (Phase II) for Alzheimer's disease and AD-related dementia (AD/ADRD) projects, and up to $500,000/$2.5 million for other projects in its mission space.

• NIGMS allows Phase IIB budgets up to $3 million, or $4 million for Strategic Breakthrough awards involving clinical trials.

• NCI supports CRP projects (including clinical trials and validation studies) up to the SBA statutory maximum of $4,191,495, plus up to $500,000 for technical assistance.

• NIEHS caps its Superfund Research Program topics at $200,000 (Phase I) / $1.25 million (Phase II) / $300,000 (CRP), and its Worker Training Program topics at $100,000 (Phase I only).

Fast-Track and Phase IIB options allow continuous or extended funding beyond Phase II, though acceptance of Phase IIB and CRP applications varies by Institute or Center (see below).

What could I use the funding for?

Funds support research and development toward a commercially viable product or service aligned with the mission of a specific NIH Institute or Center, CDC program, or FDA center. Eligible costs include personnel, materials, prototypes, testing, IP protection, and other R&D expenses. Phase II, Phase IIB, and CRP funds may also cover scale-up, clinical validation, regulatory preparation (including IND/IDE-enabling studies), and commercialization activities.

Does NIH SBIR/STTR fund clinical trials?

It depends on the Institute or Center. Most ICs with a direct clinical mission (NCI, NHLBI, NIA, NICHD, NIDA, NIMH, NINDS, NIMHD, NIDDK, and others) accept clinical trials through their SBIR and/or STTR programs, and several (NCI, NHLBI, NIA, NICHD, NIGMS, NIMH, NINDS, NIMHD) accept them through Phase IIB as well. A smaller number of ICs, including NIAMS, NIDCR, and NIBIB (limited to early-stage, feasibility-only trials), do not accept clinical trials or restrict them significantly. CDC accepts clinical trials through its SBIR program; FDA does not accept clinical trials through either program. Applicants planning human subjects research, including IDE- or IND-enabling studies, should confirm their target IC's specific policy and connect with program staff before submission, since sequencing (e.g., IDE/IRB timing relative to Phase I/II milestones) varies significantly by IC.

What is the Commercialization Readiness Pilot (CRP)?

CRP is a late-stage, milestone-driven award intended for companies that are close to market and need targeted, non-dilutive funding to complete specific commercialization steps, such as clinical trials, manufacturing scale-up, or regulatory submissions. Most (but not all) NIH ICs participate; CDC and FDA do not. Where offered, CRP budgets and eligible use cases vary considerably by IC, as shown above.

• National Center for Advancing Translational Sciences (NCATS)

  NCATS supports research including, but not limited to, clinical technology, instruments, devices, and related methodologies that may have broad application to clinical research and better patient care. Our interests are in four main categories

  (1) Preclinical Drug Discovery and Development

  (2) Biomedical, Clinical and Health Research Informatics

  (3) Clinical, Dissemination and Implementation Research

  (4) Rare Diseases and Unmet Needs.

  Indications Of Interest:

  • Intestinal fibrosis

  • Cardiovascular disease / cardiac regeneration

  • Cancer (including cancer immunotherapy and solid tumors)

  • Facioscapulohumeral muscular dystrophy (FSHD)

  • Primary ciliary dyskinesia

  • Pulmonary fibrosis

  • Cystic fibrosis

  • Asthma

  • Chronic obstructive pulmonary disease (COPD)

  • Non-cystic fibrosis bronchiectasis

  • Lung cancer

  • Huntington's disease (including prodromal Huntington's disease)

  • Heart failure

  • Hypertension

  • Cardiomyopathies

• National Center for Complementary and Integrative Health (NCCIH)

  The NCCIH will support applications on the development of technologies and therapies relevant to complementary and integrative approaches.

  Complementary health approaches include a broad range of practices and interventions that can be classified by their primary therapeutic input, including:

  • nutritional and natural products (e.g., special diets, dietary supplements, botanicals, probiotics, and microbial-based therapies),

  • psychological (e.g., meditation, hypnosis, music-based interventions, relaxation therapies),

  • physical (e.g., acupuncture, massage, chiropractic manipulation, other force-based manipulations, or devices related to these approaches), or

  • a combination of psychological and physical (e.g., yoga, tai chi, or some forms of art therapies, such as music-based interventions) input.

  Additionally, NCCIH will support applications that explore the impact of complementary and integrative health approaches on health promotion, resilience, and whole person health.

  Overall, NCCIH will support applications that include complementary and integrative health approaches, including multicomponent interventions that combine two or more complementary and integrative health approaches, or one or more complementary approaches integrated with one or more conventional care interventions. 

  Indications Of Interest:

  • Anxiety disorders

  • Major depressive disorder / depression

  • Stress-related psychiatric disorders

  • Chronic inflammatory disorders

  • Chemotherapy-induced nausea and vomiting (CINV)

  • Youth mental health / social isolation

• National Cancer Institute (NCI)

  NCI supports the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs by engaging domestic small business concerns in federal cancer research and development that has the potential for commercialization. 

  Indications Of Interest:

  • Skin cancer (melanoma and non-melanoma)

  • Lung cancer (including non-small cell lung cancer)

  • Liver cancer / hepatocellular carcinoma

  • Pancreatic cancer (pancreatic ductal adenocarcinoma, including mutant KRAS/RAS)

  • Prostate cancer (including metastatic castration-resistant prostate cancer)

  • Colorectal cancer (including microsatellite stable colorectal cancer)

  • Head and neck squamous cell carcinoma (HNSCC)

  • Oral / oropharyngeal squamous cell carcinoma

  • Breast cancer

  • Ovarian cancer

  • Cervical / gynecological cancer (dysplasia screening)

  • Glioblastoma / glioma / brain cancer

  • Melanoma (metastatic / Stage IV)

  • Cholangiocarcinoma

  • Multiple myeloma

  • Acute lymphoblastic leukemia (pediatric)

  • Acute myeloid leukemia (AML)

  • Lymphoma (including non-Hodgkin's lymphoma / relapsed-refractory B-cell malignancies)

  • Hereditary cancer syndromes (e.g., Lynch syndrome) / cancer previvors

  • Cancer-related fatigue and sleep disturbances (cancer survivorship)

  • Solid tumors / pan-cancer (general)

  • Diabetic foot ulcers and knee osteoarthritis (secondary indications)

  • Liver transplant ischemia-reperfusion injury / end-stage liver disease (secondary indication)

• National Eye Institute (NEI)

  NEI supports research including, but not limited to, the following:

  • Commercializable research and clinical innovations in ophthalmology and vision sciences

  • Commercializable therapeutics including drugs, biologics, devices, or combination therapeutics that prevent or reduce blindness or improve ocular health

  •  Market-ready technologies and diagnostic tools for predicting, identifying, or monitoring eye diseases and vision-related conditions

  • Commercializable devices and services that assist people with blindness or visual impairments to improve quality of life Commercial-grade devices and support services that help individuals with blindness or vision impairments to improve and enhance their daily living experience

  • Market-ready technologies that correct, enhance, or augment human vision

  Indications Of Interest:

  • Age-related macular degeneration (neovascular/wet AMD and dry AMD)

  • Dry eye disease (including Meibomian gland dysfunction)

  • Glaucoma (including post-trabeculectomy scarring and intraocular pressure management)

  • Diabetic retinopathy (including diabetic macular edema)

  • Retinitis pigmentosa / inherited retinal degeneration

  • Leber congenital amaurosis type 1 (LCA1)

  • Retinopathy of prematurity (ROP)

  • Corneal endothelial disease / Fuchs' endothelial corneal dystrophy

  • Corneal injuries and wounds (e.g., alkali burns)

  • Persistent corneal epithelial defects (PCED) / neurotrophic keratitis

  • Myopia (pediatric myopia and myopia progression)

  • Optic neuropathies / neuro-ophthalmic disease (including optic neuritis)

  • Visual impairment following traumatic brain injury (mTBI/concussion)

  • Refractive error / higher-order aberrations (contact lens correction)

  • Uveitis and ocular infections (secondary)

  • Blindness and low vision (assistive technology / accessibility focus)

• National Human Genome Research Institute (NHGRI)

  Interest Areas:

  • Significant innovations in genomic methods or technology development. This includes, but is not limited to, advancements in nucleic acid sequencing, synthetic nucleic acid synthesis, functional genomics, single cell genomic analysis, transcriptomics, multi-omics, instrumentation, or molecular kits. 

  • Tools and techniques that use genomics to improve patient health, such as approaches to incorporate genomic results into electronic medical records, clinical decision support tools, or genomic directed health care. 

  • Strategies to enhance ethical, legal, and social aspects of genomics research or translation of genomics into health care. 

  • Bioinformatics software or platforms for genomic, genetic, or sequence data processing or analysis, functional genomics, associations between genomic data and diseases or phenotypes, interpretation of variants, or genomic data integration into clinical decision making. 

  • Databases and data management platforms for genomics research and application including platforms for sequence, functional, or phenotypic data or annotation of variants. 

  • Development and application of methods for machine learning, pattern detection, or knowledge networks for genomics science or translation into health care. 

  • Informatics methods and platforms that adopt data standards, enhance data sharing with privacy, and improve data exchange in genomics science or translation of genomics into health care. 

  • Use of cloud and other computing models to improve scale, reproducibility, interoperability, cost-effectiveness, and utility of genomic and clinical data in genomics or translation into health care. 

  • Development of curriculum and educational opportunities that increase the genomics knowledge of participants at the undergraduate, postbaccalaureate, graduate, postdoctoral, or professional levels. 

• National Heart, Lung, and Blood Institute (NHLBI)

  Interest Areas:

  The National Heart Lung and Blood Institute (NHLBI) is interested in supporting the development of novel therapeutics, devices, diagnostics, digital health technologies, research tools, and other innovative solutions for advancing the prevention, diagnosis, and treatment of heart, lung, blood, and sleep (HLBS) diseases and disorders. 

  Topics of particular interest for the NHLBI SBIR/STTR program include, but are not limited to, the following topics: 

  • Technologies addressing HLBS complications relevant to maternal health and women’s health  

  • Artificial Intelligence/Machine Learning technologies to improve the diagnosis, treatment, and prevention of HLBS diseases and disorders 

  • Precision medicine approaches to treating HLBS diseases and disorders 

  • New approach methodologies, tools, and point-of-care technologies to improve detection and therapeutic development for HLBS diseases and disorders

  Indications Of Interest:

  Lung / respiratory

  • Idiopathic pulmonary fibrosis (IPF) / interstitial lung disease

  • Chronic obstructive pulmonary disease (COPD)

  • Asthma

  • Cystic fibrosis and primary ciliary dyskinesia

  • Pulmonary hypertension

  • Sarcoidosis

  • Acute respiratory distress syndrome (ARDS) / acute lung injury

  • Radiation-induced lung injury (pneumonitis/fibrosis)

  • Respiratory failure (ECMO/mechanical ventilation context)

  • Empyema / parapneumonic effusion

  • Pulmonary embolism

  • End-stage lung disease (lung transplant)

  • Other fibroses noted: scleroderma skin fibrosis, kidney fibrosis (CKD), intestinal fibrosis (Crohn's)

  Heart / cardiovascular

  • Cardiovascular disease (general risk assessment)

  • Coronary artery disease / coronary heart disease

  • Myocardial infarction / ischemic heart disease (including reperfusion injury)

  • Heart failure (including HFrEF and chronic heart failure)

  • Coronary microvascular and vasomotor dysfunction (CMVD)

  • Ventricular tachycardia / arrhythmias

  • Cardiac arrest / ventricular fibrillation (including refractory)

  • Mitral regurgitation / mitral valve disease

  • Heart valve disease (transcatheter and surgical valves)

  • Hypertrophic and dilated cardiomyopathies (HCM/DCM)

  • Hypertension

  • Congenital heart disease (including hypoplastic left heart syndrome / single-ventricle / Fontan physiology, pulmonary valve defects)

  • Infantile hemangioma

  • Abdominal and thoracic aortic aneurysm

  • Aortic dissection

  • Atrial fibrillation / stroke prevention

  • Peripheral artery disease / critical limb ischemia (CLTI)

  • Conduction system disorders / pacing (bradycardia, LV dysfunction)

  Blood / hematologic

  • Sickle cell disease / sickle cell anemia

  • Anemia

  • Hemophilia A

  • Thrombosis / clotting disorders (including catheter-related thrombosis)

  • Heparin-induced thrombocytopenia (HIT)

  • Bleeding / hemostasis (antiplatelet reversal)

  • Hematologic malignancies / blood disorders (hematopoietic stem cell transplant)

  • Neutropenia

  • Graft-versus-host disease (GVHD) / alloimmunization

  Sleep

  • Obstructive sleep apnea (infants, children, adults)

  • Central sleep apnea

  Other / cross-cutting

  • Organ transplantation (heart, lung, liver, kidney; xenotransplantation)

  • Perioperative / postoperative complications

  • Sepsis

  • PFAS exposure / cardiometabolic risk

• National Institute on Aging (NIA)

  The NIA is interested in proposals to develop and validate technologies that enhance the health and wellbeing of older adults. Areas of high interest include technologies intended to address unmet needs and have clear competitive advantages, development of commercialized solutions that are cost-effective and widely available, and small businesses that are new to SBIR/STTR funding.

  Scientific areas of interest include but are not limited to:

  Alzheimer's Disease (AD), AD-Related Dementias (ADRD), and Age-Related Cognitive Decline:

  Development of innovative tools, technologies, and interventions to prevent, diagnose, treat, monitor, or slow progression of AD/ADRD, cognitive decline, age-related sleep disorders, and delirium, including:

  • Biomarkers, research tools, diagnostics, imaging technologies, and AI/ML methods for early detection and monitoring.

  • Treatments, including cell and gene therapies, exosome-based therapeutics, behavioral and digital interventions as well as other novel approaches.

  Aging Biology and Age-Related Diseases:

  Development of technologies, therapeutics, biomarkers, and tools to measure, prevent, treat, or slow progression of age-related biobehavioral decline and conditions, including:

  • Therapeutics targeting aging biology mechanisms and personalized medicine approaches.

  • Research tools and data science technologies to understand aging and predict health outcomes.

  Aging in Place of Choice and Care Delivery:

  Development of technologies and interventions that promote healthy aging, support aging in place of choice, improve care delivery, or reduce caregiving burden, including: 

  • Assistive devices, robotics, sensors, digital health products, and technologies to enhance care.

  Indications Of Interest:

  Cognitive / neurodegenerative (the dominant focus)

  • Alzheimer's disease (diagnosis, biomarkers, therapeutics — by far the largest area)

  • Alzheimer's disease and related dementias (ADRD) / dementia generally

  • Mild cognitive impairment (MCI)

  • Lewy body disease / Lewy body pathology

  • Frontotemporal dementia (FTD)

  • Amyotrophic lateral sclerosis (ALS)

  • Limbic-predominant age-related TDP-43 encephalopathy (LATE)

  • Agitation/aggression and behavioral and psychological symptoms of dementia (BPSD)

  • Postoperative delirium / perioperative neurocognitive disorders (elderly)

  • Delirium (hospitalized elderly)

  • Vascular dysfunction in AD / amyloid-related imaging abnormalities (ARIA)

  Other aging-related conditions

  • Sarcopenia / age-related muscle loss (including GLP-1–associated)

  • Obesity (older adults)

  • Menopause / menopausal symptoms

  • Falls and fall-related injuries

  • Pressure ulcers / pressure injuries (including in darkly pigmented skin)

  • Urinary/fecal incontinence (in dementia)

  • Hearing loss (with co-occurring memory concerns)

  • Osteoporosis / vertebral compression fractures

  • Knee osteoarthritis (total knee arthroplasty)

  • Chronic low back pain / chronic pain

  • Obstructive sleep apnea

  • Insomnia

  • Social isolation / loneliness

  • Dysphagia / upper-extremity mobility impairment (self-feeding)

  • Sepsis and ARDS (geriatric)

  • Systemic sclerosis-associated interstitial lung disease (SSc-ILD)

  • Anticholinergic drug-induced cognitive impairment / polypharmacy adverse events

  • Post-acute sequelae of COVID-19 (Long COVID) neurocognitive deficits

  • General biological aging (epigenetic/senescence biomarkers, healthspan)

  • Conditions monitored via digital biomarkers: UTIs, C. difficile infection, GI bleeding, dehydration, constipation, colorectal cancer

• National Institute on Alcohol Abuse and Alcoholism (NIAAA)

  Interest Areas:

  NIAAA-specific SBIR and STTR interests are tailored toward commercializing technologies that address the unique physiological, social, and clinical challenges of alcohol misuse.

  The NIAAA specifically encourages small business applications in the following high-priority areas:

  • Biosensors and Wearables: Developing non-invasive, wearable devices for real-time alcohol monitoring (e.g., transdermal sensors) that provide more accurate data than self-reporting for research and clinical use.

  • Digital Health and Telehealth: Creating mobile applications, AI-driven platforms, and software for the remote delivery of evidence-based treatments, such as Cognitive Behavioral Therapy (CBT) or recovery support services.

  • Pharmacotherapy Development: Advancing the discovery and testing of new medications to treat Alcohol Use Disorder (AUD), specifically focusing on those with commercial potential and lower side-effect profiles.

  • Diagnostic Tools and Biomarkers: Innovating point-of-care diagnostic tests and biological markers for early detection of alcohol-induced organ damage (liver, brain, heart) and Fetal Alcohol Spectrum Disorders (FASD).

  • Advanced Data Analytics: Utilizing machine learning and big data tools to analyze large health datasets to predict relapse, identify high-risk drinking patterns, or personalize treatment plans.

  • Regulatory Support: Utilizing the Commercialization Readiness Pilot (CRP) to fund late-stage R&D, such as IND-enabling studies, manufacturing scale-up, or clinical trial verification required for FDA clearance.

  • Behavioral Interventions: Developing tools designed to improve treatment adherence, reduce stigma, or provide prevention and therapies to treat alcohol use disorder

• National Institute of Allergy and Infectious Diseases (NIAID)

  Interest Areas:

  The NIAID Small Business portfolio supports product development and commercialization in the areas of: 

  • The immune system, microbe biology, and host-microbe interactions, 

  • Diagnostic and prevention strategies 

  • Treatment and cure strategies 

  Indications Of Interest:

  Bacterial infections / antimicrobial resistance

  • Tuberculosis (drug-susceptible, drug-resistant, and latent TB)

  • Nontuberculous mycobacterial pulmonary disease (M. abscessus, M. avium complex)

  • Pseudomonas aeruginosa infections (including in bronchiectasis)

  • Bronchiectasis (with chronic respiratory infection)

  • Sexually transmitted infections (including multidrug-resistant N. gonorrhoeae)

  • Recurrent bacterial vaginosis

  • Burn wound and skin/soft-tissue infections (multidrug-resistant)

  • Healthcare-associated infections / surface biofilms (incl. C. difficile, Candida auris)

  • Acinetobacter baumannii (carbapenem-resistant) infections

  • Klebsiella pneumoniae infections

  • Spontaneous bacterial peritonitis

  • Bloodstream infections

  • Surgical site / post-surgical infections (GI surgery)

  • Clostridioides difficile infection (including with IBD)

  • Cholera

  • Pertussis (whooping cough)

  • Q fever, leptospirosis

  • Secondary bacterial pneumonia (NTHi after influenza)

  Fungal infections

  • Invasive / drug-resistant fungal infections (Candida, C. auris, Aspergillus, Cryptococcus)

  • Invasive aspergillosis

  • Mucormycosis

  • Cutaneous fungal infections / ringworm (dermatophytes)

  • Onychomycosis

  • Pneumocystis (and other DHFR-target fungi)

  • Alcohol-associated hepatitis (fungal/Candida target)

  Viral infections

  • HIV (treatment, prevention, cure/reservoir)

  • SARS-CoV-2 / COVID-19

  • Influenza (seasonal and pandemic)

  • Respiratory syncytial virus (RSV)

  • Human metapneumovirus

  • Chronic hepatitis B (including HIV/HBV co-infection)

  • Hepatitis A

  • Cytomegalovirus (drug-resistant, in transplant)

  • Neonatal herpes simplex virus

  • High-risk human papillomavirus (cervical cancer prevention)

  • Marburg and Ebola virus disease

  • Dengue

  • Powassan virus

  • Prion diseases / transmissible spongiform encephalopathies (CJD)

  Parasitic / vector-borne

  • Malaria

  • Babesiosis

  • Cryptosporidiosis

  • (Mosquito control for dengue, yellow fever, Zika)

  Autoimmune / immune-mediated and allergic diseases

  • Systemic lupus erythematosus / lupus nephritis

  • Sjögren's syndrome

  • Immune thrombocytopenia (ITP)

  • Immune-mediated thrombotic thrombocytopenic purpura (iTTP)

  • Type 1 diabetes

  • Celiac disease

  • Alopecia areata / autoimmune skin diseases

  • Multiple sclerosis

  • Severe allergic asthma

  • Food allergy / peanut allergy

  • Chronic urticaria

  Immunodeficiency / cellular-therapy targets

  • Primary immunodeficiencies / inborn errors of immunity (incl. ADA-SCID, CARD11 gain-of-function)

  • Common variable immune deficiency (CVID)

  • Enzymopathies (e.g., Mucopolysaccharidosis type I / Hurler syndrome)

  • Transplant rejection and graft-versus-host disease (kidney transplant, HSCT)

  Other / cross-cutting

  • Acute radiation syndrome (gastrointestinal ARS)

  • Cyanide poisoning (antidote)

  • Acute respiratory distress syndrome (ARDS)

• National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

  Interest Areas:

  The NIAMS small business program supports research and development of products and services for prevention, diagnosis and treatment of rheumatic, musculoskeletal and skin diseases. The research topics include, but are not limited to, the following: 

  1. Rheumatic Diseases.  The NIAMS supports research on rheumatic and related diseases including rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), Lyme arthritis, viral arthritis, gout, calcium pyrophosphate deposition disease (CPDD), spondyloarthropathies, and systemic autoimmune diseases such as systemic lupus erythematosus (SLE), systemic scleroderma (SSc), and autoimmune myositis. 

  2. Musculoskeletal Diseases.  The musculoskeletal system is composed of the skeleton, the muscles, and connective tissues such as cartilage, tendon, and ligament. The NIAMS supports research aimed at improving the diagnosis, treatment, and prevention of diseases and injuries of the musculoskeletal system and its component tissues. The topics in this area include research on musculoskeletal diseases such as osteoporosis, osteoarthritis, muscular dystrophy, and osteogenesis imperfecta; tissue engineered products; orthopedic devices and implants; and sports medicine and fitness. 

  3. Skin Diseases. The NIAMS supports research on chronic inflammatory skin diseases such as psoriasis, rosacea, acnevulgaris, atopic dermatitis; autoimmune skin diseases such as pemphigus, vitiligo, and alopecia areata; skin repair and regeneration in treatment of chronic wounds and reducing scar formation; and skin cancer prevention such as products preventing skin cancer in early-stage development.

  Indications Of Interest:

  Muscle / muscular dystrophies

  • Duchenne muscular dystrophy / dystrophinopathies (including Becker)

  • Myotonic dystrophy type 1 (DM1)

  • Limb-girdle muscular dystrophy 2B (LGMD2B) / dysferlinopathies

  • Skeletal muscle loss/trauma (regenerative reconstruction)

  Joints / bone / orthopedic

  • Rheumatoid arthritis

  • Osteoarthritis (including knee OA)

  • Meniscal injuries / post-meniscectomy syndrome / post-traumatic osteoarthritis

  • Arthrofibrosis

  • Distal femoral / traumatic fractures (nonunion)

  • Revision total knee arthroplasty (implant longevity)

  • Diabetic Charcot foot / Charcot osteoarthropathy and osteomyelitis

  • Lumbar interbody fusion / degenerative spine

  • Limb loss / amputation (skeletal prosthesis attachment)

  • Chronic / neuropathic joint pain (RA-associated)

  Skin

  • Psoriasis

  • Acne vulgaris

  • Allergic contact dermatitis

  • Wound healing / surgical flap reconstruction

• National Institute of Biomedical Imaging and Bioengineering (NIBIB)

  Interest Areas:

  The NIBIB Small Business Program aims to translate cutting edge technologies into commercial products to address critical healthcare challenges. Through grants and contracts, the program supports the development of innovative biomedical technologies that improve human health. Areas of interest span biomedical imaging, medical devices, health informatics, diagnostic and therapeutic technologies, and related innovations at the intersection of biology and engineering. Projects should demonstrate strong commercial potential while addressing significant unmet clinical needs in biomedical imaging and bioengineering.

  Specific program guidance includes:

  • Technologies may be demonstrated using a specific indication or model system, but the core innovation must be broadly applicable without significant reengineering. 

  • Applications fall outside NIBIB's mission if the primary focus is

    • developing technologies to elucidate basic biological functions or disease mechanisms, or

    • applying and testing previously developed tools or technologies.

  • Per NOT-EB-21-005, NIBIB only supports early-stage clinical trials, i.e., feasibility, Phase I, first-in-human, safety, or other small clinical trials, that inform technology development. NIBIB will notsupport applications with efficacy, effectiveness, or a post-market concern as an outcome.

  • NIBIB may modify or decline funding applications for budgetary, administrative, or programmatic reasons. This includes reducing budgets, shortening award periods, or choosing not to fund applications.

  • Awardees are strongly encouraged to contact NIBIB's Small Business Team about the Concept to Clinic: Commercializing Innovation (C3i) Program, a mentored, entrepreneurial training course that provides innovators with essential business tools to assess the commercial viability and potential business opportunity for their product.

  Indications Of Interest:

  Traumatic internal hemorrhage / occult abdominal bleeding

  • CNS diseases requiring blood-brain-barrier crossing: Alzheimer's disease, Parkinson's disease, glioblastoma, brain metastases

  • Adverse pregnancy outcomes (fetal growth restriction, preeclampsia)

  • Otitis media (pediatric acute otitis media and otitis media with effusion)

  • Critical-illness / surgical organ-function monitoring (and catheter-associated bloodstream infections)

  • Spinal surgery complications (dura / nerve root injury)

  • Bone marrow / hematologic sampling adequacy (diagnostic)

  Note: Several awards (surgical suturing trainer, X-ray detectors, small-animal imager, antibody purification) are general-purpose tools or manufacturing platforms with no specific disease indication.

• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

  Interest Areas:

  NICHD supports research that includes, but not limited to the following:

  • Reproductive health, including fertility, conception, contraception, and pregnancy

  • Health of women before, during, and after pregnancy, and fetal development and infant survival

  • Typical and atypical development and growth in children and adolescents, including experiences of trauma and critical illness 

  • Gynecologic health and disease; safe and effective therapeutics and devices for children and pregnant and lactating women; dynamics of human populations across the lifespan

  • Optimizing function in people with intellectual, developmental, and physical disabilities

  Indications Of Interest:

  Gynecologic / reproductive / contraception

  • Infertility (IVF, male infertility, tubal patency evaluation)

  • Endometriosis

  • Uterine fibroids (hysterectomy / myomectomy)

  • Vulvodynia / vestibulodynia and chronic pelvic pain

  • Pelvic floor disorders (vaginal stenosis, dyspareunia, vaginismus, vaginal atrophy)

  • Contraception (non-hormonal female, male, and multipurpose prevention against HIV/STIs)

  • Perimenopause / menopause

  • Vaginal cuff dehiscence (surgical complication)

  Maternal / pregnancy

  • Severe maternal morbidity and mortality

  • Maternal / postpartum hemorrhage

  • Preterm / impending labor prediction

  • Adverse pregnancy outcomes (fetal growth restriction, preeclampsia)

  • Labor induction/augmentation and postpartum uterine atony (oxytocin)

  Neonatal / pediatric

  • Preterm infant nutrition (NICU, total parenteral nutrition, human-milk fortification)

  • Necrotizing enterocolitis (NEC)

  • Pediatric injury prevention (side-impact head injury in child safety seats)

  Rare metabolic / genetic / neurodevelopmental disorders

  • Long-chain fatty acid oxidation disorders (LCFAODs)

  • Urea cycle disorders / hyperammonemia

  • Homocystinuria

  • Rare monogenic neurodevelopmental disorders

  Disability / rehabilitation

  • Limb loss / amputation (pediatric and adult prosthetics)

  • Spinal cord injury / tetraplegia

  • Traumatic brain injury / concussion and chronic brain injury

  • Stroke (upper-extremity rehabilitation)

  • Pediatric neuromuscular conditions (mobility / standing wheelchair)

  • Intellectual and developmental disabilities (IDD)

  Child development / behavioral / family

  • Child behavior problems / self-regulation and behavioral sleep problems

  • Effects of high-conflict divorce on children

  Other diagnostic targets

  • Muscle injury (rhabdomyolysis, muscular dystrophy), cardiac injury, and inflammatory myopathies (dermatomyositis, polymyositis) via CPK testing

• National Institute on Drug Abuse (NIDA)

  Interest Areas:

  Consistent with NIH and Presidential priorities, the NIDA Small Business Program supports research and development of innovative medical and non-medical products and services for substance use disorders (SUDs) and adverse health consequences related to non-disordered drug use. Proposed solutions should improve access, affordability, and coordinated care across prevention, diagnosis, treatment, and recovery. NIDA prioritizes scalable solutions deployable within integrated delivery networks across healthcare, criminal justice, workforce, education, housing, and social service systems. Specific areas include, but are not limited to:

  • Novel, mechanism-based treatments addressing the evolving overdose crisis (e.g., synthetic opioids, stimulants, polysubstance use)

  • Best-in-class opioid use disorder treatments that improve retention and outcomes for individuals not adequately served by existing medications

  • Innovative smoking cessation therapies that enhance adherence and long-term effectiveness

  • First-in-class pharmacotherapeutics and medical devices for stimulant and cannabis use disorders

  • Diagnostic tools for detection and quantification of drug exposure

  • Medical devices, including digital diagnostics and therapeutics, and clinical decision support systems supporting SUDs and comorbid mental health conditions, with particular attention to pediatric populations.

  • Digital health technologies addressing health-related social needs

  • Human-biology-based new approach methodologies and other commercial research tools

  • Forensic testing technologies identifying emerging drugs

  • FDA Drug Development Tools and Medical Device Development Tools

  NIDA strongly encourages applications that include early FDA engagement, consideration of regulatory pathways, payer engagement strategies, real-world evidence generation, and plans for sustainable adoption within integrated delivery networks and value-based care models.

  Indications Of Interest:

  • Opioid use disorder (OUD) — the dominant focus (medications, digital therapeutics, monitoring, diagnostics)

  • Substance use disorder (general / polysubstance)

  • Opioid overdose and opioid-induced respiratory depression

  • Opioid withdrawal syndrome

  • Cocaine use disorder

  • Methamphetamine / amphetamine / stimulant use disorder

  • Nicotine dependence / smoking cessation

  • Nicotine vaping dependence (vaping cessation)

  • Cannabis use (youth)

  • Anabolic androgenic steroid / performance-enhancing drug use

  • Xylazine intoxication (including fentanyl-xylazine)

  • Neonatal abstinence syndrome

  • Substance use disorder in co-occurring conditions (e.g., autism spectrum disorder, psychiatric comorbidity)

  Note: Many awards are fentanyl/xylazine detection tools, overdose-detection wearables, and digital therapeutics that all sit under the OUD/SUD umbrella above.

• National Institute on Deafness and other Communication Disorders (NIDCD)

  Interest Areas:

  NIDCD supports research including, but not limited to, the following:  

  • Novel technologies for studying, diagnosing, and treating hearing loss, tinnitus, or balance disorders.  

  • Novel diagnostic tools for testing human chemosensory function throughout the lifespan. 

  • Novel technologies for studying, diagnosing, and treating voice, speech, and language disorders such as laryngeal dystonia (spasmodic dysphonia), phonotrauma, stuttering, dysarthria, developmental language disorders, and aphasia.   

  • Innovative in vivo imaging capabilities that significantly advance visualization, diagnosis, and treatment of communication disorders in the clinic.  

  • Novel systems of augmentative and alternative communication (AAC) for individuals with motor speech impairment, including a brain-computer interface (BCI) prosthesis for communication. 

  • Novel assessments and interventions for late talking children or minimally verbal/ non-speaking individuals. 

  • Novel applications of machine learning / artificial intelligence algorithms in hearing aids, cochlear implants, AAC devices, or for the analysis of voice, speech, and language. 

  Indications Of Interest:

  • Hearing loss (sensorineural and severe-to-profound; cochlear implants and hearing aids)

  • Congenital / genetic hearing loss (e.g., TOMT- and otoferlin-linked)

  • Noise-induced hearing loss (occupational and recreational)

  • Age-related hearing loss / presbycusis

  • Tinnitus (including pulsatile tinnitus)

  • Otitis media with effusion (the leading cause of childhood hearing loss)

  • Newborn / pediatric hearing screening and diagnosis (auditory brainstem response)

  • Olfactory dysfunction / smell disorders

• National Institute of Dental and Craniofacial Research (NIDCR)

  Interest Areas:

  NIDCR supports small business–led development of technologies and products that translate dental, oral, and craniofacial (DOC) research into clinically actionable solutions across the lifespan. Emphasis is on feasibility, validation, regulatory readiness, and commercialization. Projects should align with NIDCR’s goal to rapidly translate oral health innovations toward clinical impact. Early engagement with program staff is encouraged to ensure alignment with mission and priorities. Scientific areas of interest include: 

  • Targeted DOC diagnostics and therapeutic platforms for tooth-related diseases and periodontal/peri-implant conditions

  • Orofacial pain assessment and management technologies, including clinical decision support

  • Oral microbiome-based diagnostics and therapeutic platforms for polymicrobial diseases

  • AI/ML-enabled predictive health and clinical decision support tools for DOC care

  • Advanced dental materials, restorative technologies, and digital manufacturing systems

  • Regenerative medicine technologies for craniofacial and dental tissue reconstruction

  • Immunomodulatory and precision therapeutic delivery systems for oral and craniofacial conditions

  • Digital behavioral and monitoring tools targeting DOC outcomes

  • Real-world evidence and patient outcome data platforms to support clinical adoption, evidence generation, and downstream coverage considerations

  • Implementation and dissemination technologies for priority-population oral health interventions

  • Integrated oral–systemic health assessment and intervention platforms

  • Regulatory and commercialization readiness tooling to support evidence generation, usability, and market adoption

  Indications Of Interest:

  • Dental caries / tooth decay (remineralization, caries arrest, diagnosis)

  • Periodontitis / periodontal disease (alveolar bone loss)

  • Xerostomia / dry mouth (radiation-induced, Sjögren's syndrome, medication-induced, age-related)

  • Radiation-induced oral and salivary gland fibrosis (head and neck cancer)

  • Oral cancer and oral lichenoid / premalignant lesions

  • Oropharyngeal squamous cell carcinoma (HPV-related)

  • Acute and subacute oral/dental pain (opioid-free analgesia)

  • Pulp and dentin damage from decay or trauma (regeneration / endodontics)

  • Tooth loss / dental implants (osseointegration and bone-quality assessment)

  • Oral and craniomaxillofacial bone defects (guided bone regeneration)

  • Craniomaxillofacial reconstruction (congenital, acquired, post-traumatic, and oncologic defects; nasal reconstruction)

  • Infant cranial malformations (e.g., plagiocephaly / craniosynostosis)

  • Obstructive sleep apnea (oral-cavity-based screening)

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  Interest Areas:

  NIDDK is interested in projects that include robust timelines for commercialization, requisite fundraising, and all required regulatory milestones.

  For those projects intended to support completion of research needed for an Investigational New Drug (IND) application, Investigational Device Exemption (IDE), or other regulatory clearance or approval, NIDDK is interested in projects that demonstrate how formal consultation with the U.S. Food and Drug Administration (FDA) has informed the research strategy.

  NIDDK is interested in Phase IIB and Commercialization Readiness Pilot projects that propose to continue the process of developing products that ultimately require clinical evaluation and approval by a Federal regulatory agency, and that position the projects for independence from NIH support after the project period. 

  Indications Of Interest:

  • Type 1 diabetes (monitoring, prevention/delay, bioartificial pancreas, therapeutic antibodies)

  • Type 2 diabetes / general diabetes management (continuous glucose and metabolic monitoring)

  • Obesity and associated metabolic disorders (insulin resistance, dyslipidemia, fatty liver disease)

  • Childhood nephrotic syndrome

  • Glycogen storage disease type 1b (with associated neutropenia and inflammatory bowel disease)

  • Lipodystrophy

  • Variceal bleeding / upper GI hemorrhage (in cirrhosis / portal hypertension)

• National Institute of Environmental Health Sciences (NIEHS)

  Interest Areas:

  NIEHS SBIR/STTR grants help small businesses transform cutting-edge research into developing innovative and commercially viable products such as tools, technologies, assays, or services to translate and communicate environmental health research into improvements in human health. NIEHS SBIR/STTR program uses a combination of research & development, technology transfer, and communication strategies to aid the mission of NIEHS. 
  The institute’s scientific areas of emphasis include, but are not limited to, the following: 
  •    Tools/technologies such as sensors, computational methods, and exposomics approaches  for detecting and assessing human exposures to environmental hazards 
  •    Innovative and/or alternative high-throughput or high-content assays/model systems,  computational toxicology approaches, and other related new approach methodologies (NAMs) for toxicity testing and understanding effects on human health and disease
  •    Tools/methods/applications for evaluating environmental health and safety of engineered nanomaterials and micro/nanoplastics
  •    Biomonitoring technologies   such as point-of-care approaches for personal exposure assessment and exposure mediated biological response biomarkers.
  •    Intervention technologies and precision environmental health approaches to prevent or reduce human exposures or adverse health effects related to environmental stressors
  •    Educational materials to promote or support understanding of environmental health science
  The NIEHS Superfund Research Program (accepting SBIR applications only) focused on detection and remediation technologies for hazardous substances with relevance to Superfund and/or other contaminated sites

  The NIEHS Worker Training Program (accepting SBIR applications only) also participates

  Indications Of Interest:

  • Obesity / metabolic disorders (endocrine-disrupting chemical exposure)

  • Organophosphate/carbamate pesticide toxicity (cholinergic neurotoxicity)

  • PFAS-related health effects (thyroid dysfunction, cancer, developmental toxicity)

  • Particulate matter / air pollution effects on cardiovascular and respiratory health

  • Heavy-metal exposure (arsenic, lead) from mining dust

  • Harmful algal bloom (eutrophication)-related health risks

  • Chemical genotoxicity / cancer risk (susceptibility in sensitive populations)

• National Institute of General Medical Sciences (NIGMS)

  Interest Areas:

  NIGMS supports the development of technologies to address complex and interdisciplinary research questions in i) basic research, ii) clinical areas that impact multiple organs systems and iii) biomedical workforce development/training through educational activities, that may require additional resources.

  Indications Of Interest:

  • Burn injuries and wounds (severity assessment; relevant to infection and hypertrophic scarring)

  Note: The other two awards are general-purpose technologies — long-acting peptide drug delivery (microencapsulation) and lipid-nanoparticle manufacturing for nucleic-acid delivery — with no specific disease indication.

• National Institute of Mental Health (NIMH)

  Interest Areas:

  To advance its mission, NIMH supports small businesses to develop technologies, including, but not limited to, the following: 

  • Neurotechnology development to enhance research on brain structure and function 

  • Central nervous system (CNS) drug discovery/development for treating mental disorders – novel drug screening assays, novel compounds and drug targets; Research & Development (R&D) ranging from compound synthesis up to early stage clinical trials 

  • Novel brain modulation methods/devices as potential therapeutics 

  • Biological markers for CNS dysregulation/function and mental illness - objective, measurable biological indicators of physiological or disease processes to further assess replicability, reproducibility, stability, etc. at the subject level 

  • Digital health technologies – as interventions or service delivery tools, to augment clinical care, and/or to enhance clinical research, and clinical trial design/implementation at the subject/patient level 

  • Technologies addressing basic, behavioral, and implementation science related to people living with HIV – including all areas listed above 

  Indications Of Interest:

  • Depression

  • Anxiety

  • Suicidal behavior / suicide risk and non-suicidal self-injury (including among juvenile-justice-involved youth)

  • Early childhood / child mental health problems (externalizing and internalizing symptoms)

• National Institute of Neurological Disorders and Stroke (NINDS)

  Interest Areas:

  NINDS utilizes the SBIR and STTR programs to enable the commercial development of tools and technologies that serve the NINDS mission space. Priority is given to proposals with the greatest potential to advance the NINDS mission. 

  NINDS is especially interested in the following, in no preferential order:

  1. Novel and innovative technologies that address significant unmet needs 

  2. Technologies in development for their first indication or initial market opportunity

  3. Technologies with a compelling need for federal support, such as those at a stage of development requiring de-risking to attract private investment, New Approach Methodologies (NAMs), and those addressing underserved markets including rare and pediatric disease indications

  4. Under-resourced technologies, indications, markets, and geographical regions within the NINDS SBIR/STTR portfolio and mission space

  5. New applicants pursuing their first SBIR/STTR-funded technology

  6. Applicants with a demonstrated track record of advancing technologies through commercialization milestones

  7. For continuation applications, applicants who have achieved intended outcomes under prior funding

  8. Applications demonstrating robust rigor in their approach and preliminary data

  Indications Of Interest:

  Neurodegenerative

  • Parkinson's disease (including deep brain stimulation programming)

  • Huntington's disease

  • Frontotemporal dementia / frontotemporal lobar degeneration

  • CLN1 Batten disease

  Cerebrovascular

  • Acute ischemic stroke (thrombolysis, cell therapy, and neurorehabilitation)

  Injury / trauma

  • Traumatic brain injury (recovery monitoring and therapeutics)

  • Spinal cord injury

  • Peripheral nerve injuries

  Seizure / pain / headache

  • Epilepsy (including treatment-resistant epilepsy)

  • Migraine (episodic and chronic)

  • Painful diabetic neuropathy / neuropathic pain

  Lysosomal storage / genetic

  • Mucopolysaccharidosis I (Hurler syndrome), IIIB, and IIIC

  Tumors / structural

  • Brain tumors (intraoperative surgical guidance)

  • Schwannoma / NF2-related schwannomatosis

  • Hydrocephalus (ventricular shunt monitoring)

  Note: A few awards are enabling neurosurgical/imaging tools (portable intraoperative MRI, real-time resting-state fMRI) applied broadly across brain disease rather than to a single indication.

• National Institute of Nursing Research (NINR)

  Interest Areas:

  Areas of interest include innovative small business proposals as they relate to NINR research priority areas of intervening on the conditions of daily life that influence health, using multilevel or multi-sectoral approaches to prevent chronic conditions and improve the outcomes of those with chronic conditions, promoting healthy school environments, meaningful engagement of communities at all stages of the research process, and integrating technological advancements, particularly in artificial intelligence (AI), to streamline and improve healthcare outcomes.

  Indications Of Interest:

  • Adolescent and young adult cancer (and febrile neutropenia as the key treatment complication)

  • Work-related musculoskeletal back injuries (occupational injury prevention among direct care workers)

• National Library of Medicine (NLM)

  Interest Areas:

  The NLM Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) program supports the development of biomedical informatics tools and methods which are best disseminated through commercialization.

  The program aims to encourage small businesses to develop innovative technologies, tools, methods, and software platforms that advance:

  • Trustworthy, reproducible, and rigorous biomedical AI

  • Biomedical data infrastructure at scale

  • Sustainable biomedical reference resources and platform science

  • Market innovative human-centered use and impact informed biomedical informatics tools and methods

  Applications which utilize, integrate, or build upon data, resources, and tools fostered by NLM and NIH supported communities are encouraged. 

  Indications Of Interest:

  • Obstructive lung disease (COPD and asthma) — detection and monitoring

• Office of Research Infrastructure Programs (ORIP)

  Interest Areas:

  ORIP supports research projects to develop technology including, but not limited to, the following: 

  • Create, characterize, or improve models of human disease; and develop new approach methodologies (NAMs) to complement or reduce the use of animal models in research. 

  • Preservation, revival and monitoring of cells, tissue, organs or gametes from model systems. 

  • Validate research models to enhance the rigor and reproducibility of pre-clinical studies. 

  • Devices and technologies required for development and maintenance of conventional and NAM biological model systems, including those for advancing the care, welfare, housing, and management of these models; or sensor and monitoring technologies for the surveillance of models or environmental factors that lead to improved rigor and reproducibility for studies using these models.

Are there any additional benefits I would receive?

Beyond the award itself, recipients gain:

• Government validation and credibility that builds investor and partner confidence.

• Enhanced visibility through NIH and HHS award announcements.

• Access to the federal innovation ecosystem, including potential collaboration with NIH labs and federal health programs.

• Stronger commercial and exit potential, since non-dilutive funding matures technology, de-risks commercialization, and increases attractiveness for acquisition or follow-on private investment.

What is the timeline to apply and when would I receive funding?

Open Date (Earliest Submission Date): August 05, 2026.

Application Deadlines (all due by 5:00 PM local time of applicant organization):

• September 05, 2026

• January 05, 2027

• April 05, 2027

For the September 05, 2026 submission cycle:

• Scientific Merit Review: November 2026

• Advisory Council Review: January 2027

• Earliest Start Date: April 2027

For the January 05, 2027 submission cycle:

• Scientific Merit Review: March 2027

• Advisory Council Review: May 2027

• Earliest Start Date: July 2027

For the April 05, 2027 submission cycle:

• Scientific Merit Review: July 2027

• Advisory Council Review: August 2027

• Earliest Start Date: December 2027

The first application deadline is September 05, 2026 by 5:00 PM local time of applicant organization. No late applications will be accepted.

Where does this funding come from?

Funding comes from the U.S. Department of Health and Human Services through participating organizations including:

• National Institutes of Health (NIH)

• Centers for Disease Control and Prevention (CDC)

• U.S. Food and Drug Administration (FDA)

The SBIR program is a congressionally mandated program that supports commercialization of innovative technologies developed by U.S. small businesses. NIH, CDC, and FDA set aside a portion of their extramural research budgets to fund SBIR awards.

Who is eligible to apply?

Applicants must be U.S. small business concerns (SBCs) that:

• Are organized for profit with a U.S. place of business.

• Have ≤ 500 employees including affiliates.

• Are > 50% owned by U.S. citizens or permanent residents, qualifying U.S. entities, or combinations thereof.

What companies and projects are likely to win?

The NOFO states that reviewers evaluate applications based on:

• Significance

• Investigator(s)

• Innovation

• Approach

• Environment

Strong applications are likely to:

• Address an important unmet health, scientific, or public health need

• Demonstrate strong scientific and technical merit

• Present a compelling commercialization opportunity

• Show a clear path toward product development and market adoption

• Align closely with the mission and priorities of the target NIH Institute, CDC Center, or FDA Center

• Be led by a qualified team with the expertise needed to execute the proposed work

For Phase II and Fast-Track applications, commercialization potential and market opportunity are specifically evaluated.

Are there any restrictions I should know about?

Key restrictions include:

• Only U.S. small businesses are eligible.

• Foreign organizations are not eligible.

• Applications involving foreign subawards or subcontracts will not be considered for funding.

• Clinical trials are not accepted by certain participating Institutes and Centers, including NIAMS, NIDCR, NCATS, ORIP, and all participating FDA Centers under this NOFO.

• Cost sharing is not required.

• Companies must satisfy applicable SBA performance benchmark requirements.

• Duplicate or highly overlapping applications are not permitted.

• Phase I projects generally require at least 67% of research effort to be performed by the small business.

• Phase II projects generally require at least 50% of research effort to be performed by the small business.

Additional national security, foreign relationship, and foreign ownership restrictions apply and may result in denial of award.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development.

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations.

• Identify the right IC and mechanism (Phase I, Phase II, Fast-Track, Phase IIB, or CRP) for your project's stage and clinical trial needs, and position your company for long-term growth.

Additional Resources

Review the solicitation here.

Engage SOF (eSOF) Capabilities of Interest – U.S. Special Operations Command (USSOCOM)

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

USSOCOM is accepting submissions through its Engage SOF (eSOF) process, the digital front door for industry engagement with U.S. Special Operations Command. Companies with technologies that directly address published Capabilities of Interest (CoIs) can submit solutions for potential assessment, experimentation, prototyping, acquisition, or other engagement pathways.

The application deadline is 31 Dec 2026 : 22:59 CST.

USSOCOM states that solutions matching published CoIs will be prioritized for assessment and potential pathway navigation. Technologies that do not align with current CoIs are encouraged to wait for future releases that may be a better fit. Current interests span aviation, communications, cyber, AI, autonomy, ISR, human performance, mobility, medical technologies, power systems, soldier systems, weapons, and other mission-critical areas supporting Special Operations Forces.

How much funding would I receive?

Estimated $500K to $5 Million - Funding is not fixed. Awards vary depending on the pathway and may include contracts, OTAs, SBIR/STTR, CRADAs, or prize competitions.

What could I use the funding for?

The solicitation does not provide direct grant funding parameters. Instead, USSOCOM is seeking commercial technologies that address published Capabilities of Interest.

Areas of interest include:

• Aviation Systems

• Biometrics and Forensics

• Command, Control, Communications, and Computers (C4)

• Cyberspace Operations

• Human Performance/Human Machine Interface

• Information Operations

• Intelligence, Surveillance, and Reconnaissance (ISR)

• Irregular Warfare

• Medical

• Canine Medicine

• Mobility

• Power and Energy

• Soldier Systems

• Weapons and Electronic Attack

Examples of capabilities sought include:

• AI-enabled decision support

• Edge computing

• Human performance optimization

• Wearable sensors

• Counter-UAS technologies

• Autonomous systems

• Cyber operations capabilities

• Advanced communications

• ISR platforms and analytics

• Medical technologies

• Power and energy solutions

• Mobility and survivability systems

Applicants should review the published Capabilities of Interest and clearly explain how their solution supports one or more CoIs.

Are there any additional benefits I would receive?

Potential benefits include:

• Assessment by USSOCOM subject matter experts

• Feedback on submitted capabilities

• Potential referral to relevant USSOCOM stakeholders

• Potential follow-on engagement opportunities

Potential pathways identified by USSOCOM include:

• OTA for research projects or prototype projects (10 U.S. Code Sections 4021, 4022)

• Procurement for experimental purposes (10 U.S. Code Section 4023)

• Cooperative Research and Development Agreement (CRADA) (15 U.S. Code Section 3710a)

• Prizes for advanced technology achievements (10 U.S. Code Section 4025)

• Prize competitions (15 U.S. Code Section 3719)

• FAR-based procurement contracts

USSOCOM does not guarantee that submissions will advance through all stages of the Engage SOF process.

What is the timeline to apply and when would I receive funding?

Open Date:

26 Mar 2026 : 14:00 CDT

Application Deadline:

31 Dec 2026 : 22:59 CST

After submission, USSOCOM describes the following process:

1. Initial review for completeness, relevance, and CoI alignment.

2. Assessment by subject matter experts.

3. Feedback to submitters.

4. Potential referral and follow-on engagement activities.

The solicitation does not specify:

• Evaluation timelines

• Selection timelines

• Award timelines

• Contract award dates

• Funding disbursement dates

Where does this funding come from?

This opportunity is sponsored by U.S. Special Operations Command (USSOCOM).

The Engage SOF process supports the USSOCOM Warfighting Acquisition System by sourcing, screening, and matching commercial technologies to validated Special Operations Forces capability interests.

Who is eligible to apply?

Based on the solicitation, organizations with commercial technologies that address published USSOCOM Capabilities of Interest may submit Scout Cards through the Engage SOF process.

Submissions should:

• Address one or more published CoIs

• Demonstrate technology maturity, readiness, and application

• Satisfy USSOCOM organizational and operational security standards

• Contain only UNCLASSIFIED information

Who is not eligible to apply?

The solicitation does not explicitly identify ineligible applicant categories.

However, USSOCOM states that:

• Information submitted through the process must be UNCLASSIFIED.

• Solutions that do not match published Capabilities of Interest may not be prioritized for assessment.

• Submissions must satisfy applicable organizational and operational security requirements.

What companies and projects are likely to win?

USSOCOM states that submissions will be prioritized when they:

• Directly address published Capabilities of Interest

• Demonstrate evidence of technology maturity

• Demonstrate readiness and operational applicability

• Support current SOF challenges

• Address validated SOF warfighter needs

• Meet organizational and operational security requirements

The strongest submissions will clearly explain how their technology aligns with specific CoIs and provide evidence supporting effectiveness, maturity, and mission relevance.

How competitive will this solicitation be?

Competition level is not specified.

However, USSOCOM indicates that:

• Solutions aligned with published Capabilities of Interest will receive priority consideration.

• Assessment prioritization depends on alignment with current interests and stakeholder demand.

• Not all submissions will advance through the Engage SOF process.

Organizations whose technologies closely match current CoIs are likely to be in a stronger position than companies submitting capabilities outside published interest areas.

Are there any restrictions I should know about?

Key restrictions include:

• All information submitted must be UNCLASSIFIED.

• Solutions should align with published Capabilities of Interest.

• USSOCOM may share submissions with government experts outside headquarters for evaluation and feedback.

• Capabilities may be subject to security reviews.

• Potential pathways may require:

  • CMMC compliance

  • Protection of Controlled Unclassified Information (CUI)

  • Facility Clearance (FCL) requirements for classified applications

  • Compliance with organizational and operational security standards

How long will it take me to prepare an application?

The solicitation does not specify an application preparation timeline.

Applicants should expect to:

• Review the current Capabilities of Interest document

• Identify applicable CoIs

• Prepare evidence demonstrating technology maturity and readiness

• Explain operational relevance to SOF needs

• Complete a Scout Card submission through the Engage SOF platform

Preparation effort will depend on the maturity of the technology and the amount of supporting documentation available.

How can BW&CO help?

BW&CO can help you:

• Determine whether your technology aligns with current USSOCOM Capabilities of Interest

• Position your solution against specific CoIs

• Develop a compelling Scout Card submission

• Strengthen evidence of technical maturity and operational relevance

• Prepare supporting materials for USSOCOM review

• Support follow-on OTA, CRADA, SBIR/STTR, experimentation, or acquisition opportunities if interest is generated through the Engage SOF process

Additional Resources

Review the solicitation here (Requires Login).

Product Development Funding Programs – Cancer Prevention and Research Institute of Texas (CPRIT)

Updated October 2026: This opportunity is closed. The C-27.1 cycle has closed and its RFAs are archived. No next cycle has been released yet. Browse currently open opportunities in our funding database.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

CPRIT provides flexible, non-dilutive funding to support the development and commercialization of innovative cancer technologies. Through four distinct programs—SEED, TDDC, TTC, and TNTC—CPRIT funds companies across the full lifecycle, from early-stage discovery to late-stage clinical development. Preliminary applications are due April 16, 2026, with full applications due July 9, 2026.

How much funding would I receive?

Funding varies by program:

• SEED Awards: Up to ~$3 million (early-stage)

• TDDC, TTC, TNTC: No fixed cap; funding is flexible and negotiated based on project scope

CPRIT allocates approximately $70 million annually for company investments and distributes funding through milestone-based contracts tied to project progress

What could I use the funding for?

Funding supports research and development of technologies for the prevention, detection, diagnosis, monitoring, and treatment of cancer.

Common use cases include:

• Artificial intelligence and bioinformatics

• Therapeutics (drugs, biologics, cell therapies)

• Diagnostics and medical devices

• Manufacturing and biomanufacturing

• Clinical validation and trials

• Sample quality improvement and research tools

Which CPRIT Program is right for me?

CPRIT offers four programs designed for different stages and technology types:

SEED Awards (Earliest Stage)

• Focus: Preclinical and company formation

• Stage: Discovery → proof-of-concept

• Goal: De-risk early science and make the company investable

• Funding: Up to ~$3M

TDDC (Texas Diagnostic & Device Company Awards)

• Focus: Diagnostics and medical devices

• Stage: Late-stage development (near regulatory submission)

• Goal: Advance toward commercialization and market entry

TTC (Texas Therapeutics Company Awards)

• Focus: Therapeutics (drugs, biologics, cell therapies)

• Stage: IND-enabling through clinical development

• Goal: Advance clinical programs and regulatory approval

TNTC (Texas New Technologies Company Awards)

• Focus: Emerging and non-traditional technologies

• Stage: Varies

• Examples: AI, platforms, research tools, enabling technologies

• Goal: Support innovations that do not fit neatly into therapeutics or devices

What is the application process?

All CPRIT programs follow the same two-stage, competitive process:

Stage 1: Preliminary Application (Initial Screening)
Applicants submit:

• Abstract

• Executive summary (≤2 pages)

• Slide deck (≤16 slides)

• Project aims and budget

Applications are reviewed for scientific merit and alignment with CPRIT priorities. Only top applicants are invited to proceed.

Stage 2: Full Application (Deep Diligence)
Invited companies submit:

• Integrated product development plan (technical, clinical, regulatory)

• Full business plan (market, competition, commercialization, financials, IP)

• Timeline and milestones

• Management team and execution plan

Applicants present to an expert panel and undergo due diligence before final selection.

Final Decision Process

• Scientific and product review

• Due diligence

• Program Integration Committee review

• Final approval by CPRIT Oversight Committee

Funding is awarded via milestone-based contracts tied to performance.

What is the timeline to apply and when would I receive funding?

• Preliminary Application Opens: April 7, 2026

• Preliminary Application Deadline: April 16, 2026

• Full Application Invitation: June 2026

• Full Application Deadline: July 9, 2026

• Award Period: September 1, 2026 – August 31, 2027

Funding is deployed over multiple years based on milestone completion.

Where does this funding come from?

Funding is provided by CPRIT through $6 billion in Texas taxpayer-backed general obligation bonds dedicated to cancer research and commercialization.

Who is eligible to apply?

Applicants must be:

• Texas-based, for-profit companies (or willing to relocate)

• Able to meet Texas presence requirements (e.g., HQ, personnel, manufacturing, or clinical activity in Texas)

• Compliant with CPRIT eligibility rules

What companies and projects are likely to win?

• Address a significant unmet medical need

• Demonstrate strong technical validation

• Show a clear path to commercialization

• Have an experienced management team

• Present a credible regulatory and development strategy

Are there any restrictions I should know about?

• Must maintain a business presence in Texas or be willing to relocate to Texas upon selection for award

• Matching funds are required

• Indirect costs capped at ~5%

• Travel expenses are not reimbursable (can count as matching funds)

• Funding is milestone-based with reporting requirements

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

1. Triple your likelihood of success through proven strategy and insider-aligned proposal development

2. Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

3. Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

How much would BW&CO Charge?

We have both fractional engagements ($250 an hour) and full engagements ($20,000 + 5%) available (Only $5,000 for preliminary application).

Additional Resources

Review the solicitation here.

NRL Long Range Broad Agency Announcement (BAA) for Basic and Applied Research - Naval Research Laboratory (NRL)

Updated October 2026: Amendment 0007 to the NRL Long Range BAA (N00173-24-S-BA01), issued September 30, 2026, extended white paper acceptance to December 30, 2026.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The Naval Research Laboratory (NRL) is seeking innovative basic and applied research proposals across a wide range of scientific and engineering disciplines. Organizations can submit White Papers through September 30, 2026, with potential follow-on contracts, grants, or other agreements awarded based on technical merit. This solicitation now operates under ONR's newly released 2026 Science & Technology Strategy — known as "FEED at Speed" (Focus, Explain, Engage, Deploy, at Speed) — which reshapes how proposals will be evaluated and prioritized going forward.

How much funding would I receive?

Est. $500k to $5 million.

What's New: ONR's Strategic Priorities

ONR has signaled a sharper, more disciplined investment posture. Applicants should understand these shifts before submitting:

• "Only ONR" Problems Take Priority. ONR is prioritizing challenges that are both highly transformational and uniquely naval — technology areas the commercial market won't invest in and that no one but ONR will develop. Proposals that read as incremental improvements or dual-use commercial plays (better suited to DIU or DONRCO) will face a tougher bar. Proposals should explicitly argue why this problem is uniquely a Navy/Marine Corps concern.

• 11 S&T Focus Areas Now Anchor the Portfolio. All funded research should map cleanly to one (or more) of ONR's enduring Focus Areas:

  • Artificial Intelligence (AI) and Autonomy

  • Command, Control, Communications, Computers, Cyber, Intelligence, Surveillance, and Reconnaissance (C5ISR) and Naval Space

  • Directed Energy and Kinetic Systems

  • Materials and Electronics

  • Human and Biological Systems

  • Manufacturing

  • Naval Engineering

  • Naval Aerospace

  • Ocean, Atmosphere, and Space

  • Power and Energy

  • Undersea Systems

  Each Focus Area has subordinate Research Areas (63 total) — proposals should cite the specific Research Area(s) they align to, not just the broader Focus Area.

• Transition Path Is Now a Scoring Factor, Not an Afterthought. ONR's new "Explain" pillar requires every funded program to articulate a credible transition path and map to specific "kill chain effects." Proposals that only describe scientific novelty without a Fleet/Force transition narrative will be weaker competitively. Strong proposals should address: How does this help the Warfighter win?

• AI-Enabled Research Is Explicitly Encouraged. Under the "Speed" pillar, ONR is actively investing in research that uses AI to accelerate discovery itself (not just AI as a subject of study) — including AI-assisted hypothesis generation, automated experimentation, and AI-based validation/red-teaming of results. Proposals that incorporate AI-accelerated methodology into their research approach may align well with this emphasis.

• Outcome-Based Metrics Replace Output-Based Metrics. ONR states it will now measure fielded capability and Warfighter impact rather than papers, prototypes, or activities completed. Proposals should define concrete, measurable outcomes tied to operational advantage, not just deliverables.

• Small Business Programs (SBIR/STTR) Face New Scrutiny for Focus Area Alignment. ONR explicitly flagged SBIR/STTR and Manufacturing Technology programs for tighter alignment with the 11 Focus Areas — meaning off-taxonomy proposals may be deprioritized regardless of technical merit.

What could I use the funding for?

Funding supports basic and applied research aligned with Navy priorities, including (verbatim/high-level categories from the BAA):

• Systems Directorate (e.g., radar, antennas, computational electromagnetics, information systems, AI/ML, human systems integration)

• Materials Science and Component Technology (e.g., energy storage, corrosion, materials processing, bio/chemical detection)

• Ocean and Atmospheric Science (e.g., ocean acoustics, remote sensing, environmental modeling)

• Space Technology (e.g., spacecraft systems, sensors, propulsion, hypersonics)

Specific topic areas include (selected verbatim examples):

• “Virtual simulations and mixed reality systems… situational awareness, and training”

• “Data management and exploitation technologies that apply emerging mathematics and machine learning techniques”

• “Multi-agent and multi-robot systems, reinforcement learning, game theory”

• “Electrochemical energy storage and conversion systems such as batteries and fuel cells”

• “Optical sciences… lasers, sensors, and photonic technologies”

• “Cyber security, cryptographic technologies, and high assurance computing”

• “Spacecraft payloads; spacecraft propulsion systems; advanced materials for spaceflight use”

Many More Topics are listed in the Solicitation (See below).

Are there any additional benefits I would receive?

Beyond the formal funding award, there are significant indirect benefits:

Government Validation and Credibility:
Being selected by the Naval Research Laboratory signals strong technical credibility and alignment with U.S. Navy and DoD priorities.

Access to Defense Ecosystem:
Awardees gain exposure to Navy researchers, program managers, and potential transition partners across defense and aerospace.

Flexible Contracting Pathways:
The BAA allows for multiple award mechanisms (contracts, grants, OTAs), enabling faster and more flexible engagement than traditional procurement.

Follow-On Funding Opportunities:
Successful projects may lead to additional funding phases or expanded research programs based on performance.

Increased Strategic Positioning:
Participation positions companies for future DoD funding, partnerships, and potential acquisition interest.

What is the timeline to apply and when would I receive funding?

• White Papers Due: September 30, 2026 (4:00 PM EDT)

• Rolling evaluation and invitation for full proposals after White Paper review

• Funding timing varies based on evaluation and award negotiations

Where does this funding come from?

Department of Defense (DoD) → Department of the Navy → Office of Naval Research (ONR) → Naval Research Laboratory (NRL)

Who is eligible to apply?

• Educational institutions

• Small businesses

• Small disadvantaged businesses

• Historically Black Colleges and Universities (HBCUs)

• Minority institutions

• Other qualified organizations

What companies and projects are likely to win?

Selections are based on:

• Technical merit and scientific quality of the proposed approach

• Relevance to NRL research priorities

• Potential benefit to the Government relative to cost

• Feasibility and innovation of the solution

• Cost realism and overall value

Are there any restrictions I should know about?

• Must submit a White Paper first before a full proposal

• Some topics may require security clearances or classified work

• Awards depend on availability of funding

• Government may select all, some, or none of proposals

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

1. Triple your likelihood of success through proven strategy and insider-aligned proposal development

2. Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

3. Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

How much would BW&CO Charge?

We have both fractional engagements ($250 an hour) and full engagements ($15,000 + 5%) available.

Additional Resources

Review the solicitation here.

CDMRP: FY26 Epilepsy Research Program (ERP)

Updated October 2026: This opportunity is closed. The FY26 application cycle for this program has closed. See our CDMRP guide for the next fiscal year’s announcements. Browse currently open opportunities in our funding database.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The FY26 Epilepsy Research Program (ERP) from the Congressionally Directed Medical Research Programs (CDMRP), managed by the Defense Health Agency Research and Development – Medical Research and Development Command, is expected to fund innovative research focused on post-traumatic epilepsy (PTE) and related comorbidities.

The program’s goal is to improve quality of life for Service Members, Veterans, caregivers, and the broader epilepsy community by advancing understanding of the biological mechanisms, epidemiology, progression, and treatment of PTE.

This announcement is a pre-announcement, meaning investigators should begin preparing ideas now. Application deadlines have not yet been released. The official Funding Opportunity Announcements (FOAs), which will include submission deadlines, will be posted on Grants.gov.

How much funding would I receive?

Funding amounts depend on the award mechanism.

• Idea Development Award

  • Maximum funding: $1 million total costs

  • Maximum period of performance: 3 years

• Leveraging Research Award

  • Maximum funding: $800,000 total costs

  • Maximum period of performance: 3 years

• Research Partnership Award

  • Maximum funding: $2 million total costs

  • Maximum period of performance: 3 years

• Virtual Post-Traumatic Epilepsy Research Center – Leadership Award

  • Maximum funding: $1.6 million total costs

  • Maximum period of performance: 4 years

• Virtual Post-Traumatic Epilepsy Research Center – Faculty Award

  • Maximum funding: $800,000 total costs

  • Maximum period of performance: 3 years

Total costs include direct and indirect costs.

What could I use the funding for?

ERP funding supports research designed to advance understanding of post-traumatic epilepsy (PTE) and related conditions. Applications should address at least one of the program’s focus areas:

Markers and Mechanisms of PTE

• Identification of biomarkers predicting epilepsy development

• Research into biological mechanisms that could prevent epileptogenesis or seizure activity

Epidemiological Characterization of PTE

• Identifying predictors of epilepsy development

• Studying patient outcomes such as latency to epilepsy onset, comorbidities, and mortality

• Measuring impacts on quality of life for patients and caregivers

Longitudinal Studies of PTE Progression

• Tracking disease progression over time

• Evaluating treatment outcomes and quality of care

• Studying interactions between epilepsy and comorbid conditions such as psychiatric disorders, cognitive deficits, sleep disorders, and fatigue

Innovative Research Tools and Technologies

• Artificial intelligence or bioinformatics tools

• Clinical databases and advanced device technologies for seizure detection and diagnosis

• Models for studying post-traumatic epilepsy

• Tools enabling future clinical trials

Are there any additional benefits I would receive?

Some award mechanisms provide benefits beyond funding.

For example:

• Research Partnership Award

  • Supports collaborative research between two named Principal Investigators

• Virtual Post-Traumatic Epilepsy Research Center – Leadership Award

  • Provides funding to lead a virtual research center

  • Includes responsibilities such as mentoring investigators and facilitating collaboration

• Virtual Post-Traumatic Epilepsy Research Center – Faculty Award

  • Supports early-career researchers or investigators new to the PTE field

  • Includes mentorship and career development within a collaborative research environment

What is the timeline to apply and when would I receive funding?

The process will include:

• Pre-application submission through eBRAP

• Pre-applications will be Letters of Intent

• Full applications will follow the requirements outlined in the final FOAs on Grants.gov

Where does this funding come from?

Funding comes from the FY26 Defense Appropriations Act, which provides funding for the Epilepsy Research Program (ERP).

The program is administered by:

• Congressionally Directed Medical Research Programs (CDMRP)

• Defense Health Agency Research and Development – Medical Research and Development Command

ERP focuses on research that benefits Service Members, Veterans, caregivers, and the broader epilepsy community.

Who is eligible to apply?

Eligibility depends on the award mechanism:

• Idea Development Award

  • Independent investigators at any career level may serve as Principal Investigator

• Leveraging Research Award

  • Independent investigators at any career level may serve as Principal Investigator

• Research Partnership Award

  • Two named Principal Investigators who are independent investigators at any career level

• Virtual P-TERC Leadership Award

  • Director and Deputy Director must be independent investigators with:

    • Strong history of PTE research funding

    • Peer-reviewed publications

    • Mentorship experience

• Virtual P-TERC Faculty Award

  • Early-career investigators or investigators new to the PTE field

What companies and projects are likely to win?

ERP prioritizes research that:

• Advances understanding of post-traumatic epilepsy and associated comorbidities

• Improves quality of life for Service Members, Veterans, and caregivers

• Demonstrates innovation or high creativity

• Challenges existing research paradigms

• Leverages existing datasets, cohorts, or research infrastructure

• Includes strong collaborations where appropriate

Are there any restrictions I should know about?

Key requirements include:

• Pre-applications must be submitted through eBRAP

• All pre-applications are Letters of Intent

• Full applications must follow the requirements of the final Funding Opportunity Announcements on Grants.gov

• Applications must align with the ERP’s focus areas on post-traumatic epilepsy

How long will it take me to prepare an application?

Preparation time will depend on the complexity of the project and research team.

Typical CDMRP submissions involve:

• A Letter of Intent (pre-application)

• A full application including research plan, budget, and supporting documentation

Because official deadlines have not yet been released, investigators should begin developing project concepts now so they are ready once the FOAs are posted.

How can BW&CO help?

BW&CO supports companies and research teams pursuing CDMRP and other federal research funding by:

• Identifying the most competitive award mechanism

• Developing a compelling proposal narrative aligned with program priorities

• Structuring the research plan and milestones

• Coordinating multi-institution collaborations

• Managing the full submission process through eBRAP and Grants.gov

Our team has extensive experience helping applicants pursue defense health and biomedical research funding.

How much would BW&CO Charge?

We have both fractional engagements ($250 an hour) and full engagements ($13,000 + 5%) available.

Additional Resources

Review the solicitation here.

CDMRP: FY26 Alzheimer’s Research Program (AZRP)

Updated October 2026: This opportunity is closed. The FY26 application cycle for this program has closed. See our CDMRP guide for the next fiscal year’s announcements. Browse currently open opportunities in our funding database.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The Fiscal Year 2026 (FY26) Alzheimer’s Research Program (AZRP) is expected to release funding opportunities through the Congressionally Directed Medical Research Programs (CDMRP) to support impactful research addressing Alzheimer’s disease and Alzheimer’s disease–related dementias (AD/ADRD).

06-22-2026 - (Pre-application - Pre-Proposal)
09-24-2026 - (Application)

The program’s mission is to fund solution-oriented research that improves quality of life for people living with Alzheimer’s disease and related dementias, including Service Members, Veterans, their Families, and the general public.

Congress appropriated $15.0 million for the FY26 Alzheimer’s Research Program.

The FY26 AZRP is expected to support research that improves diagnosis, prevention, risk reduction, and quality of life for individuals affected by AD/ADRD.

How much funding would I receive?

Funding depends on the award mechanism.

Transforming Care Award

• Maximum funding: $1.6M total costs

• Maximum period of performance: 4 years

Career Initiation or Transition Partnership Option (CITPO):

• Maximum funding: $1.8M total costs

• Maximum period of performance: 4 years

Transforming Diagnosis Award

• Maximum funding: $1.5M total costs

• Maximum period of performance: 4 years

Career Initiation or Transition Partnership Option (CITPO):

• Maximum funding: $1.7M total costs

• Maximum period of performance: 4 years

Transforming Research Award

• Maximum funding: $1M total costs

• Maximum period of performance: 3 years

What could I use the funding for?

Funding supports non-incremental, solution-focused research addressing Alzheimer’s disease and related dementias (AD/ADRD).

The allowable research depends on the mechanism.

Transforming Care Award

Supports well-designed non-incremental clinical research or clinical trials in dementia care that provide solutions for individuals living with AD/ADRD.

Projects may address:

• Care interventions

• Strategies or technologies for dementia care

• Tools that improve daily living and support systems

• Approaches that reduce caregiver burden and stress

• Methods that improve quality of life for individuals with dementia

Applications are encouraged to prioritize both:

• Individuals living with AD/ADRD

• Their care partners

Transforming Diagnosis Award

Supports solutions-oriented research addressing barriers to diagnosis, disease monitoring, or prognosis.

Barriers may include:

• Diagnostic technologies

• Cost barriers

• Access to diagnostic tools

• Clinical implementation challenges

• Biomarker validation

• Disease monitoring methods

• Lack of longitudinal data for prediction or prognosis

Research may include:

• Prospective human subject recruitment

• De-identified human samples, specimens, or datasets

Transforming Research Award

Supports research that reduces risk and prevents the development of AD/ADRD.

Applications must address one of two focus areas:

Risk factor knowledge

• Identification or validation of risk or protective factors

• Environmental, epigenetic, genetic, lifestyle, or occupational risks

Risk reduction solutions

• Non-pharmacological methods

• Technologies

• Prevention strategies that reduce risk of AD/ADRD

The program encourages studies leveraging existing cohorts or datasets, including cohorts 65 years or younger.

Are there any additional benefits I would receive?

The pre-announcement does not specify additional non-funding benefits.

However, CDMRP programs typically provide:

• Access to a two-tier review system combining scientific peer review and programmatic review to ensure scientific merit and mission relevance.

• Opportunities to collaborate with researchers, clinicians, and community stakeholders affected by the disease.

What is the timeline to apply and when would I receive funding?

06-22-2026 - (Pre-application - Pre-Proposal)
09-24-2026 - (Application)

Where does this funding come from?

This funding comes from the Congressionally Directed Medical Research Programs (CDMRP) within the Department of Defense.

Key facts:

• Funding was appropriated through the Consolidated Appropriations Act, 2026.

• CDMRP manages biomedical research programs supporting the health of Service Members, Veterans, their Families, and the American public.

Who is eligible to apply?

Detailed eligibility criteria will be provided in the official Funding Opportunity Announcements.

What companies and projects are likely to win?

The AZRP supports projects that:

• Address critical needs in Alzheimer’s disease and related dementias

• Deliver solution-oriented outcomes

• Improve diagnosis, prevention, or patient quality of life

• Demonstrate clear relevance to Service Members, Veterans, their Families, or the broader public

Projects that show strong scientific merit and mission relevance are prioritized through CDMRP’s two-tier review process.

Are there any restrictions I should know about?

Restrictions and requirements are not specified in the pre-announcement.

These details—including allowable costs, research scope limitations, and regulatory requirements—will be defined in the full Funding Opportunity Announcements.

How long will it take me to prepare an application?

The preparation timeline is not specified in the pre-announcement.

CDMRP programs often use a two-stage process that may include:

• Pre-application submission

• Invitation to submit a full application

However, the specific process for FY26 AZRP is not specified in the pre-announcement.

How can BW&CO help?

BW&CO supports teams pursuing CDMRP funding by:

• Assessing project fit with the AZRP mission and research priorities

• Developing a competitive technical narrative

• Structuring proposals to align with CDMRP review criteria

• Managing submission strategy, compliance, and timeline

• Coordinating collaborators, investigators, and supporting documentation

Our team has extensive experience supporting Department of Defense CDMRP grant applications.

Additional Resources

Review the solicitation here.

CDMRP: FY26 Autism Research Program

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The Fiscal Year 2026 (FY26) Autism Research Program (ARP) from the Congressionally Directed Medical Research Programs (CDMRP) will fund innovative, high-impact research with clinical relevance that improves outcomes for individuals with autism and their families. The program released this pre-announcement to allow investigators time to plan proposals before the formal Funding Opportunity Announcements (FOAs) are released.

The FY26 ARP was funded through the FY26 Defense Appropriations Act. Investigators should begin preparing now because the program will require a pre-application before submission of a full proposal once the FOAs are released.

Application deadline: The deadline is not specified in the solicitation. Deadlines will be published in the FY26 ARP funding opportunity announcements when they are released on Grants.gov.

How much funding would I receive?

Funding depends on the specific award mechanism.

Career Development Award

• Maximum funding: $750,000 total costs

• Maximum period of performance: 3 years

Clinical Trial Award

• Maximum funding: $1.5 million total costs

• Maximum period of performance: 4 years

Clinical Trial Award – Nested Early-Career Investigator Option

• Maximum funding: $1.75 million total costs

• Maximum period of performance: 4 years

Idea Development Award

• Maximum funding: $750,000 total costs

• Maximum period of performance: 3 years

Total costs include direct and indirect costs.

What could I use the funding for?

Each mechanism supports different types of autism research.

Career Development Award

• Supports early-career independent investigators or established investigators transitioning into autism research.

• Projects must pursue research with the potential to have a major impact on autism.

• Supported activities include:

  • Innovative, high-impact research ideas

  • Early-phase, proof-of-principle clinical trials

• Preliminary data is required.

Clinical Trial Award

• Supports research with the potential to have a major impact on the treatment and/or management of autism.

• Projects must involve clinical trials supported by preliminary data.

Clinical Trial Award – Nested Early-Career Investigator Option

• Allows a senior investigator (initiating PI) to collaborate with a young investigator.

• Supports the development of investigators pursuing careers in autism clinical trial research.

Idea Development Award

• Supports innovative, high-impact ideas that advance understanding of autism and lead to improved outcomes.

• Includes a Partnering PI Option allowing collaboration between two investigators.

• Clinical trials are not allowed under this mechanism.

All mechanisms require preliminary data relevant to the proposed project.

Are there any additional benefits I would receive?

The program includes several structural benefits:

• Career Development Award supports the transition of researchers into the autism field.

• Clinical Trial Award – Nested Early-Career Investigator Option provides structured development for young investigators.

• Idea Development Award – Partnering PI Option encourages collaboration between investigators.

These structures are designed to expand the autism research workforce and accelerate impactful research.

What is the timeline to apply and when would I receive funding?

• Pre-announcement released: March 2, 2026

• Funding Opportunity Announcements (FOAs) will be posted on Grants.gov.

• Pre-application submission through eBRAP is required before submitting a full application.

• Application submission is by invitation only after review of the pre-application.

• Pre-application and full application deadlines are not specified in the pre-announcement.

• Funding start dates are not specified in the pre-announcement.

Where does this funding come from?

Funding for the program comes from the FY26 Defense Appropriations Act and is administered by the Congressionally Directed Medical Research Programs (CDMRP) within the Defense Health Agency Research and Development – Medical Research and Development Command.

The program is part of the Department of Defense’s Autism Research Program (ARP).

Who is eligible to apply?

Eligibility varies by mechanism.

Career Development Award
Applicants must:

• Be independent investigators at or below the level of Assistant Professor, or equivalent,

  or

• Be established investigators in a field other than autism at or above the level of Assistant Professor seeking to transition into autism research.

Additional requirements:

• Must not have previously received a Career Development Award (or equivalent) from any CDMRP program or other federal agency.

• Must not have received more than $250,000 in total direct costs for previous or concurrent autism research as a PI of federally or privately funded non-mentored peer-reviewed grants.

• Must hold a Ph.D., M.D., M.D./Ph.D., or equivalent at the time of pre-application submission.

• Must not be a graduate student, postdoctoral fellow, or other mentored researcher.

Clinical Trial Award

• Independent investigators at any career level.

Clinical Trial Award – Nested Early-Career Investigator Option
Young investigator must:

• Be currently in postdoctoral training or have completed postdoctoral training.

• Be no more than 7 years from receipt of a terminal degree.

• Commit at least 50% time to the project.

Idea Development Award

• Independent investigators at any career level.

What companies and projects are likely to win?

Based on the pre-announcement, competitive applications will likely:

• Propose innovative, high-impact research addressing autism

• Demonstrate strong preliminary data

• Show potential for major impact on understanding, treatment, or management of autism

• Align with the goals of the specific award mechanism

• For collaboration options, demonstrate meaningful partnerships between investigators

Applications must clearly demonstrate scientific merit and potential impact.

Are there any restrictions I should know about?

Key restrictions include:

• Pre-application submission through eBRAP is required before submitting a full application.

• Full applications are submitted by invitation only.

• Preliminary data is required for all mechanisms.

• Idea Development Award applications cannot support clinical trials, including a clinical trial aim.

• Career Development Award applicants must meet prior funding and career stage restrictions.

All applications must conform to the final Funding Opportunity Announcements posted on Grants.gov.

How long will it take me to prepare an application?

The solicitation does not specify preparation time.

However, because the ARP uses a two-stage process (pre-application followed by invitation-only full application), applicants typically need time to:

• Prepare a competitive pre-proposal

• Develop preliminary data and a detailed research plan

• Assemble collaborators and institutional approvals

Investigators are encouraged to begin planning early before FOAs are released.

How can BW&CO help?

BW&CO can support applicants throughout the ARP application process, including:

• Evaluating project fit with ARP mechanisms

• Developing a competitive proposal strategy

• Structuring impact-focused research narratives

• Managing the pre-application and full application process

• Preparing supporting documents and compliance materials

• Coordinating multi-investigator collaborations

Our team has extensive experience supporting Department of Defense CDMRP grant applications.

How much would BW&CO Charge?

We have both fractional engagements ($250 an hour) and full engagements ($13,000 + 5%) available.

Additional Resources

Review the solicitation here.

Installation Energy & Water - Environmental Security Technology Certification Program (ESTCP)

Updated October 2026: ESTCP posted a new Open Topics BAA (W912HQ26S0051) on August 21, 2026 that includes Installation Energy and Water. White papers are accepted through August 20, 2027.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The Environmental Security Technology Certification Program (ESTCP) is soliciting pre-proposals for FY 2027 to fund formal demonstrations of innovative Installation Energy & Water technologies. ESTCP supports mature technologies that improve energy resilience, water resilience, cybersecurity, and building performance at DoD installations through real-world demonstrations conducted at DoD facilities. Pre-proposals are due March 26, 2026 at 2:00 p.m. ET.

How much funding would I receive?

ESTCP awards typically support multi-year demonstration projects funded through cost-type or firm fixed-price contracts. While individual award sizes are not specified in the solicitation, projects commonly range from hundreds of thousands to several million dollars, depending on scope, duration, and demonstration scale.

What could I use the funding for?

Funding may be used to demonstrate and validate innovative technologies in one of the following ESTCP FY 2027 Installation Energy & Water Topic Areas:

Improve Energy Resilience with Long-Duration Energy Storage
This topic area seeks demonstrations of Long Duration Energy Storage (LDES) technologies integrated into military microgrids to meet the DoD’s requirement to power critical loads for 14 days during a grid outage. Technologies of interest include electrochemical, chemical, thermal, subsurface, and other LDES approaches, evaluated through Hardware-in-the-Loop (HIL) testing. The focus is on reducing or eliminating reliance on diesel fuel while improving lifecycle cost-effectiveness, resilience, and cybersecurity of installation microgrids.
Read more here.

Improving the Cyber Resilience of DoW Installation Energy Systems
This topic focuses on closing critical cybersecurity gaps in Facility-Related Control Systems (FRCS) that support energy and water infrastructure. ESTCP is seeking demonstrations of novel solutions that improve secure connectivity, threat detection, and cyber defense at machine speed, including alternatives to fiber connectivity, high-fidelity honeypots, and AI-driven defensive cyber agents. The goal is to reduce the risk of cyber-physical disruption to mission-critical installation systems without requiring major infrastructure modifications.
Read more here.

Improving the Energy Resilience of DoW Installations
This topic area solicits technologies that enhance the ability of military installations to continue mission-critical operations during energy disruptions. Solutions may include hardware, software, planning tools, infrastructure hardening, or integrated energy-water-control approaches, but exclude LDES-only solutions, which must submit under the LDES topic. Technologies should reduce dependence on imported energy, address regional challenges (e.g., arctic, remote, or arid locations), and demonstrate scalability across multiple installations.
Read more here.

Solutions to Improve Energy Efficiency and Performance of DoW Buildings
This topic seeks demonstrations of innovative retrofit-ready technologies that reduce energy use intensity, lower maintenance burden, improve occupant health, and decrease lifecycle costs in DoD buildings. Technologies of interest include HVAC, building envelope systems, lighting, water heating, waste heat recovery, and integrated control solutions. ESTCP prioritizes solutions that work with existing infrastructure, deliver measurable energy savings, and have a clear pathway to adoption through ESCOs, ESPCs, or utility programs.
Read more here.

Water Resilience on DoW Installations
This topic area focuses on technologies and methodologies that improve the reliability, security, and efficiency of water systems supporting military missions. Areas of interest include potable water reduction, water storage (minimum 8,000 gallons), desalination improvements, leak detection, corrosion-resistant materials, building-scale water reuse, and advanced water monitoring. Solutions should reduce operational burden, address water-stressed regions, and support long-term resilience of aging installation water infrastructure.
Read more here.

Are there any additional benefits I would receive?

Beyond the direct funding award, ESTCP provides significant strategic advantages:

• DoD Validation and Credibility: ESTCP selection signals that your technology meets high-priority DoD installation needs and has passed rigorous technical review.

• Accelerated Adoption Pathways: Demonstrations are explicitly designed to support transition, regulatory acceptance, and scaling across multiple DoD installations.

• Non-Dilutive Growth: ESTCP funding allows companies to mature and validate technology without giving up equity, strengthening long-term enterprise value.

• Visibility with Defense Stakeholders: Successful projects are published, presented, and shared across DoD, regulatory, and industry communities—raising profile and credibility.

What is the timeline to apply and when would I receive funding?

• Pre-Proposals Due: March 26, 2026 (2:00 p.m. ET)

• Full Proposal Invitations: May 2026

• Full Proposals Due: July 2026

• Technical Committee Briefings: August 2026

• Project Selection: September 2026

• Anticipated Contract Awards: Q3 FY 2027.

Where does this funding come from?

Funding is provided by the Environmental Security Technology Certification Program (ESTCP) under the Office of the Deputy Assistant Secretary of Defense (Energy Resilience & Optimization) within the U.S. Department of Defense.

Who is eligible to apply?

Eligibility depends on organization type:

• Private industry and universities: Apply under the FY27 ESTCP Broad Agency Announcement (BAA)

• DoD organizations: Apply under the FY27 DoD Call for Proposals

• Other Federal agencies: Apply under the FY27 Federal Call for Proposals

All proposers must submit a pre-proposal and respond to an eligible Topic Area.

What companies and projects are likely to win?

Successful proposals typically:

• Address a clearly defined, enterprise-wide DoD installation need

• Demonstrate technologies at TRL or ARL 5–7

• Provide strong cost, performance, and risk-reduction benefits

• Include a clear DoD end user and transition pathway

• Are scalable across multiple installations and Services

Are there any restrictions I should know about?

Projects will not be considered responsive if they:

• Are already broadly deployed across the DoD enterprise

• Require access to large volumes of high-quality DoD data

• Solve a problem unique to a single installation

• Represent basic research or early-stage exploratory development

How long will it take me to prepare an application?

For first time applicants, pre-proposals will likely take 35 to 50 hours with assistance.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Fractional support is $300 per hour.

For startups, we offer a discounted rate of $250 per hour to make top-tier consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

Review the solicitation here.

Science & Technology Long Range Broad Agency Announcement (LRBAA 24-01) – Department of Homeland Security

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The Department of Homeland Security (DHS) Science and Technology Directorate (S&T) is funding scientific and technical research projects that significantly improve or increase capabilities across the Homeland Security Enterprise. This Long Range Broad Agency Announcement (LRBAA 24-01) supports near-term operational needs, foundational science, and future/emerging threat research through contracts, grants, cooperative agreements, and Other Transaction Agreements (OTAs). Apply before funds are fully utilized.

How much funding would I receive?

Est. $500K to $5 million. The LRBAA does not specify minimum or maximum award sizes. Funding amounts depend on the technical merit of the proposal, relevance to DHS mission needs, and availability of funds. DHS may fund all, some, or none of the proposals received, and multiple awards are anticipated

What could I use the funding for?

Funding under this LRBAA may be used for research, development, test, and evaluation (RDT&E) activities aligned with DHS Science & Technology Directorate mission needs. DHS is currently seeking projects across the following priority research topic areas. See full topic descriptions here.

Counter Terrorism and Homeland Security Threats (CTHOM)
DHS S&T works to identify individuals or groups that intend to conduct terrorist attacks and/or illicitly move weapons, dangerous goods, and contraband. It also provides assessments of high-consequence attack methods such as CBE threats that terrorists may use to attack the United States.

CTHOM 01: Development of Tools for Test and Evaluation of Machine Learning Algorithms
DHS S&T seeks development of cost-effective methodologies and tools for training and testing of Machine Learning-based (ML-based) algorithms for detecting explosives and contraband in Computed Tomography (CT) and Millimeter Wave (MMW) images. This includes methods to synthesize training and testing data, methods to perturb empirical data in order to explore and explain algorithm performance characteristics, and tools to assess the completeness and diversity of training and test data sets.

CTHOM 03: Novel Approaches and Locations for Explosive Performance Characterization and Testing
Enabling research for the characterization and testing of explosives poses a unique challenge for threat characterization. Innovative tools and methods are needed to provide improvements in evaluating legacy approaches to characterization, adapting state-of-the-art technologies in related disciplines, and integrating emerging innovations.

Secure U.S. Borders and Approaches (BORAP)
DHS secures U.S. borders, territorial waters, ports, terminals, waterways, and air, land, and sea transportation systems. DHS S&T invests in border security research and development for technologies and solutions to prevent illicit movement and the illegal entry or exit of people, weapons, dangerous goods, and contraband.

BORAP 01: Screening at Speed
Screening at Speed seeks to mature transformative technologies that increase aviation security effectiveness from curb-to-gate while dramatically reducing wait times and improving passenger experiences.

BORAP 04: Countering Unmanned Aircraft Systems
The primary objective of this LRBAA is to develop enhanced technologies and methods that allow for the detection, tracking, identification, and mitigation of unmanned aircraft systems under varied terrains and environmental conditions such as dense urban environments, mass gatherings, critical infrastructure, mobile platforms, and remote terrain.

BORAP 07: Detection Canine Technologies
Detection Canine development interests are focused on canine research and development structure and function, development and testing of canine training aids, and independent operational test and evaluation to advance detection canine performance in operational environments.

Secure Cyberspace and Critical Infrastructure (CYBCI)
Protecting individuals and organizations from cyber attacks requires RDT&E, test and evaluation, and the technology transition of advanced cybersecurity and information assurance solutions to secure current and future critical cyber infrastructure.

CYBCI 02: Shared Cyber Resilience
The research and development of improved models of resilience across networked hardware and software systems and organizations, including automated cyber attack mitigation, resilient machine learning approaches, privacy preservation techniques, secure multi-party computing, and human-machine teaming for cybersecurity.

CYBCI 03: Software and Hardware Supply Chain Assurance
The research and development of tools and techniques to ensure the resilience of the data, software, and hardware used to execute homeland security mission functions, including post-quantum cryptography, secure-by-design architectures, microelectronics, IoT, cloud and edge computing, and DevSecOps supply-chain assurance techniques.

CYBCI 04: Trustworthy and Responsible Artificial Intelligence
Research and development to enable DHS to effectively assess AI/ML systems against technical and mission metrics, provide operators an appropriate level of trust and confidence, and inspire trust in the general public toward AI/ML systems deployed by DHS.

CYBCI 05: Advanced and Emerging Data Computation and Analytics
This topic focuses on novel computational and analytic methods and capabilities for large-scale data sets for DHS missions, including real-time analytics, privacy-enhancing technologies, high-performance computing, digital twins, synthetic data, and advanced analytics to improve mission effectiveness and efficiency.

Are there any additional benefits I would receive?

Beyond the direct funding, LRBAA awards provide several indirect advantages:

• Government Validation and Credibility: Selection signals strong technical merit and alignment with DHS mission priorities.

• Pathway to Transition and Deployment: Projects are designed to support operational relevance and transition to DHS components.

• Access to DHS Test and Evaluation Infrastructure: DHS may provide access to government laboratories and operational test facilities where appropriate.

• Stronger Long-Term Commercial and Contracting Potential: DHS-funded R&D can increase credibility with future government customers and partners.

What is the timeline to apply and when would I receive funding?

This LRBAA is open through May 31, 2029 at 11:59 PM ET. Companies should apply as soon as possible while funds are available. Submissions follow a three-step process:

1. Industry Engagement Submission (initial research concept)

2. Virtual Pitch (by invitation only)

3. Written Proposal (by invitation only)

Typical DHS response timelines (subject to change):

• Industry Engagement feedback: ~10 business days

• Virtual Pitch evaluation: ~21 business days

• Written Proposal evaluation: ~21 business days

Award timing depends on evaluation outcomes and funding availability.

Where does this funding come from?

Funding is provided by the Department of Homeland Security Science and Technology Directorate (DHS S&T) through the Office of Procurement Operations.

Who is eligible to apply?

Eligible applicants include:

• U.S. small businesses and large businesses

• Academic institutions

• Government laboratories and Federally Funded Research and Development Centers (FFRDCs)

• Nonprofits and research organizations

Foreign or foreign-owned entities may participate but are subject to export control, foreign disclosure, and other federal review requirements. There are no set-asides, but DHS strongly encourages small business participation.

What companies and projects are likely to win?

Proposals are evaluated based on:

• Alignment with DHS mission needs and topic relevance

• Scientific and technical merit of the proposed approach

• Degree of innovation and potential capability improvement

• Operational relevance and transition potential

• Reasonableness of cost and feasibility of execution

Are there any restrictions I should know about?

Key restrictions include:

• Proposal preparation costs are not reimbursable

• Only unclassified materials may be submitted

• Mature commercial products and support services are not eligible

• Participation in later proposal stages is invitation-only

• Export control, IP, and data rights requirements apply

How long will it take me to prepare an application?

Without BW&CO’s assistance the Industry Engagement submission would typically take 35-50 hours.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available for a flat fee of $4,000 for the Industry Engagement Submission.

Fractional support is $300 per hour.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

Review the solicitation here.

Agriculture and Food Research Initiative (AFRI): Strengthening Agricultural Systems – USDA NIFA

Updated October 2026: This opportunity is closed. The FY26 NOFO closed in April 2026. No FY27 NOFO has been posted yet. Browse currently open opportunities in our funding database.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The USDA National Institute of Food and Agriculture (NIFA) is awarding up to $10 million per project through the Agriculture and Food Research Initiative (AFRI) Strengthening Agricultural Systems (SAS) program to support large-scale, integrated research, education, and extension projects that transform U.S. food and agricultural systems, increase agricultural production, and enhance farmer prosperity. Applications are due March 26, 2026 (or April 23, 2026 for the AI for K-12 priority).

How much funding is available?

Awards range from $1 million to $10 million per project, with total anticipated FY 2026 program funding of approximately $140 million. Grant durations may be up to 60 months.

What could I use the funding for?

See a detailed description here.

New Uses and Expanding Markets for Agriculture and Forestry Products Sub-priority:

Proposals should focus on the most pressing challenges faced by agricultural producers, farmers, ranchers, and foresters with a focus on creating new and expanding existing markets for agriculture and forestry products to ensure a strong U.S. economy and protect the fuel and fiber supply. Proposals responding to this sub-priority must address items a) and b). Proposals may also address item c) below:

a) Work with established U.S. commodity crops, specialty crops, or forest products that develop new uses for crop residues for meal, feed, or oils will be considered. Pursuit of this goal depends on the development of new innovative solutions and initiatives that bring more jobs, economic opportunities, and expand existing markets to new regions particularly to rural communities. The focus should be on equipping and empowering current and next generations of American farmers, ranchers, producers, and foresters; and

b) Address the long-term efforts necessary for growth of agriculture and/or forestry products markets while preserving our nation’s natural resources through conservation, restored forests, improved watersheds, and healthy private working lands.

c) May also address: Develop or enhance systems to produce reliable sources of biofuels, biomaterials, or biobased chemical intermediates, including emphasis on high-value or value-added products from agricultural and/or forestry products to foster rural prosperity and enhance national security.

Solutions to Pests and Diseases of Plants or Animals Sub-priority:

Proposals responding to this sub-priority must address at least two (2) of the following:

a) Protect the food, fuel, and/or fiber supply as well as enhance national security by developing innovative solutions to combat pests, diseases, or weeds (invasive/established species) negatively affecting plant and/or animal agricultural systems.

b) Address important crop, livestock, or forest losses due to pest and/or pathogen damage.

c) Develop effective disease or pest solutions, including weed management solutions in grasslands/rangelands, as they occupy a substantial portion of the United States and impact both plant and animal production and are critical to the nation’s economy.

d) Drive innovation, promote proven agricultural or forest production practices, reduce input costs, and increase outputs that result in maximizing productivity of American farmers, ranchers, and foresters.

Combating Food and Diet-Related Chronic Diseases Sub-priority:

Proposals responding to this sub-priority must address item a) or item b). Proposals must also address at least two (2) of the following items: c), d), and/or e):

a) Address factors linked to achieving healthy diets from sustainable food production systems with the goal of increasing nutrient content and bioavailability of nutrients from plant and/or animal food products to improve human health.

b) Identify and implement innovative solutions that result in healthy dietary patterns, support the Dietary Guidelines for Americans, and lead to long-term large population-level reductions of diet-related chronic diseases.

c) Upscale or maximize impacts of existing scientifically proven interventions/solutions.

d) Incorporate stakeholders’ perspectives, particularly American farmers’ or ranchers’ voices as they play a critical role in ensuring an abundant, healthy and safe food supply.

e) Explore value-add solutions that benefit agricultural producers, farmers, ranchers, or foresters.

Artificial Intelligence for K-12 Food and Agricultural Sciences:

Proposals responding to this priority must address at least four (4) of the following:

a) Develop and/or strengthen the pipeline of AI-literate and skilled next-generation agriculturalists, with special emphasis in K-12 youth, to support the advancements in food, agricultural, and forest sciences.

b) Adapt or develop AI-based tools and modalities that can be effectively integrated into classrooms, non-formal educational experiences, and/or curriculums to support the understanding and training of the next generation of agriculturalists and foresters.

c) Build and expand comprehensive teacher and non-formal educator training in AI in food, agricultural, and/or forest sciences to equip them with knowledge to train students about AI and to utilize AI in their classrooms to improve educational outcomes.

d) Support AI resource sharing mechanisms that make curriculum, training materials and courses, and resources accessible for the nation’s K-12 teachers and Cooperative Extension educators in food and agricultural sciences.

e) Equip learners to become future innovators of agricultural AI.

f) Advance the scientific, economic, environmental, social, and/or workforce training innovations in food, agriculture, and/or forestry to keep U.S. farmers, ranchers, producers, and foresters at the forefront of productivity by leveraging AI.

g) Use AI to help strengthen youth’s understanding of the importance of America’s food, fuel, and fiber supply and its role in national security.

Are there any additional benefits I would receive?

Beyond the funding itself, AFRI SAS awards provide substantial indirect value. Selection by USDA-NIFA signals strong technical merit and national relevance, which can enhance credibility with partners, stakeholders, and future funders. Awardees gain visibility within the federal agricultural innovation ecosystem and may benefit from collaboration opportunities across universities, industry, government, and extension networks. Long-term, this type of nondilutive funding can strengthen institutional capacity and position organizations for future large-scale federal awards.

What is the timeline to apply and when would I receive funding?

• Letter of Intent (optional): February 26, 2026

• Application Deadline:

  • March 26, 2026 (Strengthening Agricultural Systems)

  • April 23, 2026 (AI for K-12 Food and Agricultural Sciences)

Awards are expected to be made within the FY 2026 federal fiscal year, with project start dates no later than September 30, 2026, subject to appropriations.

Where does this funding come from?

Funding is provided by the U.S. Department of Agriculture (USDA) through the National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI), Assistance Listing 10.310.

Who is eligible to apply?

Eligible applicants for Integrated Projects include:

• Colleges and universities

• 1994 Land-Grant Institutions

• Hispanic-Serving Agricultural Colleges and Universities

Only public or nonprofit, accredited institutions are eligible to apply directly.

Other entities may participate as subcontractors or partners. If you are a for profit business with technology relevant and need assistance finding a partner, please contact robert@bwcoconsulting.com.

What companies and projects are likely to win?

Successful projects typically:

• Address a clearly defined SAS sub-priority aligned with USDA priorities

• Demonstrate full integration of research, education, and extension

• Use a systems-based and transdisciplinary approach

• Engage farmers, producers, and stakeholders from project inception

• Show measurable, long-term economic and agricultural impact

Are there any restrictions I should know about?

• Projects must include research, education, and extension components

• Indirect costs are capped at 30% of total federal funds awarded

• Funds may not be used for construction, renovation, or facility acquisition

• Certain applied research projects may require dollar-for-dollar matching funds, depending on scope and commodity specificity

How long will it take me to prepare an application?

Applicants should expect a significant preparation effort, typically 8–12+ weeks, due to the scale of funding, required partnerships, integrated project design, and extensive narrative, budget, data management, and management plan requirements.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Flat fee pricing available upon request.

Fractional support is $300 per hour.

For startups, we offer a discounted rate of $250 per hour to make top-tier consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

See the solicitation here.

FBI Enterprise Technology Broad Agency Announcement (BAA) – Federal Bureau of Investigation (FBI)

Updated October 2026: A June 10, 2026 notice extended the FBI Enterprise Problem Sets BAA through May 16, 2027.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The FBI’s Enterprise Technology Broad Agency Announcement (BAA) is open through May 16, 2026 and accepts white paper submissions at any time during the open period. The program seeks innovative R&D concepts from industry and academia across multiple FBI problem sets (including AI, cybersecurity, biometrics, counterintelligence, digital exploitation, and enterprise data fabric). Submissions are emailed to BAA@FBI.GOV and follow a two-step process: Step 1 is a white paper (or recorded oral presentation), and selected applicants may be invited to Step 2 to submit a full proposal.

How much funding is available?

Although not explicitly mentioned in the solicitation, typical awards range from $500k to $2m for periods of performance ranging from 6-24 months

What could I use the funding for?

Funding supports R&D efforts aligned to the FBI’s “Problem Set Areas”. See an overview below and full description here:

1. Leverage Artificial Intelligence (AI) and its Sub-Fields

• Content Extraction and Triage

• All-Source Data Management

• Workflow Automation

• Actionable Analysis and Alerting

• Semi-Autonomous Multi-Sensor Fusion

• Business Operations

• Data Science

• Knowledge Management

• Open-Source Information Gathering

• Correspondence Management from Multiple Sources

• Dynamic Threat Analysis

• Human Resource (HR) Recruiting

• Signature Identification

• Cybersecurity

• Artificial Intelligence (AI) Governance

2. Enhance Counterintelligence and Security

• Counterintelligence (CI) Capability

• Personnel Assessment and Evaluation

• Cyber Behavior

• Foreign Contacts

3. Mission-Enhancing Science and Technology

• Digital Exploitation

  • Document and Media Acquisition

  • Human Language Technologies

  • Computer Vision

  • Digital Signals Processing

  • Data, Process, and User Artifact Analysis

  • Document and Media Exploitation (DOMEX)

• Directed Energy Weapons (DEW)

• Biometrics

• Weapons of Mass Destruction

• Electro-Optical Detection

• Pulsed Power Detection

• Radio Frequency Detection

4. Improve Mission Support Capabilities

• Information Technology (IT)

  • IT Governance

  • Data Management and Analytics

  • Infrastructure and Cloud Management

  • Information Assurance and Cyber Defense

  • Operations Support

  • Strategic Information and Operations (SIOC)

• Cyber Capability Requirements Process

• Enterprise Common Data Fabric Solutions

5. Increase Organizational Effectiveness

• Performance Management

  • Applicant Screening

  • Career Advancement

  • Workplace Learning and Performance

Are there any additional benefits I would receive?

Beyond the formal funding award, there are meaningful indirect benefits to winning an FBI BAA award:

• Government validation and mission alignment: Selection indicates the FBI sees strong technical merit and mission value in your R&D approach, which can accelerate future government relationships and contracting credibility.

• Partnership acceleration: The FBI explicitly encourages partnering among industry and Government to speed adoption of new science and technology into fielded systems—awardees may benefit from stronger collaboration opportunities.

• Higher valuation via nondilutive R&D: Funding supports R&D without equity dilution, allowing companies to mature technology and strengthen valuation narratives for future financing or acquisition (general commercial benefit; not explicitly stated in BAA).

• Positioning for follow-on work: Award performance may strengthen eligibility and competitiveness for future FBI or broader federal procurements in adjacent mission areas.

What is the timeline to apply and when would I receive funding?

BAA open period: Effective 5/17/2023 – 05/16/2026.

1. When to submit: White papers may be submitted at any time during the open period to BAA@FBI.GOV.

2. Two-step process:

   • Step 1: Submit white paper

   • Step 2: If selected, FBI requests a formal proposal (do not submit full proposal unless requested)

3. Selection timing: FBI may make selections anytime during the open period and up to six months after closing for white papers submitted during the open period.

4. Funding receipt timing: Not specifically stated; awards depend on selection, negotiations, and funding availability.

Where does this funding come from?

This is a Federal Bureau of Investigation (FBI) Broad Agency Announcement run through the FBI Finance Division | Procurement Section.

The BAA is conducted under the Federal Acquisition Regulations (FAR) for R&D.

Who is eligible to apply?

The BAA is intended to encourage participation by:

• Science and technology firms

• Educational institutions

Additional eligibility-related requirements include:

• Offerors must be registered in SAM prior to submission and maintain active SAM registration.

• Offerors may propose subcontracting and teaming arrangements, including industry-academia and industry-government partnerships.

• Submissions are generally expected to be UNCLASSIFIED, but classified approaches require prior FBI approval.

What companies and projects are likely to win?

The FBI evaluates white papers using three equal factors:

• Technical Approach: strong scientific/technical merit, innovation, sound concept, awareness of state of the art, understanding scope, and potential FBI mission benefit.

• Capabilities and Relevant Experience: evidence the team/facilities can execute and safeguard controlled unclassified/classified info (if applicable), and prior work can be leveraged.

• Rough Order of Magnitude (ROM): cost realism based on total estimated labor, materials, subcontracts, ODCs, indirect, and fee/profit.

Are there any restrictions I should know about?

Key restrictions and compliance items include:

• White paper page limit: written submissions must not exceed 10 pages (pages beyond are not evaluated).

• Communications must be UNCLASSIFIED and emailed to BAA@FBI.GOV; do not email classified info.

• Security requirements: work expected unclassified, but some efforts may require personnel clearable to Top Secret (TS) and potentially SCI access with NDAs and polygraph.

How long will it take me to prepare an application?

Not explicitly stated, but the required Step 1 white paper format suggests typical preparation time depends on complexity:

• Written white paper: up to 10 pages plus additional sections (program plan, experience, ROM).

• Alternative format: a pre-recorded oral presentation up to 10 minutes may be submitted instead of written format.

How can BW&CO help?

BW&CO can provide fractional or full support to increase the likelihood of success and save you a significant amount of time in the application process. Most clients don’t spend more than 3 hours a week in their engagement with us and our success rates are 2x-3x the national average. We collect your data, write an initial draft, have your team approve, and then move on to the next deliverable.

How much would BW&CO Charge?

Fractional support is $300 per hour. For full grant writing support, we would charge a $9,000 fee for submitting the initial white paper. If you receive an invitation for a full submission, there would be a follow-on payment of $9,000 to submit the full proposal with a 5% success fee contingent on award.

For startups, we offer a discounted rate of $250 per hour to make top-tier consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

See the solicitation here.

AFRL Multiple Award Contract (AMAC) – Air Force Research Laboratory

Updated October 2026: This opportunity is closed. The deadline for this opportunity has passed. Browse currently open opportunities in our funding database.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The Air Force Research Laboratory (AFRL) AMAC program establishes a multiple-award IDIQ contract vehicle enabling qualified U.S. companies to compete for future AFRL-funded science and technology (S&T) research task orders. There is no funding awarded at the base contract level; funding is provided only through competitively awarded task orders after selection. Proposals are due February 27, 2026.

How much funding would I receive?

There is no fixed funding amount awarded at the base IDIQ level. Each awardee is guaranteed a minimum of $500 over the life of the contract. Actual funding is awarded later through individual task or delivery orders, which may range from small research efforts to very large programs. The estimated ceiling value across all AMAC contracts is $10 billion.

How does the program work?

AMAC is not a single grant but a long-term contract vehicle that allows AFRL to rapidly fund unclassified science and technology research through future task orders. If you meet the criteria, you will receive the long-term contract vehicle. Companies selected to the AMAC vehicle become eligible to compete for AFRL-funded projects covering basic and applied research, technology development, modeling and simulation, manufacturing, experimentation, integration, and technology transition. Importantly, there is no funding awarded upfront—all funding is issued later through individual task orders, each with its own scope, budget, and performance period.

Are there any additional benefits I would receive?

Beyond task-order funding, AMAC awardees gain several indirect but material benefits:

• Government Validation and Credibility: Selection confirms AFRL validation of your company’s technical experience as a prime contractor.

• Long-Term AFRL Access: Awardees are eligible to compete for AFRL task orders for up to 8 years.

• Increased Visibility: Awardees become part of AFRL’s active R&D contractor ecosystem.

• Non-Dilutive Growth: Task-order funding enables technology maturation without equity dilution.

• Stronger Strategic Positioning: Proven AFRL work can enhance acquisition, partnership, and future DoD contracting opportunities.

What is the timeline to apply and when would I receive funding?

Proposals must be submitted by February 27, 2026 at 5:00 PM ET. Base IDIQ awards are made after evaluation. Funding is only received after winning individual task orders, which may be issued at any point during the contract’s ordering period.

Where does this funding come from?

Funding for task orders comes from AFRL directorates and partner agencies using AFRL as the contracting vehicle. The base AMAC contract itself does not carry dedicated funding.

Who is eligible to apply?

Eligible applicants include U.S.-based companies that can demonstrate qualifying prime contractor experience in federal S&T research. This includes:

• Small businesses

• Large businesses

• Joint ventures

• Universities and non-profits

Foreign-owned or foreign-influenced companies are not eligible unless formally approved through the National Industrial Security Program.

What companies will receive the contracting vehicle?

To receive an AMAC award, offerors must:

• Be a responsible source under FAR Part 9

• Submit a compliant proposal following Section L instructions

• Achieve a validated minimum score of 1,000 points in the self-scoring technical experience evaluation here

• Demonstrate prime contractor experience in AFRL technical Areas of Interest

• Receive an Acceptable rating for both Technical Experience and Small Business Participation Commitment

There is no price competition at the base contract level.

Are there any restrictions I should know about?

Yes. Key restrictions include:

• No classified work is permitted under the AMAC base contract

• Only prime contractor experience counts toward technical scoring

• Subcontractor experience does not qualify for scoring

How can BW&CO help?

The AMAC solicitation is fundamentally a compliance-driven, pass/fail process. AFRL has stated that any offeror who submits a fully compliant proposal and meets the minimum technical threshold will receive an AMAC contract—while even minor non-compliance can result in elimination, regardless of technical merit. BW&CO helps ensure your proposal is structured correctly, fully compliant, and strategically positioned so you don’t lose this opportunity due to avoidable errors.

How much would BW&CO Charge?

Fractional support is $300 per hour.

For startups, we offer a discounted rate of $250 per hour to make top-tier consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

See the solicitation here.

Chemical and Biological Technologies Fundamental Research BAA – Defense Threat Reduction Agency (DTRA)

Updated October 2026: This opportunity is closed. The umbrella BAA remains in force, but the current topic white paper window closed March 2, 2026 and no new topics have been posted. Browse currently open opportunities in our funding database.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The Defense Threat Reduction Agency (DTRA) is accepting rolling submissions through 2034 for fundamental research projects that advance chemical and biological defense capabilities. This Broad Agency Announcement (BAA) supports basic and applied research addressing counter–weapons of mass destruction (C-WMD) challenges, with a current white paper deadline of March 2, 2026 for Topic Areas B1–B6.

How much funding would I receive?

$300,000 to $5 million depending on the topic.

What could I use the funding for?

For research and development that aligns with the topics below. For more details on each topic click here.

B1. Deriving Human Physiological Endpoints via Microphysiological Systems (MPS): Bridging the Gap for Predictive Translation

DTRA is seeking fundamental research that advances microphysiological systems (organs-on-a-chip) to derive reliable, human-relevant physiological endpoints that can be translated into real-world exposure detection. Projects should develop standardized, measurable physiological signals across multi-organ MPS platforms and link those signals to in-vivo human responses, particularly for early detection of chemical and biological exposures. Emphasis is placed on novel sensing technologies, data integration, and predictive algorithms rather than therapeutics or animal studies. Read full description here.

B2. Self-Improving AI Systems for Adaptive Defense

This topic funds research into AI systems that can autonomously adapt to new chemical and biological threats without human retraining. DTRA is specifically interested in self-modifying AI architectures that can safely update their own models, structures, or code while maintaining formally verified performance and safety guarantees. Projects must focus on foundational AI theory and methods—such as formal verification, containment, and meta-learning—rather than static or manually retrained detection systems. Read full description here.

B3. Quantum-Enhanced Topological Data Analysis for Chemical and Biological Defense

DTRA seeks interdisciplinary research combining quantum computing and topological data analysis to identify complex patterns in high-dimensional chemical and biological data that classical methods cannot detect. The goal is to enable earlier warning of engineered or novel threats, improve pathogen classification, and accelerate countermeasure discovery. Projects should focus on developing quantum-enabled analytical frameworks and demonstrating clear advantages over classical computational approaches. Read full description here.

B4. Advanced Repellent Materials for Omniphobic Resistance (ARMOR)

This topic supports fundamental research into durable, PFAS-free repellent materials for textiles that resist chemical and biological threats, oils, and industrial contaminants. DTRA is looking for new material chemistries and surface architectures—particularly reentrant or textured surfaces—that achieve strong oil repellency, mechanical durability, and safety for skin contact. Research should emphasize materials science, characterization methods, and performance against chemical simulants rather than full protective suit development. Read full description here.

B5. Sensing Engineered Chemical and Biological Threats with Synthetic Biology Designs

DTRA is funding early-stage research into synthetic biology-based sensing materials that enable rapid, adaptable detection of engineered or emerging biological threats. Projects should integrate computational design, AI/ML, and synthetic biology to create novel affinity reagents or sensing elements that outperform traditional antibodies in speed, adaptability, or stability. The focus is on proof-of-concept platforms and fundamental sensing science, not deployable sensor systems. Read full description here.

B6. Free-Standing Films Used as Detection Wipes

This topic seeks fundamental research on free-standing, self-indicating films that can be used as low-cost detection wipes for chemical threats on surfaces. DTRA is interested in understanding the structural, optical, and electrical properties of cross-linked polymer films embedded with non-dye-based recognition elements that change color upon exposure to chemical agents or simulants. Research should prioritize material synthesis, reproducibility, environmental robustness, and early prototype integration rather than full system fielding. Read full description here.

Are there any additional benefits I would receive?

Beyond the formal funding award, there are significant indirect benefits to receiving a DTRA fundamental research award:

Government Validation and Credibility: Selection by DTRA signals strong technical credibility and alignment with national counter-WMD priorities, which can accelerate trust with defense partners and future government sponsors.

Enhanced Visibility Within the Defense Research Community: Awardees are part of DTRA’s extramural research ecosystem, increasing exposure to DoD laboratories, academic collaborators, and future funding opportunities.

Nondilutive Technology Maturation: By advancing early-stage science with nondilutive funding, companies can de-risk core technology while preserving equity and strengthening long-term exit potential.

What is the timeline to apply and when would I receive funding?

For Topic Areas B1–B6, pre-application white papers are due March 2, 2026 at 11:59 PM EST. Submissions follow a two-phase process, with invited full proposals submitted after successful white paper review.

Where does this funding come from?

Funding is provided by the Department of Defense through the Defense Threat Reduction Agency (DTRA) under CFDA 12.351.

Who is eligible to apply?

Eligibility is defined at the topic level. In general, the BAA supports extramural performers conducting basic or applied research, including universities, industry, and other research organizations, subject to topic-specific requirements. is cost-shared by non-government sources

What companies and projects are likely to win?

Competitive projects typically:

• Address high-impact chemical or biological defense challenges relevant to C-WMD

• Advance fundamental scientific knowledge or revolutionary technical approaches

• Align with early-stage research (TRLs 1–4)

• Demonstrate strong scientific rigor and feasibility

• Fit within DTRA’s stated thrust areas or published topic needs

Are there any restrictions I should know about?

Pre-application coordination is generally required before submitting a white paper, and submissions without coordination may not be reviewed. Proprietary product development and later-stage commercialization activities are outside the scope of this announcement.

How long will it take me to prepare an application?

Most first-time applicants (without any assistance from BW&CO) should plan for 40–60 hours of effort to prepare the white paper over 8–12 weeks, including technical writing, budget preparation, and internal reviews.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available for $4000 Initial Fee for the white paper.

Fractional support is $300 per hour.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

Learn more about the program here.

Compact Oxygen Generation Medical Devices (COGM / COGM-A) – Defense Health Agency (DHA)

Updated October 2026: This opportunity is closed. The deadline for this opportunity has passed. Browse currently open opportunities in our funding database.

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The Defense Health Agency (DHA) is soliciting prototype proposals to develop compact medical oxygen generation devices for use in austere and expeditionary military environments. This Other Transaction Authority (OTA) program supports the development of FDA-cleared oxygen generation systems for battlefield care and aeromedical evacuation. Proposals are due March 6, 2026.

How much funding would I receive?

Estimated $1-$2 million. The RPP does not specify a minimum or maximum award size. The government anticipates making multiple prototype OTA awards, with funding incrementally obligated over the period of performance. Total award size will depend on proposed scope, schedule, and cost realism.

What could I use the funding for?

The DHA needs to provide medical oxygen solutions in austere environments to treat service members with compromised lung function or injuries requiring oxygen therapy. The WEMT PMO is developing multiple oxygen generation and delivery systems through its Portable Oxygen (O2) program. This program aims to support casualties across all care settings, including evacuation platforms (Roles of Care 1-3 and en route). Development and approval of candidate solutions will adhere to the U.S. Food and Drug Administration (FDA), and other relevant regulatory and industry best practices.

This effort focuses on developing two expeditionary, easy-to-maintain oxygen generation devices meeting Joint Enroute Care Equipment Test Standard and airworthiness standards:

FOCUS AREA #1: Compact Oxygen Generation, Medical (COGM)

• Priority: High

• Primary Use: Role 1 (but still usable across all Roles, including en route care)

• Capabilities: Adjustable flow rate (3-7 lpm minimum, 15 lpm desired) for use with nasal cannulas, face masks, and nebulizers.

• Target Timeline: Regulatory approvals by 2029, procurement by 2031 (shorter timeline preferred)

FOCUS AREA #2: Compact Oxygen Generation, Medical – At Altitude (COGM-A)

• Primary Use: Aeromedical evacuation platforms

• Capabilities: Similar to COGM, but with adjustable flow up to 15 lpm and high-pressure output for ventilators.

• Target Timeline: Regulatory approvals by 2030, procurement by 2032 (shorter timeline preferred)

Are there any additional benefits I would receive?

Beyond the direct funding, awardees gain several strategic advantages:

Government Validation and Credibility:
Selection by the Defense Health Agency signals strong technical credibility and alignment with DoD operational medical priorities—often accelerating trust with military customers, primes, and investors.

Nondilutive Technology Advancement:
This OTA enables companies to mature medical devices without equity dilution, preserving cap table value while advancing toward procurement readiness.

Follow-On Production Potential:
Successful prototypes may lead directly to a follow-on production OTA, reducing acquisition friction and shortening the path to revenue.

Enhanced Defense Market Visibility:
Awardees become part of DHA’s Warfighter Expeditionary Medicine ecosystem, increasing exposure across DoD medical and acquisition communities..

What is the timeline to apply and when would I receive funding?

1. Questions Due: February 6, 2026

2. Proposals Due: March 6, 2026 (5:00 PM EST)

3. Period of Performance:

   • Up to ~24 months for COGM

   • Up to ~36 months for COGM-A

Where does this funding come from?

This program is funded by the U.S. Department of Defense, administered through the Defense Health Agency (DHA) using Prototype Other Transaction Authority (10 U.S.C. §4022).

Who is eligible to apply?

To be eligible, proposals must meet at least one of the following OTA statutory conditions:

• Include a nontraditional defense contractor or nonprofit research institution participating to a significant extent

• All significant participants are small businesses or nontraditional defense contractors

• At least one-third of total project cost is cost-shared by non-government sources

What companies and projects are likely to win?

Proposals are evaluated on three primary factors:

• Strength and feasibility of the technical approach to meeting SOO requirements

• Credibility of the management and execution plan, including regulatory and manufacturing readiness

• Cost realism and completeness of the proposed budget

Projects starting near TRL 4 with a clear path to FDA clearance and military deployment are strongly aligned.

Are there any restrictions I should know about?

• Proposals must comply with FDA medical device regulations

• Foreign collaborators require additional justification

• Participation in malign foreign talent programs is prohibited

• Cost sharing rules apply if nontraditional or small business criteria are not met

• Files must be submitted exactly as instructed; noncompliance may result in elimination

How long will it take me to prepare an application?

Most first-time applicants (without any assistance from BW&CO) should plan for 120–200 hours of effort over 8–12 weeks, including technical writing, budget preparation, and internal reviews.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available for $13000 Initial Fee + 5% Success Fee.

Fractional support is $300 per hour.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

Learn more about the program here.

ERDC BAA - ARMY

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The U.S. Army Corps of Engineers’ Engineer Research and Development Center (ERDC) is issuing a continuously open Broad Agency Announcement to fund basic, applied, and advanced research across a wide range of engineering, environmental, and defense-relevant technology areas. Awards are made on a rolling basis through cooperative agreements, subject to the availability of funds so interested companies should submit as soon as possible.

How much funding would I receive?

ERDC does not specify a standard award size. Individual awards may range from small research efforts to very large, multi-year programs, with an overall program ceiling of $1 billion. Funding levels are determined based on technical scope, relevance, and available funding within the sponsoring ERDC laboratory.

What could I use the funding for?

To be eligible for consideration and possible contract award, the technology or methodology shall be either basic research, applied research, advanced technology development not for a specific system/hardware, or demonstration and validation.

If your technology is novel and fits into one of the following Areas of Interest, you could potentially be funded:

Coastal and Hydraulics Laboratory (CHL)

• Overview

  Research is performed in the areas of hydraulic structures such as locks, dams, outlet works, control gates, stilling basins, spillways, channels, fish handling systems, and pumping stations, flood control channels, navigation channels, riverine and estuarine hydrodynamics and transport processes, groundwater, hydrology; dredgingrelated equipment, and on coastal problems related to coastal storm hazards and risk management, beach erosion, navigation, sedimentation, Regional Sediment Management, inlet stabilization, and construction, operation and maintenance of coastal structures (breakwater, jetties, groins, seawalls, etc.). Major areas of interest include coastal hydrodynamics (wind waves, tides, currents, wind related water levels); coastal sedimentation (longshore transport, inlet sedimentation); coastal geology and geomorphology; design and stability of coastal structures; erosion and storm reduction potential and life-cycle performance of natural and nature-based features; system optimization methods and performance metrics for coastal operations; coastal resiliency; and interaction of structures and coastal processes. Other activities include descriptions of coastal processes; theoretical studies; watershed and regional sediment and water systems studies; numerical and physical model techniques; data collection and analysis techniques; and development of laboratory and prototype instrumentation and equipment. The following sections contain information on these research areas and specific research thrusts.

• A. Physical Processes in Estuaries (CHL-1)

  Research in estuarine physical processes deals with the hydrodynamic and transport characteristics of water bodies located between the sea and the upland limit of tidal effects. Research is directed toward knowledge that will improve field measurements and predictions of these processes. Specific areas of required research include the following physical processes in estuaries and other tidal waters. Specific areas of required research include the following physical processes in estuaries and other tidal waters. a. The propagation of tides. b. Transport of salinity, mixing processes, stratified flows. c. Transport, erosion, and deposition of sediments, including settling velocity, aggregation of sediment, consolidation of sediment. d. Behavior and characteristics of sediment beds, including movement, consolidation, armoring, bonding, physical chemical characteristics, density, erodibility. e. Flow between aquifers and surface waters.

  Specific areas of required research include the following activities with respect to the physical processes listed. a. The effect of human activities, including dredging construction, vessel traffic, flow diversion, training, structures, and protective structures. b. Measurements of parameters that are indicative or descriptive of the processes listed in the 2nd paragraph by in-situ and remote methods in the lab and field. c. Prediction of processes listed in the 2nd paragraph by analytical methods, physical models, numerical models, and other techniques. d. Conceptual and mathematical descriptions of the processes listed in the 2nd paragraph. e. Development of materials, equipment, and methods that potentially lead to applied research that would make human activities listed safer, more economical, or more effective. f. Development of methods, techniques, and procedures that enable the treatment of an estuary as a system.

• B. Inland Hydraulic Structures (CHL-2)

  Research in hydraulic structures is related to the hydraulic performance of locks, dams, outlet works, control gates, stilling basins, spillways, channels, bank protection, riprap stability, pumping plants and other hydraulic structures, and with physical and/or numerical model studies to predict and analyze the physical water quality aspects of water resources projects. Specific areas of required research include the following: a. Conduct physical and numerical hydraulic model investigations of a wide variety of hydraulic structures to verify proposed designs and develop more effective and economical designs. b. Analyze model and prototype data and inspection of field installations to develop design criteria for hydraulic structures. c. Develop methods of correlating theoretical and experimental information with design methods used by the Corps of Engineers to improve existing procedures and provide material for inclusion in appropriate manuals. d. Develop physical and/or numerical models to predict and analyze the water quality aspects of water resources projects and design appropriate hydraulic structures to control water as well as water quantity while satisfying the desired objectives. e. Conduct research and/or develop numerical codes to advance techniques for analyzing physical aspects of water quality in lakes and rivers through a better understanding of the hydrodynamics in density-stratified environments and for improving water quality within and downstream of density-stratified reservoirs and to investigate the ability of existing and proposed water resources projects to satisfy established water quality standards. f. Conduct basic studies for development of hydraulic design and operation guidance for hydraulic structures used in inland waterways for navigation and flood control purposes, including wave forces/loads on gates (tainter, miter, etc.). g. Conduct/analyze tests, both model and prototype, of the performance of hydraulic appurtenances to flood control and navigation dams such as spillways, outlet works, energy dissipaters, and approach and exit channels, to develop design guidance that will provide structures of maximum efficiency and reliability with minimum maintenance. h. Develop innovative methods to prepare and revise engineering manuals for hydraulic design of various hydraulic structures. i. Develop innovative methods to conduct training courses on design of various hydraulic structures. j. Develop innovative methods to prepare technical reports of all work conducted.

• C. Open Channel Flow and Sedimentation (CHL-3)

  Research in open channel flow and sedimentation includes basic studies related to development of hydraulic design guidance for designing modifications to natural stream channels to provide for local flood risk reduction. Emphasis is placed on channel stability as well as channel flow capacity. Specific areas of required research include the following: a. Studies related to the development of effective methods to analyze a natural stream's response to modifications made for flood control purposes. b. Studies applicable to development of stream bank and streambed protection methods where channel instability exists. c. Studies applicable to development of sediment transport, local scour, and stream form relationships for a broad range of stream types, bed and bank materials, and meteorological and hydrological conditions. d. Collection and analysis of data that aid in evaluating existing methods and/or developing new methods to analyze channel stability for the variety of channel flow conditions and stream types existing in natural stream systems.

• D. Dredging Research (CHL-4)

  Protection and enhancement of the environment associated with operation and maintenance of navigable U.S. waterway infrastructure through dredging activities is a national priority. Dredging operations and environmental requirements of navigation projects are inseparable. Research is required to predict the time-dependent movement of non- contaminated sand and sand/silt mixtures of dredged materials placed in the nearshore zone, and all materials placed in the offshore region. The cost of dredging operations attributable to compliance with environmental windows that are determined to be over-restrictive, inconsistent, or technically unjustified can be reduced. More effective contaminated sediment characterization and management will reduce costs and enhance the reliability of methods associated with the assessment, dredging, placement, and control of sediments from navigation projects. Better instrumentation for dredge and site monitoring is required to implement automated dredge inspection and payment methods and accurately monitor placement of contaminated materials. Emerging technologies regarding innovative equipment and processes should be expeditiously introduced into the dredging arena. Enhanced ecological risk management for dredging and disposal projects through technically sound approaches for characterizing, managing, and conducting risk-based evaluations are required for expanding options regarding both contaminated and non-contaminated dredged materials.

• E. Navigation Channel Design (CHL-5)

  Research in navigation channel design involves basic research to develop design guidance for the design of new channels and modifications of existing waterways. It involves identifying maneuvering requirements in restricted waterways that affect the channel dimensions, alignment, and location of appurtenances in the navigation channel under various environmental and vessel traffic conditions. It also involves identifying the stability of the channel, maintenance requirements and designing structures that reduce or eliminate the maintenance requirements. Finally, it involves quantifying the flow and pressure fields generated by a tow or ship passing through a waterway and the related impacts on the sediment resuspension in the channel, channel border, and side channel/backwater areas. Studies involve deep and shallow draft navigation channels and physical and mathematical models. Human factors are included in research and project studies using a ship and tow simulator.

  Specific areas of required research include the following: a. Physical model investigations of a wide variety of navigation channel configurations in many environments with different type vessels to verify proposed designs and to develop more efficient and safe designs and to lower environmental impacts. b. Development and enhancement of mathematical models of vessels, both ships and push-tows, for use on the simulator to add vessel types not available or to increase the accuracy with which the model reproduces the vessels response. c. Development of methods and modeling techniques to predict the currents and sediment transport characteristics of various channel designs and integrate this with the navigation model studies, including those generated by the vessel movement. d. Development of methods and modeling techniques to predict the currents and sediment transport characteristics of various channel designs and integrate this with the navigation model studies. e. Development of methods and techniques to prepare and display visual information for the pilot on the simulator projection system. f. Development of methods and measurement equipment, techniques for measuring scale model performance in physical model navigation studies. g. Development of methods and techniques to improve the ship simulator and increase reliability of design estimates, including data and tools for ship motions, draw down, squat, ship-generated waves, and ship maneuvering. h. Development of methods and techniques for the analysis and evaluation of model results to optimize the channel design and to determine the level of safety, or conversely, risk involved with the various designs and ship transits.

• F. Computer-Aided Hydraulic Engineering (CHL-6)

  Research in this topic area develops computer-aided design tools that can be used by hydraulic engineers in planning, design, construction, operation, and maintenance of navigation and flood control projects. The scope includes open channel and closed conduit flows, equipment, structures, and sediment transport analysis and modeling.

• G. Groundwater (CHL-7)

  Research in groundwater is structured to enhance understanding and prediction of the flow of water and various transported constituents through the environment, including groundwater issues from contaminant remediation to levee erosion as well as surface water problems from flash flooding to nearshore coastal flows. Primary tools are computer models that solve (approximately) conservation equations for mass, momentum, and energy in various physical systems. Work includes developing the numerical methods for solving these equations, writing the computer code to implement the approximations in desktop and high-performance computing environments, and applying the models as part of engineering studies to investigate processes like levee erosion and overtopping, seawater intrusion, and flow through vegetation.

• H. Hydrology (CHL-8)

  Research in this area primarily addresses military applications related to mobility, counter mobility, and water supply. Specific research involves the following areas: a. Large-scale hydrologic modeling. b. Rapid procedures for flood forecasting. c. Groundwater-surface water interaction processes. d. Multi-scale, multi-physics hydrologic modeling. e. Remote sensing and quantification of precipitation. f. Development of spatially varying precipitation hydrology models. g. Visualization of results for hydrology and dam break models. h. Interfacing with existing and new hydrology models. i. Interfacing watershed models with water quality and other environmental models.

• I. H&H GIS/Database Development (CHL-9)

  Research involves the following areas: a. Electronic Navigation Charting. b. Integration of GIS/Database and H&H models. c. Watershed management for erosion control. d. Larger River System management for flood control navigation. e. Visualization Techniques

• J. Coastal Hydrodynamics, Coastal Processes (CHL-10)

  Research in this area includes: shallow water wave estimation; forecasting and hindcasting of wind generated waves for oceanic to local regions; wave theory; statistical distribution of wave parameters; simulation of spectral and phase resolved conditions in wave basins; infragravity (free and bound) waves; nearshore currents; wave breaking; wave/current and wave structure interactions; wave and sediment interactions with natural and nature-based features; long and short waves in ports and harbors; tsunami modeling; wind generated currents; storm surge; tidal circulation; twoand three dimensional numerical simulation models (including finite difference, finite element, finite volume and curvilinear coordinate techniques); coastal meteorology; explosion generated waves; ship response to winds, currents and waves; moored ship response; mooring design and analysis, ribbon bridge hydrodynamics and turbulence.

• K. Coastal Inlets, Navigation Channels (CHL-11)

  Research includes sediment shoaling in coastal inlet channels; stability and performance of inlet channels; scour at structures; sediment transport modeling; influence of structures such as jetties and breakwaters on wave, current, and sedimentation processes. Numerical modeling of inlet hydrodynamics and sedimenttransport processes, including long-term geomorphologic evolution of inlet channels, shoals, and adjacent beaches, and the interaction with navigation structures. Nearshore placement of dredged sediment to foster wave reduction and sediment supply to adjacent beaches. Short- and long-term dune evolution in vicinity of coastal inlets. Shoreline evolution modeling and storm erosion of beaches, particularly concerning over wash and breaching near inlets; wind and wave generated sediment transport; sediment budget analysis; coastal and inlet geomorphology; and PC-, workstation-, and mainframe-based automated coastal engineering software (including relational and GIS data bases)

• L. Coastal Structure and Facility Design (CHL-12)

  Research includes development of functional and stability design criteria for coastal structures and facilities (breakwaters, seawalls, jetties, groins, harbors, marinas, etc.); wave run-up, over-topping, refraction, diffraction, transmission, reflection, etc.; design of floating breakwaters; breakwater stability; application of spectral wave conditions to coastal engineering; stability of riprap to irregular wave attack; stability and functional design of overtopped rubble mound breakwaters; scale modeling of armor unit strength; analysis of structural data for floating breakwaters; investigation of numerical structural models for floating breakwaters; development of wave run-up gage for rough and porous slopes; investigation of attenuation/mooring force models of floating breakwaters; development of materials and techniques to produce high quality breakwater model armor units; analysis of wave run-up overtopping, refraction, diffraction, transmission and/or reflection data on coastal structures and beaches and design of structures for Logistics-Over-The-Shore (LOTS) operations.

• M. Field and Laboratory Measurements, Data Collection, and Analysis (CHL13)

  This topic area includes research in technologies, instrumentation, and monitoring systems in coastal and riverine settings for collecting, analyzing, and disseminating data related to measurements of coastal waves, surface currents, water levels, water quality, sediment, and wind, primarily in the field, but also in a sediment laboratory; advanced data analysis (spectral and non-spectral) techniques; remote sensing techniques; bedload and suspended sediment transport; monitoring and evaluating technical and structural stability of coastal projects; advanced hydrographic survey techniques, field measurement of coastal processes; bathymetric survey systems.

• N. Experimental Coastal Model Equipment, Operation and Analysis (CHL-14)

  Research includes development of equipment and techniques for specialized model construction, experimental wave generation equipment, specialized data acquisition and analysis systems, advanced model operations techniques, and laboratory and scale effects in movable bed model studies.

• O. General Coastal Engineering, Coastal Geology, Dredging Investigations CHL-15)

  This topic area includes topics such as sand bypassing systems and equipment; beach fill design; coastal geology and geomorphology; functional design and evaluation of coastal works and coastal structures; methodologies to assess and track coastal resilience performance; littoral transport; coastal and offshore dredging studies; agitation dredging systems and equipment; physical monitoring of dredged material; physical processes in coastal wetlands; application of Geographic Information Systems; design of nearshore and offshore dredged material placement; evaluation of dredged material disposal sites; analysis of dredging operations management.

• P. Regional and Watershed Sediment Management (CHL-16)

  Regional Sediment Management (RSM) research is intended to provide knowledge and tools that the Corps and the Nation need for effective water resource projects. RSM implies the holistic management of sediment within systems or regions to produce environmentally and economically sustainable projects. Goals include improved project design, operation, and maintenance methods, minimized disruption of natural sediment pathways and processes, and mediation of natural processes that have adverse environmental or economic impact. The approach of the Corps research is to produce targeted R&D serving multiple Corps business areas; to employ ongoing projects’ experience (including Demonstration Projects) to provide data and lessons learned; to use enabling technologies of localscale products and tools, including those generated by other R&D programs within and outside the Corps; to generate technologies that integrate the best available knowledge on sediment behavior and regional morphology into management decision support tools for a) regional and basin scale analyses and b) evaluation of the impacts of projects and management decisions on and by long-term, large-scale sedimentation processes. A key element in ERDC research is full coordination with other organizations with sediment management or monitoring expertise.

• Q. Marine Transportation Technologies (CHL-17)

  Research in this topic area serves one of the USACE’s primary missions, to provide safe, reliable, efficient, effective, and environmentally sustainable waterborne transportation systems for movement of commerce, national security needs, and recreation. To accomplish this mission, the USACE requires R&D to facilitate tracking of vessels on inland waterways (shallow draft) and coastal ports (deep draft). Knowing what vessels are arriving, when, the commodities being carried, etc., will provide lock operators and operations project managers valuable tools to improve safety, efficiency, asset management, and help to make decisions on performance-based funding for navigation project maintenance and improvements. Work in this area focuses on software that uses the United States Coast Guard’s (USCG) Automated Identification Systems (AIS) vessel mounted transmitters which broadcasts a radio signal with the vessels name, position, heading, velocity, and a wide range of other information. Proposals are sought for developing the following: a. Capability that will take the full suite of standard CG AIS messages and provide them in near real time to the Corps facilities in the immediate area of the vessel. b. Capability to allow collection of the full suite of standard AIS messages simultaneously at all pertinent Corps Inland and Deep Draft facilities. c. Capability to customize user interface to allow the Corps operations staff to view vessels in the vicinity of the Corps facilities to make decisions on the order in which to allow commercial tows to pass through lock. d. Provide the capability for Corps facilities to transmit pertinent information to the vessels in the immediate vicinity of the Corps facilities via AIS. e. System optimization methods and performance metrics for vessel operations. Special Considerations: The level of understanding of AIS technology and signal processing, the number of successful installations of similar AIS software processing capabilities; experience with USCG staff, facilities, regulations, and procedures.

• R. Post-Wildfire Hydrologic, Sediment, and Geomorphologic Management (CHL-18)

  Post-Wildfire research is focused on improving understanding of post-fire impacts through exploitation of affordable data acquisition methods and enhancement of numerical modeling capabilities to assist with planning, management, and mitigation in post-wildfire environments. Immediately following a wildfire, vegetation is removed, organic soil horizons are reduced to ash, and hydrophobic soils combine to result in increased water and sediment discharge and debris, mud, and hyper concentrated flows. In the years following a wildfire, ecotone shifts, gully formation, and channel incision alter the hydrologic system response, resulting in dramatic changes in hydraulic and sediment impacts down system. Wildfires represent a significant perturbation to natural systems that dramatically alter the morphologic, hydrologic, and sediment regimes of impacted watersheds. The overall purpose of this area of research and development is to investigate post-wildfire impacts on hydrologic and hydraulic response, geomorphic evolution, and sedimentation, with specific research needed in the following areas: a. Studies related to cost-effective (in situ and remotely sensed) data acquisition and processing methods. b. Studies related to better understanding the longer-term geomorphic impacts and subsequent recovery processes in post-fire environments. c. Studies related to hydrological physical processes, empirical approaches, and numerical modeling. d. Studies related to hydraulics and sediment transport physical processes and numerical modeling.

• S. Nearshore Coastal Research in Support of the U.S. Coastal Research Program (CHL- 19)

  Proposals are invited to address nearshore coastal research needs within three broad research themes as identified by the U.S. Coastal Research Program (USCRP) (see Nearshore Process Community, 2015 for more details). Nearshore systems include the complex interactions of physical, biological, chemical, and human influences within the transition region across the land and the continental shelf, spanning (from onshore to offshore) coastal plains, wetlands, estuaries, coastal cliffs, dunes, beaches, surf zones, and the inner shelf. Worldwide, nearly 1 billion people live at elevations within 10 m of present sea level, an elevation zone in need of engineering solutions that reduce risks to life and property produced by various extreme events. The nearshore is a societally relevant region that requires and improved understanding of the feedbacks and couplings that shape, sustain, and alter coastal landscapes. The three broad research themes include a need to understand, better predict, and respond to (1) Long-term coastal evolution due to natural and anthropogenic processes; (2) Extreme Events including: flooding, erosion, and the subsequent recovery; and (3) The physical biological and chemical processes impacting human and ecosystem health. Each is detailed below a. Long-term coastal evolution due to natural and anthropogenic processes: As storms impact increasingly urbanized coastal communities, an understanding of long-term coastal evolution is critical. Improved knowledge of long-term morphological, ecological, and societal processes and their interactions will result in an improved ability to simulate coastal change and develop proactive solutions for resilient coasts and better guidance for reducing coastal vulnerability. b. Extreme Events including flooding, erosion, and the subsequent recovery: U.S. coastal extreme event related economic losses have increased substantially over the past decades. Addressing this research theme will result in an improved understanding of the physical processes during extreme events, leading to improved models of flooding, erosion, and recovery. Utilization and application of the improved models will produce societal benefit in the form of more resilient coastal communities. c. The physical, biological, and chemical processes impacting human and ecosystem health: Nearshore regions are used for recreation, tourism, human habitation, and provide habitat and valuable ecosystem services. These areas must be sustained for future generations, however overall coastal water quality is declining due to microbial pathogens, fertilizers, pesticides, and heavy metal contamination, threatening ecosystem and human health. To ensure sustainable nearshore regions, predictive real-time water- and sediment-based pollutant modeling capabilities must be developed, which requires expanding our knowledge of the physics, chemistry, and biology of the nearshore. The resulting societal benefits will include better beach safety, healthier ecosystems, and improved mitigation and regulatory policies.

• T. Comprehensive Water Risk Management (CWRM) (CHL- 20)

  Proposals are invited to develop and explore the application of next generation technologies, methods and approaches that lead to the creation of a seamless national hydro-terrestrial capability within the USACE and partner agencies. CWRM includes advanced data collection, prediction and management technologies that can provide water managers the tools required to minimize, mitigate, and better manage water hazards under present and future design requirements. Proposals for research in the following specific areas are needed: a. Inland and Coastal Compound Flooding: Research to support the inclusion of inland and coastal compound flooding in the reduction of comprehensive flood risk from riverine flows, precipitation, coastal storms, groundwater emergence, sea level change, snowmelt, wildfires, subsidence, and other natural as well as anthropogenic events. b. Data Collection: Research to support the collection and analysis of water data through in-situ and standoff measurements including satellite, and various uncrewed systems (UxS). For UxS this includes sensing, perception, control, and data process techniques. Needs include data collection techniques for snowpack analysis, soil-moisture determination, wave environment, estimation of under-water bathymetry, reservoir capacity, etc. c. Probabilistic Modeling – Uncertainty quantification and Data Assimilation: Research to support development of methodology for quantifying numerical uncertainty and forward propagation of that uncertainty into numerical prediction. Additionally, research to develop methods for assimilating observations into probabilistic numerical methods to refine predictions for wave, circulation, and morphologic models. d. Artificial Intelligence and Machine Learning (AI/ML) Technologies: Research to support the use AI/ML technologies to increase the accuracy and efficiency of hydrologic and hydraulic numerical models. Capabilities include advanced data assimilation technologies for error reduction and longer forecasts. e. Flash Flooding: Research to improve the technologies to predict and mitigate water hazards due to flash flooding. Research requirements include downscaling of weather forecasts including precipitation, wind speeds, atmospheric pressure, etc. f. Cold Weather Water Hazards: Research to improve the performance of predictive techniques in cold regions including the arctic. Research requirements include the effects of ice cover on wave and storm mitigation, the effects of the permafrost on hydrologic processes, the effects of flood risk mitigation features on freshwater sources, etc. g. Arid Region Water Hazards: Research to improve the performance of predictive techniques in arid regions. Research requirements include infiltration processes, groundwater and surface water interaction, aquifer recharge, wildfire hydrology, etc. h. Numerical Model Coupling Techniques: Research to improve the performance of numerical model coupling methods. Research requirements include inter and intra-model communication for inter-agency model collaboration.

• U. Innovations in Sediment Management (CHL- 21)

  Proposals are invited to develop leap-ahead innovative and sustainable dredging and sediment management solutions to dramatically reduce costs, increase channel/infrastructure reliability, and add significant economic, environmental, and social value to the Nation. Proposals for research in the following specific areas are requested: a. Coastal/ Hydrodynamic Engineering Nature-Based Solutions (NBS) and Hybrid Solutions: Research to inform the development of tools, techniques and guidance behind designing and engineering nature-based solutions (NBS) and hybrid solutions. This R&D will help in the development of methods and standards which support effective planning, designing, construction, and O&M of NBS/hybrid solutions to support the reduction of coastal and inland flooding risks. This research should focus on exploring the potential for integrating NBS/hybrid solutions within existing hydrodynamic engineering and land use planning practices. b. Innovative Dredging Technologies/ Autonomous Methods: Research to develop technologies and techniques for improved dredging operations. R&D can address evaluating next-generation technologies and dredging operations (e.g., hydrodynamic dredging), real-time dredge position and bottom mapping techniques, autonomous dredging to reduce costs, increase beneficial use of dredged material, sediment transfer and placement equipment to facilitate more beneficial uses (e.g., thin layer placement, strategic placement), reduce channel and reservoir infilling to reduce dredging need, or renewing reservoir capacity through application of technologies developed for navigation channel maintenance. Proposals are invited to develop leap-ahead innovative and sustainable dredging and sediment management solutions to dramatically reduce costs, increase channel/infrastructure reliability, and add significant economic, environmental, and social value to the Nation. Proposals for research in the following specific areas are requested: a. Coastal/ Hydrodynamic Engineering Nature-Based Solutions (NBS) and Hybrid Solutions: Research to inform the development of tools, techniques and guidance behind designing and engineering nature-based solutions (NBS) and hybrid solutions. This R&D will help in the development of methods and standards which support effective planning, designing, construction, and O&M of NBS/hybrid solutions to support the reduction of coastal and inland flooding risks. This research should focus on exploring the potential for integrating NBS/hybrid solutions within existing hydrodynamic engineering and land use planning practices. b. Innovative Dredging Technologies/ Autonomous Methods: Research to develop technologies and techniques for improved dredging operations. R&D can address evaluating next-generation technologies and dredging operations (e.g., hydrodynamic dredging), real-time dredge position and bottom mapping techniques, autonomous dredging to reduce costs, increase beneficial use of dredged material, sediment transfer and placement equipment to facilitate more beneficial uses (e.g., thin layer placement, strategic placement), reduce channel and reservoir infilling to reduce dredging need, or renewing reservoir capacity through application of technologies developed for navigation channel maintenance. c. Hydrodynamic and Geomorphologic Response of Biomaterials: Research into the use of bio-based materials, such as biopolymers, to enhance and increase the resiliency of NBS, including earthen levees, coastal dunes, and dam embankments. This research should focus on the hydrodynamic and geomorphologic response of biomaterials to the impacts of hydrological and meteorological extremes. Considering the performance and sustainability of biobased materials, we seek to understand the potential of bio-based materials to reduce the risk and cost of rehabilitating and maintaining these structures and increase their resiliency against potential threats. We invite research that furthers our understanding and application of bio-based materials for this purpose, as a component of comprehensive water risk management and abilities to adapt to dynamic environmental forcing requirements. The research should be designed to provide evidence and support decision making. It should be based on research available at existing open-source platforms, or data that is proposed to be collected for the research. d. Monitoring of NBS and Beneficial Use of Dredged Sediment Projects: Research to improve the understanding of the performance of NBS and beneficial use of dredged sediment projects through monitoring. Monitoring could include the project’s response to storm events and the post-storm recovery. Monitoring techniques will vary based on the project but may be comprised of satellite data, remote sensing measurements, in-situ measurements, or engaging the public to crowdsource data collection. The monitoring research may also include the development or testing of innovative sensors or monitoring techniques.

• V. Next Generation Water Management (CHL-22)

  Proposals are invited to explore the application of next generation technologies, methods and approaches that are aimed at improving water management practice within the USACE and partner agencies, including efforts that support research, development and implementation of capabilities to support Forecast Informed Reservoir Operations (FIRO). FIRO is a management approach that seeks to improve water supply, enhance flood risk reduction and achieve additional ecosystem benefits through application of advanced weather and watershed forecast capabilities in water management practice.

  FIRO envisions advanced observation and prediction technology that can provide water managers more lead time to selectively retain or release water from reservoirs based on longer- term forecasts. When storms cause moderate-to-high reservoir levels, normal operation is to release water to re-establish flood control space. FIRO pilot studies have demonstrated that some of that water can be retained for future supply as long as no major precipitation is expected and it can be shown that the retained water can be released past downstream flood prone areas prior to the arrival of the next storm. This strategy permits earlier supply capture in some years, improving supply reliability for downstream water users and improving the timing and volume of releases to protect water quality and provide flows needed for ecosystem benefits. Proposals for research in the following specific areas are needed: a. Improvement of forecast skill to support advanced water management, including meteorological phenomena that are major drivers for floods in various regions across the country including atmospheric rivers, tropical storms/hurricanes, clusters of long-lived thunderstorms and Nor’Easters. This can also include improvements in weather observations and numerical weather forecasting models that result in improved forecasting lead times for water management decision-making.

  b. Improvements in data synthesis, decision support systems and data visualization capabilities to enhance water management decision-making.

  c. Hydrologic and reservoir model development and application, including improvements in watershed monitoring to enhance hydrologic and reservoir models.

  d. Application of FIRO screening process tools to regions of the United States where FIRO has not previously been applied or tested.

  e. Application of FIRO viability assessment processes to systems of dams where multiple dams are operated within a watershed to achieve overall system water management objectives.

  f. Research to support updates to USACE Water Control Manuals (WCMs) using FIRO approaches, scenarios and principles. Updates to WCMs require numerous studies in areas of meteorology, hydrology, hydraulics, ecology and economics. Incorporation of next generation approaches such as FIRO require research efforts to identify best management practices on how to safely and effectively incorporate these new approaches into water management practice as defined in WCMs.

Geotechnical & Structures Laboratory (CHL)

• Overview

  Research performed by the Geotechnical and Structures Laboratory’s (GSL) eight branches consists of investigations in the areas of soil mechanics, engineering geology, geophysics and seismology, earthquake engineering, pavements (both expedient and permanent), mobility and traffic ability of military vehicles, structural design and performance of structures under both static and dynamic loadings, earth dynamics, and the uses and performance of concrete, cement, and other construction materials. Research areas also include measurement and analysis of seismic and acoustic signals to locate airborne and ground military targets and buried objects (including unexploded ordnance) and to characterize earth media. Research on concrete and cement is predominantly related to current recognized needs, both civil and military. Military expediency focuses additional attention on ease and speed of concrete placement, development of very high-strength materials, and use of non-traditional, indigenous, and other special materials in concrete construction. Civil works research focuses primarily on the need to improve the performance of both new and old concrete structures. Structures research involves development, testing, and evaluation of a broad class of structures to resist the effects of static and dynamic loads induced by earthquakes and other sources. The Geotechnical and Structures Laboratory also conducts research involving all aspects for improving the survivability of fixed installations.

• A. Earthquake Engineering (GSL-1)

  Research areas of interest include the dynamic behavior of soil and rock; liquefaction of soils, including coarse-grained and fine-grained soils; in-situ testing to evaluate properties related to dynamic behavior; centrifuge scale-model testing using a multi-waveform shake table; in-situ testing to evaluate susceptibility to liquefaction; methods of analysis of dynamic behavior of earth materials; methods of analysis of dynamic soil- structure interaction; risk-based and probability-based methods of analysis; seismic wave propagation in earth materials; seismically induced settlements in soils and remedial treatment of soils potentially susceptible to earthquake-induced instability or strength loss; computer visualization and dynamic simulation; site response analysis; and strong motion instrumentation.

• B. Geophysics (GSL-2)

  ERDC supports research in the development of land, air, or waterborne geophysical methods to be used for characterization of hazardous waste sites, detection and monitoring of seepage, nondestructive investigation of archeological sites, location of groundwater, and detection of buried objects; analytical and data-processing techniques, borehole surveys, cross hole seismic imaging, electromagnetic detection of anomalies, seismic surveys, sub bottom profiling, and acoustic impedance surveys; and uses of microgravity.

• C. Mobility of Vehicles (GSL-3)

  The Mobility Systems Branch addresses engineering research on the performance of vehicles operating cross country and on-road, and/or in negotiating dry and wet obstacles in worldwide terrains. This is a highly specialized technical area involving engineering mechanics, vehicle dynamics, mathematics, statistics, computer specialties, geology, and soil mechanics. Research in this area includes developing fundamental relations between soil and vehicle running gear; improving criteria concerning the effects of vehicle vibration and ride shock on sensors and data streams from rapidly moving sensors over rough terrain; developing algorithms describing weather effects on terrain, multi-vehicle movements along road nets, stochastic processes describing influence of uncertainties of data elements, and developing modeling and simulation capabilities for near real-time assessments of mobility and counter mobility for battlefield operations and operations other than war.

• D. Pavement Technology (GSL-4)

  Research in this area is conducted in support of the Corps mission to design and construct roads and airfields worldwide and other related engineering functions. This research includes the development of engineering criteria for the design, construction, evaluation, maintenance, and rehabilitation of permanent and expedient airfields, pavements, and ports. Research areas of interest include improved design procedures, structural performance modeling, material characterization and evaluation, nondestructive testing, rapid repair of structures, expedient surfacing (to include novel, composite, and metallic systems), aircraft and vehicular ground flotation, access/egress systems, gravel surfaced and non-surfaced areas, the use of geotextiles and geomembranes, grid-confining systems, soil stabilization, dust-control materials and techniques, advanced binder systems, remote assessment, earth anchoring, pavement evaluation, and advanced testing, monitoring, and evaluation equipment, software, and methods to support pavement and pavement related functions.

• E. Soil and Rock Mechanics (GSL-5)

  Research is needed to: (a) improve methods for prediction and control of erosion of unlined spillway channels during uncontrolled releases; (b) develop innovative methods for flood protection and flood fighting, including field evaluations of promising technologies; (c) develop guidance for applications of trenchless technology (e.g., micro tunneling, horizontal directional drilling, pipe ramming, pipe jacking, auger boring, etc.) on Corps structures, including measures to ensure safety and stability of Corps structures when trenchless technology is used to install pipelines, cables, or conduits through or beneath levees and other structures;(d) develop improved methods, including risk-based methods for analyzing earth and rock fill dams and other water control structures for both static- and earthquake-induced stresses; (e) improve the state of knowledge of physical and engineering properties of soil, rock, and clay shales; earth-rock mixtures, granular filters, cohesive and non-cohesive fine- grained soils susceptible to liquefaction; and soils susceptible to drastic volume changes (collapse, consolidation, swell); (f) develop rational analytical procedures and more reliable prediction of behavior of partially saturated soils; (g) determine the response of soils in situ to static and dynamic loading and unloading; (h) determine the susceptibility of earth dams to cracking, hydraulic fracturing, and internal erosion; (i) evaluate improved defensive design measures in use of materials, particularly in filter and transition zones and impervious barriers; (j) improve procedures for monitoring and analysis of the performance of new and existing structures, particularly the use and interpretation of observations and data from specialized instrumentation, and expedient systems for rapid inspection and evaluation of the integrity of dams; (k) improve the understanding of the aging processes in dams and the influence of aging (particularly deterioration of safety-related features) on long-term maintenance and/or rehabilitation requirements for dams; (l) develop a better understanding of failure mechanisms to improve design of defensive measures, to provide information for remedial repairs, to assess potential damages resulting from failure, and to provide a basis for emergency actions; (m) develop expedient remedial measures when hazardous conditions are identified and, thus, reduce the damages and catastrophic potential of dam failures; (n) develop methodology to evaluate forces exerted on structural elements by adjacent soil masses that result from long- term variation in soil properties; (o) develop improved methodology for design and construction procedures for shallow and deep foundations, including mats, footings, piers, and piles for buildings, hydraulic structures and waterfront structures; (p) large-scale physical and numerical modeling of deep underground structures (tunnels, shafts, chambers, and intersections); (q) predictions of rock mass dredgability; (r) acoustic emission (micro-seismic) applications in geotechnical engineering; (s) geotechnical aspects of hazardous and low-level radioactive waste disposal; (t) evaluation of rock for use as riprap; (u) grouting of soil and rock masses; (v) sliding stability of gravity structures, and (w) centrifuge modeling of structures founded on or in rock.

• F. Dam Research (GSL-6)

  Research is conducted in support of the Army’s Dams and Transportation Infrastructure Program, specifically the Dam Safety subcomponents. Research covers design, construction, maintenance, repair, and inspection procedures of Army dams as well as other engineering functions as they relate to transportation structures. This involves the formulation of engineering criteria for the design, construction, evaluation, maintenance, and rehabilitation of dams. Research areas of interest include improved inspection procedures, material characterization and evaluation, nondestructive testing, rapid repair, scour, unknown material properties, unknown foundations, and underwater inspection.

• G. Engineering Geology (GSL-7)

  The GSL conducts a broad range of research in the field of engineering geology in support of federal or other Government technical missions. Specific areas of interest within this field include application of remote sensing to geologic and geomorphic assessments; geo-archeological investigations; applied and numerical geomorphic analysis; computer applications in geotechnical engineering; 3-D visualization systems; uses of geographic information systems; geo hydrology in military and civil applications; including water quality and supply issues; geologic mapping; geologic applications of mathematical techniques and geo statistics; groundwater monitoring, including well installation and design; geologic application of groundwater models; integration of geological and geophysical subsurface exploration techniques; land-loss studies; remedial measures at groundwater contamination sites; seismic hazard characterization and evaluation; subsurface exploration methods (drilling and sampling techniques); test site selection; conceptual and geologic and hydro geologic models.

• H. Excavation, Structural Demolition, and Obstacle Creation (GSL-8)

  Current criteria for improved demolitions call for significantly reduced manning levels and preparation times to accomplish assigned missions. Cost effectiveness, versatility, and safety are also of great importance. Current efforts involve technologies for the standoff creation and reduction of all types of battlefield obstacles, and the excavation of fighting positions. A prime consideration is the development of more efficient means for the application of various types of energetic materials to targets of interest. In addition, modern materials and design principles used in typical target structures must be incorporated into future plans and guidelines for demolitions. Typical missions of interest are road cratering, anti-tank ditching, bridge and tunnel demolition, and the breaching of walls, bunkers, levees, and dams.

• I. Ammunition Storage Safety (GSL-9)

  The military services must store large amounts of munitions, both for war reserves and for training purposes. New conceptual designs for components or systems for storage are needed to reduce the likelihood of an accidental detonation of stored munitions, limit the propagation of air blast and fragments, or mitigate the safety hazards produced by an accidental detonation. In addition, test data and simulation techniques are needed to aid in the definition of the safety hazards from such detonations, and the mechanics of blast propagation among munition stores. Obsolete munitions are often disposed of by deliberate, controlled detonation. Research is needed on new methods for safe, efficient, and environmentally acceptable methods for deactivation of a wide variety of munition types.

• J. Physical Simulation of Munition Phenomenology (GSL-10)

  The mechanical effects induced by munition detonations are physically simulated using a variety of energy sources. Simulations are performed at full- and small (1/2 to 1/10) scale. The mechanical effects from conventional energetic materials are normally performed at small scale. These studies could benefit from improved (better fidelity, less expensive) simulators and simulation techniques. They could also enhance the development of test methodology for micro-scale (1/100 to 1/10) testing including centrifuge testing. Micro-scale test methodology includes the miniature high- fidelity energy sources, miniature sensors, advanced optical techniques, high-fidelity construction techniques for miniature structures, and theoretical developments in the scaling of material behavior.

• K. Geophysical Phenomenology - Multi-Modal Geophysical Phenomenology, Modeling, Data Processing, and Data Management (GSL-11)

  The objectives include detecting, classifying, and locating airborne and ground military targets and buried objects using geophysical methods for homeland defense and homeland security applications. Also included are invasive and non-invasive approaches for measuring and quantifying the geophysical/geologic signatures of diverse geo-environments. This can include the development of new and/or improved analytical and numerical models, rapid data- processing techniques, and new subsurface imaging techniques that include active and passive sensor modalities in a variety of rural and urban terrains.

  Of particular interest is the broadband propagation of energy including, but not limited to seismic/acoustic/infrasonic/electromagnetic/ thermal/chemical, under variable conditions using a variety of sensing platforms (fixed, mobile, airborne, space). The development of new tactics, techniques, and procedures for the employment of novel sensing methods as well as the development and/or verification of empirical testing and evaluation techniques is also desirable. Data management and multi-mode integration techniques and platforms are also of interest.

• L. Laboratory Tests and Constitutive Model Development for Geologic Materials (GSL-12)

  This research requires the formulation of mathematical constitutive models to simulate the mechanical behavior of geological and structural materials and incorporation of models into application-oriented prediction/analysis techniques. Also of interest are the development of dynamic test equipment and techniques and the experimental evaluation of geological and structural material response to high-pressure transient loadings.

• M. Projectile Penetration (GSL-13)

  Theoretical and experimental studies of projectile stresses and trajectories due to impact and penetration into geologic and man-made targets and development of design criteria for shield systems include development of equipment and diagnostic techniques to examine the response of targets to low- and high-velocity impact of penetrators, rods, etc.

• N. Computational Structural Mechanics for DOD Applications (GSL-14)

  The efficient use of scalable computers will require fundamentally new concepts in computational mechanics algorithms. Research includes mathematical formulations and development of scalable computational mechanics algorithms in the areas of structural response, penetration, contact impact, structure-medium interaction, multi-scale, multi-physics, and interdisciplinary flow-thermal-structural interactions. This research area also includes development of computational models for new materials and composite construction (consisting of concrete, composite, and/or geologic materials), as well as the behavior and control of structures composed of such composite construction for military applications.

• O. Concrete Materials (GSL-15)

  Research in this area includes improving the performance of concrete materials and systems. Performance could include very high tensile or compressive strength, high ductility, high fracture toughness, low shrinkage, rapid hardening, very low permeability, resistance to abrasion and erosion durability, chemical resistance, shock-attenuating properties, ultra-low density, thermal insulation properties, workability, and other unique attributes. This includes improvements in the materials typically used in a concrete mixture such as aggregate, cement, supplementary cementitious materials, and chemical admixtures. Aggregates could include waste and/or manmade materials such as fly ash (traditional, blended, or reclaimed), silica fume, ground granulated blast-furnace slag, recycled concrete, lightweight aggregates other potentially low cost and/or green materials. Micro- and Nanoscale aggregates, inclusions, pozzolans, cements and reinforcements such as microspheres, nanosilicates, microfibers and low-cost nanotubes or nanofibers would also be included in this research area. Chemical admixtures such as water reducers, set retarders, set accelerators, air-entraining admixtures, and foaming and defoaming agents that lend unique properties would also be considered in this research area. Since reinforcement is a critical element to the ductility and durability of concrete materials, advanced reinforcement materials that enhance these properties fall under this research area. Additionally, this topic area would include research involving nontraditional cement binders including polymer- impregnated concrete, polymer or resin concrete, polymer Portland-cement concrete and geopolymer concretes.

• P. Concrete Properties and Analysis (GSL-16)

  Research in this area if focused on the development of new nondestructive and destructive test methods and analysis techniques to better characterize the properties and performance of concretes and the constituents that they are composed of at scales ranging from the nano-level to the macro-level. There are a vast number of topics in testing and analysis that could be included in this area as related to the physical and chemical properties of aggregates, cements, pozzolans, admixtures, fibers, and their interaction during the mixing, placing, curing, and service phases of a concrete. This could include but is not limited to: 1. Developing test methods and analysis techniques to better quantify material properties at aggregate-paste and fiber-paste transition zones.

  2. Developing tools, test methods and analysis techniques to non-destructively define the spatial distribution of components in a concrete specimen.

  3. Developing better assessment tools and criteria for predicting durability and longevity of concrete and grout.

  4. Developing better methods to define and classify chemical admixtures by chemical composition and mechanism of performance.

  5. Developing innovative systems to construct concrete materials and structures more economically.

  6. Developing theoretical, computational, and experimental methods for effectively characterizing stress, strain, progressive damage, and fracture of engineering materials subjected to static and dynamic loads.

• Q. Maintenance, Repair, and Rehabilitation of Concrete (GSL-17)

  Forensic analyses such as assessment of remaining life, maintenance and minor remedial measures, repair and rehabilitation, and surveillance and monitoring are topics of interest. Structures of interest include concrete locks and dams and appurtenant concrete and steel structures (outlet works, retaining walls, gates, piles, bulkheads, tunnels, intakes, etc.), other horizontal and vertical concrete infrastructure, and metals and polymer systems related to those concrete components.

• R. Other Areas of Materials Research (GSL-18)

  Research is needed in the development, properties, and performance of a range of materials for military and civil applications. Needed materials research for concrete applications includes such materials as: curing compounds, coatings, and overlays; polymers or other agents for improving bond between old and new concrete; water stop materials for use in hydraulic structures, and methods for characterizing and testing such materials; grouts for injection underground in very fine fracture systems or porous media; organic and inorganic composites that are used in construction; and grout materials and technologies for waste-disposal and containment such as for both commercial and defense-related low-level and high-level radioactive wastes.

  Other materials research needs include the development, testing, and prototyping of metals, composites, or other novel materials exhibiting advanced mechanical, thermal, rheological, chemical, electrical, and multi-functional properties, and performances. Research is performed on energy absorbing materials for impact, ballistic and blast resistance; hierarchical, multi- layered, and functionally graded material systems; multi-scale reinforcement for macro performance; self-sensing and self-healing materials; and materials demonstrating advancements in durability, high strength-to-weight, fatigue resistance, and ease of application.

• S. Bridge Research (GSL-19)

  Research is conducted in support of the Army’s Dams and Transportation Infrastructure Program, specifically the Bridge Safety and Waterfront Facilities subcomponents. Research covers design, construction, maintenance, repair and inspection procedures of Army bridges and waterfront facilities worldwide as well as other engineering functions as they relate to transportation structures. This involves the formulation of engineering criteria for the design, construction, evaluation, maintenance, and rehabilitation of permanent and expedient bridge and port facilities. Research areas of interest include improved inspection procedures, material characterization and evaluation, nondestructive testing, rapid repair, scour, unknown material properties, unknown foundations, traffic safety, underwater inspection, fracture critical and fatigue evaluations, load capacity, load testing, and load ratings.

• T. Structures Research (Civil Works) (GSL-20)

  Research is conducted in assessing the performance of critical structures to extreme loads, such as those resulting from seismic, terrorist attack, and storm events, as well as the effects of flow-induced vibrations. Efforts include assessing sensitivity of structural design and analysis procedures, vulnerability of structures, and critical design parameters to develop appropriate load-resistance factors. Techniques for retrofit, including use of new and innovative materials, of structures to resist extreme loads is of interest. Also, a better understanding of long-term behavior and deterioration of civil structures is needed, including factors such as material interactions, thermal stresses, and any issues affecting design of new structures and operation and maintenance of existing structures.

  Nonlinear and linear system identification research includes vibration testing, data acquisition, data processing, and analysis techniques for determining linear and nonlinear dynamic and static response properties of structures and structural systems subjected to earthquakes, blast effects from mining (or other) operations, other transient random, harmonic dynamic loads, and static or pseudo static loads.

• U. Structures Research (Military) (GSL-21)

  1. Research is needed on the response of aboveground and shallow-buried structures subjected to military dynamic loads; specifically, the prediction of the load and response to failure of aboveground and shallow-buried structures. This effort will involve the following research:

  a. Development of techniques to simulate military dynamic loads on aboveground and mounded structures.

  b. Development of design procedures for components in semihardened and protected facilities.

  c. Analysis of structural loading and damage resulting from internal or external detonations.

  d. Development of fast-running models for PC based applications to predict the response of structures, both hardened and unhardened, to single and multiple explosive detonations.

  2. Research on deeply based structures and hardened existing systems involving the following:

  a. Development of comprehensive structural design for deeply buried and surface-buried structures subjected to air blast-induced and direct-induced ground shock from surface and shallow earth-penetrating high-energy sources.

  b. Formulation of computer models for SSI and pre- and post-test analysis of structural response to include correlation and comparison with experimental data.

  3. Research on surveillance and intrusion detection sensors involves the constraints of the environment on sensor systems used to detect intruders and placed along the perimeter of high-value military installations. Improved methods for rapid and accurate measurement of predetermined influential environmental parameters must be developed. Analytical techniques relating to specific sensing phenomenology’s and target/nontarget-generated signatures and signature wave interactions to variations in environmental characteristics are required. Of particular interest is the integration of multiple sensor systems (both detection-type and environmental/background monitoring transducers) that use various sensing phenomena for enhanced target detection and classification and increase nuisance and background signature rejection. Research studies are required in the determination of automated techniques for monitoring sensor system response and sensitivity to provide optimum and consistent performance as a function of time varying changes of influential environmental characteristics.

  4. The Corps of Engineers is involved with research on the design of military facilities for protection from high-energy sources. These efforts include the following research:

  a. Prediction of the response of structural elements common to conventional or expedient construction to military loads.

  b. Methods of retrofitting conventional buildings to harden them against nearby military high-energy sources.

  c. Development of innovative design of structural components, such as windows and doors, subject to high-energy sources.

  d. Development of analytical methods for predicting the effects of forced entry devices on structural components.

  e. Development of innovative designs using low-density materials for expedient protection of troops and equipment from the effects of military high- energy sources.

  f. Development of microprocessor-based software/hardware and supporting documentation to aid in the assessment of structural survivability to the effects of conventional and advanced weapons systems. The software will address the integration of databases, weapons effects calculations, and operational factors associated with engineer survivability missions.

  g. Development of a procedure to ensure robust codes, user-friendly interfaces, and supporting documentation for use in the testing and development of microprocessor-based survivability and structural assessment software/hardware.

  5. Composite Materials for Force Protection-Research in this area includes developing, characterizing, modeling, and testing of layered composite materials for protection against air blast and penetration/fragmentation. These materials are intended for use in lightweight expedient protective systems to protect against improvised explosive devices and conventional weapons such as small arms, standoff weapons, fragmenting weapons, and shape charges. It is envisioned that panels of these materials could be incorporated into protective structure designs to increase survivability of personnel or to protect mission-critical assets. Performance measures include such attributes as build time, low mass, cost, penetration resistance, ductility, and environmental durability. Additionally, this topic area includes methods to develop appropriate material anisotropic and or non-homogeneous material models for incorporation into advanced computational models such as Abaqus, LS-DYNA, and EPIC. Protocols for evaluation and performance testing of composite materials subjected to energetic, high-strain rate events are desired.

  6. Worldwide Construction Practices- This research includes capturing typical construction practices and construction material properties worldwide. Information of interest is material properties of structural components, building types and construction techniques, building footprints, construction timeframe/era of buildings, and location of the building (country, world region, urban terrain zone).

• V. Multispectral Camouflage Research (GSL-22)

  This research area involves all aspects of fixed-facility survivability incorporating signature management and other technical effects. Fixed facilities include stationary and relocatable high-value targets. The general goal is to directly and indirectly increase the survivability of U.S. and Allied facilities and improve the U.S. and allied counterintelligence, Surveillance, and Reconnaissance (counter-ISR) capability against adversaries. Multispectral refers to those areas of the electromagnetic spectrum used by the United States and potential adversaries in reconnaissance and surveillance and in attack platform target acquisition and detection. Major objectives include: quantifying or otherwise evaluating counter-ISR technology effectiveness; investigating materials and techniques for signature modification; developing technical effects and physical countermeasures, procedures, and applications; developing computer-based analytical procedures for simulating scenes; developing instrumentation for and conducting target/background signature measurements; assessing the United States and threat operations and sensor capabilities with both currently fielded and new design reconnaissance and surveillance and attack platform sensors and systems; developing applications for intelligence information for military missions; providing guidance to field commanders and information for the RDT&E community; and studies of the interaction of camouflage technology with other operational factors, particularly in determining operational supportability, costs and manpower, interoperability, and joint interoperability requirements.

• W. Advanced Maneuver Technologies (GSL-23)

  This research addresses ground vehicle maneuver in urban environments which poses many new operational and tactical challenges for the Army and Joint Forces. While many improvements have been made in protecting ground vehicles in the last decade, these improvements come with a cost, namely limited situational awareness due to reduced visibility and limited maneuverability in tight spaces because of larger vehicle size. Both of these constraints seriously reduce the mobility of ground vehicles in urban environments. To address these constraints, research is needed to develop technologies to identify nearby dynamic hazards for ground vehicles in urban environments and provide early warning to ground vehicle operators or autonomous driving systems. Specifically, this research will address methods and procedures to develop advanced technologies that will be used for detecting dynamic hazards in urban environments such as traffic flow rates and congestion, pedestrians, buried threats, constricted roads, and other obstacles or anomalous objects in real-time. In addition, further research is needed to develop technologies that will deliver the information in a consolidated or data excerpt manner and report the locations of interest and concern to the driver and or operator. The performance of emerging technologies in sensors and data processing to provide better situational awareness in near real-time to ground vehicle operators maneuvering in dynamic urban terrain is also of interest.

• X. Railroad Technology (GSL-24)

  Research in this area is conducted in support of the Corps mission to design, construct, and operate railroad systems worldwide. This research includes railroad design, construction, inspection, evaluation, maintenance, and rehabilitation. Research areas of interest include advanced and composite materials, rapid repair, non-destructive evaluation, geotextile use in construction, in-situ additive manufacturing of components, soil stabilization, GIS, and remote assessment.

Environmental Sensing

• Overview

  Current research is in the acquisition of information by remote sensor systems, the impact of the environment on imaging and other sensor systems, and advanced signal processing. Sensors using electromagnetic, seismic, and acoustic energy forms are of interest. In addition, work is conducted to determine terrain and other environmental effects on high- technology sensor systems. Sensor systems include optical and infrared millimeter wave (active and passive). Briefly described below are specific research areas.

• A. Sensing (EL-1)

  The EL has an ongoing program to develop and demonstrate advanced technologies that support the Army’s requirements for improved detection and discrimination of unexploded ordnance (UXO), depleted uranium (DU) munitions, radiological threats, and deployment platforms. Additional research work is needed for subsurface (land-based) and underwater (proud and buried) UXO sensing, data analysis, display, and platform navigation/positioning. Special areas of interest include novel sensing concepts for the detection and relocation of buried objects (DU, metallic, and nonmetallic targets) using magnetic, electromagnetic induction, ground penetrating radar, seismic/acoustic, chemical, and/or radiological methods or a combination thereof. Fundamental measurements and models that define/predict the performance of these sensing methodologies in varying environmental conditions for UXO, DU and radiological targets are also of interest. Research is also needed to develop advanced data analysis techniques that can significantly reduce the number of false positives arising from natural anomalies and man-made sources.

• B. Environmental and Military Sensing (EL-2)

  1. Research in this area includes basic and applied research to develop environmental sensing, characterization, and monitoring capabilities necessary to quantify environmental site conditions and trends at local and regional scales. In the military area, research is conducted on basic signature research, to better understand target and environmental background signature characteristics.

  2. Specific areas of required research include:

  a. Development, integration, and application of remote sensing technologies and the use of these data in geospatial models to characterize site conditions over large areas.

  b. Development of innovative data fusion approaches, particularly the combined use of hyper spectral and bathymetric and/or topographic LIDAR data for the extraction of environmental information.

  c. Research to identify, model, and mitigate the effects of the environment on novel sensing techniques that address environmental and military requirements.

  d. Development of ground-based and airborne remote sensing approaches, and associated modeling, for unexploded ordnance detection, minefield detection, military targets and vehicles, and smart weapons development.

  e. Rapid collection, analysis, and visualization of sensor data for environmental quality and military applications.

• C. Environmental, Sensing, Characterization, and Modeling (EL-3)

  There is growing need to utilize and develop artificial intelligence (AI) and machine learning (ML) technologies for enhanced characterization of forested environments. Novel technologies should leverage remotely sensed and high fidelity in-situ data to improve understanding of complex forest conditions. Numerous benefits for military defense, environmental stewardship, forest resource monitoring and evaluation, and military readiness exist from identifying, quantifying, visualizing, and understanding forest data. Research is needed to capitalize on recent developments in AI-based big data analytics to characterize forests and forest-dwelling species and habitats data to better understand vegetated ecosystems that is traditionally obtained through in situ sampling. Research is needed to capitalize on recent developments in AI based big data analytics to characterize forests and other ecosystems.

  Specific areas of required research include:

  a. Developing novel forest modeling frameworks that utilize remote-sensing and in-situ field data to inform and validate forest characterization—to include vertical stratification.

  b. Quantifying forest characteristics and associated forest-dwelling fauna—to include threatened and endangered species. Provide specialized expertise in the application and deployment of advanced environmental sensors to detect and monitor rare and sensitive species—particularly focused in tropical forested habitats.

  c. Demonstrated experience deploying, managing, and analyzing data from remotely deployed autonomous environmental sensor platforms, including paired acoustic/visual monitoring systems such as Autonomous Recording Units (ARUs), omnidirectional microphones, trail cameras, and related technologies to document rare and sensitive species presence, behavior, and responses to anthropogenic noise disturbances and military training activities.

  d. Tailoring sensor arrays to rapidly detect, evaluate, and quantify both acoustic and visual data in Pacific Island forested ecosystems.

• D. Environmental Instrumentation (EL-4)

  1. Research and development in this area includes basic and applied research and technology demonstrations that support rapid measurement of biological and chemical hazards of the environment.

  2. Specific areas of required research include:

  a. The integration and interoperability of environmental instrumentation with future and existing military robotic systems: this includes unmanned aerial systems, ground robotics, autonomous submersibles, and robotic surface watercraft.

  b. Provide new applications that support faster processing on small low-power hardware to triage environmental measurements to immediately identify biological and chemical hazards.

  c. Techniques that support biomimicry in robotic systems and the differentiation of biotic from abiotic systems. Instruments that are low-power, small, and compact to assess the biological and chemical characteristics of water, soil, and air, in surface and subterranean environments.

  d. Research into sensing of aerosols and/or plumes from either ground or airborne platforms.

  e. Research into novel uses of unmanned aerial systems for environmental characterization and change detection - including fusion of active and passive modalities.

Contaminated Site Characterization, Assessment & Remediation

• Overview

  An extensive research and development program is being conducted by the Department of Defense to assist in the cleanup of contamination at military installations. The EL is developing technologies for characterizing, monitoring, and applying physical, chemical, and biological treatment of toxic and hazardous waste in contaminated surface and ground waters and soils. The EL is also developing, evaluating, and verifying numerical models and guidance for solid waste disposal systems.

• A. Innovative Technology for Environmental Sensors and Tools. (EL-5)

  The EL has an ongoing research program to develop advanced technologies for environmental sensing, characterization, and monitoring in order to quantify environmental conditions at sites of interest. The program is actively developing field-based tools and sensors to conduct rapid site characterization/screening for environmental contaminants. Additional research is needed in the areas of novel sensing technologies for detection of chemical and biological contaminants allowing for rapid field-based data acquisition. Also, research is needed to develop technologies and platforms allowing for rapid data analysis/interpretation/reporting. Fundamental measurements and models that define/predict the performance of new sensing methods in soil, water and air are also of interest.

• B. Innovative Technologies for Treating Contaminated, Sediment, Soil, Surface Water, Ground Water, and Hazardous Waste (EL-6)

  Presently, EL is continuing to conduct research, develop technologies and apply strategies to treat complex organic- and metal-contaminated hazardous liquids, off-gases, soils, sludges, sediments, and residuals from past disposal practices. Research is divided into two major categories: technologies for treating contaminated soils and sediments, and innovative technologies for treating contaminated surface and ground waters. Areas of R&D include: (1) physical and chemical technologies to destroy/detoxify or reduce the quantity and/or toxicity of the contaminated materials, (2) biological processes and methods to detoxify/destroy hazardous waste constituents, (3) techniques for in situ treatment of groundwater aquifers, (4) laboratory design criteria for and field implementation of piloting equipment for promising technologies, (5) computer-based techniques to assess operational performance of various treatment processes/systems and (6) improved analytical chemistry techniques and methodology to assess treatment technologies.

• C. Design, Evaluation, Verification and Modeling of Solid and Hazardous Wastes and Contaminated Sediments (EL-7)

  Efforts are continuing to develop water balance and leachate models for solid waste disposal systems and dredged material disposal facilities. Additional work is needed to model innovative designs, nonsoil surface materials, cobbled surfaces, preferential flow through heterogeneous waste materials and other layers, and effects of complex mixtures of vegetation including trees. Similarly, additional work is needed to verify the existing models.

Sediment Geochemistry and Biological Effects

• Overview

  Potential adverse environmental impacts of disposal of contaminated sediments must be assessed prior to permitting operations. This includes the determination of the impacts that contaminated dredged materials exert on the environment prior to dredging.

• A. Environmental Risk Assessment (EL-8)

  Current research on the fate and effects of environmental contaminants occurs under the general paradigm of Environmental Risk Assessment. Specific studies fall into one or more of the following areas:

  1. Hazard Identification. This is the process of showing causality (i.e., a chemical or complex mixture can cause some adverse effect). If this causality can be demonstrated, the chemical is referred to as a "hazard." If there is no causal link, risk need not be quantified. Important target receptors are also identified by this stage (for example, humans, endangered species, and ecologically or economically important species). Research is conducted to develop the technology for hazard identification and the establishment of causality.

  2. Effects Assessment. While Hazard Identification decides if a chemical or complex mixture is toxic; Effects Assessment establishes the relationship of the toxicant dose and associated biological response. This is accomplished via experimental research in which surrogate species are exposed to gradients (spatial, concentration, etc.) of the hazard in question, and biological effects are monitored. Biologically important endpoints measured include survival, growth, reproduction, and population-level parameters. These endpoints must be accompanied by technically sound interpretive guidance. Results are expressed in dose- response or exposure-response relationships. Research is conducted to develop the necessary experimental/statistical designs, technically sound tests (for example, chronic sub lethal sediment bioassays) and appropriate extrapolations (for example, high dose to low environmentally realistic exposures, and surrogate test species to receptor of interest). Analysis of the uncertainty associated with these effects assessments is also conducted.

  3. Exposure Assessment. In Exposure Assessment, the magnitude, frequency, and duration of contaminant exposure relative to the target receptor(s) are determined. This research is model-intensive, with both descriptive and quantitative models being used to evaluate pathways and routes. A pathway exists if the hazard travels between the initial source of contamination and the ultimate biological receptor. An exposure route is pathway that the chemical contacts the receptor (for example, ingestion, inhalation, dermal absorption, bioaccumulation, trophic transfer). Analysis of the uncertainty associated with these exposure assessments is also conducted.

  4. Risk Characterization, Management, Communication, and Analysis. Outputs from the Effects Assessment and Exposure Assessments are joined in Risk Characterization to yield an estimate of risk. Research is conducted to determine the best ways to characterize risk both numerically and descriptively. Also, uncertainty analysis is undertaken to identify the qualitative and quantitative important sources of uncertainty. Techniques employed include error propagation, probability distributions, sensitivity analysis, Monte Carlo simulation and others. Once environmental risk has been quantified, management action may be required.

  5. Research is conducted to develop management alternatives, which range from no action to extensive (and expensive) remediation. Results of the Environmental Risk Assessment are weighed and balanced with other factors such as applicable laws and regulations, engineering feasibility, potential benefits, costs, economic impacts, and the socio-political decision environment.

  Risk Communication is a dialogue that occurs at two levels: between the risk assessor and the risk manager, and between the risk manager and the public. Research is conducted to identify optimal procedures for communicating environmental risks, including an appreciation for the limits and uncertainties of the numerical results. Risk Analysis is a broad, inclusive term encompassing the processes of Risk Assessment, Risk Management, and Risk Communication as well as any field verification or monitoring activities. Field verification is a study or studies carried out to determine the accuracy of laboratory observations and predictions. Field monitoring (in the context of Risk Assessment) is undertaken to ensure that steps taken to manage the chemical risks were successful. Field research studies are carried out for both verification and monitoring purposes.

  6. Engineering With Nature® (EWN®) Research Supporting Innovative Field Sampling Practices, Natural Infrastructure (NI) Construction/Deployment and Related Technologies. Conduct a broad array of EWN research and development that may include, but is not limited to: research pertaining to placement of scientific instruments and/or pursuit of novel experiments that advance field-based sampling and laboratory practices for the purpose of measuring and archiving the performance of natural infrastructure (NI); conduct research and/or test innovative instrumentation that records/monitors natural and engineering processes resulting from the placement of NI and/or hybrid infrastructure; conduct research and test new technologies that result in accelerated construction/placement of natural and nature based features and/or improved placement strategies for dredged sediment used to construct EWN projects.

  7. Technology Transfer Development for Engineering With Nature® (EWN®) Research Areas. Research, develop and analyze technology transfer concepts; analyze target audiences for technical information; test innovative methods of transferring EWN research results and technology to supplement conventional technology transfer. Included may be such items as interactive internet and PC technology applied to training and general information transfer; technology applications of electronic media using the Internet; and innovative public information systems/products. Audiences include Corps of Engineers and the Department of Defense; Congress and other Federal, State, and local agencies; port and transportation authorities; universities; environmentalists and other public interest groups; and the general public.

• B. Sediment Water Interactions (EL-9)

  Sediment/Soil Water Properties. Current research encompasses a wide range of investigations designed to increase understanding of sediment-water interactions. Emphasis is on conduct of investigations for determining the impacts that sediment/soil properties have on sorption and transformation of explosives and release of semi-volatile contaminants to the atmosphere. Factors responsible for sorption and transformation of explosives include redox potential, pH, and the geochemical characteristics of the soil or sediment. Factors affecting the release of semi volatile contaminants from soil or sediment to the atmosphere include relative humidity, wind speed, contaminant concentration, moisture content, porosity, and organic carbon content. Research is also conducted on colloidal system contaminant transport, accelerated sediment oxidation, and the role of solution chemistry in contaminant partitioning between sediment and water.

  Diverse research activities focused on characterizing microorganisms and microbial communities in natural and engineered environments relevant to contaminant transformations, biogeochemical cycling, host-microbiome-contaminant interactions, bio- enabled materials, synthetic biology, and environmental biological threats are currently underway.

  1. Biodegradation of Contaminants. Studies in the biodegradation area emphasize destruction of organic contaminants for remediation purposes. Emphasis is on (1) bioinformatics of microbial community diversity and activities in various ecosystems; (2) delineating biodegradation pathways, enzymes, and genes; (3) determining intermediate and final end- products; (4) assessing the role of environmental and genetic factors regulating the pathways utilized and the rate and extent of destruction of the parent compound; (5) determining the survival and activity of microorganisms added to ecosystems, and biotreatment systems; and (6) enhancing biodegradation to obtain the maximum destruction of organic contaminants within a soil, sediment, or treatment system.

  2. Microbial Sensing. Novel microbial, cellular, molecular and/or genomic approaches are sought and developed for the rapid functional and DNA-based identification, detection, and monitoring of microorganisms in various environmental matrices including soils, sediments, and surface waters. Novel ecological approaches to detect, monitor and predict prokaryotic/eukaryotic microbes are sought that combine physiology, molecular tools, biochemistry, modeling, and remote sensing for the management of high biomass events and environmental toxins.

  3. Biomaterials and Composite Structures. Novel biological materials and/or techniques are sought to manipulate bioprocesses and biomineralization pathways as additives to aggregate and composite products. These products will support advancements in material structural properties that support civil works and military operations.

  4. Insect and plant field collections, insect husbandry, plant maintenance with greenhouse access is sought for various microbiome projects. Needs will be seasonal and very specific to limited insect or plant systems as dictated by internal projects.

  5. Soil, Sediment and Environmental Chemistry. Research interests broadly center on deciphering environmental processes that shape the emergent chemical, physical and biological properties of soils and sediments in natural and built environments. Studies aim to bridge the gap between fundamental science and practical engineering solutions to enhance understanding of environmental processes, improve infrastructure resilience, and promote sustainable practices in soil and sediment management.

  a. Geochemistry of Soils and Sediments. Topics of interest include understanding i) the cycling of nutrients, metal(loid)s, and radionuclides in soils and sediments, ii) the impact of dynamic chemical conditions on soil physical properties, and iii) complex interactions between chemical reactions and dynamic fluid flow (reactive transport). Of particular interest are soil systems impacted by seawater inundation, wildfire, and other natural and anthropogenic disturbances, which alter the productivity, erodibility and trafficability of soils, and soil characteristics that influence military operations and natural disasters. Studies employ the use of novel field measurements, laboratory experiments, and advanced methods of soil analysis, such as synchrotron-based X-ray absorption spectroscopy, -X-ray diffraction, and X-ray fluorescence microprobe analysis. Molecular to field-scale processes occurring in soils and sediments are modeled using computational tools such as geochemical and reactive transport modeling.

  b. Soils and Sediments in the Built Environment. Research broadly focuses on the function and characteristics of soil and sediment within built environments, including dynamic urban coastal zones. In the built environment, soils and sediments are altered by human activities and/or derived from human-transported materials. Anthropogenic impacts on soil may be intentional (e.g., engineered for a specific purpose) or unintentional (e.g., accidental release of waste). Our research aims to decipher both intentional and unintentional consequences of anthropogenic activities on the health and function of soils and sediments. Focus area includes (1) standardizing approaches to soil health assessment (2) methods to enhance soil functions in nature-based features such as carbon sequestration and water retention, and (3) fate of legacy contaminants such as lead.

• C. Techniques for Contaminated Dredged Material Disposal and Treatment (EL-10)

  1. Development/implementation of innovative technologies to reduce or eliminate contamination present in surface sediment and/or dredged materials. Research to include 1) technologies for cost effective in situ treatment of surface sediments to reduce bioavailability/toxicity; 2) ex situ treatment technologies to reduce contamination and facilitate expanded opportunities for beneficial use of treated material.

  2. Development or enhancement of computer models to be included in the Automated Dredging and Disposal Alternatives Modeling System (ADDAMS) to evaluate the environmental impacts of dredged material disposal. Evaluations include water quality impacts of initial release in open water, effluent discharge, runoff and leachate, benthic impacts, plant and animal uptake, and volatilization.

  3. Development and/or application of new or improved environmental chemistry methodologies to assess contaminant concentrations of dredged material and other complex matrices (e.g., elutriates, bioaccumulation tissues, etc.) focusing on specific compounds or classes, cost effectiveness, quality assurance, lower detection limits, and removal/reduction of challenging matrix interferences.

• D. EMERGING CONTAMINANTS IN THE ENVIRONMENT (EL-11)

  1. Presently, EL is continuing to conduct research, develop technologies and apply strategies to address emerging contaminants (ECs) in the environment. Research falls into for 5 broad categories:

  a. Detection and Measurement:

  b. Development and application of technologies for the detection and measurement of ECs in environmental media at environmentally relevant concentrations.

  c. Application of innovative technologies to discern source of EC contamination.

  d. Screening level methodologies to facilitate near real time detection and measurement of ECs in the field.

  e. Development of forensic methodologies and computational approaches for detection, measurement, prediction of EC precursors and/or degradation products in environmental media.

  2. Exposure Assessment:

  Development and application of technologies for measuring/predicting the movement and fate of ECs in the environment.

  3. Effects Assessment:

  Development and/or application of technologies for establishing the effects of ECs on important ecological and human health receptors/endpoints.

  4. Risk Characterization/Management:

  a. Development and/or application of innovative technologies for characterizing risk of ECs in environmental media. Development and/or application of decision-making tools to support EC related risk management decision-making.

  b. Development and/or application of innovative technologies to remove, concentrate, and/or destroy ECs in environmental media.

  c. Development and/or application of innovative technologies to assist in identification of safer alternatives.

Environmental and Water Quality Modeling

• Overview

  The Corps of Engineers is involved in research and development related to water quality and contaminant fate/transport modeling for surface water, watersheds, and the subsurface, or groundwater. This encompasses a wide range of environmental issues, such as water quality and ecosystem linkages, contaminant transport and fate, eutrophication, effects of land use/management on watershed runoff quality, total maximum daily loads (TMDLs), and ecological and human health risk assessment as related to contaminants in the environment. Research may include model development and field and laboratory investigations to improve model descriptions and to provide required data for model validation.

• A. Numerical Water Quality and Contaminant Modeling (EL-12)

  This area of work is oriented toward development and application of water quality and contaminant fate/transport models for surface water and the subsurface, or groundwater. Surface water modeling includes watersheds and receiving waters, e.g., riverine, reservoir, wetland, estuarine, and coastal water bodies. Groundwater modeling includes modeling both the unsaturated and saturated zones, as well as multi-component flow and transport. Models are utilized for conventional water quality (e.g., nitrogen, phosphorus, carbon, dissolved oxygen, etc.) and contaminants, i.e., toxic substances, such as organic chemicals, trace metals, radionuclides, explosives, and other military unique compounds. Emphasis includes the following: formulation of appropriated physical, chemical, and biological algorithms; improvement of mathematical and numerical methods; collection and assemblage of data for model evaluation; conduct of field and laboratory process investigations designed to develop/improve model descriptions, dynamic linkage of water quality and biological models, including biomass-based, individual-based, and population- based biological models; integration of contaminant exposure models with biological effects data or models to quantify risk; incorporation of uncertainty analysis into modeling; linkage of physical/chemical models with biological population models; linkage of cross- domain models for system wide modeling; development of routines/linkages to include the effects on water quality of watershed landscape features (e.g., buffer zones) and vegetation management; development of a risk assessment modeling system; and development of software to provide graphical user interfaces and modeling environments to enhance model utility and ease of application.

• B. Complex Adaptive Systems (EL-13)

  The central goal of this effort is to identify the rules and feedback processes that govern how interactions between modular components in natural system shape important holistic properties, like the global resiliency to disturbances, and, invariably, the fate of the individual components themselves. These tasks are central to basic research efforts in Complex Adaptive Systems (CAS); an area that impacts a wide range of critical needs in both military and civil works (e.g., immune system responses, decision-making, social feedbacks, and ecosystem management). Current research focuses on ecological systems in which the use of different species and study systems is encouraged to provide diverse and novel solutions to understanding, predicting, or improving the resiliency of complex systems. Recent case studies range from a contaminant’s (e.g., altered water quality, noise, chemical) impacts on individual development and performance, the social roots of information cascades in social vertebrates (spanning from fish and humans), to overall ecosystem functioning based on infrastructure design, overharvesting, or mismanagement. This topic area is inherently interdisciplinary and emphasizes team efforts in the combination of analytical, numerical, and laboratory experiments to test competing hypotheses.

• C. Water Quality and Behavior Modeling (EL-14)

  This research topic focuses on developing early warning indicators to demonstrate how changes in water quality can affect critical ecological processes, thereby raising the subsequent risks imposed on animal populations. We focus on demonstrating when environmental quality is not merely a potential hazard, but how it elicits a functional (e.g., physiological) change during early exposure stages that can impact future performance and, invariably, population survival. Anthropogenic disturbances would include sediment plumes, temperature spikes, or contaminants. Animals typically display stable and, generally, predictable physiological and behavioral patterns in non-stressful conditions.

  However, sub- lethal (including chronic) or acute environmental changes can drastically alter behavior and activity, remain undetected, and invariably introduce unacceptable levels of error in model predictions. Current methodologies range from simple bioassays to more complex physiological consequences at the individual level, to long-term costs/benefits at higher ecological levels (i.e., habitat use, populations, and communities). Hypothesis testing based on a combination of laboratory and modeling is encouraged, along with field data when possible. Findings from these efforts play an important role in both civil works and military activities.

Environmental Impact Prediction, Assessment and Management

• Overview

  This research program addresses environmental impact prediction, assessment, and remediation and is intended to provide Corps, Army, and other field operating elements with techniques and methodologies for environmental assessments and EIS preparation, guidance on selecting appropriate planning, design, construction, and operation alternatives, and implementation of the planning function pursuant to NEPA and other legislation and guidance. Specific objectives include:

  A. Developing, verifying, and demonstrating practical prediction and assessment techniques including applying and refining habitat-based evaluation methods, evaluating mitigation measures, developing streamlined frameworks for environmental monitoring, applying ecosystem simulation principles to environmental analysis, and estimating future habitat quality.

  B. Documenting and quantifying environmental effects associated with various types of Corps, Army, and other activities. Research has included the effects of aquatic habitat modification on anadromous fishes, the effects of selective clearing and snagging on in stream habitat, and t h e benefits of channel modification for aquatic habitat in reservoir tail waters and local flood control channels.

  C. Developing and demonstrating design, construction, and management alternatives that will minimize adverse effects and protect natural and cultural resources. Research has included techniques for managing wildlife habitats, preserving archeological sites, and stabilizing eroding shorelines.

  D. Developing, validating, and demonstrating novel systems biology-, computational biology- or bioinformatics-based approaches to understanding and quantifying toxicological impacts of environmental contaminants in environmentally relevant organisms.

• A. Biotechnical Shore Stabilization (EL-15)

  Biotechnical (sometimes called bioengineering) shore stabilization is the use of a combination of live vegetation and structural materials (for example, breakwaters, geotextiles, erosion control fabrics/mats, building materials) for erosion control of shores. Shores of particular interest are those of streams, lakes, or dredged material deposits and subject to erosion from waves, surface runoff, and wind. Research is needed to determine the causes and amounts of erosion and to identify and assess cost-effective biotechnical erosion control methods. Studies may include, but are not limited to, identifying, developing, and cultivating appropriate flood- tolerant plants and varieties or cultivars and cost-effective installation procedures of biotechnical techniques.

• B. Freshwater Fishery Investigations (EL-16)

  Primary areas of research are predicting environmental impacts of navigation and flood control projects on fishes, freshwater mussels, and other aquatic fauna; benefits of restoring aquatic habitat including environmental flows; conservation of endangered fish and mussel species; evaluating freshwater and coastal wetland fish communities; management of invasive species movement and colonization including Asian Carp; and fishery management in vegetated waterbodies. New and innovative approaches to determine physiological, behavioral, population and community level responses of fishes to habitat variables are of interest, along with technological advancements in sampling and multivariate data analysis capabilities. Demographic and landscape habitat models are anticipated products of this research.

• C. Freshwater Macro invertebrate Investigations (EL-17)

  Research focuses on assessment of aquatic and terrestrial invertebrate communities, with emphasis on insects and mussels. Studies include stream and river biotic assessments, terrestrial and aquatic insect surveys, assessment of threatened and endangered invertebrate populations, feeding ecology of fishes, and evaluation of stream and river food webs and energetics. Assessments of environmental effects of USACE activities, including stream and river impoundments and structural changes, are also performed using naturally occurring macroinvertebrate and mussel communities as indicators of current and past ecological shifts. Restoration and management recommendations are also made through the analysis of these invertebrate communities in both freshwater and terrestrial ecosystems. Technical and analytical advancements, including sampling and data analysis are of interest.

• D. Mitigation (EL-18)

  An avoidance, minimization, and/or compensation process is required for impacts from water resources projects on ecological resources (fish, wildlife, habitat, or installation activities). Planning and implementing mitigation are a complex process, and new ideas that contribute to success of mitigation are invited. Subjects such as Best Management Practices for avoiding or minimizing impacts, planning for mitigation based on impact analysis, incremental analysis to justify mitigation, mitigation banking, future predictions, and mitigation for indirect or cumulative impacts are included.

• E. In Stream Flow Requirements for Aquatic Biota (EL-19)

  Research focuses on development and application of fish habitat assessment methods. Currently, the most widely used system, the Physical Habitat Simulation System (PHABSIM), is used to assess the effects of reservoir operations on downstream fish habitat. Research is needed to better quantify the relationships for fish preference and flow conditions, as well as habitat requirements for aquatic invertebrates. When appropriate, laboratory-based studies can support field-based modelling efforts. Verification studies of these models will be required as development continues. Assessment methods must be able to evaluate the impacts of a variety of reservoir operations such as base load or peaking hydropower releases and at multiple scales from single project to basin – wide studies.

• F. Behavioral and Structural Fish Barriers (EL-20)

  Entrainment of fish at Corps hydropower projects may result in passage of fish through turbines with attendant death or injury from impact with runner blades, pressure changes, or shear forces. Evaluations of a number of behaviorally based technologies and structural barrier designs conducted under laboratory and field conditions have yielded results that are generally inconsistent. Consequently, there currently exist no consistent guidelines for selection of appropriate technology for site-specific applications at Corps dams. Research is required to relate effectiveness of different technologies to size and species of fish, dam design, operations, season, and other site-specific conditions. The information produced by this research will be used to develop specifications and guidelines for fish protection technologies at Corps dams to reduce entrainment and mortality. This effort may involve literature synthesis, laboratory research, design and fabrication of prototype systems, or field studies as well as simulation analysis of fish movement/passage patterns.

• G. Fish Guidance and Bypass Systems (EL-21)

  CE water resource activities may result in blockage of historical fish migration routes through waterways. These blockages, with associated fragmentation of habitats, may have severe impacts on anadromous and catadromous fish populations. A variety of bypass system technologies are available to guide fish around dams. However, many of these systems operate at reduced efficiencies because they damage fish, fish are unable to locate entrances to the systems, or because fish become disoriented and "fall back" after an initial successful passage. Research is required to better understand the hydraulic and behavioral characteristics of fish bypass systems, including the use of behavioral technologies to guide fishes towards these systems and to successfully orient them within the system.

• H. Coastal Ecology (EL-22)

  Research topics in coastal ecology include multidisciplinary investigations of the environmental impacts of engineering activities in the coastal zone, such as dredging, dredged material disposal, and construction of coastal structures (e.g., jetties, breakwaters, groins, seawalls, marinas). Emphasis is placed on improved technologies for assessment, protection, and management of fish and shellfish resources and their habitats. Of particular relevance are proposals dealing with endangered species (e.g., sea turtles, marine mammals), beneficial uses of dredged material and habitat restoration in the coastal zone (e.g., marsh, oyster reef or mudflat creation), and application of population dynamics and ecological models for impact prediction and assessment at population/community/ecosystem/watershed levels. Other areas of interest include effects of beach nourishment and use of offshore borrows areas, seasonal restrictions on dredging and disposal operations, artificial reef technologies, and cumulative impact determination and mitigation techniques.

  Other focus areas include:

  a. Effects of beach nourishment on benthic communities and surf-zone (near- shore) fishes,

  b. Active and passive fisheries acoustics to assess fish migratory patterns, spawning habitat, fish density and spatial distribution patterns near dredging operations and placement sites.

  c. Essential Fish Habitat (EFH) protection from increases in turbidities and suspended sediments.

  d. Fish entrainment

  e. Behavioral changes to marine organisms (e.g., migratory blockage of migratory fishes due to the presence of the dredge, particularly in narrow or constricted waterways).

  f. Underwater noise impacts to aquatic species due to dredging and disposal operations.

  g. Ecosystem restoration (e.g., filling offshore/near-shore borrow areas to natural bathymetry).

  h. Artificial reef creation using dredged rock and other suitable material to enhance fisheries and shell fisheries resources.

  i. Thin-layer placement, re-contouring natural bathymetries. Increased costs associated due to compliance with environmental windows/seasonal restrictions imposed on dredging and disposal operations, and cumulative impact determination and mitigation techniques.

• I. Techniques for Designing, Operating and Managing Dredged Material Disposal Facilities and Beneficial Use Projects (EL-23)

  1. Refinement and verification of techniques for designing, operating, and managing dredged material disposal areas.

  2. Development of a computerized economic database for costs associated with dredging sediments; disposing of dredged material; and constructing, rehabilitating, and operating and managing dredged material disposal areas.

  3. Development and refinement of computer models for dredged material management and beneficial use to be included in the ADDAMS.

• J. Systems Biology, Computational Biology, and Bioinformatics for Environmental Impact Assessment (EL-24)

  A wide spectrum of research in systems toxicology, biological networks, synthetic biology, predictive toxicology, genomics, bioinformatic data mining of next-generation sequencing data, adverse outcome pathway development, toxicological modes of action discovery, herbicide resistance mechanisms, structural biology, chemoinformatics, and molecular modeling is currently underway. Proposed research in mechanistic/predictive toxicology, structural biology, bioinformatics, or computational biology would complement current research areas.

  1. Novel genomics, epigenetics and synthetic biology approaches are sought and developed to assess biochemical, physiological, or other toxicological (adverse) effects on the biota at molecular, cellular, tissue/organ, individual, population, community, or ecosystems levels.

  2. Novel in silico modeling and data mining approaches that are based on computational biology, biophysical or bioinformatics principles and techniques are sought and developed to systematically analyze and interpret big data generated using cutting-edge and high- dimensional biotechnologies such as next-generation DNA sequencing, hybridization-based microarray, proteomics, and metabolomics technologies. Novel mathematical approaches and analysis methodologies are also sought to interpret or describe data generated using novel experimental protocols, and which may account for internal forces, energy and information flows that regulate biological, biophysical, or bioenvironmental processes.

  3. Tools for assessing environmental impacts of synthetic biology. This work involves identifying synthetic biology technologies and understand their current state of use, development, technology readiness, as well as their potential environmental impact. This includes hazard identification, effects assessment, fate, transport, and transferability of various technologies. Moreover, the work entails quantifying environmental impacts of synthetic biological technologies through experimental and modeling approaches. This includes establishing screening mechanisms for genetic and physiological traits for synthetically derived systems, microcosm experiments with tractable organisms to assess potential for spread/transfer of synthetic constructs.

Environmental Criteria for Stream Channel Alteration Projects

• Overview

  The Corps of Engineers is involved in the alteration of stream channels for flood damage reduction, navigation, channel stabilization, and ecosystem restoration, as well as alterations performed by others as part of the Clean Water Act. Modifications to channels include removal of snags and vegetation, channel alignment (straightening), channel enlargement, construction of levees, stream bank protection, and grade control. The Corps is also involved in regulating and furnishing technical assistance to States in regard to other types of channel alterations such as gravel mining. Work at the US Army Engineer Research and Development Center’s Environmental Laboratory (EL) and elsewhere has generated environmental design criteria for stream channel alterations to improve the net effect of these projects. Examples of environmental design features include low-flow channels, combinations of structure and vegetation, management of cutoff bend ways and other backwater areas, and recreational trails.

• A. Riparian and In Stream Habitat Restoration (EL-25)

  Current research includes formulating guidelines for stream restoration and environmental enhancement of flood control and aquatic ecosystem restoration projects. Among the general issues addressed are, in-stream and riparian habitat assessment; benefits of habitat improvement, structures, and techniques; impacts of vegetation on flow conveyance and/or sustainability, channel stability, and sediment transport; construction practices; and monitoring and maintenance. Proposals are invited in these general areas and related efforts. In addition, specific needs include the following: (1) Techniques to quantify habitat and other environmental benefits of restoration efforts, as well as quantification of adverse impacts to the aquatic environment, (2) Algorithms that account for momentum losses at vegetated floodplain/channel interfaces, (3) Data supporting evaluations of the hydraulic impacts of in-stream structures, (4) Development and refinement of related computerized databases and models, and (5) Calculating impacts to and identifying vulnerabilities of riparian systems.

• B. Assessing Benefits of Channel Modifications (EL-26)

  Dams and local flood control structures may degrade aquatic habitat conditions in tail waters and streams. In some cases, habitat degradation can be eliminated, stabilized, or reversed through channel modification for aquatic habitat (i.e., construction of low-cost, low head weirs to create pools) with minimal changes in dam operation or flood channel design. However, there are no widely accepted methods available to incrementally relate in stream aquatic habitat value, channel modifications, and in stream flows to allow trade-off analyses among cost, design, and habitat benefits. It is desirable to modify existing in stream flow methods or develop new methods that will allow incremental assessment of habitat values, alternative flows, and different channel designs. This work may involve data collection, analysis, interpretation, and software development.

More topics in progress (see solicitation for all topics).

Are there any additional benefits I would receive?

Beyond the direct funding, ERDC awards provide meaningful strategic advantages:

Government Validation and Technical Credibility:
Selection by ERDC signals strong alignment with U.S. Army and national infrastructure priorities, which can materially strengthen your credibility with customers, primes, and investors.

Non-Dilutive Technology Maturation:
Companies can advance core technology without equity dilution, preserving ownership while increasing enterprise value.

Long-Term Government Relationship Building:
ERDC BAAs are often a gateway into follow-on DoD contracts, reimbursable work, and sole-source opportunities.

Increased Visibility Across DoD and Civil Works:
Successful projects frequently expand beyond a single lab, creating exposure across USACE, DoD, and federal infrastructure stakeholders.

What is the timeline to apply and when would I receive funding?

This BAA is continuously open until January 1, 2027, and all submissions initially enter the process as pre-proposals. Pre-proposals may be submitted at any time through the ERDCWERX portal and are limited to five pages, plus a one-page executive summary.

ERDC conducts a preliminary technical review of pre-proposals as they are received. Offerors can expect a response within 60 days of submission, either encouraging submission of a full proposal or advising that the pre-proposal was not favorably reviewed.

If a pre-proposal receives a favorable review, ERDC will issue a formal invitation from the Contracting Office to submit a full proposal. Full proposals then undergo scientific peer review, cost evaluation, and funding availability assessment.

There is no fixed award cycle or batch deadline. Awards may be made at any time following successful evaluation and are subject to availability of funds.

Where does this funding come from?

Funding is provided by the U.S. Army Corps of Engineers (USACE) through its Engineer Research and Development Center (ERDC) and supported DoD research programs.

Who is eligible to apply?

Eligibility is unrestricted, meaning any qualified U.S. or international entity may apply, subject to statutory and regulatory requirements. This includes:

• For-profit companies

• Startups and small businesses

• Universities and nonprofit research organizations

What companies and projects are likely to win?

ERDC evaluates proposals based on:

• Clear alignment with ERDC mission and stated research areas

• Strong scientific or technical merit

• Demonstrated capability of the proposing team

• Practical relevance to military or civil works challenges

• Realistic scope and cost relative to expected outcomes

Are there any restrictions I should know about?

• ERDC may limit awards based on funding availability in specific technical areas

• Some projects may be subject to export control, security, or publication restrictions

• Proposals must clearly identify whether research is considered “fundamental”

• Full proposals must be submitted only through designated laboratory channels, not directly to technical staff

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive pre-proposal under this BAA will likely take 20–40 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available for a flat fee of $4,000 for the Pre-Proposal Submission.

Fractional support is $300 per hour.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

See solicitation on sam.gov