USSOCOM BAA for Extramural Biomedical and Human Performance Research and Development

Executive Summary:

United States Special Operations Command (USSOCOM) is awarding $2,000,000 to $10,000,000 for projects across defined Research Areas of Interest (RAIs) to advance biomedical, human performance, and canine medicine relevant to Special Operations Forces. This BAA is open continuously through 31 July 2028; applicants must first submit a pre-proposal via eBRAP and, if invited, a full application (generally within 60 days of invitation).

How much funding would I receive?

1. Typical project size: $2 Million to $10 Million

2. Program capacity: “Anticipated total costs… will not exceed $20 Million annually” across all awards funded under this BAA.

What could I use the funding for?

A primary emphasis of the USSOCOM Biomedical, Human Performance, and Canine Research Program is to identify and develop techniques, knowledge products, and materiel (medical devices, drugs, and biologics) to support far-forward early intervention of life-threatening illnesses or injuries within an Irregular Warfare or asymmetric, multi-domain operational environment. Special Operations Forces (SOF) medical personnel place a premium on medical equipment that is small, lightweight, ruggedized, modular, multi-use, and designed for operation in extreme environments. The equipment must be simple to employ, require minimum maintenance, and have low power consumption. Drugs and biologics should optimally not require refrigeration or other special handling. All materiel solutions must be capable of commercialization. Research projects may apply existing scientific and technical knowledge for which concept and/or patient care efficacy have already been demonstrated to meet SOF requirements. The proposed research must be relevant to active-duty service members, veterans, military beneficiaries, and/or the American public. Relevant research must be responsive to the health care needs of the U.S. Armed Forces, family members of the U. S. Armed Forces, and U.S. Veterans.

Proposals must address a relevant health problem responsive to one of the Research Areas of Interest below (Clinical trials are normally not funded by this BAA):

• Damage Control Resuscitation (DCR)

  SOF medical personnel require capabilities for far-forward medical care to reduce the mortality and morbidity associated with critical wounds and injuries. The proposed research, application, and/or development of medical techniques and materiel (medical devices, drugs, and biologics) for optimal triage and early intervention in critical life-threatening injuries when casualty evacuation is not possible or is delayed. The project areas under DCR to which the USSOCOM will give highest consideration are:

  • Global Treatment Strategies and Next Generation Wound Management:
    The proposed project must research, apply, and/or develop effective treatment strategies that address the following elements: resuscitation, optimal resuscitation fluid(s), uncomplicated shock, noncompressible hemorrhaging, traumatic brain injuries, and austere damage control surgery. These strategies must be optimized for medics in austere, far-forward areas, with minimal logistical or specialty support, who must stabilize and treat patients for extended periods (days, not hours). Projects that research and develop an all-in-one traumatic wound care treatment that can achieve hemostasis, and incorporate analgesia are preferred.

  • Analgesia:
    The proposed project must research, apply, and/or develop novel, safe, efficacious, peripherally, and centrally acting analgesia that provide easy administration in the field, tolerance of extreme environments, and effectiveness at the point of injury for a prolonged period of field care (days, not hours) and does not sensitize the patient to topical analgesia. Maximum analgesia with minimal sedation is preferred.

  • Far Forward Blood, Blood Components, Blood Substitute, & Injectable Hemostatics:
    The proposed project must research novel strategies to increase the ease, efficacy, and safety of blood transfusions (i.e., person to person, pre-hospital blood banking, rolling blood banks, and blood substitutes) forward of normal logistics support; (e.g., evaluating blood for type/cross matching and for the presence and/or reduction of pathogens, leucocytes, and AB antibodies to improve safety of whole blood transfusion at the point of injury). Projects that will be considered also include injectable medications to address the coagulopathy of trauma and novel strategies to improve tissue oxygenation.

  • Austere Surgical Stabilization:
    Future theatres where SOF personnel will operate are likely to be much less medically robust than the past decade of fighting in our current theatres (this can translate to remote civilian areas), and there will be a mismatch between capability and need. Rather than sitting at hardened structures waiting on patients, surgical personnel may be increasingly asked to go to the patient. Research should focus on mobility/portability of medical and surgical equipment, including support equipment such as sterilization, with emphasis on equipment with greater capabilities than currently fielded devices, smaller size and weight, low power demands, and flexibility in power supplies. Additionally, research and development efforts should include telehealth technologies linking forward surgical providers with higher medical authority consultation and effective, relevant, and dynamic surgical training capabilities. Lastly, research into future procedures and devices may also include a human systems approach to define limitations and mitigation strategies of surgical capability in austere environments (i.e., low light, temperature variability, improving surgical access in distributed maritime environment, surgery in flight, etc.) to bridge time to surgery when patient load exceeds surgical capability.

• Prolonged Field Care (PFC)

  SOF medical personnel require capabilities for far-forward medical care to reduce the mortality and morbidity associated with critical wounds, injuries, diseases, and associated sepsis. PFC should focus on novel treatments that support the ability to manage 3-5 patients across the spectrum of illness to multi-system injury for a minimum of 5-7 days. SOF medical personnel require capability to expedite evacuation and increase survivability with limited site of injury support in austere environments including: hyperbaric, mountainous, high-altitude, arctic, and distributed maritime operations.

• Medical Sensors and Devices

  The primary emphasis is to research, apply and/or develop field-sustainable, rapidly deployable medical sensors and/or devices for extended care beyond initial trauma resuscitation, to include austere/forward surgery while operating in areas where casualty evacuation is delayed or unavailable. In addition, proposals that investigate or develop wireless biosensors should demonstrate physiological monitoring capabilities to include, but not limited to, heart rate, blood pressure, pulse oximetry, respiration rate, capnography, core temperature, heart rate variability and compensatory reserve index (CRI). Research and development of devices and sensors should include or plan for the capability to transmit (Bluetooth 4.2) to Android handheld devices and be designed with an open architecture to allow for sensors to be incorporated into a family of sensors that may or may not report to a central handheld device. (NOTE: Ideally, sensor and equipment technologies should be electronically readable, scannable, or transmittable to the Battlefield Assisted Trauma Distributed Observation Kit (BATDOK), an Android-driven, multi-patient, point of injury casualty monitoring capability being fielded by U.S. Air Force (USAF) Pararescuemen and other SOF Medics. Novel devices are required which aid in measuring physiologic decompensation and/or adequacy of treatment/resuscitation in the field environment and/or provide a trigger for a pre-hospital medical intervention (i.e., validation of tissue (muscle) oxygen saturation (StO2), CRI, traumatic brain injury (TBI) measures, etc.

• Portable Lab Assays and Diagnostics

  The proposed project must research, apply and/or develop novel concepts for portable and environmentally stable far forward laboratory assays and diagnostics. Equipment should be extremely portable, ruggedized, use limited or no external power, and any reagents should be self- contained and stable in extreme environmental conditions. Preference will be given to proposals that are field oriented, rugged, low weight/cube space and have little to no refrigeration requirements. Additionally, novel wireless, transmittable or scannable solutions such as patches, scanner/readers or other noninvasive technologies are encouraged.

• Force Health Protection and Environmental Medicine

  SOF personnel must often operate for extended periods of time in austere environments that expose them to extremes in altitude, temperature, humidity, wind, kinetosis, infectious diseases, toxic industrial chemicals, toxic industrial materials, and environmental hazards (including envenomation). In addition, the environment may be compromised due to chemical, biological, and radiological contamination. The primary emphasis of this research area is to research, apply, and develop techniques, therapeutic measures, and materiel (personal protective equipment (PPE), medical devices, drugs, and biologics) to ensure sustained human performance and effectiveness while operating in harsh environmental conditions and/or wearing appropriate PPE.

  • Chemical, Biological, Radiological, Nuclear, and Explosive (CBRNE) Rapid Diagnostics, Treatment, and Prophylaxis:
    The proposed projects must research, apply, and/or develop novel approaches that will diagnose, treat, and protect SOF personnel from exposure to chemical, biological, radiological, nuclear, and high yield explosives in near real time.

  • Occupational and Environmental Health (OEH) Hazards:
    The proposed project must focus on development of novel methods and devices for rapid identification and analysis of exposures to OEH hazards. Research must support the development and analysis of handheld, field hardened, and environmentally stable analytical devices, monitoring devices, dosimetry, assays for rapid on-site identification, and real-time analysis of OEH hazards in air, water, and soil that could pose an acute or chronic health hazard to SOF personnel. Such OEH hazards include toxic industrial chemicals/toxic industrial materials (TICs/TIMs), lead exposures, food and water borne pathogens, toxins, biological agents, and radiological material exposures.

  • Operational Exposure Monitoring:
    The proposed project must seek to develop wireless biosensors for monitoring SOF personnel in extreme environments (i.e., high altitude, whether in-flight or the environment itself, excessive heat or cold, etc.), and potentially hazardous material exposure. Sensors should address physiological measurements and/or chemical, biological and/or radiological hazards. For hazards monitoring, a personal dosimetry device is desired that can detect and alarm based on radiation and chemical presence. The alarming function can be pre-determined to account for known environmental conditions (i.e., natural occurring radiation levels that are below threshold/detrimental health levels) and parts per million (PPM) counts that would trigger an alert. This detection device needs to be able to alarm differently to identify the "type" of hazard(s), and to trigger a back-off and/or donning of additional PPE. Monitoring should be capable of wirelessly communicating via Bluetooth 4.2 to Android handheld devices, tablets, or compatible wrist-mounted displays.

• Brain Health

  Brain Health research efforts include, but are not limited to: determining if repeated low-level blast exposure (rLLBE) causes brain injury or repeated blast brain injury (rBBI), development and validation of fieldable Neurocognitive Assessment Tools (NCATs) and baseline testing, Comprehensive Symptom History (CASH) collection, blast exposure and impact monitoring, determination of safe acceptable limits for blast exposure, development and validation of capabilities to easily identify/diagnose rBBI, methods to prevent, screen for, monitor, and correct neuroendocrine dysfunction. Additionally, Brain Health research efforts include, but are not limited to: methods to prevent TBI from impact and blast such as redesign of helmets, body armor, and munitions, development of pharmaceuticals to prevent and/or treat brain injury, validation of brain injury prevention strategies, and development of return to duty decision support tools.

  • Environmental Exposures Protection:
    Research that develops novel material and/or approaches to protect SOF personnel from the neurological effects of single and repetitive auditory (impulse noise) and non-auditory (overpressure) blast exposures and other environmental factors determined to affect nervous system function.

  • Environmental Exposure Effects:
    Research that determines the neurocognitive, nervous system, and auditory effects from single and repeated low- and high-level blast exposures, impulse noise, and other potential hazardous environmental factors.

  • Biomarkers:
    Research to determine which biomarkers are indicative of rBBI; sequelae from rBBI causing further injury; recovery status; and recovery rate from rBBI. Testing and validating diagnostic biomarkers for rBBI. Proposals should also consider incorporation of validated biomarkers onto existing or future diagnostic platforms. Use of machine learning and/or model development to interpret and report biomarkers that are indicative of rBBI are of interest.

  • Neuropsychological Testing:
    Research to validate neurocognitive assessment tools (NCATs) to determine baseline neurocognitive status, readiness, neurocognitive degradation, sensitivity to various exposures, TBI and recovery status post injury. Proposals to improve the speed, accuracy, specificity, and proximity to injury for the use of NCATs, as well as to compare new technologies and/or modalities (including passive assessment of cognition) to existing NCATs.

  • Olfactory, Oculomotor, Auditory, Vestibular, Cranial Nerve, and Vocal-Acoustic Performance:
    Research and proposals to perform and validate oculomotor, auditory, vestibular, cranial nerve, and vocal acoustic assessments. Research and proposals to assess the effect of nervous system injury to oculomotor, auditory, vestibular, cranial nerve, and vocal-acoustic performance and strategies to restore their performance after injury and prevent injury or further decline.

  • Postural Stability:
    Research to assess the effects of blast exposure on postural stability including the proprioceptive component. Novel treatment strategies, therapies, and therapeutics to prevent and/or correct detriment to postural stability from TBI and neurotrauma caused by blast, impact, and/or other environmental exposures.

  • Neuroendocrine Dysfunction:
    Methods to prevent, screen for, monitor, and correct neuroendocrine dysfunction.

  • Neuroimaging:
    Research into novel imaging and imaging interpretation techniques including, but not limited to computed axial tomography (CAT), magnetic resonance imaging (MRI), and positron emission tomography (PET) scans, to diagnose brain tissue pathologies including, but not limited to, axonal injury, myelin injury, and interface astroglial scarring without the need for immunohistochemistry, immunofluorescence, or histopathology testing.

  • Analytics:
    Research into analysis including machine learning, natural language processing, and artificial intelligence enabled analysis of data including, but not limited to, NCATs; environmental exposures likely to affect brain health; blast, impact, and noise exposures; auditory, vestibular, and vocal acoustic assessments; postural stability assessments; and neuroimaging.

  • Neuromodulation:
    Research into the use of neuromodulation techniques for treating TBI, neurotrauma, pain, restoring and improving function, improving behavioral health, and cognitive performance.

  • Brain Lymphatics and Glymphatics:
    Research into measuring the fluid dynamics of the brain lymphatic system, diagnosing dysfunction, and validation for tools or techniques to improve brain lymphatic clearance.

  • Pupillometry, Pupillary Response, and Microsaccades:
    Research into field capable pupillary response measurement capture and analysis, with or without the ability to capture Microsaccades to assess central nervous system loading and/or damage.

• Automation of Systematic Reviews and Metanalysis

  Research into Automation of Systematic Reviews and Metanalysis using the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) or a similar method

• Human Performance

  USSOCOM requires SOF personnel to withstand extraordinary physical demands and psychological stress to complete their missions. The optimization of SOF personnel’s ability to perform at very high levels for long durations, in addition to processing information and making critical decisions in a timely manner, while operating in extreme environments, will significantly improve their overall operational effectiveness. This research area explores alternatives and/or new approaches to sustain and optimize SOF human performance both to increase mission capability and to extend the career longevity of SOF personnel.

  • Improved Sleep:
    The proposed project must research, apply and/or develop novel approaches to achieve the restorative effects of sleep. This may include methods to induce, maintain, or improve the quality of sleep throughout the entire night. Additionally, the ability to accelerate the effects of sleep through methods requiring less time (e.g., the effects of sleeping eight hours are realized in four hours’ time) or enabling the SOF personnel to quickly reach and adequately cycle through the stages of sleep where the highest restorative effects occur (i.e., Stage 3/ deep sleep, and Stage 4/rapid eye movement sleep).

  • Optimal Acclimatization Strategies:
    The proposed project must research, apply, and/or develop novel approaches and/or technologies that provide rapid and sustainable human acclimatization in austere environments, to include fatigue countermeasure, extremes in temperature, extremes in altitude, and time-zone change (i.e., circadian acclimatization).

  • Wearables:
    The proposed project must research, apply, and/or develop novel approaches and/or wearable technologies, and/or leverage commercial-off-the-shelf wearable technologies that will monitor physiological measures of human performance to include, but not limited to, caloric expenditure, heart rate/heart rate response, heart rate variability, body fat percentage, sleep hygiene (deep and REM sleep duration) in real-time. Measures should be accurate with low fixed bias, wirelessly communicated via Bluetooth, Near Field Magnetic Induction or Radio Frequency technology in real-time and provide the command the capability to utilize the data for analysis of individuals and/or team performance via the USSOCOM Human Performance Data Management System. The device should be able to be turned on/off and/or have an inactive mode, provide real-time feedback on a display screen, be capable of displaying time, and be adjustable to fit users of different statures. Of parallel interest to address is a proposed project to track sleep, fatigue, and performance degradations through a wearable device that provides quantitative data (rather than qualitative surveys often seen in Fatigue Studies), that in turn will be gathered and amalgamated from entire units, in order to track individual performance, unit performance, mission impacts to performance levels, length of time for acclimatization (if it is ever achieved), and potential risk of mishaps.

  • Diagnostics for Performance Sustainment:
    The proposed project must research, apply, and/or develop minimally invasive diagnostic devices to provide actionable information on nutritional gaps, hormonal response to training, physiological response to performance interventions and recovery, and epigenetic predictors of potential injury.

  • Performance Nutrition:
    The proposed projects must research, apply and/or develop methods to accurately measure nutritional status of SOF personnel. The proposed project should focus on cost effectiveness, accuracy, and end-user compatibility (i.e., user friendly) methods or devices for identifying and optimizing an individual’s nutrient status. Consideration of alternative fuel (energy) sources, dietary supplementation, biomarkers, and nutrient volume/timing are specific areas of interest.

  • Physiological Performance:
    The proposed project must research, apply, and/or develop novel approaches and/or technologies to maximize the physiological performance of SOF personnel in austere and/or training environments, to include increased endurance, enhanced senses, tolerance to environmental extremes, and enhanced overall fitness, to maintain operational posture/ability in high stress scenarios without noticeable augmentation, and without hampering personnel mobility.

  • Cognitive Performance:
    The proposed project must research, apply, and/or develop novel approaches and/or technology that provide greater mental acuity or neuroenhancement (i.e., targeted enhancement and extension of cognitive and affective abilities). Encompasses pharmacological and non-pharmacological methods of improving cognitive, affective, motor functionality and performance, to include neuromodulation.

  • Psychological Performance and Suicide Prevention:
    The proposed project must research, apply, and/or develop novel approaches to the assessment and improvement of behavioral health within the force. Examples include but are not limited to, novel approaches to treatment and rehabilitation from acute and/or chronic post-traumatic stress, depression, and anxiety, improved emotional and nervous system self-regulation, digital/virtual engagement strategies, methods to measure behavioral health performance over time, and improved suicide prevention tools/strategies.

• Canine Medicine and Performance

  SOF personnel rely on canines’ exceptional capabilities as combat multipliers. This research area explores alternatives and/or new approaches to preserve and enhance SOF canine combat performance. SOF medical personnel place a premium on canine-specific approaches that are effective in extreme environments and do not require significant additional logistical support (i.e., maximize use of available SOF Medic materiel). The eight “Canine Medicine and Performance” project areas, to which SOF will give consideration, in priority order, are:

  • Trauma Resuscitation:

    The proposed project must support development of innovative techniques/strategies for canine trauma resuscitation (e.g., hypotensive resuscitation, whole blood/blood component replacement, and non-compressible hemorrhaging), particularly to address ballistic projectile injuries, in diverse/austere environments that lack immediately available medical evacuation or restorative surgical capacity.

    Note: Research should minimize or refrain from utilizing canine specific equipment or devices; this will allow treatment from existing trauma kits fielded by SOF Medics.

  • Non-Traditional Anesthesia Protocols:

    The proposed project must develop novel approaches for routine and emergency/post- traumatic canine field sedation and/or anesthesia in diverse environments and, utilizing pharmaceuticals available to SOF Medics.

  • Canine Performance:

    The proposed project must research, apply, and/or develop novel approaches and/or technologies that address optimization of canine performance through improved physical conditioning programs, reduction of cognitive decline, enhanced nutrition, and genetics research.

  • Sensory Optimization and Protection:

    Research must be oriented toward innovative methods that enhance or conserve SOF canine olfactory, visual, and/or auditory performance during combat operations.

  • Chemical, Biological, Radiological, Nuclear, and Explosive (CBRNE) Canine Decontamination, Treatment, and PPE Against Possible Exposure:

    The proposed projects must research, apply, and/or develop novel approaches that will diagnose, treat, decontaminate, and protect canines from exposure to chemical, biological, radiological, nuclear, and high yield explosives.

  • Environmental Extremes:

    Project proposals must research, apply, and/or develop novel strategies that address acclimatization to acute extremes in temperature, altitude, and/or time zone change (circadian acclimatization), and/or prolonged marine environmental exposure in SOF canines.

  • Brain Health and TBI

    Brain health research efforts include but are not limited to development and validation of NCATs, blast exposure and impact monitoring, determination of safe acceptable limits for blast exposure, validation of neurocognitive baseline testing, capabilities to easily determine mild, moderate, and severe TBI, pharmaceuticals to prevent or treat brain injury, validation of brain injury treatment strategies, and procedures to determine safe return to duty decisions for SOF canines.

  • Pre- and Post-Trauma Training / Behavioral Issues:

    The proposed project must address unique approaches to diagnosing and treating SOF-peculiar training and post-traumatic canine behavioral issues, to optimize pre-purchase selection and post-purchase training strategies across the enterprise and restore performance in canines with behavioral and/or post-trauma issues.

• Medical Sustainment

  SOF medical personnel require sustainment capabilities to support far-forward medical requirements to reduce the patient and supply risk associated with operational medicine. The proposed research, application, and/or development of medical sustainment techniques and materiel must address unique approaches to optimizing supply management and safeguarding equipment requirements. The project areas under “Medical Sustainment” to which the USSOCOM will give highest consideration are:

  • Power and Energy

    Project proposals must research, apply, and/or develop novel strategies that conserve or optimize medical equipment in-field use to reduce sustainment burden in prolonged, austere environments.

  • Austere Medical Logistics Procurement

    SOF personnel, operating in austere environments, may not have the ability to receive conventional resupply efforts. Project proposals must research, apply, and/or develop novel approaches to assist SOF personnel in developing and receiving medical resupplies or repair parts to meet their needs while in the field. These efforts must meet shipping and handling considerations (i.e. temperature control) for a wide range of medical products from batteries to blood. Efforts may include, but are not limited to, fabrication, improvisation, and/or delivery methods from sea, ground, air, or suborbital domains.

  • Equipment Protection

    Research that develops novel material and/or approaches to protect SOF medical equipment from environmental (i.e. CBRNE, freezing temperatures, etc.) and/or adversarial effects (i.e. jamming, electromagnetic pulse weapons, etc.).

  • Supply Monitoring Capability

    Project proposals must research, apply, and/or develop novel approaches to rapidly forecasting and calculating supply requirements based on patient treatment requirements, shelf-life, and storage considerations.

Are there any additional benefits I would receive?

Beyond direct funding, participation under the USSOCOM Biomedical and Human Performance BAA offers significant strategic advantages:

Government Validation and Credibility:
Being selected for funding by USSOCOM demonstrates exceptional technical capability and mission relevance to U.S. Special Operations Forces. This validation enhances your organization’s credibility with DoD program managers, defense primes, and dual-use technology investors seeking field-proven innovation.

Enhanced Market Visibility and Notoriety:
Awardees often gain visibility through federal award announcements, DoD communications, and defense medical research forums—positioning your company as a recognized contributor to national security and elite force readiness.

Ecosystem Access and Collaboration Opportunities:
Projects funded under this BAA operate within the broader military biomedical and human performance ecosystem, connecting recipients with military laboratories, medical R&D commands, and operational units. This access frequently leads to additional collaboration, follow-on funding, and contracting opportunities.

Stronger Exit and Acquisition Potential:
Advancing your technology with nondilutive government support and demonstrating validation in demanding SOF environments can significantly increase company valuation and strategic attractiveness for acquisition or investment by defense, medical, and performance technology leaders.

What is the timeline to apply and when would I receive funding?

• Open period: Continuously open through 31 July 2028.

• Two-step submission: Pre-proposal via eBRAP; if invited, submit the full application (generally within 60 days).

• Review & notice: Applicants should receive disposition within ~180 days of submission; awards may be made any time throughout the year and are contingent on funding and successful negotiations.

• Regulatory lead times: Allow 2–3 months for DoD human-subjects review (OHRO/HRPO) and 1–2 months for animal research review (VRO), as applicable.

Where does this funding come from?

Funding is provided by the Department of Defense (USSOCOM) and administered by the U.S. Army Medical Research Acquisition Activity (USAMRAA); the program leverages CDMRP/eBRAP systems. Any funds received by USSOCOM appropriate to the BAA’s research areas may be used, up to a program total of $20M annually.

Who is eligible to apply?

Organizations only: national/international, for-profit, non-profit, public, and private. FFRDCs are not eligible for direct awards but may team under their sponsoring agreements. Eligible investigators are individuals employed by/affiliated with eligible organizations. No cost sharing is required.

What companies and projects are likely to win?

Winning projects consistently score high on USSOCOM’s evaluation factors, which include:

• Technical Merit and Scientific Rigor: The proposed approach must be well-founded, methodologically sound, and clearly linked to measurable outcomes.

• Innovation and Impact: Reviewers favor projects that introduce novel methods, materials, or technologies capable of significantly improving SOF medical or performance capabilities. Incremental improvements without clear operational relevance tend to score poorly.

• SOF Relevance: Proposals must explicitly tie their work to unique SOF operational needs—such as portability, durability, limited logistics support, or extreme-environment applicability.

• Feasible Study Design and Realistic Execution Plan: Reviewers expect achievable milestones, well-defined deliverables, and credible transition pathways for eventual use by operational forces or integration into DoD systems.

• Qualified Team and Institutional Capability: Teams with demonstrated expertise in biomedical R&D, human performance, or defense health technology—and with access to appropriate facilities and regulatory infrastructure—are prioritized.

• Appropriate and Realistic Budget: Budgets should align with the scope and complexity of work, typically falling between $2 million and $10 million total costs for projects up to five years in duration.

Companies that combine strong technical innovation, credible execution capability, and a direct line of sight to SOF mission impact are most likely to be selected for funding.

Are there any restrictions I should know about?

• Project length: Up to 5 years.

• Pre-proposal required; unsolicited full proposals without invitation are rejected.

• Clinical trials are typically not associated with this BAA.

• Human/animal research approvals required.

• Administrative pitfalls leading to rejection/withdrawal include: missing/over-limit narratives, missing budget, inclusion of URLs in prohibited sections, and inconsistencies between pre-proposal and full application.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive pre-proposal will likely take 120–200 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

How much would BW&CO Charge?

Our full service support is available for the pre-proposal for $7000. Full proposal quoted upon invitation.

Fractional support is $300 per hour.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

View the Funding Announcement: HT9425-23-S-SOC1 BROAD AGENCY ANNOUNCEMENT (BAA) for Extramural Biomedical and Human Performance Research and Development Department of Defense