DARPA BTO: Protean

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

DARPA’s Biological Technologies Office has released DARPARA2601: Protean, a high-impact research announcement focused on developing next-generation medical countermeasures that protect critical human proteins from chemical threat agents. This program aims to create prophylactics (and optionally therapeutics) that protect protein function against chemical threat challenges over 10,000x LD50s . Abstracts are due March 12th, 2026 at 4:00pm ET.

How much funding would I receive?

• Award instruments: Cooperative Agreements or Research Other Transactions (OTs)

• Period of performance: 33 months total

  • Phase 1 (Base): 18 months

  • Phase 2 (Option): 15 months

• Funding levels will depend on proposal quality and availability of funds.

What could I use the funding for?

Funding must support work aligned with Protean’s objective: restoring or protecting protein function against chemical threat agents at the mechanistic level .

Focus Areas (You must propose both phases)

You may propose in one or more of the following:

1. Nerve agents

2. Synthetic opioids

3. Ion channel toxins

Work must target DoD-relevant proteins such as:

• Acetylcholinesterase

• Mu Opioid Receptor

• Ion channels

Phase 1 – Non-Classical Protection (18 months)

Funding may support:

• Discovery of novel regulatory points in protein conformational landscapes

• Identification of distal regulatory sites (>1 required by Month 6 milestone)

• Structural biology and computational modeling of bound/unbound conformations

• Experimental validation of novel conformational states

• Mechanistic characterization of intoxication pathways

• In vitro demonstration of functional rescue or protection

• Demonstrating:

  • 10-fold decrease in threat simulant binding affinity (Month 12)

  • 10x increase in ED50 of >3 threat surrogates (Month 16)

End of Phase 1 requires in vitro evaluation by a government Test & Evaluation (T&E) partner .

Phase 2 – Countermeasure Design (15 months)

Funding may support:

• Structure-based or ligand-based drug design

• Optimization of non-competitive chemical matter

• In vitro and in vivo efficacy improvements

• Pharmacokinetics and pharmacodynamics studies

• ADME validation

• Safety and acute toxicity screening

• In vivo rodent validation against real CWAs

Key metrics include:

• 1,000x increase in ED50 in vitro (Month 24)

• LD50 with intervention >1000x baseline (Month 24, rodent model)

• 10,000x increase in ED50 in vitro (Month 30)

• LD50 with intervention >10,000x baseline exposure (Month 33, rodent model)

Are there any additional benefits I would receive?

• Access to government Test & Evaluation (T&E) partners for real chemical warfare agent testing

• Potential use of flexible Other Transaction (OT) authority

• Early technical feedback via invitation-only pre-award sessions (if selected after Gate 1)

• Opportunity for DoD transition and chemical/biological defense positioning

What is the timeline to apply and when would I receive funding?

Key Dates:

• Posting Date: February 11th, 2026

• Protean Virtual Proposers Day: February 20th, 2026

• Question Submittal Closed: March 9th, 2026 by 4:00 PM ET

• Gate 1 Due Date (Abstract): March 12th, 2026 by 4:00 PM ET

• Gate 2 Due Date (Full Proposal): May 7th, 2026 by 4:00 PM ET

Gate 1 selection is required to submit a full proposal.

The program period of performance is 33 months .

Where does this funding come from?

Funding comes from the Defense Advanced Research Projects Agency (DARPA), Biological Technologies Office (BTO) .

Funding Opportunity Number: DARPARA2601
NAICS Code: 541714

Who is eligible to apply?

All responsible sources capable of satisfying the Government's needs, including U.S. and non-U.S. sources, may submit proposals .

• Historically Black Colleges and Universities, small businesses, small-disadvantaged businesses, and minority institutions are encouraged to apply .

• Proposers must be registered in SAM and have a valid Unique Entity ID .

• Proposals must be UNCLASSIFIED or CUI .

• FFRDCs, UARCs, and Government entities must contact the agency POC prior to submission to discuss eligibility , competitive proposals will:

• Present highly innovative, non-classical mechanistic approaches

• Identify >1 novel distal regulatory site by Month 6

• Demonstrate feasibility across both Phase 1 and Phase 2 metrics

• Provide experimentally validated structural insights (not purely computational)

• Show credible in vivo translation plans

• Demonstrate strong relevance to DoD chemical and biological defense

Proposals that fail to address both phases will be deemed non-conforming .

Are there any restrictions I should know about?

Key restrictions include:

• Must propose to both Phases

• Must comply with Controlled Unclassified Information (CUI) handling requirements (NIST 800-171 compliant systems)

• IP ownership or licensing must be clearly documented

• Potential publication restrictions for non-fundamental research

• Organizational Conflict of Interest disclosures required

• No classified submissions allowed at Gate 1

How long will it take me to prepare an application?

Gate 1 is intentionally streamlined:

• 10-minute Video Abstract (max 5 slides)

• 5-page Abbreviated Technical Volume

• Rough Order of Magnitude cost estimate

Most well-prepared teams should expect 3–6 weeks to develop a competitive Gate 1 submission, depending on technical maturity and team alignment.

Gate 2 preparation will require significantly more effort if invited.

How can BW&CO help?

We help founders and research teams:

• Reverse-engineer DARPA evaluation criteria

• Position non-classical mechanisms to align with milestone language

• Translate structural biology and modeling approaches into milestone-driven narratives

• Architect Phase 1 → Phase 2 transition logic

• Draft Gate 1 materials that maximize selection probability

• Build credible in vivo translation pathways

Our role is to make sure your science aligns exactly with DARPA’s stated metrics and exclusion criteria.

How much would BW&CO Charge?

We charge a flat $4,000 fee to submit the pre-proposal for Gate 1. We also have an hourly rate to strategize, review, and edit applications of $250.

Additional Resources

Review the solicitation here.

Naval Air Warfare Center Aircraft Division (NAWCAD) Office-Wide Broad Agency Announcement (BAA)

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The Naval Air Warfare Center Aircraft Division (NAWCAD) Office-Wide Broad Agency Announcement (BAA) is open through June 22, 2026 at 5:00 PM ET, with white papers accepted on a rolling basis throughout the open period.

This BAA solicits innovative basic research, applied research, advanced technology development, and prototype efforts that advance naval aviation capabilities and directly support Department of the Navy mission needs.

NAWCAD may make awards using contracts, grants, cooperative agreements, or Other Transaction (OT) agreements depending on the nature of the work and the level of government involvement required.

Funding & Award Structure

Number of Awards: Multiple awards anticipated

• Estimated: $500K to $5 million. Award Size: Not predetermined; varies based on technical merit, relevance, and available funding

• Period of Performance: Varies by project

Possible Award Instruments:

• Procurement contracts

• Grants

• Cooperative agreements

• Other Transaction (OT) agreements for research or prototypes

The Government reserves the right to fund all, some, or none of the submitted proposals and may fund efforts incrementally or with options.

Research Areas

Advanced Manufacturing (Priority). Areas of research include but are not limited to the following: multi-functional aircraft components to enable mission flexibility and platform interoperability, aircraft part digital repository and large-scale complete part printing, and manufacture-on-demand of Naval aviation assets.

Aeromechanics. Areas of research include but are not limited to the following: aerodynamic and flight controls (manned and unmanned), aeromechanics modeling and analysis tools, flight performance, rotorcraft aerodynamics and performance, ship/aircraft aerodynamic interactions, and unmanned aviation and integration including pilot augmentation and automation and UAV autonomous landing flight mechanics.

Artificial Intelligence (AI) / Machine Learning (ML) (Priority). Areas of research include but are not limited to the following: AI/ML-driven signal and analysis type sensing, complex reasoning, multi-agent based operation and decision making, airspace integration including sense and avoid algorithms, deep reinforcement learning, neural networks, and demand forecasting.

Autonomy (Priority). Areas of research include but are not limited to the following: autonomous air-to-air refueling, autonomous system development, testing, evaluation, verification and validation tools, airworthiness and risk quantification/acceptance, collaborative autonomy, and autonomous system precision takeoff and landing.

Avionics, Sensors & Electronic Warfare. Areas of research include but are not limited to the following: multi-modal sensors, passive and active sensor systems (RF, EO/IR, and acoustic), advanced or alternative precision navigation and timing (PNT), advanced computational and open system architectures, advanced signal and image processing, flight information and control systems, and advanced concepts in electronic warfare systems.

Cyber (Priority). Areas of research may include but are not limited to the following: high accuracy threat detection, cyber effects modeling, reverse engineering, behavioral analysis, intrusion, adaptive cybersecurity, simulation and interface research, concolic testing, and systems configuration management.

Data Science & Visualization. Areas of research include but are not limited to the following: predictive modeling algorithms, complex big-data environments, data access, storage and retrieval, data visualization techniques, risk assessment and uncertainty quantification, and statistical analysis.

Digital Engineering (Priority). Areas of research include but are not limited to the following: advancements in the use of Digital Twin technology to support predictive maintenance, automated sustainment environments, diagnostics and prognostics, digital communication of system requirements using model-based systems engineering (MBSE) and Systems Modeling Language (SysML) views, and engineering models and virtual environments to test designs across broader parameters than what live testing permits.

Human Systems. Areas of research include but are not limited to the following: human performance assessment and modeling, cognitive performance and workload, human-machine interface and teaming, protective equipment, controls and displays, ergonomics, anthropomorphic measurement, virtual environments, human factors engineering (social, behavioral, health, and cultural), cognitively enhanced operator-state monitoring, prediction, and recommendation, and human-machine fusion AI-supported operator enhancement.

Hypersonic Systems. Areas of research include but are not limited to the following: external and internal high-speed aerodynamics, multi-physics modeling and simulation, hypersonic system testing and evaluation, high-temperature and high-specific-strength materials, structures and coatings, guidance, navigation and control, and advanced air-breathing propulsion.

Materials and Aircraft Structures. Areas of research include but are not limited to the following: additive manufacturing, corrosion prevention, non-destructive inspection, structural repair and repair processes for metals and ceramics, polymers and composites, analysis and simulation of aircraft structures, structural mechanics, fouling, low observable materials, high-temperature materials, low-temperature icing-resistant materials, and life management of airframes.

Mechanical Systems. Areas of research include but are not limited to the following: fire and ice protection for aviation systems, fuel containment, hydraulic systems, pneumatic systems, and landing gear systems analysis.

Power and Propulsion Systems. Areas of research include but are not limited to the following: reliability engineering, fuel systems, prognostics and diagnostics, energy storage and efficiency, air-breathing engines, fuels and lubricants, electrical power generation, auxiliary power, low observable signature technologies, propulsion life management, mechanical and drive systems, and affordable small- to medium-scale propulsion systems.

Quantum (Priority). Areas of research may include but are not limited to the following: precise self-reliant onboard navigation and threat detection, secure communication and sensing capabilities, nitrogen vacancy diamond sensing, quantum encryption, and quantum computing.

Secure Communications & Networks (Priority). Areas of research include but are not limited to the following: resilient data and communications networks for command and control, architecture, analysis and software development, information assurance including blockchain networks and security, platform and system health monitoring, effective data transfer of communications and video, and end-to-end security integration in software development for autonomous applications operating in dynamic and contested environments.

Support Equipment. Areas of research include but are not limited to the following: launch and recovery equipment, forward-deployed sustainment and resupply, rapid assessment and repair technologies for contested environments, electromagnetics, high-energy generation and control, environmental sensing, prognostics and health monitoring, automatic testing of hardware and software, displays, advanced maintenance technologies, information systems and intelligent agents, and advanced computer and data processing applications.

Test and Evaluation Engineering. Areas of research include but are not limited to the following: telemetry, communications, data links and data acquisition, signature technologies, mission system testing, system-of-systems testing environments, virtual reality (VR), augmented reality (AR), extended reality (XR), target engineering, airborne threat simulation, integrated battlespace simulation (Live Virtual Constructive Environments), hardware-in-the-loop testing, flight instrumentation, ground radar analysis, test article configuration, navigation and identification, manned-unmanned teaming, advanced training systems including instructional techniques and strategies, and game-based training.

Warfare Analysis. Areas of research include but are not limited to the following: operational suitability, signal extraction, clutter reduction, modeling and simulation, maritime effectiveness, vulnerability and capability-based assessment, and conceptual aircraft design.

NAWCAD may also consider submissions outside these areas if the white paper involves the development of novel-based capabilities with potential to enhance naval capabilities.

Who Should Pay Attention

• Small businesses, startups, and non-traditional contractors (explicitly encouraged)

• Mid-size and large defense R&D firms

• Universities and research institutions

• Teams with novel sensing hardware, algorithms, or system concepts

This is an unrestricted solicitation. Cost sharing is allowed but not required. Foreign entities may not serve as primes.

Deadline

White Paper Deadline: June 22, 2026 at 5:00 PM ET. Only proposers whose white papers are deemed of interest will be invited to submit a full technical and cost proposal.

Evaluation Criteria

Proposals are evaluated using the following criteria, in descending order of importance:

1. Technical Approach – Innovation, feasibility, completeness, and risk mitigation

2. Potential Contribution & Naval Relevance – Alignment with NAWCAD and Navy mission needs

3. Cost – Realism and consistency with the proposed technical approach

Proposals are not evaluated against each other but on their individual merit and relevance.

Bottom Line:

1. NAWCAD has flexibility to award OTs, which can be more startup-friendly than FAR-based contracts

2. Successful prototype OTs may be eligible for noncompetitive follow-on production awards

3. White paper quality is critical; there is no guarantee of a Phase II invitation

How long will it take me to prepare an application?

For a first-time applicant on your own, preparing an White Paper under this BAA will likely take 20–50 hours in total. BW&CO offers services to save you time and increase your likelihood of success.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available for a flat fee of $5,000 for the White Paper Submission.

Fractional support is $300 per hour, with most AFRL proposal projects requiring 10-20 hours of expert support from strategy through submission of full proposal.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

Review solicitation here.

Air Force Research Lab (AFRL) Multi-Spectral Sensing Technologies R&D (MuSTeR) BAA

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The Air Force Research Laboratory is seeking innovative research and development in advanced radio frequency (RF) and electro-optical / infrared (EO/IR) sensing technologies to support future air, space, and command-and-control sensor systems.

White Papers submissions are due May 20th, 2026 at 5:00pm ET.

This BAA supports basic research, applied research, and advanced technology development, with an emphasis on advancing the state of the art and transitioning capabilities to future Air Force systems.

How much funding would I receive?

Total Program Value: ~$250M (across all awards)

1. Typical Award Size: ~$100K to $10M

2. Period of Performance:

   • Individual awards: 12–48 months

   • Overall BAA effort: up to 60 months

3. Award Volume: Multiple awards anticipated (but not guaranteed)

Research Areas

Multiband Multifunction Radio Frequency Sensing (RYMF)

1. Multiband Multifunction Array Development

2. Fully Adaptive Radar

3. Advanced Digital Multifunction Arrays

Laser Radar Technology (RYMM)

4. Laser Radar Imaging, Systems, Components, and Applications Passive Radio Frequency Sensing (RYMP)

5. Passive Radio Frequency Sensing Distributed Radio Frequency Sensing (RYMS)

6. Waveform Phenomenology, Design and Applications

7. Sensor Information Processing and Integration

EO Target Detection & Surveillance (RYMT)

8. Passive Electro-optic and Infrared Sensor Technology

9. Novel EO/IR Hardware and Algorithms

10. Hyperspectral Imaging Technology

11. Standoff High Resolution Imaging (SHRI)

12. Infrared Search and Track Technology

13. Passive EO/IR Space-Based Sensing

Who Should Pay Attention

• Small businesses, startups, and non-traditional contractors (explicitly encouraged)

• Mid-size and large defense R&D firms

• Universities and research institutions

• Teams with novel sensing hardware, algorithms, or system concepts

This is an unrestricted solicitation. Cost sharing is allowed but not required. Foreign entities may not serve as primes.

How the Process Works

Step 1: White Paper

• Rolling acceptance through May 20, 2026

• 6 pages, technical summary + ROM cost

• Used to determine Air Force interest

Step 2: Full Proposal

• Invitation-only

• Requested from white papers that meet AFRL needs

• Technical merit is the top evaluation factor
  

How Proposals Are Evaluated

White Paper Criteria (Equal Weight):

• Alignment with BAA technical areas

• Government interest

• Novelty and technical advancement

• Availability of funding based on ROM

Full Proposal Criteria (Descending Priority):

1. Technical innovation and approach

2. Understanding of scope and risks

3. Transition potential to Air Force systems

4. Cost realism
   

Bottom Line:

This is a long-running, high-dollar AFRL BAA designed to continuously onboard cutting-edge sensing technologies. If your company is building novel RF, EO/IR, or multispectral sensing capabilities, this BAA is a durable entry point into Air Force R&D funding—starting with a relatively low-cost white paper.

How long will it take me to prepare an application?

For a first-time applicant on your own, preparing an White Paper under this BAA will likely take 20–50 hours in total. BW&CO offers services to save you time and increase your likelihood of success.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available for a flat fee of $5,000 for the Abstract Submission.

Fractional support is $300 per hour, with most AFRL proposal projects requiring 10-20 hours of expert support from strategy through submission of full proposal.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

Review solicitation here.

Tactical Technology Office (TTO) Office-Wide BAA - DARPA

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

The DARPA Tactical Technology Office (TTO) is soliciting innovative executive summaries and proposals to demonstrate revolutionary defense platforms, systems, and manufacturing approaches that enhance the nation’s ability to rapidly build, adapt, and sustain force structures. Awards may be made using multiple instrument types, and proposals are accepted on a rolling basis through June 22, 2026.

How much funding would I receive?

Est. $500K to $5 million. DARPA anticipates making multiple awards, but no minimum or maximum award size is specified in the solicitation. Award amounts will be determined based on technical scope, merit, and cost realism.

What could I use the funding for?

The Defense Advanced Research Projects Agency (DARPA), Tactical Technology Office (TTO) is soliciting innovative executive summaries and proposals in the following focus areas:

1. Design/Build/Buy – Using innovative design approaches throughout the system lifecycle to acquire new defense systems, from disrupting systems engineering processes to reimagining test, certification, and accreditation. This includes (1) new design approaches to make manufacturable designs or to dramatically reduce human engineering effort; (2) new approaches to fabrication that enable rapid start-up, reduced production lead times, and frequent changes to military systems; (3) testing and validation approaches that dramatically shorten the timeline from initial delivery to full military utility.

2. Surge and Sustain – Developing technologies that make existing military systems easy to replenish and abundantly available at time of need. Builds upon the legacy of public and private cooperation for national security to make and maintain existing systems rapidly, on-demand, and at high volume, ensuring that the U.S. can win a long-term conflict. This focus area includes (1) development of manufacturable lower-cost systems with “good-enough” capabilities; (2) adaptive manufacturing solutions that allow shifting production seamlessly among products; (3) approaches to broaden and revitalize the supply chain to permit ready use of alternative suppliers for defense products and components; and (4) methods to rapidly leverage non-defense production capabilities and knowledge for defense applications.

3. Long Range Effects – Creating new systems and approaches that enable decisive military effects at distances from the tactical to strategic in areas where anti-access and area-denial (A2/AD) strategies are employed by an adversary. This includes (1) approaches that increase range, or which provide alternative paths for access that circumvent A2/AD; (2) systems or technologies to enable constant presence within an adversary’s A2/AD zone; and (3) innovative approaches to re-engineer or re-configure existing systems to confound adversary defenses.

4. Disruptive Innovation – Rapidly fielding novel engineering, technology, and systems approaches that disrupt the battlefield in unexpected or non-obvious ways and change the traditional calculus for military advantage. This focus area includes (1) low-cost autonomous systems that can use mass to overwhelm defensive systems; (2) approaches that disrupt the escalation of hide-and-seek between sensors and stealthy platforms by using decoy and deception or new sensing modalities; (3) capabilities that undermine the readiness or efficacy of adversary systems, creating doubt and deterring attacks.

Submissions that identify potential rapid technological disruption to the tactical battlefield are of interest.

Proposed research should investigate innovative approaches that enable revolutionary advances in science, devices, or systems. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice. Individual submissions are not required to include the focus areas outlined above, but proposers are encouraged to address at least one of them, and to make clear which are being addressed.

Are there any additional benefits I would receive?

Beyond direct funding, awardees gain significant strategic advantages:

Government Validation & Credibility
DARPA selection signals elite technical quality and national-security relevance — often accelerating partnerships with primes, OEMs, and investors.

Enhanced Market Visibility
Awards frequently lead to increased visibility through DARPA communications, publications, and industry attention.

Ecosystem Access & Collaboration
Awardees join a national innovation community spanning quantum, photonics, microelectronics, and advanced materials — opening doors to long-term collaborations and follow-on opportunities.

Stronger Exit & Acquisition Potential
Non-dilutive support enables deep tech maturation without equity loss. Companies validated by DARPA historically see improved valuation, stronger commercial traction, and increased acquisition interest.

What is the timeline to apply and when would I receive funding?

• Executive Summary Due: April 17, 2026 at 4:00 PM ET

• Full Proposal Due: June 22, 2026 at 4:00 PM ET

DARPA will generally respond to Executive Summaries within 45 calendar days and notify proposers of Full Proposal selection decisions within 60 calendar days of receipt.

Where does this funding come from?

This funding is provided by the Defense Advanced Research Projects Agency (DARPA) within the U.S. Department of Defense, specifically through the Tactical Technology Office (TTO).

Who is eligible to apply?

All responsible U.S. and non-U.S. organizations capable of satisfying DARPA’s needs may apply, including commercial companies, startups, universities, and research institutions, subject to export control, security, and regulatory compliance. Historically Black Colleges and Universities, small businesses, and minority institutions are encouraged to participate.

What companies and projects are likely to win?

DARPA evaluates proposals based on the following criteria (summarized from Section II):

• The technical approach is innovative, feasible, and clearly defined

• The work supports DARPA’s mission to create or prevent technological surprise

• The team demonstrates strong expertise and execution capability

• Technical risks are identified with credible mitigation strategies

• Costs are realistic and aligned with the proposed technical approach

Are there any restrictions I should know about?

• Research must be revolutionary, not incremental

• Full Proposals require a signed “Encourage Full Proposal” letter from DARPA

• Non-conforming or duplicative submissions may be rejected without review

• Certain entities (e.g., FFRDCs and UARCs) are highly discouraged except by exception

• Proposers may not misrepresent data using AI or automated tools

How long will it take me to prepare an application?

For a first-time applicant, preparing an executive summary under this BAA will likely take 20–50 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available for a flat fee of $5,000 for the Abstract Submission.

Fractional support is $300 per hour, with most DARPA proposal projects requiring 10-20 hours of expert support from strategy through submission of full proposal.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

Review solicitation here.

Defense Sciences Office (DSO) Office-wide BAA – DARPA

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

DARPA’s Defense Sciences Office (DSO) is soliciting proposals under its Office-wide Broad Agency Announcement (BAA) to fund revolutionary basic or applied research that enables breakthrough advances in science, devices, or systems for national security applications. Proposals are accepted on a rolling basis through June 2, 2026, and may be submitted as executive summaries, abstracts, or full proposals. This BAA is designed to capture novel, high-risk, high-reward ideas not already addressed by existing DARPA programs.

How much funding would I receive?

DARPA anticipates making multiple awards, but no fixed award size or funding range is specified in the BAA. Award amounts, duration, and structure are determined based on the proposed technical scope, cost realism, and selected award instrument. An accelerated award option is available for select proposals not exceeding $2,000,000, with awards made within approximately 30 days of selection.

What could I use the funding for?

Funding may be used to pursue innovative basic or applied research concepts that enable revolutionary (not evolutionary) advances aligned with DARPA’s mission. Proposals may address, but are not limited to, the following DSO technical thrust areas:

• Materials, Manufacturing, and Structures - Breaking the tension between performance and efficiency for critical parts, production processes, energetics, superconductors, and propulsion

• Sensing, Measuring, and Affecting - Developing and leveraging new science to overcome existing barriers limiting the performance and/or practicality of sensing, measurement, and control, to achieve orders of-magnitude improvement in operational capabilities.

• Math, Computation, and Processing - Enabling quantum, reimagining classical, and developing entirely new forms of computing for enhanced efficiency and new capabilities. Solutions may range from new approaches to hardware (implementation) to representation and computation.

• Complex, Dynamic, and Intelligent Systems - Creating new scientific capabilities for classes of systems that evolve and adapt and for which traditional reductionist, data-driven, and statistical methods fail. Systems of interest include, but are not limited to, foundations of intelligence, human-AI ecosystems, homeostatic mechanisms, and global systems.

Proposals focused primarily on incremental improvements or manufacturing scale-up are explicitly excluded.

Are there any additional benefits I would receive?

Beyond direct funding, selection under a DARPA DSO BAA provides substantial indirect value:

• DARPA Validation and Credibility: Being selected signals strong technical merit and alignment with DARPA’s mission to create or prevent technological surprise.

• Increased Visibility: Awardees gain visibility within the national security R&D ecosystem and among DARPA program managers.

• Access to DARPA Engagement Pathways: Participation can lead to future invitations to targeted DARPA programs, Disruption Opportunities (DOs), or Advanced Research Concepts (ARCs).

• Nondilutive De-Risking: Advancing frontier technology with nondilutive capital can materially improve company valuation and future exit outcomes.

What is the timeline to apply and when would I receive funding?

1. Review Process: Rolling through June 2, 2026

2. Accelerated Award Option: Awards made within ~30 days of selection for qualifying proposals

Where does this funding come from?

Funding is provided by the Defense Advanced Research Projects Agency (DARPA) within the U.S. Department of Defense, through the Defense Sciences Office (DSO).

Who is eligible to apply?

1. U.S. and non-U.S. organizations may apply

2. Small businesses, startups, universities, and large firms are eligible

3. FFRDCs, UARCs, and Government Entities (including National Labs) are not eligible

4. Non-U.S. participants must comply with export control, security, and nondisclosure requirements

What companies and projects are likely to win?

DARPA evaluates proposals based on the following criteria:

• Scientific and technical merit of a novel, feasible, and well-reasoned approach

• Relevance and contribution to DARPA’s mission and national security impact

• Clear articulation of technical risk and credible mitigation strategies

• Strong alignment between scope, cost, and schedule realism

• Ability to enable revolutionary—not incremental—advances

Are there any restrictions I should know about?

• Incremental or evolutionary improvements are not of interest

• Manufacturing scale-up is explicitly excluded

• Some projects may involve Controlled Unclassified Information (CUI) and require compliance with NIST SP 800-171

• Projects involving human subjects or animal research must follow DARPA approval procedures

• DARPA retains discretion to determine whether work is fundamental or non-fundamental research

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission under this BAA will likely take 120–160 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available for a flat fee of $5,000 for the Abstract Submission.

Fractional support is $300 per hour, with most DARPA proposal projects requiring 80–100 hours of expert support from strategy through submission of full proposal.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

See solicitation on sam.gov

Generative Optogenetics - DARPA BTO

Executive Summary:

DARPA’s Biological Technologies Office is awarding $1.7M–$1.99M Phase 1 awards to teams developing optically controlled, template-free DNA or RNA synthesis in living cells under the Generative Optogenetics (GO) program. The program uses a staged process beginning with 5-page abstracts due January 16, 2026, followed by invitation-only oral proposals.

How much funding would I receive?

If selected, you would receive a fixed-price Phase 1 award of $1.7M for Research Objective 1 (RO1) or $1.99M if addressing both RO1 and the optional Research Objective 2 (RO2). DARPA anticipates multiple Phase 2 awards for teams that successfully pass the Phase 1 Concept Design Review at month 9.

What could I use the funding for?

The DARPA GO program aims to develop a protein complex, referred to here as a nucleic acid compiler (NAC), that can be expressed within living cells to allow an end user to program genetic instructions into those cells, template-free, using nothing but light to transfer the genetic information to the cells (Figure 1). The central challenge of developing the NAC involves integrating protein domains / subunits for precise optical responsiveness (i.e., optogenetic domains), substrate binding, and enzymatic activity into a functional complex of proteins (i.e., a holoenzyme). While many of these domains have precedence as either engineered or naturally occurring proteins, the challenge lies in developing the interoperability and seamless integration of these domains into a functional holoenzyme, the NAC. Advances in computational design, which allow for accurate prediction of protein structures and binding interactions, are essential for optimizing substrate binding sites, allosteric interactions, and domain integration. These computational tools are crucial for designing the NAC to respond rapidly and predictably to optical signals, enabling the synthesis of long, accurate nucleic acid sequences that can precisely alter cellular function as intended. Moreover, expression of the NAC itself must not be deleterious to host cell function or viability.

To develop the NAC, the GO program consists of two Research Objectives (ROs):

• Research Objective 1 (RO1): De Novo Synthesis

  All GO performers MUST address RO1, which focuses on developing the core capability of the NAC for template-free DNA or RNA synthesis, where optical inputs precisely dictate the sequence of the nucleic acid produced by the NAC in a living cell. A NAC can be designed using a variety of architectures, ranging from extremes of a single, monolithic protein comprised of multiple domains to multi-unit complex (Figure 2). To accomplish this, performers will need to solve three critical challenges: achieving multiplexed optogenetic control, ensuring stability and the precise polymerization of the NAC-nucleic acid sequences, and successfully integrating the molecular components into the NAC.

  1.3.2.1. Multiplexed Optogenetics

  Achieving distinct multiplexed optical programming of the NAC presents a significant challenge, as it requires precise engineering of multiple protein domains capable of responding to distinct wavelengths of light. Currently optogenetic systems have been demonstrated to support up to three distinguishable wavelengths (red, green, and blue) within a cell, but expanding this capability is essential for enabling the NAC to incorporate nucleotides with high precision. This expansion may involve optimizing existing optogenetic domains or developing new ones with improved photophysical properties, such as enhanced spectral separation, faster on/off kinetics, and reduced phototoxicity. By leveraging photons as massless information carriers, these optogenetic domains must facilitate precise molecular motion and interaction, ensuring accurate nucleotide incorporation and enzymatic activity. Computational protein design tools and directed evolution approaches offer potential strategies to overcome these limitations, enabling the multiplexed optical control required for the NAC to function effectively.

  1.3.2.2. Stable and Precise Polymerization

  The NAC must achieve precise polymerization, including initiating synthesis, maintaining processivity to stabilize elongating nucleic acid sequences, and efficiently releasing the synthesized strand to meet program metrics for length and accuracy. The NAC design may need to include strategies to address the challenge of selectively binding the correct nucleotide substrate at the correct time from the mixture of these substrates that exists within the cellular environment. Overcoming this challenge will be necessary for the NAC to achieve desired sequence accuracy metrics for the GO program. Additionally, the stability of the complex formed between the NAC and the nucleic acid sequence it is synthesizing must be sufficient to avoid unwanted dissociations that will result in truncated sequences. Similarly, NACs that synthesize single-stranded nucleic acids will need to overcome issues associated with secondary structures (e.g., hairpin loops) in the DNA/RNA molecule that could interfere with continued synthesis. Achieving stable NAC-based nucleic acid synthesis may necessitate designs that incorporate accessory subunits/domains to improve processivity by holding on to the newly synthesized strand and/or single-stranded binding proteins/domains that hinder the formation of problematic secondary structure in DNA/RNA molecules. Finally, the performers will need to resolve the challenge of releasing synthesized sequences, which may involve strategies such as natural termination signals or engineering inducible cleavage mechanisms.

  1.3.2.3. Integration of Molecular Components

  A fully functional NAC must integrate optogenetic, substrate binding, catalytic, and other domains into a cohesive holoenzyme capable of precise and predictable operation. This integration presents significant challenges, as the domains must interact seamlessly to ensure accurate nucleotide incorporation and overall system functionality. For example, optogenetic domains may need to regulate substrate binding to ensure that nucleotide incorporation into the DNA or RNA sequence aligns precisely with the optical illumination pattern. Similarly, designs involving protein subunit binding must coordinate these interactions with substrate binding domains to maintain synchronization and fidelity. Addressing these challenges may involve strategies such as identifying domains that interact effectively to control the NAC, ensuring synchronous activation and deactivation of multiple NACs within a living cell, and optimizing domain interfaces for efficient communication. Potential approaches include leveraging computational tools to map allosteric pathways, modeling molecular motion to predict domain interactions, and employing high-throughput empirical methods to refine and validate integration strategies.

• Research Objective 2 (RO2): Error Mitigation

  OPTIONAL, GO performers may elect to address RO2 in addition to RO1. Note that GO performers shall not pursue RO2 without addressing RO1. RO2 addresses the challenge of achieving high-fidelity synthesis in NACs by incorporating mechanisms to detect and filter out sequence errors. Some applications of GO technology will necessitate NACs capable of synthesizing longer sequences, and it is anticipated that increasing the length of the sequence will increase the likelihood it contains errors. To this end, RO2 aims to investigate the tradeoffs involved in designing a NAC with enhanced error detection capabilities to meet stricter error tolerance requirements, including how these design choices impact overall NAC performance. There are several potential approaches to address RO2 (Figure 3), an example includes developing doublestranded synthesis methods that incorporate components such as mismatch-binding proteins (e.g., MutS homologs). These proteins can either flag errors for downstream correction or be engineered to degrade faulty sequences, ensuring that only high-fidelity nucleic acid strands are retained. Other strategies may include utilizing base editors to identify nucleotide incorporation errors or synthesizing palindromic sequences that fold onto themselves to increase error detection. RO2 provides an opportunity to explore innovative solutions to error mitigation while considering the tradeoffs in performance, complexity, and scalability inherent to these approaches.

Are there any additional benefits I would receive?

Beyond the direct award, companies benefit from:

DARPA Validation & Technical Credibility
Selection by DARPA’s Biological Technologies Office (BTO) signals exceptional technical rigor and alignment with DARPA’s high-risk, high-reward biotechnology priorities. This validation materially strengthens credibility with strategic partners, investors, and future government customers.

Non-Dilutive Advancement of Breakthrough Biotechnology
GO awards enable teams to mature foundational, high-risk biological technologies using non-dilutive capital. Companies can advance technically ambitious platforms without sacrificing equity, increasing both technical readiness and enterprise value.

Access to DARPA Program Leadership & Expert Networks
Awardees engage directly with DARPA program managers, technical reviewers, and advisory working groups throughout the program. This access provides rare insight into government priorities, technical expectations, and future transition considerations.

Commercialization Support & Structured Market Exposure
GO performers receive guidance from an Independent Commercialization and Consulting Group (ICCG) and participate in structured commercialization workshops and pitch events. These activities help teams refine business hypotheses, market positioning, and transition strategies alongside experienced investors and operators.

Enhanced Visibility Across the Biotechnology Ecosystem
Participation in a DARPA flagship biology program elevates company visibility across the defense, academic, and commercial biotech ecosystems—positioning awardees as leaders in next-generation genetic and optogenetic technologies.

Stronger Long-Term Exit & Transition Potential
By maturing core technology under DARPA sponsorship and demonstrating government-backed technical progress, companies strengthen their positioning for follow-on funding, strategic partnerships, and long-term acquisition or licensing opportunities.

What is the timeline to apply and when would I receive funding?

The process begins with a 5-page abstract due January 16, 2026.. Selected teams are invited to present an in-person Oral Proposal Package. Phase 1 awards follow oral presentations, subject to funding availability. Phase 1 runs 12 months, with a major down-selection at month 9. Phase 2, if awarded, runs an additional 30 months

Where does this funding come from?

Funding is provided by the Defense Advanced Research Projects Agency (DARPA) within the Department of Defense, through DARPA’s Biological Technologies Office (BTO), using Other Transaction (OT) for Prototype authority.

Who is eligible to apply?

Eligible applicants include U.S. and non-U.S. companies, startups, universities, nonprofits, and research institutions, including nontraditional defense contractors and small businesses. Federally Funded Research and Development Centers (FFRDCs) and government entities may apply with additional eligibility documentation. All performers must be able to accept an OT agreement and comply with export control and CUI requirements.

What companies and projects are likely to win?

Competitive teams will demonstrate deep expertise in protein engineering, optogenetics, enzymatic nucleic acid synthesis, and computational biology, with a credible plan to integrate these into a functioning system in living cells. DARPA emphasizes technically bold, high-risk approaches that directly address program metrics rather than incremental biology research.

Are there any restrictions I should know about?

Yes. The program excludes human and animal research, embryonic stem cells, bioprospecting for new natural proteins, substantial hardware development, in vitro assembly workflows, and systems that operate outside the central dogma. Phase 2 work involves Controlled Unclassified Information (CUI), requiring NIST 800-171–compliant systems and DARPA security coordination.

How long will it take me to prepare an application?

Most teams should expect 4–6 weeks to prepare a competitive abstract, including technical framing, team formation, and compliance review. Invited teams will need additional time to prepare a detailed Oral Proposal Package, cost models, and milestone plans under DARPA’s OT structure

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

$4,000 for Abstract Submission.

Fractional support is $300 per hour.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

See solicitation on sam.gov

DARPA Information Innovation Office (I2O) Broad Agency Announcement (BAA)

Executive Summary:

DARPA’s Information Innovation Office (I2O) Office-Wide BAA invites proposals for multiple awards to develop revolutionary information and computational technologies in areas such as transformative AI, resilient and secure software, cyber operations, and information-domain capabilities. Abstracts may be submitted on a rolling basis until November 1, 2026, and full proposals until November 30, 2026.

How much funding would I receive?

DARPA does not publish fixed award amounts for this BAA. I2O funds a limited number of proposals, and budgets are determined by the technical approach, the scope of work, and alignment with I2O priorities.

What could I use the funding for?

The Information Innovation Office (I2O) creates groundbreaking science and delivers future capabilities in the information and computational domains to surprise adversaries and maintain enduring advantage for national security. I2O efforts typically address one or more of the following key thrust areas:

• Transformative AI

  We seek to invest in trustworthy, disruptive artificial intelligence (AI) technologies and methodologies relevant to national security. We define trustworthy systems as ones that operate competently, interact appropriately with humans, and behave ethically and morally.

• Resilient, Adaptable, and Secure Software and Complex Systems

  We believe a world without software vulnerabilities is possible. We seek to use formal methods and third-wave AI to make it easier to understand, build, update, repair, and restore complex software and cyber-physical systems with multi-system-wide, securityrelevant correctness guarantees. We also seek methods to provide continuing operation of a system under duress. Techniques and tools are provided as open-source software for use by the research and software development communities, the defense industrial base (DIB), and the Department of Defense (DoD). Example systems are large scale manufacturing, financial systems, large scale infrastructure, and transportation systems.

• Offensive and Defensive Cyber Security and Privacy

  We're leveraging advances in state-of-the-art AI and secure and resilient tools and technologies to produce trustworthy cyber capabilities that operate beyond human capacity and speed. We seek capabilities to assure the privacy of users and user information and actions. Our efforts anticipate adversary countermeasures to create enduring capabilities.

• Fighting in the Information Domain

  We focus on measuring the health of and protecting and detecting attacks on the information domain, broadly construed. Our research portfolio spans many levels: 

  • Cognitive: Beliefs and attitudes 

  • Semantic: Knowledge that's specialized to particular domains, e.g., scientific discourse, the financial system, supply chains, and other areas 

  • Tracking: Recording the digital artifacts of interactions with the myriad digital devices required by modern life 

  • Transport: Delivery of electronic messages in many forms and with various gradations of observability

• Other

  I2O may also consider submissions outside these thrust areas if the proposal involves the development of novel capabilities having a promise to provide decisive information or computational advantage for the United States and its allies. I2O seeks unconventional approaches that are outside the mainstream, challenge accepted assumptions, and have the potential to change established practices radically. Proposed research should enable revolutionary advances in science, technology, or systems. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of the art.

Are there any additional benefits I would receive?

Beyond the direct award, DARPA funding offers significant strategic advantages:

Government Validation and Credibility:
Receiving a DARPA award signals exceptional scientific and engineering merit, which accelerates engagement with primes, integrators, strategic partners, and investors.

Enhanced Visibility and Notoriety:
DARPA programs are frequently highlighted in federal communications, technical conferences, and defense media—boosting your company’s profile across the national security sector.

Ecosystem Access and Collaboration Opportunities:
Awardees gain access to DARPA program managers, government labs, test ranges, and a high-level innovation network—opening doors to future contracts and partnerships.

Stronger Exit and Acquisition Potential:
Nondilutive funding that matures breakthrough technology, combined with the DARPA “stamp,” often increases valuation and attractiveness to large defense, aerospace, semiconductor, and AI-focused acquirers.

What is the timeline to apply and when would I receive funding?

Abstracts: May be submitted on a rolling basis until November 1, 2026, at 5:00 p.m. Eastern.

Full proposals: May be submitted on a rolling basis until November 30, 2026, at 5:00 p.m. Eastern.

The BAA does not specify dates for award decisions or when funding would be released; those depend on DARPA’s evaluation and negotiation timelines.

Where does this funding come from?

Funding comes from the U.S. Department of Defense through the Defense Advanced Research Projects Agency (DARPA), specifically the Information Innovation Office (I2O).

Who is eligible to apply?

The BAA does not restrict eligibility. Typical DARPA BAAs accept proposals from:

• U.S. businesses of any size

• Universities

• Nonprofits

• Federally-funded research and development centers (with limitations)

Foreign entities may be subject to additional restrictions depending on classification and export-control considerations.

What companies and projects are likely to win?

The evaluation criteria (in descending order of importance) are:

• Overall Scientific and Technical Merit

  • Innovative, feasible, and complete technical approach.

  • Team expertise and experience aligned with proposed tasks.

  • Clear deliverables and logical task sequence.

  • Identification and credible mitigation of key technical risks.

• Potential Contribution and Relevance to the DARPA Mission

  • Strengthens the national security technology base.

  • Supports DARPA’s mission to make pivotal early technology investments that create or prevent technological surprise.

• Plans to Implement Resilient Software (when applicable)

  • Clear capability to design, implement, and deliver resilient software.

  • Ensures interoperability, security, and ability to meet DoD/DARPA mission objectives.

  • Uses formal methods when appropriate to work toward eliminating software vulnerabilities.

• Cost Realism

  • Costs are realistic and consistent with the technical approach and Statement of Work.

  • Effort leverages relevant prior research to maximize benefit from available funding.

Are there any restrictions I should know about?

• Abstract requirement: A proposal will not be reviewed unless an abstract has been submitted and DARPA has issued an invitation to propose.

• Scope of work: Proposers may not propose work that they have already completed or that has already received funding or a positive funding decision from DARPA or another Government agency.

• Revolutionary advances only: Research that primarily yields evolutionary improvements to existing state of the art is explicitly excluded.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission under this BAA will likely take 120–160 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available to submit an abstract for a flat fee of $5,000.

Fractional support is $300 per hour, with most DARPA proposal projects requiring 80–100 hours of expert support from strategy through submission of full proposal.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

See solicitation on sam.gov

DARPA Microsystems Technology Office (MTO) Office-Wide BAA

Below is a brief summary. Please check the full solicitation before applying (link in resources section).

Executive Summary:

DARPA’s Microsystems Technology Office (MTO) is offering funding for revolutionary research across microelectronics, photonic circuits, quantum systems, biological/organic circuits, advanced manufacturing ecosystems, and dual-use microsystems. Multiple awards are anticipated, with no predefined funding limits. Abstracts are accepted until January 15, 2026, and proposals until March 2, 2026.

How much funding would I receive?

Funding amount is flexible. DARPA anticipates multiple awards, and efforts may span basic research (6.1), applied research (6.2), or advanced technology development (6.3). Proposers can also elect an Accelerated Award Option for awards under $2 million with 30-day award timelines.

What could I use the funding for?

Research areas of current interest to MTO include, but are not limited to, the following topics:

• Quantum circuits

  1. Interconnect technologies for transferring quantum states between qubit platforms

  2. Generalizable improvements for processing chain for all types of quantum sensors

  3. High density low loss mixed signal transfer between room and quantum temperatures

• Biological circuits

  1. High throughput molecular readers for full spectrum sequencing

  2. 3-dimensional bio-templated self-assembly of microsystems

  3. Highly-parallel DNA writing platforms for long DNA writes for genome-scale complexity with low error

• Photonic circuits

  1. Applications for purely photonic circuits not realizable in electronic circuits

  2. Chip scale photonics for ultralow noise microwave sources

  3. Tunable chip scale ultrafast (<10 ps) lasers

  4. Fiber-inspired ultralow loss integrated photonics

• Manufacturing Ecosystem

  1. Litho- and etch-free direct nanoscale semiconductor manufacturing

  2. Low-loss high permeability/permittivity materials

  3. High density cryogenic-to-room-temperature interconnects

  4. Atomically precise, multi-chemistry molecular manufacturing technologies

  5. Energy reclamation from low-grade waste heat

  6. Reconfigurable multiscale manufacturing for onshore manufacturing

• Dual Use by Design

  1. All-weather long distance high bandwidth communications

  2. Commercially relevant tool development challenge problems

  3. Conformal and malleable batteries

  4. Design and assembly of complex microsystems in supply-chain-free environments

  5. Reconfigurable additive manufacturing for multiple classes of materials

  6. Context aware imaging

Are there any additional benefits I would receive?

Beyond direct funding, awardees gain significant strategic advantages:

Government Validation & Credibility
DARPA selection signals elite technical quality and national-security relevance — often accelerating partnerships with primes, OEMs, and investors.

Enhanced Market Visibility
Awards frequently lead to increased visibility through DARPA communications, publications, and industry attention.

Ecosystem Access & Collaboration
Awardees join a national innovation community spanning quantum, photonics, microelectronics, and advanced materials — opening doors to long-term collaborations and follow-on opportunities.

Stronger Exit & Acquisition Potential
Non-dilutive support enables deep tech maturation without equity loss. Companies validated by DARPA historically see improved valuation, stronger commercial traction, and increased acquisition interest.

What is the timeline to apply and when would I receive funding?

Abstract Deadline: January 15, 2026, 1:00 PM ET

Proposal Deadline: March 2, 2026, 1:00 PM ET

DARPA reviews proposals on a rolling basis.

If you select the Accelerated Award Option (<$2M projects), DARPA may issue an award within 30 days of selection notification.

Where does this funding come from?

Funding comes from the Defense Advanced Research Projects Agency (DARPA) under the Microsystems Technology Office (STO).

Who is eligible to apply?

The BAA does not restrict eligibility. Typical DARPA BAAs accept proposals from:

• U.S. businesses of any size

• Universities

• Nonprofits

• Federally-funded research and development centers (with limitations)

Foreign entities may be subject to additional restrictions depending on classification and export-control considerations.

What companies and projects are likely to win?

DARPA will select proposals that score highly on scientific merit, mission relevance, and cost realism.

• High Scientific & Technical Merit: Innovative, feasible, and well-justified approaches with clear deliverables, identified risks and credible mitigations, and a team with the expertise to execute.

• Strong Contribution to DARPA’s Mission: Efforts that meaningfully advance U.S. national security capabilities, show a credible transition path to U.S. defense applications, and include an IP strategy that does not hinder government use.

• Realistic, Well-Substantiated Costs: Budgets that accurately reflect the level of effort, materials, labor, and technical scope—avoiding artificially low estimates and demonstrating efficient use of prior research and existing capabilities.

Are there any restrictions I should know about?

• Research must be revolutionary, not incremental.

• CMMC Level 2 is required for procurement contracts beginning Nov 10, 2025.

• Foreign influence and security review applies to fundamental research teams.

• Classified submissions require coordination with DARPA security.

• Export control and CUI restrictions apply.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission under this BAA will likely take 120–160 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available for a flat fee of $5,000 for the Abstract Submission.

Fractional support is $300 per hour, with most DARPA proposal projects requiring 80–100 hours of expert support from strategy through submission of full proposal.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

See solicitation on sam.gov

DARPA Strategic Technology Office-Wide Broad Agency Announcement (BAA)

Executive Summary:

DARPA’s Strategic Technology Office (STO) BAA is soliciting breakthrough research concepts that create new mission-level capabilities beyond the current state of practice. The agency will fund a limited number of high-risk, high-reward proposals across a broad range of defense and national-security technical domains. Applications are due December 19, 2025.

How much funding would I receive?

DARPA does not publish fixed award amounts for this BAA. STO funds a limited number of proposals, and budgets are determined by the technical approach, the scope of work, and alignment with STO priorities.

What could I use the funding for?

DARPA's STO seeks innovative ideas and disruptive technologies that provide the U.S. military and national security leaders with trusted, disruptive capabilities across all physical domains (Air, Space, Sea, and Land) and across the spectrum of competition. STO programs deliver solutions at speed and scale for today's warfighters while developing the resilient "breakthrough" systems and technologies needed for future battlespaces. STO does not focus on one area of responsibility or phenomenology. Rather, STO programs capture the strategic, logistical, and tactical complexity of today's national security environments. STO is a "systems office" seeking to create new "proof-of-concept" mission systems. Its goals are to develop and demonstrate new capabilities that expand what is technically possible.

Research areas of current interest to STO include, but are not limited to, the following topics:

•  Acoustic communication and sensing

•  Adaptability

•  Advanced computing

•  Additive manufacturing

•  Architecture and advanced systems engineering

•  Artificial intelligence

•  Autonomy and control algorithms

•  "Big data" analytics

•  Combat identification

•  Command and control (C2)

•  Communications and networking, virtual and adaptive

•  Complexity management

•  Critical infrastructure defense

•  Decision aids and C2 technology

•  DevOps and novel software development and integration

•  Directed energy (DE)

•  Distributed autonomy and teaming (machine-machine, human-machine)

•  Economic security

•  Effects chain functions (disaggregated find, fix, finish, target, engage, assess)

•  Electro-optic/infrared sensors

•  Electromagnetic warfare (EW)

•  High-frequency (HF) communications and sensing

•  High voltage electric power systems and architecture

•  Human behavior modeling

•  Human-machine symbiosis

•  Industrial engineering

•  Integration and reliability technologies

•  Interoperability

•  Logistics

•  Modeling and simulation

•  Microwave and millimeter wave communications and sensing

•  Novel kinetic effects

•  Non-kinetic effects (EW, DE, cyber)

•  Optical technologies

•  Photonics

•  Radio technologies (especially software-defined and novel waveforms and processing)

•  Radar and adaptive arrays

•  Resilient systems

•  Robotics

•  Seekers and other expendable sensors and processing

•  Sensors and analytics

•  Signal processing

•  Space sensors, communications, autonomy, and architectures (especially supporting proliferated low earth orbit constellations)

•  Strategy analysis technology

•  Supply chain analytics

•  System of systems

•  Undersea and seabed technology

•  Tactics development technology

•  Testing and data collection

•  Very low earth orbit (VLEO) technology

•  Very low frequency (VLF) technology

Are there any additional benefits I would receive?

Beyond the direct award, DARPA funding offers significant strategic advantages:

Government Validation and Credibility:
Receiving a DARPA award signals exceptional scientific and engineering merit, which accelerates engagement with primes, integrators, strategic partners, and investors.

Enhanced Visibility and Notoriety:
DARPA programs are frequently highlighted in federal communications, technical conferences, and defense media—boosting your company’s profile across the national security sector.

Ecosystem Access and Collaboration Opportunities:
Awardees gain access to DARPA program managers, government labs, test ranges, and a high-level innovation network—opening doors to future contracts and partnerships.

Stronger Exit and Acquisition Potential:
Nondilutive funding that matures breakthrough technology, combined with the DARPA “stamp,” often increases valuation and attractiveness to large defense, aerospace, semiconductor, and AI-focused acquirers.

What is the timeline to apply and when would I receive funding?

Applications are due December 19, 2025.

DARPA does not publish a fixed award timeline.

Where does this funding come from?

Funding comes from the Defense Advanced Research Projects Agency (DARPA) under the Strategic Technology Office (STO), a DoD organization responsible for advanced mission-level systems and emerging technologies.

Who is eligible to apply?

The BAA does not restrict eligibility. Typical DARPA BAAs accept proposals from:

• U.S. businesses of any size

• Universities

• Nonprofits

• Federally-funded research and development centers (with limitations)

Foreign entities may be subject to additional restrictions depending on classification and export-control considerations.

What companies and projects are likely to win?

DARPA will select proposals that score highly on scientific merit, mission relevance, and cost realism.

• High Scientific & Technical Merit: Innovative, feasible, and well-justified approaches with clear deliverables, identified risks and credible mitigations, and a team with the expertise to execute.

• Strong Contribution to DARPA’s Mission: Efforts that meaningfully advance U.S. national security capabilities, show a credible transition path to U.S. defense applications, and include an IP strategy that does not hinder government use.

• Realistic, Well-Substantiated Costs: Budgets that accurately reflect the level of effort, materials, labor, and technical scope—avoiding artificially low estimates and demonstrating efficient use of prior research and existing capabilities.

Are there any restrictions I should know about?

• Proposals must not duplicate existing STO programs or other active STO BAAs.

• Research that yields incremental or “evolutionary” improvements is specifically excluded.

• Offerors are strongly encouraged to review current STO programs and speak with program managers before applying.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission under this BAA will likely take 120–160 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available for a flat fee of $15,000 Project + a 5% Success Fee.

Fractional support is $300 per hour, with most DARPA proposal projects requiring 80–100 hours of expert support from strategy through submission of full proposal.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

See solicitation on sam.gov

DARPA Track at Big Distances with Track-Before-Detect (TBD2)

Executive Summary:

DARPA’s Strategic Technology Office (STO) is funding the Track at Big Distances with Track-Before-Detect (TBD2) program to develop advanced algorithms and payload designs for real-time space situational awareness in cislunar space. Selected teams may receive multi-million-dollar OTAs to build prototypes over a 15-month effort. Abstracts are due December 4, 2025, and companies should begin preparing materials now to meet the deadline.

How much funding would I receive?

DARPA anticipates multiple OTA prototype awards ranging from approximately $500K to $5M+, depending on technical scope, cost realism, and contribution to program goals. Larger awards are possible for high-complexity payload and algorithm development efforts.

What could I use the funding for?

1.Background

The goal of the TBD2 program is to enable continuous space-based detection and tracking of objects in cislunar space on relevant timelines. This effort will increase the safety of cislunar commercial and civilian traffic contributing to the peaceful use of space for the benefit of all nations and enabling a sustainable space ecosystem. To accomplish this, TBD2 seeks to advance the state of the art for signal processing algorithms so that when combined with commercial off-the-shelf (COTS) or quasi-COTS optical sensors and/or focal plane arrays (FPAs), they can a) detect and track faint objects at gigameter (Gm) distances, b) operate using available onboard processing capabilities, and c) do so on relevant timelines (within hours).

Figure 1: TBD2 seeks to extend space situational awareness beyond GEO to cislunar space

Existing space situational awareness (SSA) capabilities are primarily focused on objects in geosynchronous orbit (GEO) or closer. Extending SSA to cislunar space presents unique challenges as the distances are much greater and the volume of space needing to be scanned is ~1,200 times greater than GEO. Ground-based systems can combine large optics with complex, resource-intensive algorithms to enable cislunar detections, but are limited by their fixed location on the ground, inability to detect or track objects during hours of sunlight, and having to contend with weather and the Earth’s atmosphere. TBD2 seeks to solve this by moving the sensor to space, specifically to the Sun-Earth Lagrangian point 1 (SEL1) in order to negate any blinding of the sensor by the sun and enable a continuous view of most of cislunar space via a single sensor. To achieve this, TBD2 will require a novel approach to signal processing to detect faint objects (magnitude 23) at distances up to 2 Gigameter (Gm), while also minimizing processing time to the point that all cislunar space can be scanned within 12 hours. For a sensor at SEL1, sending image data to the ground for processing would require a continuous high-rate downlink that is impractical, if not infeasible, due to limitations in bandwidth, latency, energy budgets, and relative positions of the sensor and Earth. Therefore, TBD2 aims to develop or adapt signal processing algorithms that can be run in quasi-real time via onboard processing.

In addition to signal processing, TBD2 will also develop two distinct payload designs that optimize the combination of the signal processing with sensors/space-based compute platforms for two distinct scenarios: SEL1 and beyond GEO orbits. While SEL1 is of particular interest, alternate employment options could potentially enable a closer view of certain cislunar areas while also allowing for the detection and tracking of <1-meter objects that could endanger government, commercial or civil space operations. TBD2 will have three final deliverables:
1. The low complexity algorithm software implementation

2. Two payload designs that include the optics/sensor and compute platform combinations to be used for:

a. placement in SEL1.

b. placement in beyond GEO/cislunar orbits.

If successful, TBD2 will improve early warning capabilities for defense and civilian agencies who track potential threats and objects of interest originating from or transiting cislunar space, contributing to the safe and peaceful use of space for all nations. The fully developed signal processing algorithms capable of meeting program metrics and program goals and payload designs approved through Systems Requirements Review (SRR) constitute the Prototypes developed under the TBD2 Program.

TBD2 is a 15-month single-phase effort with two tasks.

Task 1 is to reduce the computational needs (and associated power consumption) of signal processing algorithms needed to detect faint moving objects at distances of millions of kilometers (km), and

Task 2 is to develop a payload design trade study that optimizes quasi-COTS sensors, onboard processors, and algorithms to achieve overall TBD2 goals.

1.2. Program Description/Scope
While many limitations of current approaches for cislunar SSA can be mitigated by placing sensors far from Earth (such as at SEL1), this introduces several technical challenges. Primarily, detecting and tracking faint moving resident space objects (RSOs) of 1 meter from SEL1 requires sensitivity levels capable of detecting objects as faint as 23 visual magnitude.

Achieving such sensitivity with quasi-COTS optics/sensors requires carefully optimized signal processing algorithms, which would traditionally be run via terrestrial compute platforms.

One theoretical path to achieving high sensitivity is through long integration times, stacking hundreds or thousands of image frames to boost signal-to-noise ratio (SNR), but this approach introduces latency which undermines achieving detection within appropriate timelines. While current synthetic tracking and track-before-detect algorithms can theoretically reach these sensitivities, they are computationally expensive—requiring around 300 Trillion Floating-Point Operations Per Second (TFLOPs) (FP32) to operate effectively from SEL1 with limited SNR loss. Addressing this compute need without compromising performance is the main goal of the TBD2 program.

There are several algorithms, generally belonging to the Track-Before-Detect family of Algorithms (TBDAs), developed for or adapted to the detection of faint moving objects in deep space – including near-Earth asteroids, main belt asteroids, and cislunar RSOs. While some methods linearly scale with the number of frames, pixels, and motion hypotheses, alternative strategies may yield sublinear or logarithmic scaling in some dimensions. TBD2 encourages the development of such efficient architectures to enable quasi–real-time onboard detection capability while also maintaining adequate performance.

TBD2 actively encourages exploration of innovative techniques, including but not limited to:

• Coarse-to-fine search methods (e.g., motion-aware pyramidal stacking).

• Radon transforms and their efficient approximations such as the Fast discrete X-ray Transform (FaXT).

• Probabilistic voting schemes to prune velocity hypothesis space over time.

• Techniques developed in the broader Infrared Search and Track (IRST) community combined with cislunar SSA algorithms to reduce complexity, e.g., exploiting their capability of treating hypothesized trajectories stochastically and pruning them early keeping complexity bounded, and their capability to operate at low SNR.

• Multi-sensor per platform designs, as multiple telescopes lower revisit time and reduce computational needs by reducing the number of pictures, shortening integration time, and reducing the number of hypothesized velocities.

DARPA is interested in the performance of TBD2 algorithms in several areas, and the government will provide data sets to test each of these areas individually as well as together. Some of the data sets provided will be real data from an optical sensor, others will be partially synthetic (i.e., real data with fake moving objects added to the data), and others will be totally synthetic data sets.

Data sets will be provided to each performer for “practice” with their approach, while additional data sets will be used for evaluating the algorithms. In general, the number of data sets provided for "practice" will not be sufficient for training Artificial Intelligence (AI)/Machine Learning (ML) algorithms, so AI/ML proposers are responsible for the training of their algorithms. If requested, the government team can provide guidance to each team on how to insert their own “fake” objects for training AI models. It is expected that, over the program period of performance, thousands of data cubes will be analyzed to collect performance statistics. The government has not finalized the data format yet, and the final data format may address discussions between selected performers and the government team.

At the midpoint and conclusion of the period of performance, performer algorithms will be evaluated on a government team-hosted platform to assess accuracy of detection and tracking of dim targets of various magnitudes and required computational power for quasi real-time execution. Each performer will need to provide an executable code that will be run on a common computer they will have access to. At the midpoint and final evaluations, approaches will be evaluated according to the program metrics (Section 1.5), but additional attributes will also be considered:

• Sensitivity vs. integration time tradeoffs.

• Peak TFLOPs and memory (gigabytes) required to store and process intermediate results.

• Astrometric accuracy (comparing output to limits imposed by optics, point spread function (PSF), and photon statistics; RSO velocity estimation accuracy, etc.).

• Weight and rough order of magnitude (ROM) cost of payload and bus.

In addition to the signal processing approaches, performers will be expected to develop two distinct payload designs: one for employment at SEL1, and another for employment in a beyond GEO/cislunar orbit. While SEL1 may be a good location to perform continuous cislunar SSA of ~1m sized RSOs, it is important to also explore additional options, such as orbits beyond GEO and around EMLs (Earth-Moon Lagrangians). These orbits offer closer views of the Moon and the Earth-Moon corridor thus allowing detection and tracking of smaller objects of magnitude 23 (10-20 cm at 200,000-400,000 km), as well as covering the remaining part of cislunar space that is obstructed from SEL1.

Four possible missions for the placements of a few TBD2 sensors include:

1. Monitoring the Earth-Moon corridor

2. Monitoring lunar orbits, including EML1 and EML2

3. Monitoring medium earth orbit (MEO)/GEO orbits

4. The small part of cislunar space that has an obstructed view from SEL1

The payload designs should suggest optimal optics and sensor, algorithm, and compute platform combinations for use at SEL1 and these additional orbits. Pursuing a single payload solution (optics and sensor plus compute platform combination) for the four cislunar missions identified above is strongly encouraged. These payload designs should consider aspects such as:

• Number of telescopes, optical aperture size, and sensor parameters

• SNR detection regimes (background-limited vs. read-noise-limited)

• Platform requirements for imaging at various integration times

• Required computational needs

• Consumed power

• Estimate of payload size, mass, power requirements

• Weight, power consumption, and ROM cost of payload and bus

For the payload design, factors such as payload mass and power consumption are of critical importance. For example, multi-sensor per platform designs are of interest as multiple telescopes reduce the number of pictures and shorten integration time, thus lowering revisit time and reducing the number of hypothesized velocities. Any proposed multi-telescope options would need to quantifiably justify the performance increase at the cost of mass and volume.

The payload designs will be evaluated near the end of the 15-month period of performance via a Systems Requirements Review (SRR) with the government team. This SRR will include examination and evaluation of the functional and performance requirements designed for the individual components (signal processing, computer platform, sensor) and overall payload of the two employment scenarios. The intent is that at the conclusion of the TBD2 program, the SRR-approved payload designs can be used to proceed with the initial system design by a transition partner.

Overall, at the completion of the 15-month period of performance for TBD2, the government’s expectation is to have prototypes of the fully developed signal processing algorithms capable of meeting program metrics and program goals and payload designs that have been approved through SRRs. This will pave the way for designing and building the payload after the end of the program.

Are there any additional benefits I would receive?

Beyond funding, TBD2 awardees gain significant strategic and reputational advantages:

DARPA Validation and Credibility:
Selection under DARPA’s STO signals exceptional technical capability and strategic relevance in defense and space innovation—often accelerating follow-on funding, partnerships, and investor confidence.

Enhanced Market Visibility:
DARPA-funded projects receive national-level attention in defense and aerospace circles, elevating recipients’ profiles as leading-edge space technology providers.

Ecosystem Access:
Participants collaborate with top experts in signal processing, optical sensing, and SSA, building direct connections to DoD transition partners and primes seeking flight-ready technologies.

Nondilutive Growth and Exit Value:
Because TBD2 is nondilutive federal funding, awardees retain IP ownership (with limited government-use rights), strengthening their valuation and commercial leverage for future acquisitions or private investment.

What is the timeline to apply and when would I receive funding?

• Abstracts Due: December 4, 2025, 12:00 PM ET

• Oral Presentation Invitations: by government request, estimated four weeks after abstract submission.

• Awards Announced: Early 2026

• Program Start: Upon award of OTA (15-month duration)

  Funding is typically issued shortly after OTA negotiation and execution, following DARPA’s oral presentation evaluations and selections.

Where does this funding come from?

Funding is provided by the Defense Advanced Research Projects Agency (DARPA) under its Strategic Technology Office (STO) through Other Transaction Agreements (OTAs) authorized under 10 U.S.C. § 4022 for prototype projects.ds.

Who is eligible to apply?

Eligible applicants include:

• Large and small businesses

• Nontraditional defense contractors (per 10 U.S.C. § 3014)

• Academic and research institutions (per 15 U.S.C. § 638(e)(8))

What companies and projects are likely to win?

DARPA will prioritize teams that demonstrate:

• Proven expertise in signal processing, AI/ML, or SSA algorithms.

• Ability to run real-time detection on space-qualified compute platforms with limited power (≤600W).

• Designs that integrate quasi-COTS optics and sensors with innovative onboard processing.

• Clear performance metrics and feasible payload trade studies for SEL1 and beyond-GEO orbits.
  Collaborations between algorithm developers, optical engineers, and hardware integrators are strongly favored.

1.5. TBD2 Goals, Metrics, and Constraints

The objective of TBD2 is to enable continued space-based detection and tracking of objects in cislunar space within appropriate revisit timelines, thereby increasing the safety of cislunar commercial and civilian traffic and contributing to the peaceful use of space for all nations. The proposed concept is to place optical sensor(s) beyond GEO and use algorithms with reduced computational needs that run on available onboard processing to achieve this, and the program metrics are focused on key parameters for achieving space situational awareness. This includes metrics for detection range and sensitivity, revisit times, and onboard processing power consumption, combined with the ability to achieve positive detections while minimizing the chance of false detections.

In addition to the metrics, several constraints are provided in order to guide proposer solutions. The first constraint is that performers should assume a value of 20% albedo or less (i.e. assume no more than 20% of light is reflected from the RSO’s surface) for all potential RSOs. The second is to have performers assume that their processing time must be equal or less than the integration time when developing their payload trade studies. The third constraint limits any proposed optical aperture to a maximum diameter of 0.5 meters.

Are there any restrictions I should know about?

• All work must be unclassified.

• Cost-sharing may be required only for traditional defense contractors without nontraditional partners.

• Export-controlled technologies must comply with U.S. export laws (ITAR/EAR).

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive abstract will likely take 40–60 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth.

How much would BW&CO Charge?

Our full service support is available for the Abstract for $4000. Assistance with Oral Presentation quoted upon invitation.

Fractional support is $300 per hour.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

View the Solicitation here.

DARPA Biological Technologies Office (BTO) Broad Agency Announcement

Executive Summary:

DARPA’s Biological Technologies Office (BTO) is accepting rolling proposals to fund transformative biology-enabled capabilities for national security. An abstract is required before a full proposal, and both abstracts and proposals are accepted until September 30, 2026. For selected proposals ≤$2,000,000 that opt into the accelerated path, awards can be made within 30 days of selection. Companies targeting this BAA should submit an abstract as soon as possible as they are reviewed on a rolling basis.

How much funding would I receive?

Funding levels are not pre-set; BTO anticipates multiple awards across topics. An optional accelerated award path is available for selected proposals not exceeding $2,000,000 total, using model agreements tailored for small and large businesses.

What could I use the funding for?

Research & Development proposals that leverage biological properties and processes to revolutionize our ability to protect the nation’s warfighters. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.

• General Topics

  • Biological and/or chemical technology topic areas that fit the national security scope of BTO’s mission.

  • Research into market opportunities, constraints, and communities affecting financing and commercialization of bioindustrial and biomedical technologies.

• Machine Learning (ML) and Artificial Intelligence (AI)

  • Developing and advancing our understanding of the impact and principles underlying biological data generation, assessment and incorporation into the biological foundation models, or mixed-mode foundation models. This includes taking theoretical approaches as well as understanding the scaling laws of these data for various types of models.

  • Advancing the capabilities of broad or narrow biological and/or chemical or mixed-mode foundation models far beyond the state of the art.

  • Developing and proving non-experimental models or hybrid experimental/non-experimental assessment strategies for biological foundation model assessment.

  • Exponentially accelerating the time scale of biological system simulation from the subcellular through multicellular, organismal and environmental systems, including for threat prediction, impact assessment, and attribution modeling.

  • Developing ML and AI-enabled technologies to improve the accuracy, precision, and efficiency of warfighter decision-making in complex and dynamic environments (e.g., on and off the battlefield), including for real-time threat assessment and response planning.

  • The development of virtual testbeds, digital twins, and/or synthetic data to accelerate or improve the predictive modeling of human performance.

• Combat Casualty Care

  • Developing novel diagnostic, prophylactic, and therapeutic approaches for warfighter injury that can be provided even in austere settings and extreme conditions.

  • Developing capabilities and technologies that enhance the ability of non-skilled service members to perform essential medical tasks closer to the point of injury, reducing dependence on highly trained personnel through assistive devices.

  • Developing decision support tools that algorithmically optimize the alignment of medical requirements and resources in complex, data-constrained mass casualty scenarios to enhance near-real-time situational awareness and command and control (C2) planning and execution.

  • Development of capabilities and technologies that enhance the ability of non-skilled service members to perform essential medical tasks closer to the point of injury, reducing dependence on highly trained personnel through assistive devices.

• Human Performance

  • Understanding and improving treatment of and resilience in neurological health, transformative neural processing, fatigue, cognition, and optimized human performance and teaming, including in extreme stress conditions.

  • Discovering interventions that utilize biotechnology, biochemistry, molecular biology, microbiology, neuroscience, psychology, cognitive science, social and behavioral science, and related disciplines to assess and optimize human performance and teaming.

  • Developing and leveraging technologies to advance continuous or near-continuous monitoring of physiology to elucidate mechanisms of human readiness, cognitive status, and resilience.

  • Understanding and improving interfaces between the biological and physical world to enable seamless biohybrid systems and devices.

  • Developing approaches to enhance physiological resilience, performance, and survivability in extreme conditions (e.g., cold weather, extreme heat, high altitude).

  • Identifying technologies and tactics to increase or accelerate the impact of training regimens while reducing the risk of injury.

• Materials, Sensors, Processing

  • Designing novel materials, sensors, or processes that mimic or are inspired by biological systems.

  • Creating tools such as foundation models or prediction engines to understand the underlying rules defining biomolecular and biomaterial or hybrid biotic/abiotic material structure/function properties (individual properties or groups of properties) in order to predict desired outcomes for novel material development. Importantly, these predictions should hold from the molecular scale to the macro scale.

  • Developing new computational and experimental tools and predictive capabilities for engineering of biological systems, such as cells, tissues, organs, organisms, and complex communities, to both develop new products and functional systems, as well as to gain new insights into underlying mechanisms.

  • Developing technologies to leverage biological systems and enhance the acquisition and maintenance of critical and strategic organic and inorganic materials.

  • Understanding and leveraging complex biological systems into underlying functional rules and processes to provide models that govern interactions of biological systems from biofilms to organs or ecosystems.

  • Developing new platform technologies that integrate, automate, and miniaturize the collection, processing, and analysis via direct or indirect interrogation of biological and chemical samples.

  • Developing hybrid biological/engineered systems that integrate biological organisms, components, biologically-encoded circuitry, biogenic materials, or exploit biological phenomena to surpass capabilities of abiotic equivalents.

  • Developing novel biological sensor platforms with reduced size, weight, and power requirements of equivalent electro-optical or electro-mechanical systems with orders of magnitude increase in equivalent performance.

• Security, Safety, and Surveillance

  • Developing new technologies and approaches to ensure the biosafety and biosecurity of biological hardware and data. Ensuring the safety and security of AI technologies that accelerate biological research and development processes.

  • Developing innovative technologies to detect, characterize, treat, prevent, and forecast the effects of novel, engineered, or natural emerging pathogens that have the potential to cause significant health, economic, and social burdens, to prevent their spread and enable understanding of their origin.

  • Developing ML, AI approaches, and advanced data analytics for the rapid analysis, interpretation, identification, attribution, and origin tracing of large-scale, disparate biological and environmental surveillance data streams, enabling anomaly detection, pattern recognition, scalable detection, and predictive analytics to identify emerging threats or anomalous events and provide early warning and anticipatory action against natural or manmade biological threats.

  • Advancing technologies for determination and attribution along with data provenance analysis at chemical, isotopic, genetic, and community structure levels.

  • Developing novel sensing, surveillance, and processing technologies (including in-situ and remote modalities) to detect, identify, monitor, and analyze weak biological signals of emerging pathogens (novel, engineered, or natural) at all scales, including their secondary effects on the environment.

  • Developing new technologies and data analytics to support next-generation surveillance, detection, identification, and attribution of human and agricultural pathogens at scale and in near real-time.

  • Developing novel in-situ or remote sensing and surveillance technologies at the global, regional, and local scale that detect and identify novel, engineered, and/or natural emerging pathogens to prevent their spread or understand their origin.

• Biomedical & Biodefense

  • Developing new technologies for rapid, automated, and resilient manufacturing, delivery, and distribution of critical molecules for applications in therapeutics, chemical, and biological defense.

  • Developing new technologies to support next-generation cellular therapeutic applications.

  • Developing new platform technologies for targeted, effective, spatiotemporally controlled delivery of large and small molecules and biologics.

  • Leveraging biotechnology to create new platform solutions that combat antimicrobial resistance, generate novel drug and cell-based therapeutics, and treat warfighter injury and illness.

Are there any additional benefits I would receive?

Beyond the formal award, there are significant indirect benefits to receiving a DARPA Biological Technologies Office (BTO) contract or agreement:

• Government Validation and Credibility:
  Being selected by DARPA—the Department of Defense’s premier innovation agency—signals extraordinary technical credibility and alignment with national security priorities. This “DARPA validation” often accelerates partnerships with primes, OEMs, and investors who trust government-vetted innovation.

• Enhanced Market Visibility and Notoriety:
  Award recipients frequently receive public recognition through DARPA announcements, defense innovation conferences, and press coverage. This visibility helps position your company as a cutting-edge player in defense biotech and deeptech, attracting further investment and talent.

• Ecosystem Access and Collaboration Opportunities:
  DARPA performers gain access to the BTO’s extensive network, including technical advisors, transition partners, and resources. These programs support contractor readiness, compliance, and downstream transition—opening doors to additional government and industry contracts.

• Nondilutive Growth and Strategic Leverage:
  Because funding is nondilutive, companies can scale and validate core technologies without giving up equity. This validation and maturity achieved under government sponsorship often lead to higher valuations and greater leverage in future fundraising or acquisition discussions.

• Faster Execution and Credible Track Record:
  With DARPA’s accelerated contracting path, companies can move from selection to award in as little as 30 days—establishing a record of execution under one of the most selective R&D programs in the world, which strengthens competitiveness for future federal or dual-use opportunities.

What is the timeline to apply and when would I receive funding?

Abstracts are accepted on a rolling basis until September 30, 2026, 4:00 PM ET (abstract and DARPA invitation are required before any full proposal).

Full proposals are accepted on a rolling basis until September 30, 2026, 4:00 PM ET.

Accelerated option (≤$2M) awards may be issued within 30 days of selection notification if you submit the required election/attestations and use the model agreement.

Where does this funding come from?

The Defense Advanced Research Projects Agency (DARPA), Biological Technologies Office

Who is eligible to apply?

All responsible sources—U.S. and non-U.S.—may submit, except FFRDCs, UARCs, and Government entities (incl. National Labs), which are not eligible as prime proposers. NAICS: 541714 (biotech R&D). Submissions must comply with U.S. security, export control, and related laws.

What companies and projects are likely to win?

The scoring criteria reward proposals that:

1. Present a bold, high-impact technical approach. Proposals that merely increment the state of practice are explicitly out-of-scope;

2. Directly advance DARPA’s national-security mission; and

3. Show credible cost/schedule realism with clear deliverables and risk-mitigation. Prior experience executing similar efforts and leveraging relevant prior research strengthen competitiveness.

Are there any restrictions I should know about?

• Abstract is mandatory; DARPA must invite a proposal before it will be reviewed.

• Compliance areas include CUI handling, cyber (e.g., NIST SP 800-171 assessments), export controls, and human/animal research approvals where applicable.

• Certain entities/equipment (e.g., Kaspersky, certain telecom/DRONE restrictions, ByteDance apps) are prohibited by clause.

How long will it take me to prepare an application?

For a first-time applicant, preparing a competitive submission under this BAA will likely take 120–160 hours in total.

How can BW&CO help?

Our team specializes in complex federal R&D proposals and can:

• Triple your likelihood of success through proven strategy and insider-aligned proposal development

• Reduce your time spent on the proposal by 50–80%, letting your team focus on technology and operations

• Ensure you are targeting the best opportunity for your project and positioning your company for long-term growth under Federal & State R&D Initiatives.

How much would BW&CO Charge?

Our full service support is available for a flat fee of $15,000 Project + a 5% Success Fee.

Fractional support is $300 per hour, with most DARPA proposal projects requiring 80–100 hours of expert support from strategy through submission of full proposal.

For startups, we offer a discounted rate of $250 per hour to make top-tier grant consulting more accessible while maintaining the same level of strategic guidance and proposal quality.

Additional Resources

• Webinar - New Biotech Funding: $2M from the DARPA BTO Office

• See solicitation on Grants.Gov